Effect of grapefruit juice on cyclosporine pharmacokinetics in renal transplant patients

Transplantation

Volumn 62, Issue 1, 1996, Pages 123-125

  Min, David I ^a   Ku, Yi Min ^a   Perry, Paul J ^b   Ukah, Ferdinand O ^b   Ashton, Kay ^b   Martin, Maureen F ^b   Hunsicker, Lawrence G ^b  

^a UNIVERSITY OF IOWA   (United States)

^b UNIVERSITY OF IOWA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOFLAVONOID; CYCLOSPORIN A;

ADULT; AGED; ARTICLE; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG COST; DRUG EXPOSURE; FEMALE; GASTROINTESTINAL ABSORPTION; HUMAN; KIDNEY GRAFT; MALE; PATIENT COMPLIANCE; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL;

ADULT; AGED; BEVERAGES; BIOLOGICAL AVAILABILITY; CITRUS; CYCLOSPORINE; CYTOCHROME P-450 ENZYME SYSTEM; FEMALE; HUMANS; KIDNEY TRANSPLANTATION; MALE; MIDDLE AGED; MIXED FUNCTION OXYGENASES;

EID: 0029890499     PISSN: 00411337     EISSN: None     Source Type: Journal    
DOI: 10.1097/00007890-199607150-00023     Document Type: Article

References (10)

1. Guengerich FP, Kim D. In vitro inhibition of dihydropyridine oxidation and aflatoxin B1 activation in human liver microsomes by naringenin and other bioflavonoids. Carcinogenesis 1990; 11: 2275.
2. Baily DG, Arnold JM, Munoz C, Spence JD. Grapefruit juice- felodipine interaction: mechanism, predictability, and effect of naringin. Clin Pharmacol Ther 1993; 53: 637.
3. Ptachcinski RJ, Venkataramanan R, Burckart GJ, et al. Clinical pharmacokinetics of cyclosporine. Clin Pharmacokinet 1986; 11: 107.
4. Kolars JC, Awni WM, Merion RM, Watkins PB. First-pass metabolism of cyclosporine by the gut. Lancet 1991; 338: 1488- 1490.
5. Wu CY, Benet LZ, Herbert MF, et al. Differentiation of absorption and first-pass gut and hepatic metabolism in humans: studies with cyclosporine. Clin Pharmacol Ther 1995; 58: 492-7
6. First MR, Schroeder TJ, Michael A, et al. Cyclosporine-ketoconazole interaction: long-term follow-up and preliminary results of a randomized trial. Transplantation 1993; 55: 1000.
7. Yee GC, Stanley DL, Pessa LJ, et al. Effect of grapefruit juice on blood cyclosporine concentration. Lancet 1995; 345: 955.
8. Ducharme MP, Warbasse LH, Edwards DJ. Disposition of intravenous and oral cyclosporine after administration with grapefruit juice. Clin Pharmacol Ther 1995; 57: 485.
9. Hollander A, van Rooij J, Lentjes E, et al. The effect of grapefruit juice on cyclosporine and prednisone metabolism in transplant patients. Clin Pharmacol Ther 1995; 57: 318.
10. Johnston A, Holt DW. Effect of grapefruit juice on blood cyclosporine concentration. Lancet 1995; 346: 122.