Grapefruit component interacting with rat and human P450 CYP3A: Possible involvement of non-flavonoid components in drug interaction

Biological and Pharmaceutical Bulletin

Volumn 20, Issue 5, 1997, Pages 560-564

  Fukuda, Katsuyuki ^a  

^a TOHOKU UNIVERSITY   (Japan)

Author keywords

CYP3A4; Cytochrome P450; Drug interaction; Flavonoid; Grapefruit juice; Human liver

Indexed keywords

ACETIC ACID ETHYL ESTER; AURANTIIN; CYTOCHROME P450; LIMONIN; NARINGENIN; OBACUNONE; TESTOSTERONE;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; GRAPE; HUMAN; HUMAN CELL; HYDROPHOBICITY; HYDROXYLATION; INHIBITION KINETICS; LIVER MICROSOME; NONHUMAN; OXIDATION; RAT;

EID: 0030913318     PISSN: 09186158     EISSN: None     Source Type: Journal    
DOI: 10.1248/bpb.20.560     Document Type: Article

References (2)

1. Bailey D., Edger B., Spence J. D., Munoz C., Arnold J. M. O., Clin. Pharmacol. Ther., 47, 180 (1990).
2. Bailey D. G., Spence J. D., Munoz C., Arnold J. M., Lancet, 337, 268-269 (1991).