Influence of functional polymorphisms of the MDR1 gene on vincristine pharmacokinetics in childhood acute lymphoblastic leukemia

Clinical Pharmacology and Therapeutics

Volumn 76, Issue 3, 2004, Pages 220-229

  Plasschaert, Sabine L A ^a   Groninger, Ellis ^a   Boezen, Marike ^a   Kema, Ido ^a   De Vries, Elisabeth G E ^a   Uges, Donald ^a   Veerman, Anjo J P ^b   Kamps, Willem A ^a   Vellenga, Edo ^a   De Graaf, Siebold S ^c   De Bont, Eveline S J M ^a,d  

^a UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

^b DUTCH CHILDHOOD ONCOLOGY GROUP   (Netherlands)

^c RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

^d UNIVERSITY OF GRONINGEN   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

ALLOPURINOL; ANTIBIOTIC AGENT; ASPARAGINASE; BISACODYL; CEPHALOSPORIN DERIVATIVE; CYTARABINE; DEXAMETHASONE; FUROSEMIDE; GLYCOPROTEIN P; LACTITOL; METHOTREXATE; MULTIDRUG RESISTANCE PROTEIN 1; PARACETAMOL; PREDNISOLONE; VINCRISTINE;

ACUTE LYMPHOBLASTIC LEUKEMIA; ADOLESCENT; AREA UNDER THE CURVE; ARTICLE; CHILD; CHILDHOOD LEUKEMIA; CONSTIPATION; DRUG CLEARANCE; DRUG ELIMINATION; DRUG HALF LIFE; DRUG SAFETY; FEMALE; GENETIC ANALYSIS; GENETIC POLYMORPHISM; GENETIC VARIABILITY; HAPLOTYPE; HUMAN; INAPPROPRIATE VASOPRESSIN SECRETION; INFANT; MAJOR CLINICAL STUDY; MALE; PARESTHESIA; PHARMACOLOGICAL PARAMETERS; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; RESTRICTION FRAGMENT LENGTH POLYMORPHISM; RISK ASSESSMENT; SIDE EFFECT; SINGLE NUCLEOTIDE POLYMORPHISM;

ADOLESCENT; CHILD; CHILD, PRESCHOOL; CYTOCHROME P-450 ENZYME SYSTEM; FEMALE; GENES, MDR; HAPLOTYPES; HUMANS; INFANT; LEUKEMIA, LYMPHOCYTIC, ACUTE, L1; MALE; POLYMORPHISM, GENETIC; POLYMORPHISM, SINGLE NUCLEOTIDE; RETROSPECTIVE STUDIES; VINCRISTINE;

EID: 4544275099     PISSN: 00099236     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.clpt.2004.05.007     Document Type: Article

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