Homozygous disruption of the mdr1a P-glycoprotein gene affects blood-nerve barrier function in mice administered with neurotoxic drugs

Acta Oto-Laryngologica

Volumn 121, Issue 6, 2001, Pages 735-742

  Saito, T ^a   Zhang, Z J ^a   Ohtsubo, T ^a   Noda, I ^a   Shibamori, Y ^a   Yamamoto, T ^a   Saito, H ^a  

^a UNIVERSITY OF FUKUI   (Japan)

Author keywords

Blood nerve barrier; Doxorubicin; P glycoprotein; Pharmacokinetics; Vinblastine

Indexed keywords

CISPLATIN; DOXORUBICIN; GLYCOPROTEIN P; NEUROTOXIN; VINBLASTINE; ABC TRANSPORTER; ANTINEOPLASTIC AGENT; MULTIDRUG RESISTANCE PROTEIN 3;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG TISSUE LEVEL; GENE DISRUPTION; HOMOZYGOSITY; IMMUNOHISTOCHEMISTRY; KNOCKOUT MOUSE; MALE; MOUSE; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; ANIMAL; BRAIN; CYTOLOGY; GENE EXPRESSION; GENETICS; HOMOZYGOTE; METABOLISM; MOUSE MUTANT; MULTIDRUG RESISTANCE; PERIPHERAL NERVE; VASCULAR ENDOTHELIUM;

ANIMALS; ANTINEOPLASTIC AGENTS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; ATP-BINDING CASSETTE TRANSPORTERS; BRAIN; DOXORUBICIN; DRUG RESISTANCE, MULTIPLE; ENDOTHELIUM, VASCULAR; GENE EXPRESSION; HOMOZYGOTE; IMMUNOHISTOCHEMISTRY; MALE; MICE; MICE, KNOCKOUT; P-GLYCOPROTEIN; P-GLYCOPROTEINS; PERIPHERAL NERVES; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; VINBLASTINE;

EID: 0034740948     PISSN: 00016489     EISSN: None     Source Type: Journal    
DOI: 10.1080/00016480152583683     Document Type: Article

References (25)

1. Cellular localization of the multidrug-resistance gene product p-glycoprotein in normal human tissues
2. The three mouse multidrug resistance (mdr) genes are expressed in a tissue-specific manner in normal mouse tissues
3. Differential over-expression of three mdr gene family members in multidrug-resistant J774.2 mouse cells
4. Two members of the mouse mdr gene family confer multidrug resistance with overlapping but distinct drug specificities
5. Multidrug-resistance gene (P-glycoprotein) is expressed by endothelial cells at blood-brain sites
6. Disruption of the mouse mdr1a p-glycoprotein gene leads to a deficiency in the blood-brain barrier and to increased sensitivity to drugs
7. Absence of the mdr1a p-glycoprotein in mice affects tissue distribution and pharmacokinetics of dexamethasone, digoxin, and cyclosporin A
8. Structure and function of the intraneurial microvessels as related to trauma, edema formation, and nerve function
9. Vascular permeability in the peripheral nervous system
10. The blood-brain barrier
11. Multidrug resistance
12. Expression and functional activity of p-glycoprotein in cultured cerebral capillary endothelial cells
13. Modulation of multidrug resistance: At the threshold
14. The blood-brain barrier to proteins under normal and pathological conditions
15. Functional involvement of p-glycoprotein in blood-brain barrier
16. Altered pharmacokinetics of vinblastine in mdr1a p-glycoprotein-deficient mice
17. P-glycoprotein in the blood-brain barrier of mice influences the brain penetration and pharmacological activity of many drugs
18. Penetration of dexamethasone into brain glucocorticoid targets is enhanced in mdr1a p-glycoprotein knockout mice
19. A morphometric study of intrafascicular vessels of mammalian sciatic nerve
20. Intraneural microcirculation
21. P-glycoprotein expression in capillary endothelial cells of the 7th and 8th nerves of guinea pig in relation to blood-nerve barrier sites
22. A single intravenous injection of doxorubicin (adriamycin®) induces sensory neuronopathy in rats
23. Disruption of mdr1a p-glycoprotein gene results in dysfunction of blood-inner ear barrier in mice
24. Neurotoxicity of selected drugs
25. Neurotoxicity of commonly antineoplastic agents