메뉴 건너뛰기




Volumn 5, Issue 1, 2008, Pages 49-56

Molecular biology of bone remodelling

Author keywords

Bone remodelling; Osteoblast; Osteoclast; Osteoimmunology

Indexed keywords

BETA CATENIN; BETA INTERFERON; CATHEPSIN K; FIBROBLAST GROWTH FACTOR; GELATINASE B; INTERLEUKIN 1; INTERLEUKIN 6; OSTEOCLAST DIFFERENTIATION FACTOR; PARATHYROID HORMONE; PROCOLLAGEN C PROTEINASE; SOMATOMEDIN C; TRANSCRIPTION FACTOR OSTERIX; TRANSCRIPTION FACTOR RUNX2; TRANSFORMING GROWTH FACTOR BETA; TUMOR NECROSIS FACTOR ALPHA; WNT PROTEIN;

EID: 45349091141     PISSN: 17248914     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Short Survey
Times cited : (137)

References (96)
  • 1
    • 34447132814 scopus 로고    scopus 로고
    • Skeletal remodelling in health and disease
    • Zaidi M. Skeletal remodelling in health and disease. Nature Med. 2007; 13:791-801.
    • (2007) Nature Med , vol.13 , pp. 791-801
    • Zaidi, M.1
  • 2
    • 33644872519 scopus 로고    scopus 로고
    • The new bone biology: Pathologic, molecular and clinical correlates
    • Cohen MM. The new bone biology: pathologic, molecular and clinical correlates. Am J Med Genetics. 2006;140A:2646-2706.
    • (2006) Am J Med Genetics , vol.140 A , pp. 2646-2706
    • Cohen, M.M.1
  • 3
    • 0002653562 scopus 로고    scopus 로고
    • The osteocyte
    • Bilezikian JP, Raisz LG, Rodan GA eds, London UK: Academic Press;
    • Nijweide PJ, Burger EH, Klein Nulend J, et al..The osteocyte. In: Bilezikian JP, Raisz LG, Rodan GA eds. Principles of bone biology. London UK: Academic Press; 1996:115-126.
    • (1996) Principles of bone biology , pp. 115-126
    • Nijweide, P.J.1    Burger, E.H.2    Klein Nulend, J.3
  • 4
    • 0023787477 scopus 로고
    • Differentiation of muscle, fat, cartilage, and bone from progenitor cells present in a bone derived clonal cell population: Effect of dexamethasone
    • Grigoriadis AE, Heersche JN, Aubin JE. Differentiation of muscle, fat, cartilage, and bone from progenitor cells present in a bone derived clonal cell population: effect of dexamethasone. J Cell Biol. 1988;106:2139-2151.
    • (1988) J Cell Biol , vol.106 , pp. 2139-2151
    • Grigoriadis, A.E.1    Heersche, J.N.2    Aubin, J.E.3
  • 5
    • 0026095878 scopus 로고
    • Clonal osteogenic cell lines express myogenic and adipocytic developmental potential
    • Yamaguchi A, Khan AJ. Clonal osteogenic cell lines express myogenic and adipocytic developmental potential. Calcif Tissue Int. 1991;49:221-225.
    • (1991) Calcif Tissue Int , vol.49 , pp. 221-225
    • Yamaguchi, A.1    Khan, A.J.2
  • 6
    • 14744275847 scopus 로고    scopus 로고
    • Regulation of osteoblastogenesis and bone mass by Wnt 10b
    • Bennett CN, Longo KA, Wright WS, et al. Regulation of osteoblastogenesis and bone mass by Wnt 10b. Proc Natl Acad Sci USA. 2005;102:3324-3329.
    • (2005) Proc Natl Acad Sci USA , vol.102 , pp. 3324-3329
    • Bennett, C.N.1    Longo, K.A.2    Wright, W.S.3
  • 7
    • 25844509347 scopus 로고    scopus 로고
    • Canonical WNT signalling promotes osteogenesis by directly stimulating RUNX2 gene expression
    • Gaur T, Lengner CJ, Hovhannisyan H, et al. Canonical WNT signalling promotes osteogenesis by directly stimulating RUNX2 gene expression. J Biol Chem. 2005;280:33132-33140.
    • (2005) J Biol Chem , vol.280 , pp. 33132-33140
    • Gaur, T.1    Lengner, C.J.2    Hovhannisyan, H.3
  • 8
    • 34250848174 scopus 로고    scopus 로고
    • Minireview: In vivo analysis of Wnt signalling in bone
    • Glass DA II and Karsenty G. Minireview: In vivo analysis of Wnt signalling in bone. Endocrinology. 2007;148:2630-2634.
    • (2007) Endocrinology , vol.148 , pp. 2630-2634
    • Glass II, D.A.1    Karsenty, G.2
  • 9
    • 0042204967 scopus 로고    scopus 로고
    • Transcriptional mechanisms in osteoblast differentiation and bone formation
    • Nakashima K, de Crombrugghe B. Transcriptional mechanisms in osteoblast differentiation and bone formation. Trends Genet. 2003; 19:458-466.
    • (2003) Trends Genet , vol.19 , pp. 458-466
    • Nakashima, K.1    de Crombrugghe, B.2
  • 10
    • 0030678549 scopus 로고    scopus 로고
    • Osf2/Cbfa1: A transcriptional activator of osteoblast differentiation
    • Ducy P, Zhang R, Geoffroy V, et al. Osf2/Cbfa1: a transcriptional activator of osteoblast differentiation. Cell. 1997;89:747-754.
    • (1997) Cell , vol.89 , pp. 747-754
    • Ducy, P.1    Zhang, R.2    Geoffroy, V.3
  • 11
    • 0036225281 scopus 로고    scopus 로고
    • Reaching a genetic and molecular understanding of skeletal development
    • Karsenty G, Wagner EF. Reaching a genetic and molecular understanding of skeletal development. Dev Cell. 2002;2:389-406.
    • (2002) Dev Cell , vol.2 , pp. 389-406
    • Karsenty, G.1    Wagner, E.F.2
  • 13
    • 0033560784 scopus 로고    scopus 로고
    • Cbfa1-dependent genetic pathway controls bone formation beyond embryonic development
    • Ducy P, Starbuck M, Priemel M, et al. Cbfa1-dependent genetic pathway controls bone formation beyond embryonic development. Genes and Development 1999;13:1025-1036.
    • (1999) Genes and Development , vol.13 , pp. 1025-1036
    • Ducy, P.1    Starbuck, M.2    Priemel, M.3
  • 14
    • 0035494469 scopus 로고    scopus 로고
    • Overexpression of Cbfa1 in osteoblasts inhibits osteoblast maturation and causes osteopenia with multiple fractures
    • Liu W, Toyosawa S, Furuichi T, et al. Overexpression of Cbfa1 in osteoblasts inhibits osteoblast maturation and causes osteopenia with multiple fractures. J Cell Biol. 2001;155:157-166.
    • (2001) J Cell Biol , vol.155 , pp. 157-166
    • Liu, W.1    Toyosawa, S.2    Furuichi, T.3
  • 15
    • 0030927622 scopus 로고    scopus 로고
    • Missense mutations abolishing DNA binding of the osteoblast-specific transcription factor OSF2/CBFA1 in cleidocranial dysplasia
    • Lee B, Thirunavukkarasu K, Zhou L, et al. Missense mutations abolishing DNA binding of the osteoblast-specific transcription factor OSF2/CBFA1 in cleidocranial dysplasia. Nat Genet. 1997;16: 307-310.
    • (1997) Nat Genet , vol.16 , pp. 307-310
    • Lee, B.1    Thirunavukkarasu, K.2    Zhou, L.3
  • 16
    • 0030894287 scopus 로고    scopus 로고
    • Heritable diseases of the skeleton. Part II: Molecular insights into skeletal development-matrix components and their homeostasis
    • Mundlos S, Olsen BR. Heritable diseases of the skeleton. Part II: molecular insights into skeletal development-matrix components and their homeostasis. FASEB J. 1997;11:227-233.
    • (1997) FASEB J , vol.11 , pp. 227-233
    • Mundlos, S.1    Olsen, B.R.2
  • 17
    • 33645226966 scopus 로고    scopus 로고
    • TNF promotes RUNX2 degradation through up-regulation of SMURF1 and SMURF2 in osteoblasts
    • Kaneki H, Guo R, Chen D, et al. TNF promotes RUNX2 degradation through up-regulation of SMURF1 and SMURF2 in osteoblasts. J Biol Chem. 2006;281:4326-4333.
    • (2006) J Biol Chem , vol.281 , pp. 4326-4333
    • Kaneki, H.1    Guo, R.2    Chen, D.3
  • 18
    • 0037059614 scopus 로고    scopus 로고
    • The novel zinc finger-containing transcription factor osterix is required for osteoblast differentiation and bone formation
    • Nakashima K, Zhou X, Kunkel G, et al. The novel zinc finger-containing transcription factor osterix is required for osteoblast differentiation and bone formation. Cell. 2002;108:17-29.
    • (2002) Cell , vol.108 , pp. 17-29
    • Nakashima, K.1    Zhou, X.2    Kunkel, G.3
  • 19
    • 23844515714 scopus 로고    scopus 로고
    • NFAT and Osterix cooperatively regulate bone formation
    • Koga T, Matsui Y, Asagiri M, et al. NFAT and Osterix cooperatively regulate bone formation. Nat Med. 2005;11:880-885.
    • (2005) Nat Med , vol.11 , pp. 880-885
    • Koga, T.1    Matsui, Y.2    Asagiri, M.3
  • 20
    • 5044228112 scopus 로고    scopus 로고
    • Wnt signalling in osteoblasts and bone diseases
    • Westendorf JJ, Kahler RA and Schroeder TM. Wnt signalling in osteoblasts and bone diseases. Gene. 2004;341:19-39.
    • (2004) Gene , vol.341 , pp. 19-39
    • Westendorf, J.J.1    Kahler, R.A.2    Schroeder, T.M.3
  • 21
    • 27144458524 scopus 로고    scopus 로고
    • Wnt signalling pathways: A new target for the treatment of osteoporosis
    • Rawadi G and Roman-Roman S. Wnt signalling pathways: a new target for the treatment of osteoporosis. Exp Opin Ther Targets. 2005;9:1063-1077.
    • (2005) Exp Opin Ther Targets , vol.9 , pp. 1063-1077
    • Rawadi, G.1    Roman-Roman, S.2
  • 22
    • 18044386744 scopus 로고    scopus 로고
    • LDL receptor-related protein 5 (LRP5) affects bone accrual and eye development
    • Gong Y, Slee RB, Fuki N, et al. LDL receptor-related protein 5 (LRP5) affects bone accrual and eye development. Cell. 2001; 107:513-523.
    • (2001) Cell , vol.107 , pp. 513-523
    • Gong, Y.1    Slee, R.B.2    Fuki, N.3
  • 23
    • 0037118285 scopus 로고    scopus 로고
    • High bone density due to a mutation in LDL-receptor-related protein 5
    • Boyden LM, Mao J, Belsky J, et al. High bone density due to a mutation in LDL-receptor-related protein 5. New Engl J Medicine. 2002;346:1513-1521.
    • (2002) New Engl J Medicine , vol.346 , pp. 1513-1521
    • Boyden, L.M.1    Mao, J.2    Belsky, J.3
  • 24
    • 0037373341 scopus 로고    scopus 로고
    • Six novel missense mutations in the LDL receptor-related proteins (LRP5) gene in different conditions with increased bone density
    • Van Wesenbeeck L, Cleiren E, Gram J, et al. Six novel missense mutations in the LDL receptor-related proteins (LRP5) gene in different conditions with increased bone density. Am J Human Genet. 2003;72:763-771.
    • (2003) Am J Human Genet , vol.72 , pp. 763-771
    • Van Wesenbeeck, L.1    Cleiren, E.2    Gram, J.3
  • 25
    • 33746808398 scopus 로고    scopus 로고
    • Wnt/b-catenin signalling in development and disease
    • Clevers H. Wnt/b-catenin signalling in development and disease. Cell. 2006;127:469-480.
    • (2006) Cell , vol.127 , pp. 469-480
    • Clevers, H.1
  • 26
    • 17044462159 scopus 로고    scopus 로고
    • Interaction between LRP5 and Frat1 mediates the activation of the Wnt canonical pathway
    • Hay E, Faucheu C, Suc-Royer I, et al. Interaction between LRP5 and Frat1 mediates the activation of the Wnt canonical pathway. J Biol Chem. 2005;280:13616-13623.
    • (2005) J Biol Chem , vol.280 , pp. 13616-13623
    • Hay, E.1    Faucheu, C.2    Suc-Royer, I.3
  • 27
    • 34250823973 scopus 로고    scopus 로고
    • Minireview: Targeting the Wnt/β-catenin pathway to regulate bone formation in the adult skeleton
    • Baron R and Rawadi G. Minireview: targeting the Wnt/β-catenin pathway to regulate bone formation in the adult skeleton. Endocrinology. 2007;148:2635-2643.
    • (2007) Endocrinology , vol.148 , pp. 2635-2643
    • Baron, R.1    Rawadi, G.2
  • 28
    • 0037030681 scopus 로고    scopus 로고
    • Kremen proteins are Dickkopf receptors that regulate Wnt/beta-catenin signalling
    • Mao B, Wu W, Davidson G, et al. Kremen proteins are Dickkopf receptors that regulate Wnt/beta-catenin signalling. Nature. 2002; 417:664-667.
    • (2002) Nature , vol.417 , pp. 664-667
    • Mao, B.1    Wu, W.2    Davidson, G.3
  • 29
    • 0026440993 scopus 로고
    • The mouse short ear skeletal morphogenesis locus is associated with defects in a bone morphogenetic member of the TGF beta superfamily
    • Kingsley DM, Bland AE, Grubber JM, et al. The mouse short ear skeletal morphogenesis locus is associated with defects in a bone morphogenetic member of the TGF beta superfamily. Cell. 1992; 71:399-410.
    • (1992) Cell , vol.71 , pp. 399-410
    • Kingsley, D.M.1    Bland, A.E.2    Grubber, J.M.3
  • 30
    • 0028232724 scopus 로고
    • Limb alterations in brachypodism mice due to mutations in a new member of the TGF beta-superfamily
    • Storm EE, Huynh TV, Copeland NG, et al. Limb alterations in brachypodism mice due to mutations in a new member of the TGF beta-superfamily. Nature. 1994;368:639-643.
    • (1994) Nature , vol.368 , pp. 639-643
    • Storm, E.E.1    Huynh, T.V.2    Copeland, N.G.3
  • 31
    • 0030763771 scopus 로고    scopus 로고
    • Disruption of human limb morphogenesis by a dominant negative mutation in CDMP1
    • Thomas JT, Kilpatrick MW, Lin K, et al. Disruption of human limb morphogenesis by a dominant negative mutation in CDMP1. Nat Genet. 1997;17:58-64.
    • (1997) Nat Genet , vol.17 , pp. 58-64
    • Thomas, J.T.1    Kilpatrick, M.W.2    Lin, K.3
  • 32
    • 0034455051 scopus 로고    scopus 로고
    • Regulation of osteoblast differentiation mediated by bone morphogenetic proteins, hedgehogs, and Cbfa1
    • Yamaguchi A, Komori T, Suda T. Regulation of osteoblast differentiation mediated by bone morphogenetic proteins, hedgehogs, and Cbfa1. Endocr Rev. 2000;21:393-411.
    • (2000) Endocr Rev , vol.21 , pp. 393-411
    • Yamaguchi, A.1    Komori, T.2    Suda, T.3
  • 33
    • 0029955512 scopus 로고    scopus 로고
    • Subcloning of three osteoblastic cell lines with distinct differentiation phenotypes from the mouse osteoblastic cell line KS-4
    • Yamashita T, Ishii H, Shimoda K, et al. Subcloning of three osteoblastic cell lines with distinct differentiation phenotypes from the mouse osteoblastic cell line KS-4. Bone. 1996;19:429-436.
    • (1996) Bone , vol.19 , pp. 429-436
    • Yamashita, T.1    Ishii, H.2    Shimoda, K.3
  • 34
    • 0016811449 scopus 로고
    • Bone resorption restored in osteopetrotic mice by transplants of normal bone marrow and spleen cells
    • Walker DG. Bone resorption restored in osteopetrotic mice by transplants of normal bone marrow and spleen cells. Science. 1975;190:784-785.
    • (1975) Science , vol.190 , pp. 784-785
    • Walker, D.G.1
  • 35
    • 0025049142 scopus 로고
    • Origin of osteoclasts: Mature monocytes and macrophages are capable of differentiating into osteoclasts under a suitable microenvironment prepared by bone marrow-derived stromal cells
    • Udagawa N, Takahashi N, Akatsu T, et al. Origin of osteoclasts: mature monocytes and macrophages are capable of differentiating into osteoclasts under a suitable microenvironment prepared by bone marrow-derived stromal cells. Proc Natl Acad Sci. USA. 1990;87:7260-7264.
    • (1990) Proc Natl Acad Sci. USA , vol.87 , pp. 7260-7264
    • Udagawa, N.1    Takahashi, N.2    Akatsu, T.3
  • 36
    • 0033398996 scopus 로고    scopus 로고
    • Commitment and differentiation of osteoclast precursor cells by sequential expression of c-Fms and receptor activator of nuclear kappaB (RANK) receptors
    • Arai F, Miyamoto T, Ohneda O, et al. Commitment and differentiation of osteoclast precursor cells by sequential expression of c-Fms and receptor activator of nuclear kappaB (RANK) receptors. J Exp Med. 1999;190:1741-1754.
    • (1999) J Exp Med , vol.190 , pp. 1741-1754
    • Arai, F.1    Miyamoto, T.2    Ohneda, O.3
  • 37
    • 0032545465 scopus 로고    scopus 로고
    • The involvement of multiple tumour necrosis factor receptor (TNFR)-associated factors in the signalling mechanisms of receptor activator of NF-κB, a member of the TNFR superfamily
    • Galibert L, Tometsko ME, Anderson DM, et al. The involvement of multiple tumour necrosis factor receptor (TNFR)-associated factors in the signalling mechanisms of receptor activator of NF-κB, a member of the TNFR superfamily. J Biol Chem. 1998;273:34120-34127.
    • (1998) J Biol Chem , vol.273 , pp. 34120-34127
    • Galibert, L.1    Tometsko, M.E.2    Anderson, D.M.3
  • 38
    • 0033582819 scopus 로고    scopus 로고
    • Activation of NF-κB by RANK requires tumor necrosis factor receptor-associated factor (TRAF) 6 and activation of NF-κB inducing kinase. Identification of a novel TRAF6 interaction motif
    • Darnay BG, NI J, Moore PA, et al. Activation of NF-κB by RANK requires tumor necrosis factor receptor-associated factor (TRAF) 6 and activation of NF-κB inducing kinase. Identification of a novel TRAF6 interaction motif. J Biol Chem. 1999;274:7724-7731.
    • (1999) J Biol Chem , vol.274 , pp. 7724-7731
    • Darnay, B.G.1    NI, J.2    Moore, P.A.3
  • 39
    • 15444381042 scopus 로고    scopus 로고
    • RANK-mediated amplification of TRAF6 signaling leads to NFATc1 induction during osteoclastogenesis
    • Gohda J, Akiyama T, Koga T, et al. RANK-mediated amplification of TRAF6 signaling leads to NFATc1 induction during osteoclastogenesis. EMBO J. 2005;24:790-799.
    • (2005) EMBO J , vol.24 , pp. 790-799
    • Gohda, J.1    Akiyama, T.2    Koga, T.3
  • 40
    • 0033561039 scopus 로고    scopus 로고
    • TRAF6 deficiency results in osteopetrosis and defective interleukin-1. CD40, and LPS signalling
    • Lomaga MA, Yeh WC, Sarosi I, et al. TRAF6 deficiency results in osteopetrosis and defective interleukin-1. CD40, and LPS signalling. Genes Dev. 1999;13:1015-1024.
    • (1999) Genes Dev , vol.13 , pp. 1015-1024
    • Lomaga, M.A.1    Yeh, W.C.2    Sarosi, I.3
  • 41
    • 6544270833 scopus 로고    scopus 로고
    • Severe osteopetrosis, defective interleukin-1 signalling and lymph node organogenesis in TRAF6-deficient mice
    • Naito A, Azuma S, Tanaka S, et al. Severe osteopetrosis, defective interleukin-1 signalling and lymph node organogenesis in TRAF6-deficient mice. Genes Cells. 1999;4:353-362.
    • (1999) Genes Cells , vol.4 , pp. 353-362
    • Naito, A.1    Azuma, S.2    Tanaka, S.3
  • 42
    • 0035868884 scopus 로고    scopus 로고
    • Segregation of TRAF6-mediated signalling pathwavs clarifies its role in osteoclastogenesis
    • Kobayashi N, Kadono Y, Naito A, et al. Segregation of TRAF6-mediated signalling pathwavs clarifies its role in osteoclastogenesis. EMBO J. 2001;20:1271-1280.
    • (2001) EMBO J , vol.20 , pp. 1271-1280
    • Kobayashi, N.1    Kadono, Y.2    Naito, A.3
  • 43
    • 0034735773 scopus 로고    scopus 로고
    • T cell-mediated regulation of osteoclastogenesis by signalling cross-talk between RANKL and IFN-γ
    • Takayanagi H, Ogasawara K, Mida S, et al. T cell-mediated regulation of osteoclastogenesis by signalling cross-talk between RANKL and IFN-γ. Nature 2000;408:600-605.
    • (2000) Nature , vol.408 , pp. 600-605
    • Takayanagi, H.1    Ogasawara, K.2    Mida, S.3
  • 44
    • 0037673945 scopus 로고    scopus 로고
    • Osteoclast differentiation and activation
    • Boyle WJ, Simonet WS, Lacey DL. Osteoclast differentiation and activation. Nature 2003;423:337-342.
    • (2003) Nature , vol.423 , pp. 337-342
    • Boyle, W.J.1    Simonet, W.S.2    Lacey, D.L.3
  • 45
    • 33845978138 scopus 로고    scopus 로고
    • Over-expression of activated NFATc1 plus RANKL rescues the osteoclastogenesis defect of NF-κB p50/p52 double knockout splenocytes
    • Li F, Matsuo K, Xing L, et al. Over-expression of activated NFATc1 plus RANKL rescues the osteoclastogenesis defect of NF-κB p50/p52 double knockout splenocytes. J Bone Miner Res. 2004;19:S2.
    • (2004) J Bone Miner Res , vol.19
    • Li, F.1    Matsuo, K.2    Xing, L.3
  • 46
    • 20144373896 scopus 로고    scopus 로고
    • Inhibition of RANKL-induced osteoclastogenesis by (-)-DHMEQ, a novel NF-κB inhibitor, through downregulation of NFATc1
    • Takatsuna H, Asagiri M, Kubota T, et al. Inhibition of RANKL-induced osteoclastogenesis by (-)-DHMEQ, a novel NF-κB inhibitor, through downregulation of NFATc1. J Bone Miner Res. 2005;20: 653-662.
    • (2005) J Bone Miner Res , vol.20 , pp. 653-662
    • Takatsuna, H.1    Asagiri, M.2    Kubota, T.3
  • 47
    • 27744432009 scopus 로고    scopus 로고
    • Autoamplification of NFATc1 expression determines its essential role in bone homeostasis
    • Asagiri M, Sato K, Usami T, et al. Autoamplification of NFATc1 expression determines its essential role in bone homeostasis. J Exp Med. 2005;202:1261-1269.
    • (2005) J Exp Med , vol.202 , pp. 1261-1269
    • Asagiri, M.1    Sato, K.2    Usami, T.3
  • 48
    • 0027070472 scopus 로고
    • Bone and haematopoietic defects in mice lacking c-fos
    • Wang ZQ, Ovitt C, Grigoriadis AE, et al. Bone and haematopoietic defects in mice lacking c-fos. Nature. 1992;360:741-745.
    • (1992) Nature , vol.360 , pp. 741-745
    • Wang, Z.Q.1    Ovitt, C.2    Grigoriadis, A.E.3
  • 49
    • 18744366041 scopus 로고    scopus 로고
    • Induction and activation of the transcription factor NFATc1 (NFAT2) integrate RANKL signalling for terminal differentiation of osteoclasts
    • Takayanagi H, Kim S, Koga T, et al. Induction and activation of the transcription factor NFATc1 (NFAT2) integrate RANKL signalling for terminal differentiation of osteoclasts. Dev Cell. 2002;3:889-901.
    • (2002) Dev Cell , vol.3 , pp. 889-901
    • Takayanagi, H.1    Kim, S.2    Koga, T.3
  • 50
    • 2942731511 scopus 로고    scopus 로고
    • Nuclear factor of activated T-cells (NFAT) rescues osteoclastogenesis in precursors lacking c-Fos
    • Matsuo K, Galson DL, Zhao C, et al. Nuclear factor of activated T-cells (NFAT) rescues osteoclastogenesis in precursors lacking c-Fos. J Biol Chem. 2004;279:26475-26480.
    • (2004) J Biol Chem , vol.279 , pp. 26475-26480
    • Matsuo, K.1    Galson, D.L.2    Zhao, C.3
  • 51
    • 33947497852 scopus 로고    scopus 로고
    • Osteoclasts: What do they do and how do they do it?
    • Teitelbaum SL. Osteoclasts: what do they do and how do they do it? Am J Pathol. 2007;170:427-435.
    • (2007) Am J Pathol , vol.170 , pp. 427-435
    • Teitelbaum, S.L.1
  • 52
    • 0031005576 scopus 로고    scopus 로고
    • Osteoprotegerin: A novel secreted protein involved in the regulation of bone density
    • Simonet WS, Lacey DL, Dunstan CR, et al. Osteoprotegerin: a novel secreted protein involved in the regulation of bone density. Cell. 1997;89:309-319.
    • (1997) Cell , vol.89 , pp. 309-319
    • Simonet, W.S.1    Lacey, D.L.2    Dunstan, C.R.3
  • 53
    • 33947583822 scopus 로고    scopus 로고
    • Osteoimmunology: Shared mechanisms and crosstalk between the immune and bone systems
    • Takayanagi H. Osteoimmunology: shared mechanisms and crosstalk between the immune and bone systems. Nature. 2007; 7:292-304.
    • (2007) Nature , vol.7 , pp. 292-304
    • Takayanagi, H.1
  • 54
    • 33645657715 scopus 로고    scopus 로고
    • Osteoimmunology: Interplay between the immune system and bone metabolism
    • Walsh MC, Kim N, Kadono Y, et al. Osteoimmunology: interplay between the immune system and bone metabolism. Ann Rev Immunol. 2006;24:33-63.
    • (2006) Ann Rev Immunol , vol.24 , pp. 33-63
    • Walsh, M.C.1    Kim, N.2    Kadono, Y.3
  • 55
    • 33748032383 scopus 로고    scopus 로고
    • Osteoclast, rheumatoid arthritis and osteoimmunology
    • Sato K and Takayanagi H. Osteoclast, rheumatoid arthritis and osteoimmunology. Curr Opin Rheumatol. 2006;18:419-426.
    • (2006) Curr Opin Rheumatol , vol.18 , pp. 419-426
    • Sato, K.1    Takayanagi, H.2
  • 56
    • 11144354330 scopus 로고    scopus 로고
    • Costimulatory signals mediated by the ITAM motif cooperate with RANKL for bone homeostasis
    • Koga T, Inui M, Inoue K, et al. Costimulatory signals mediated by the ITAM motif cooperate with RANKL for bone homeostasis. Nature. 2004;428:758-763.
    • (2004) Nature , vol.428 , pp. 758-763
    • Koga, T.1    Inui, M.2    Inoue, K.3
  • 57
    • 11144355389 scopus 로고    scopus 로고
    • The immunomodulatory adapter proteins DAP12 and Fc receptor γ chain (FcRg) regulate development of functional osteoclasts through the Syk tyrosine kinase
    • Mocsai A, Humphrey MB, Van Ziffle JA, et al. The immunomodulatory adapter proteins DAP12 and Fc receptor γ chain (FcRg) regulate development of functional osteoclasts through the Syk tyrosine kinase. Proc Natl Acad Sci USA 2004;101:6158-6163.
    • (2004) Proc Natl Acad Sci USA , vol.101 , pp. 6158-6163
    • Mocsai, A.1    Humphrey, M.B.2    Van Ziffle, J.A.3
  • 58
    • 0033304730 scopus 로고    scopus 로고
    • Modulation of osteoclast differentiation and function by the new members of the tumor necrosis factor receptor and ligand families
    • Suda T, Takahashi N, Udagawa N, et al. Modulation of osteoclast differentiation and function by the new members of the tumor necrosis factor receptor and ligand families. Endocr Rev. 1999; 20:345-357.
    • (1999) Endocr Rev , vol.20 , pp. 345-357
    • Suda, T.1    Takahashi, N.2    Udagawa, N.3
  • 59
    • 0034681337 scopus 로고    scopus 로고
    • Tumor necrosis factor-α induces differentiation of and bone resorption by osteoclasts
    • Azuma Y, Kaji K, Katogi R, et al. Tumor necrosis factor-α induces differentiation of and bone resorption by osteoclasts. J Biol Chem. 2000;275:4858-4864.
    • (2000) J Biol Chem , vol.275 , pp. 4858-4864
    • Azuma, Y.1    Kaji, K.2    Katogi, R.3
  • 60
    • 0034677177 scopus 로고    scopus 로고
    • Tumor necrosis factor alpha stimulates osteoclast differentiation by a mechanism independent of the ODF/RANKL-RANK interaction
    • Kobayashi K, Takahashi N, Jimi E, et al. Tumor necrosis factor alpha stimulates osteoclast differentiation by a mechanism independent of the ODF/RANKL-RANK interaction. J Exp Med. 2000;191: 275-286.
    • (2000) J Exp Med , vol.191 , pp. 275-286
    • Kobayashi, K.1    Takahashi, N.2    Jimi, E.3
  • 61
    • 24344433524 scopus 로고    scopus 로고
    • Osteoclast differentiation independent of the TRANCE-RANK-TRAF6 axis
    • Kim N, Kadono Y, Takami M, et al., Osteoclast differentiation independent of the TRANCE-RANK-TRAF6 axis. J Exp Med. 2005; 202:589-595.
    • (2005) J Exp Med , vol.202 , pp. 589-595
    • Kim, N.1    Kadono, Y.2    Takami, M.3
  • 62
    • 0037129205 scopus 로고    scopus 로고
    • RANKL maintains bone homeostasis through c-Fos dependent induction of interferon-β
    • Takayanagi H, Kim S, Matsuo K, et al. RANKL maintains bone homeostasis through c-Fos dependent induction of interferon-β. Nature 2002;416:744-749.
    • (2002) Nature , vol.416 , pp. 744-749
    • Takayanagi, H.1    Kim, S.2    Matsuo, K.3
  • 63
    • 0022348139 scopus 로고
    • Cell-mediated extracellular acidification and bone resorption: Evidence for a low pH in resorbing lacunae and localization of a 100-kD lysosomal membrane protein at the osteoclast ruffled border
    • Baron R, Neff L, Louvard D, et al. Cell-mediated extracellular acidification and bone resorption: evidence for a low pH in resorbing lacunae and localization of a 100-kD lysosomal membrane protein at the osteoclast ruffled border. J Cell Biol. 1985;101:2210-2222.
    • (1985) J Cell Biol , vol.101 , pp. 2210-2222
    • Baron, R.1    Neff, L.2    Louvard, D.3
  • 64
    • 0022636291 scopus 로고
    • Omeprazole, a specific inhibitor of H+-K+-ATPase, inhibits bone resorption in vitro
    • Tuukkanen J, Väänänen HK. Omeprazole, a specific inhibitor of H+-K+-ATPase, inhibits bone resorption in vitro. Calcif Tissue Int. 1986;38:123-125.
    • (1986) Calcif Tissue Int , vol.38 , pp. 123-125
    • Tuukkanen, J.1    Väänänen, H.K.2
  • 65
    • 0025744525 scopus 로고
    • Clear zone in osteoclast function: Role of podosomes in regulation of bone-resorbing activity
    • Teti A, Marchisio PC, Zallone AZ. Clear zone in osteoclast function: role of podosomes in regulation of bone-resorbing activity. Am J Physiol. 1991;261:C1-C7.
    • (1991) Am J Physiol , vol.261
    • Teti, A.1    Marchisio, P.C.2    Zallone, A.Z.3
  • 66
    • 0033621890 scopus 로고    scopus 로고
    • Mice lacking β3 integrins are osteosclerotic because of dysfunctional osteoclasts
    • McHugh KP, Hodivala-Dilke K, Zheng MH, et al. Mice lacking β3 integrins are osteosclerotic because of dysfunctional osteoclasts. J Clin Invest. 2000;105:433-440.
    • (2000) J Clin Invest , vol.105 , pp. 433-440
    • McHugh, K.P.1    Hodivala-Dilke, K.2    Zheng, M.H.3
  • 67
    • 0024461376 scopus 로고
    • Osteoclastic bone resorption by a polarized vacuolar proton pump
    • Blair HC, Teitelbaum SL, Ghiselli R, et al. Osteoclastic bone resorption by a polarized vacuolar proton pump. Science. 1989;245: 855-857.
    • (1989) Science , vol.245 , pp. 855-857
    • Blair, H.C.1    Teitelbaum, S.L.2    Ghiselli, R.3
  • 68
    • 0024990332 scopus 로고
    • Evidence for the presence of a proton pump of the vacuolar H(+)-ATPase type in the ruffled borders of osteoclasts
    • Väänänen HK, Karhukorpi EK, Sundquist K, et al. Evidence for the presence of a proton pump of the vacuolar H(+)-ATPase type in the ruffled borders of osteoclasts. J Cell Biol. 1990;111:1305-1311.
    • (1990) J Cell Biol , vol.111 , pp. 1305-1311
    • Väänänen, H.K.1    Karhukorpi, E.K.2    Sundquist, K.3
  • 69
    • 0025283402 scopus 로고
    • Biochemical characterization of an electrogenic vacuolar proton pump in purified chicken osteoclast plasma membrane vesicles
    • Bekker PJ, Gay CV. Biochemical characterization of an electrogenic vacuolar proton pump in purified chicken osteoclast plasma membrane vesicles. J Bone Miner Res. 1990;5:569-579.
    • (1990) J Bone Miner Res , vol.5 , pp. 569-579
    • Bekker, P.J.1    Gay, C.V.2
  • 70
    • 0033946477 scopus 로고    scopus 로고
    • Defects in TCIRG1 subunit of the vacuolar proton pump are responsible for a subset of human autosomal recessive osteopetrosis
    • Frattini A, Orchard PJ, Sobacchi C, et al. Defects in TCIRG1 subunit of the vacuolar proton pump are responsible for a subset of human autosomal recessive osteopetrosis. Nature Genet. 2000; 25:343-346.
    • (2000) Nature Genet , vol.25 , pp. 343-346
    • Frattini, A.1    Orchard, P.J.2    Sobacchi, C.3
  • 72
    • 0023092664 scopus 로고
    • Carbonic anhydrase isoenzymes in isolated rat peripheral monocytes, tissue macrophages, and osteoclasts
    • Sundquist KT, Leppilampi M, Järvelin K, et al. Carbonic anhydrase isoenzymes in isolated rat peripheral monocytes, tissue macrophages, and osteoclasts. Bone. 1987;8:33-38.
    • (1987) Bone , vol.8 , pp. 33-38
    • Sundquist, K.T.1    Leppilampi, M.2    Järvelin, K.3
  • 73
    • 0024534212 scopus 로고
    • Cytoplasmic pH regulator and chloride/bicarbonate exchange in avian osteoclasts
    • Teti A, Blair HC, Teitelbum SL, et al. Cytoplasmic pH regulator and chloride/bicarbonate exchange in avian osteoclasts. J Clin Invest. 1989;83:227-233.
    • (1989) J Clin Invest , vol.83 , pp. 227-233
    • Teti, A.1    Blair, H.C.2    Teitelbum, S.L.3
  • 74
    • 0025032364 scopus 로고
    • Purification of a stilbene sensitive chloride channel and reconstitution of chloride conductivity into phospholipid vesicles
    • Blair HC, Schlesinger PH. Purification of a stilbene sensitive chloride channel and reconstitution of chloride conductivity into phospholipid vesicles. Biochem Biophys Res Commun. 1990;171:920-925.
    • (1990) Biochem Biophys Res Commun , vol.171 , pp. 920-925
    • Blair, H.C.1    Schlesinger, P.H.2
  • 75
    • 0030802421 scopus 로고    scopus 로고
    • Characterization of the osteoclast ruffled border chloride channel and its role in bone resorption
    • Schlesinger PH, Blair HC, Teitelbaum SL, et al. Characterization of the osteoclast ruffled border chloride channel and its role in bone resorption. J Biol Chem. 1997;272:18636-18643.
    • (1997) J Biol Chem , vol.272 , pp. 18636-18643
    • Schlesinger, P.H.1    Blair, H.C.2    Teitelbaum, S.L.3
  • 76
    • 0035951282 scopus 로고    scopus 로고
    • Loss of the CIC-7 chloride channel leads to osteopetrosis in mice and man
    • Kornak U, Kasper D, Bosl MR, et al. Loss of the CIC-7 chloride channel leads to osteopetrosis in mice and man. Cell. 2001;104: 205-215.
    • (2001) Cell , vol.104 , pp. 205-215
    • Kornak, U.1    Kasper, D.2    Bosl, M.R.3
  • 77
    • 0032506007 scopus 로고    scopus 로고
    • Impaired osteoclastic bone resorption leads to osteopetrosis in cathepsin-K-deficient mice
    • Saftig P, Hunziker E, Wehmeyer O, et al. Impaired osteoclastic bone resorption leads to osteopetrosis in cathepsin-K-deficient mice. Proc Natl Acad Sci. USA 1998;95:13453-13458.
    • (1998) Proc Natl Acad Sci. USA , vol.95 , pp. 13453-13458
    • Saftig, P.1    Hunziker, E.2    Wehmeyer, O.3
  • 78
    • 0032859323 scopus 로고    scopus 로고
    • Cathepsin K knockout mice develop osteopetrosis due to a deficit in matrix degradation but not demineralization
    • Gowen M, Lazner F, Dodds R, et al. Cathepsin K knockout mice develop osteopetrosis due to a deficit in matrix degradation but not demineralization. J Bone Miner Res. 1999;14:1654-1663.
    • (1999) J Bone Miner Res , vol.14 , pp. 1654-1663
    • Gowen, M.1    Lazner, F.2    Dodds, R.3
  • 79
    • 0029809357 scopus 로고    scopus 로고
    • Pycnodysostosis, a lysosomal disease caused by cathepsin K deficiency
    • Gelb BD, Shi GP, Chapman HA, et al. Pycnodysostosis, a lysosomal disease caused by cathepsin K deficiency. Science 1996; 273:1236-1238.
    • (1996) Science , vol.273 , pp. 1236-1238
    • Gelb, B.D.1    Shi, G.P.2    Chapman, H.A.3
  • 80
    • 0029800843 scopus 로고    scopus 로고
    • A nonsense mutation in the cathepsin K gene observed in a family with pycnodysostosis
    • Johnson MR, Polymeropoulos MH, Vos HL, et al. A nonsense mutation in the cathepsin K gene observed in a family with pycnodysostosis. Genome Res. 1996;6:1050-1055.
    • (1996) Genome Res , vol.6 , pp. 1050-1055
    • Johnson, M.R.1    Polymeropoulos, M.H.2    Vos, H.L.3
  • 81
    • 8444226323 scopus 로고    scopus 로고
    • A scrutiny of matrix metalloproteinases in osteoclasts: Evidence for heterogeneity and for the presence of MMPs synthesized by other cells
    • Andersen TL, del Carmen Ovejero M, Kirkegaard T, et al. A scrutiny of matrix metalloproteinases in osteoclasts: evidence for heterogeneity and for the presence of MMPs synthesized by other cells. Bone 2004;3:1107-1119.
    • (2004) Bone , vol.3 , pp. 1107-1119
    • Andersen, T.L.1    del Carmen Ovejero, M.2    Kirkegaard, T.3
  • 82
    • 33750504877 scopus 로고    scopus 로고
    • Expression of MT1-MMP during deciduous tooth resorption in odontoclasts
    • Linsuwanont-Santiwong B, Takagi Y, Ohya K, et al. Expression of MT1-MMP during deciduous tooth resorption in odontoclasts. J Bone Miner Metab. 2006;24:447-453.
    • (2006) J Bone Miner Metab , vol.24 , pp. 447-453
    • Linsuwanont-Santiwong, B.1    Takagi, Y.2    Ohya, K.3
  • 83
    • 0021285154 scopus 로고
    • Chondroclasts and osteoclasts at subchondral sites of erosion in rheumatoid joint
    • Broomley M and Woolley DE. Chondroclasts and osteoclasts at subchondral sites of erosion in rheumatoid joint. Arthritis Rheum. 1984;27:968-975.
    • (1984) Arthritis Rheum , vol.27 , pp. 968-975
    • Broomley, M.1    Woolley, D.E.2
  • 84
    • 0033581952 scopus 로고    scopus 로고
    • Activated T cells regulate bone loss and joint destruction in adjuvant arthritis through osteoprotegerin ligand
    • Kong YY, Feige U, Sarosi I, et al. Activated T cells regulate bone loss and joint destruction in adjuvant arthritis through osteoprotegerin ligand. Nature. 1999;402:304-309.
    • (1999) Nature , vol.402 , pp. 304-309
    • Kong, Y.Y.1    Feige, U.2    Sarosi, I.3
  • 85
    • 0032739075 scopus 로고    scopus 로고
    • Suppression of arthritic bone destruction by adenovirus-mediated csk gene transfer to synoviocytes and osteoclasts
    • Takayanagi H, Huji T, Miyazaki T, et al. Suppression of arthritic bone destruction by adenovirus-mediated csk gene transfer to synoviocytes and osteoclasts. J Clin Invest. 1999;104:137-146.
    • (1999) J Clin Invest , vol.104 , pp. 137-146
    • Takayanagi, H.1    Huji, T.2    Miyazaki, T.3
  • 86
    • 45349094545 scopus 로고    scopus 로고
    • Inflammatory bone destruction and osteoimmunology
    • Takayanagi H. Inflammatory bone destruction and osteoimmunology. Curr Opin Rheumatol. 2006;18:419-426.
    • (2006) Curr Opin Rheumatol , vol.18 , pp. 419-426
    • Takayanagi, H.1
  • 88
    • 10744229008 scopus 로고    scopus 로고
    • Chloride channel CICN7 mutations are responsible for severe recessive, dominant and intermediate osteopetrosis
    • Frattini A, Pangrazio A, Susani L, et al. Chloride channel CICN7 mutations are responsible for severe recessive, dominant and intermediate osteopetrosis. J Bone Miner Res. 2003;18:1740-1747.
    • (2003) J Bone Miner Res , vol.18 , pp. 1740-1747
    • Frattini, A.1    Pangrazio, A.2    Susani, L.3
  • 89
    • 33644861728 scopus 로고    scopus 로고
    • CIC-7 requires Ostm1 as a beta-subunit to support bone resorption and lysosomal function
    • Lange PF, Wartosch L, Jentsch TJ, et al. CIC-7 requires Ostm1 as a beta-subunit to support bone resorption and lysosomal function. Nature. 2006;440:220-223.
    • (2006) Nature , vol.440 , pp. 220-223
    • Lange, P.F.1    Wartosch, L.2    Jentsch, T.J.3
  • 90
    • 0037393446 scopus 로고    scopus 로고
    • Grey-lethal mutation induces severe malignant autosomal recessive osteopetrosis in mouse and human
    • Chalhoub N, Benachenhou N, Raiapurohitam V, et al. Grey-lethal mutation induces severe malignant autosomal recessive osteopetrosis in mouse and human. Nat Med. 2003;9:399-406.
    • (2003) Nat Med , vol.9 , pp. 399-406
    • Chalhoub, N.1    Benachenhou, N.2    Raiapurohitam, V.3
  • 91
    • 33745507483 scopus 로고    scopus 로고
    • Mutation in OSTM1 (grey lethal) define a particularly severe form of autosomal recessive osteopetrosis with neural involvement
    • Pangrazio A, Poliani PL, Megarbane A, et al. Mutation in OSTM1 (grey lethal) define a particularly severe form of autosomal recessive osteopetrosis with neural involvement. J Bone Miner Res. 2006;21:1098-1105.
    • (2006) J Bone Miner Res , vol.21 , pp. 1098-1105
    • Pangrazio, A.1    Poliani, P.L.2    Megarbane, A.3
  • 92
    • 34547521058 scopus 로고    scopus 로고
    • Osteoclast-poor human osteopetrosis due to mutation in the gene encoding RANKL
    • Sobacchi C, Frattini A, Guerrini MM, et al. Osteoclast-poor human osteopetrosis due to mutation in the gene encoding RANKL. Nat Genet. 2007;39:960-962.
    • (2007) Nat Genet , vol.39 , pp. 960-962
    • Sobacchi, C.1    Frattini, A.2    Guerrini, M.M.3
  • 94
    • 34147150205 scopus 로고    scopus 로고
    • Involvement of PLEKHM1 in osteoclastic vesicular transport and osteopetrosis in incisors absent rats and humans
    • Van Wesenbeeck L, Odgren PR, Coxon FP, et al. Involvement of PLEKHM1 in osteoclastic vesicular transport and osteopetrosis in incisors absent rats and humans. J Clin Invest. 2007;117:919-930.
    • (2007) J Clin Invest , vol.117 , pp. 919-930
    • Van Wesenbeeck, L.1    Odgren, P.R.2    Coxon, F.P.3
  • 95
    • 0000758497 scopus 로고
    • Röntgenbilder einer seltenen Knockenerkrankung.
    • Albers-Schönberg HE. Röntgenbilder einer seltenen Knockenerkrankung. Munch Med Wochenschr. 1904;5:365-368.
    • (1904) Munch Med Wochenschr , vol.5 , pp. 365-368
    • Albers-Schönberg, H.E.1
  • 96
    • 37349108189 scopus 로고    scopus 로고
    • Genetics, pathogenesis and complications of osteopetrosis
    • Del Fattore A, Cappariello A, Teti A. Genetics, pathogenesis and complications of osteopetrosis. Bone. 2008;42:19-29.
    • (2008) Bone , vol.42 , pp. 19-29
    • Del Fattore, A.1    Cappariello, A.2    Teti, A.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.