Mice lacking β3 integrins are osteosclerotic because of dysfunctional osteoclasts

Journal of Clinical Investigation

Volumn 105, Issue 4, 2000, Pages 433-440

  McHugh, Kevin P ^a   Hodivala Dilke, Kairbaan ^b   Zheng, Ming Hao ^a,c   Namba, Noriyuki ^a   Jonathan, Lam ^a   Novack, Deborah ^a   Feng, Xu ^a   Ross, F Patrick ^a   Hynes, Richard O ^b   Teitelbaum, Steven L ^a,d  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b HOWARD HUGHES MEDICAL INSTITUTE   (United States)

^c Department of Orthopedic Surgery ^*  (Australia)

^d BARNES JEWISH HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA3 INTEGRIN; INTEGRIN; UNCLASSIFIED DRUG; BETA INTEGRIN; BETA5 INTEGRIN; FIBRINOGEN RECEPTOR; LEUKOCYTE ANTIGEN;

ANIMAL CELL; ARTICLE; BONE METABOLISM; BONE STRUCTURE; CELL FUNCTION; GENETIC ENGINEERING; KNOCKOUT MOUSE; MOUSE; NONHUMAN; OSTEOCLAST; OSTEOLYSIS; OSTEOSCLEROSIS; PRIORITY JOURNAL; ANIMAL; BONE MARROW CELL; CELL DIFFERENTIATION; CELL MOTION; CYTOLOGY; EXTRACELLULAR MATRIX; FEMUR; GENETICS; MACROPHAGE; METABOLISM; MOUSE MUTANT; SIGNAL TRANSDUCTION;

ANIMALS; ANTIGENS, CD; BONE MARROW CELLS; BONE RESORPTION; CELL DIFFERENTIATION; CELL MOVEMENT; EXTRACELLULAR MATRIX; FEMUR; INTEGRIN BETA CHAINS; INTEGRIN BETA3; INTEGRINS; MACROPHAGES; MICE; MICE, KNOCKOUT; OSTEOCLASTS; OSTEOSCLEROSIS; PLATELET MEMBRANE GLYCOPROTEINS; SIGNAL TRANSDUCTION;

EID: 0033621890     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI8905     Document Type: Article

References (26)

1. Lacey, D.L., et al. 1998. Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activation. Cell. 93:165-176.
2. Blair, H.C.,Teitelbaum, S.L., Ghiselli, R., and Gluck, S. 1989. Osteoclastic bone resorption by a polarized vacuolar proton pump. Science. 245:855-857.
3. Horton, M.A.,Taylor, M.L., Arnett, T.R., and Helfrich, M.H. 1991. Arggly-asp (RGD) peptides and the anti-vitronectin receptor antibody 23C6 inhibit dentine resorption and cell spreading by osteoclasts. Exp. Cell Res. 195:368-375.
4. Engleman, V.W., et al. 1997. A peptidomuneric antagonist of the αvβ3 integrin inhibits bone resorption in vitro and prevents osteoporosis in vivo. J. Clin. Invest. 99:2284-2292.
5. Nakamura, I., Tanaka, H., Rodan, G.A., and Duong, L.T. 1998. Echistatin inhibits the migration of murine prefusion osteoclasts and the formation of multinucleated osteoclast-like cells. Endocrinology. 139:5182-5193.
6. Storgard, C.M., et al. 1999. Decreased angiogenesis and arthritic disease in rabbits treated with an αvβ3 antagonist. J. Clin. Invest. 103:47-54.
7. Bader, B.L., Rayburn, H., Crowley, D., and Hynes, R.O. 1998. Extensive vasculogenesis, angiogenesis, and organogenesis precede lethality in mice lacking all alpha v integrins. Cell. 95:507-519.
8. Hodivala-Dilke, K.M., et al. 1999. β3 integrin-deficient mice are a model for Glanzmann thrombasthenia showing placental defects and reduced survival. J. Clin. Invest. 103:229-238.
9. Diaz-Gonzalez, F., Forsyth, J., Steiner, B., and Ginsberg, M.K. 1996. Trans-dominant inhibition of integrin function. Mol. Biol. Cell. 7:1939-1951.
10. Kitazawa, S., Ross, F.P., McHugh, K., and Teitelbaum, S.L. 1995. Interleukin-4 induces expression of the integrin αvβ3 via transacrivation of the β3 gene. J. Biol. Chem. 270:4115-4120.
11. Abu-Amer, Y., et al. 1998. Tumor necrosis factor-alpha activation of nuclear transcription factor-κB in marrow macrophages is mediated by c-Src tyrosine phosphorylation of 1κBα J. Biol. Chem. 273:29417-29423.
12. Abu-Amer, Y., Ross, F.P., Edwards, J., and Teitelbaum, S.L. 1997. Lipopolysaccharide-stimulated osteoclastogenesis is mediated by tumor necrosis factor via its p55 receptor. J. Clin. Invest. 100:1557-1565.
13. Clohisy, D.R., Bar-Shavit, Z., Chappel, J., and Teitelbaum, S.L. 1987. 1,25-Dihydroxyvitamin D3 modulates bone marrow macrophage precursor proliferation and differentiation: upregulation of the mannose receptor. J. Biol. Chem. 262:15922-15929.
14. McHugh, K.P., Teitelbaum, S.L., Kitazawa, S., and Ross, F.P. 2000. Cloning and characterization of the murine β3 integrin gene promoter: identification of an interleukin-4 responsive element and its regulation by Stat-6. J. Bone Miner. Res. In press.
15. Feng, X., Teitelbaum, S.L., Quiroz, M.,Towler, D.A., and Ross, F.P. 1999. Cloning of the murine β5 integrin subunit promoter. Identification of a novel sequence mediating granulocyte-macrophage colony-stimulating factor-dependent repression of β5 integrin gene transcription. J. Biol. Chem. 274:1366-1374.
16. Greenfield, E.M., et al. 1992. Avian osteoblast conditioned media stimulate bone resorption by targeting multinucleating osteoclast precursors. Calcif. Tissue Int. 51:317-323.
17. v-associated integrins on murine osteoclast precursors. Mol. Endocrinol. 12:1955-1962.
18. Coccia, P.F., et al. 1980. Successful bone-marrow transplantation for infantile malignant osteopetrosis. N. Engl. J. Med. 302:701-708.
19. Holtrop, M.E. 1991. Light and electron microscopic structure of osteoclasts. In Bone. B.K. Hall, editor. CRC Press. Boca Raton, FL. 1-29.
20. Schwartz, M.A., Schaller, M.D., and Ginsberg, M.H. 1995. Integrins: emerging paradigms of signal transduction. Annu. Rev. Cell Dev. Biol. 11:549-599.
21. Abu-Amer, Y., Ross, F.P., Schlesinger, P., Tondravi, M.M., and Teitelbaum, S.L. 1997. Substrate recognition by osteoclast precursors induces s-crc/microtubule association. J. Cell Biol. 137:247-258.
22. Duong, L.T., et al. 1998. PYK2 in osteoclasts is an adhesion kinase, localized in the sealing zone, activated by ligation of α(v)β3 integrin, and phosphorylated by src kinase. J. Clin. Invest. 102:881-892.
23. Cournot, G., et al. 1992. Mineral metabolism in infants with malignant osteopetrosis: heterogeneity in plasma 1,25-dihydroxyvitamin D levels and bone histology. J. Bone Miner. Res. 7:1-10.
24. Tondravi, M.M., et al. 1997. Targeted deletion of PU.1 induces osteopetrosis rescuable by bone marrow transplantation. Nature. 386:81-84.
25. Soriano, P., Montgomery, C., Geske, R., and Bradley, A. 1991. Targeted disruption of the c-src proto-oncogene loads to osteopetrosis in mice. Cell. 64:693-702.
26. Delmez, J.A., Dusso, A.S., Slatopolsky, E., and Teitelbaum, S.L. 1995. Modulation of renal osteodystrophy by extrarenal production of calcitriol. Am. J. Nephrol. 15:85-89.