Turn-off, drop-out: Functional state switching of cadherins

Developmental Dynamics

Volumn 224, Issue 1, 2002, Pages 18-29

  Lilien, Jack ^a   Balsamo, Janne ^a   Arregui, Carlos ^a   Xu, Gang ^a  

^a UNIVERSITY OF IOWA   (United States)

Author keywords

catenin; catenin; Cadherin; Cell cell adhesion; Epithelial mesenchymal transformation; p120ctn; Protein tyrosine kinase; PTP1B protein tyrosine phosphatase

Indexed keywords

ACTIN; BETA CATENIN; CADHERIN; CALCIUM; PHOSPHATASE; PROTEIN TYROSINE KINASE;

ANIMAL CELL; CELL ADHESION; CELL JUNCTION; CONTROLLED STUDY; DEPHOSPHORYLATION; EPITHELIUM; L CELL; MESENCHYME; MOLECULAR INTERACTION; MORPHOGENESIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RETINA NERVE CELL; REVIEW;

AMINO ACID SEQUENCE; ANIMALS; BETA CATENIN; CADHERINS; CYTOSKELETAL PROTEINS; HUMANS; INTERCELLULAR JUNCTIONS; MESODERM; MODELS, BIOLOGICAL; MOLECULAR SEQUENCE DATA; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; PROTEIN-TYROSINE-PHOSPHATASE; TRANS-ACTIVATORS;

EID: 0036234842     PISSN: 10588388     EISSN: None     Source Type: Journal    
DOI: 10.1002/dvdy.10087     Document Type: Review

References (128)

1. Cytomechanics of cadherin-mediated cell-cell adhesion
2. Inhibition of RhoA by p120 catenin
3. The p120 catenin family: Complex roles in adhesion, signaling and cancer
4. The cadherin superfamily: Diversity in form and function
5. ctn acts as an inhibitory regulator of cadherin function in colon carcinoma cells
6. Impaired integrin-mediated adhesion and signaling in fibroblasts expressing a dominant-negative mutant PTP1B
7. The non-receptor tyrosine kinase Fer mediates cross-talk between N-cadherin and β1-intergrin
8. Presenilin-1 binds cytoplasmic epithelial cadherin, inhibits cadherin/p120 association, and regulates stability and function of the cadherin/catenin adhesion complex
9. The non-receptor protein tyrosine phosphatase PTP1B binds to the cytoplasmic domain of N-cadherin and regulates the cadherin-actin linkage
10. Regulated binding of a PTP1B-like phosphatase to N-cadherin: Control of cadherin-mediated adhesion by dephosphorylation of β-catenin
11. Protein-tyrosine phosphatase 1B complexes with the insulin receptor in vivo and is tyrosine-phosphorylated in the presence of insulin
12. The transcription factor Snail is a repressor of E-cadherin gene expression in epithelial tumor cells
13. Identification of the proteintyrosine phosphatase 1B as the major phosphatase capable of dephosphorylating and activating c-Src in several human breast cancer cell lines
14. Loss of epithelial differentiation and gain of invasiveness correlates with tyrosine phosphorylation of the E-cadherin/beta-catenin complex in cells transformed with a temperature-sensitive v-SRC gene
15. Epithelial-mesenchymal transitions in cancer progression
16. Geldanamycin abrogates ErbB2 association with proteasome-resistant β-catenin in melanoma cells, increases β-catenin-E-cadherin association, and decreases β-catenin sensitive transcription
17. Induction and regulation of epithelial-mesenchymal transitions
18. Src and Ras are involved in separate pathways in epithelial cell scattering
19. The E-cadherin complex in invasion and metastasis
20. Homophilic binding of PTP mu, A receptor-type protein tyrosine phosphatase, can mediate cell-cell aggregation
21. Receptor protein tyrosine phosphatase PTPμ associates with cadherins and catenins in vivo
22. Dynamic interaction of PTPμ with multiple cadherins in vivo
23. Identification of the homophilic binding site of the receptor protein tyrosine phosphatase PTP mu
24. The small GTPases Rho and Rac are required for the establishment of cadherin-dependent cell-cell contacts
25. Regulation of cadherin function by Rho and Rac: Modulation by junction maturation and cellular context
26. PTP regulates N-cadherin-dependent neurite outgrowth
27. The role of E-cadherin and integrins in mesoderm differentiation and migration at the mammalian primitive streak
28. Tyrosine phosphorylation and src family kinases control keratinocyte cell-cell adhesion
29. The transcription factor Snail controls epithelial-mesenchymal transitions by repressing E-cadherin expression
30. A novel protein-tyrosine phosphatase related to the homotypically adhering κ and μ receptors
31. The two-handed E Box binding zinc finger protein SIP1 downregulates E-cadherin and induces invasion
32. A putative catenin-cadherin system mediates morphogenesis of the Caenorhabditis elegans embryo
33. ctn interacts with Kaiso, a novel BTB/POZ domain zinc finger transcription factor
34. Differential regulation of protein-tyrosine phosphatases by integrin aIIbb3 through cytoskeletal reorganization and tyrosine phosphorylation in human platelets
35. The nontransmembrane tyrosine phosphatase PTP-1B localizes to the endoplasmic reticulum via its 35 amino acid C-terminal sequence
36. Calpain-catalyzed cleavage and subcellular relocation of protein phosphotyrosine phosphatase 1B (PTP-1B) in human platelets
37. Association of human protein-tyrosine phosphatase k with members of the armadillo family
38. Ligand activation of over-expressed epidermal growth factor receptor results in colony dissociation and disturbed E-cadherin function in HSC-1 human cutaneous squamous carcinoma cells
39. Cdc42 and Rac1 regulate the interaction of IQGAP1 with β-catenin
40. Involvement of IQGAP1, and effector of Rac1 and Cdc42 GTPases, in cell-cell dissociation during cell scattering
41. Cell-cell adhesion mediated by a receptorlike protein tyrosine phosphatase
42. Presenilin-1 forms complexes with the cadherin/catenin cell-cell adhesion system and is recruited to intercellular and synaptic contacts
43. Adherens junctions and β-catenin-mediated cell signalling in a non-metazoan organism
44. P120 catenin affects cell motility via modulation of activity of Rho-family GTPases: A link between cell-cell contact formation and regulation of cell locomotion
45. p60v-SRC causes tyrosine phosphorylation and inactivation of the N-cadherin-catenin cell adhesion system
46. An overview of epithelio-mesenchymal transformation
47. The epidermal growth factor receptor modulates the interaction of E-cadherin with the actin cytoskeleton
48. Cadherin superfamily proteins in Caenorhabditis elegans and Drosophila melanogaster
49. Inactivation of the E-cadherin-mediated cell adhesion system in human cancers
50. Identification of a Hydra homologue of the β-catenin/plakoglobin/armadillo gene family
51. β-catenin mediates the interaction of the cadherin-catenin complex with epidermal growth factor receptor
52. Tyrosine phosphorylation of human keratinocyte β-catenin and plakoglobin reversibly regulates their binding to E-cadherin and α-catenin
53. The cadherin cytoplasmic domain is unstructured in the absence of β-catenin: A possible mechanism for regulating cadherin turnover
54. The structure of the beta-catenin/E-cadherin complex and the molecular basis diverse ligand recognition by beta-catenin
55. The evolution of cell adhesion
56. Effects of regulated expression of mutant RhoA and Rac1 small GTPases on the development of epithelial (MDCK) cell polarity
57. Genetic and biochemical dissection of protein linkages in the cadherincatenin complex
58. c-erbB-2 gene product directly associates with β-catenin and plakoglobin
59. Distinct regions of the cadherin cytoplasmic domain are essential for functional interaction with Gα12 and β-Catenin
60. Altered adhesions in ras-transformed breast epithelia
61. Tyrosine phosphorylation regulates the adhesions of ras-transformed breast epithelia
62. Regulation of embryonic cell adhesion by the cadherin cytoplasmic domain
63. Protein tyrosine kinases and cancer
64. Distinct β-catenins mediate adhesion and signaling functions in C. elegans
65. Role of IQGAP1, a target of the small GTPases Cdc42 and Rac1, in regulation of E-cadherin-mediated cell-cell adhesion
66. Cdc42, Rac1, and their effector IQGAP1 as molecular switches for cadherinmediated cell-cell adhesion
67. Association between a transmembrane protein tyrosine phosphatase and the cadherin-catenin complex
68. Evidence that tyrosine phosphorylation regulates N-cadherin turnover during retinal development
69. Casein kinase II phosphorylation of E-cadherin increases E-cadherin/beta-catenin interaction and strengthens cell-cell adhesion
70. Coordinate regulation of cadherin and integrin function by the chondroitin sulfate proteoglycan neurocan
71. IQGAP1 and calmodulin modulate E-cadherin function
72. cas
73. Cadherin-mediated cell-cell adhesion is perturbed by v-SRC tyrosine phosphorylation in metastatic fibroblasts
74. Pleiotrophin signals increased tyrosine phosphorylation of beta beta-catenin through inactivation of the intrinsic catalytic activity of the receptor-type protein tyrosine phosphatase beta/zeta
75. Purification of a 92-kD cytoplasmic protein tightly associated with the cell-cell adhesion molecule E-cadherin (uvomorulin): Characterization and extractability of the protein complex from the cell cytostructure
76. Interaction of Gα12 and Gα13 with the cytoplasmic domain of cadherin provides a mechanism for β-catenin release
77. A dileucine motif targets E-cadherin to the basolateral cell surface in Madin-Darby canine kidney and LLC-PK1 epithelial cells
78. Control of N-cadherin-mediated intercellular adhesion in migrating neural crest cells in vitro
79. Phosphorylation and free pool of β-catenin are regulated by tyrosine kinases and tyrosine phosphatases during epithelial cell migration
80. Direct association of presenilin-1 with β-catenin
81. Cell binding function of E-cadherin is regulated by the cytoplasmic domain
82. Recruitment and activation of Rac1 by the formation of E-cadherinmediated cell-cell adhesion sites
83. Neural crest emigration from the neural tube depends on regulated cadherin expression
84. Differential localization of VE-and N-cadherins in human endothelial cells: BE cadherin competes with N-cadherin for junctional localization
85. Protein tyrosine phosphatases in signal transduction
86. Phylogenetic analysis of the cadherin superfamily allows identification of six major subfamilies besides several solitary members
87. P120 catenin regulates the actin cytoskeleton via Rho family GTPases
88. Cadherin engagement regulates Rho family GTPases
89. Expressed recombinant cadherins mediate cell sorting in model systems
90. Localization of specificity determining sites in cadherin cell adhesion molecules
91. c-erbB-2 gene product associates with catenins in human cancer cells
92. The catalytic activity of the Src family kinases is required to disrupt cadherin-dependent cell-cell contacts
93. Altered cell adhesion activity by pervanadate due to the dissociation of α-catenin from the E-cadherin-catenin complex
94. ctn in v-Src transfected L cells depends on its association with E-cadherin and reduces adhesion activity
95. Uvomorulin-catenin complex formation is regulated by a specific cytoplasmic region of the cell adhesion molecule
96. PTP1B regulates neurite extension mediated by cell-cell and cell-matrix adhesion molecules
97. Wnt signaling in oncogenesis and embryogenesis: A look outside the nucleus
98. A new role for E12/E47 in the repression of E-cadherin expression and epithelial-mesenchymal transitions
99. Regulation of β-catenin structure and activity by tyrosine phosphorylation
100. Loss of E-cadherin expression in melanoma cells involves up-regulation of the transcriptional repressor Snail
101. The p120 catenin partner Kaiso is a DNA methylation-dependent transcriptional repressor
102. Essential tyrosine residues for interaction of the non-receptor protein-tyrosine phosphatase PTP1B with N-cadherin
103. A constitutively activated mutant of Gαq down-regulates EP-cadherin expression and decreases adhesion between ectodermal cells at gastrulation
104. Calcium-dependent signaling pathways in T cells
105. Involvement of the tyrosine kinase fer in cell adhesion
106. Regulation of E-cadherin/catenin association by tyrosine phosphorylation
107. Receptor tyrosine phosphatase R-PTP-kappa mediates homophilic binding
108. Leaving the neighborhood: Molecular mechanisms involved during epithelial-mesenchymal transition
109. Biochemical interactions in the Wnt pathway
110. The disruption of adherens junctions is associated with a decrease of E-cadherin phosphorylation by protein kinase CK2
111. Tyrosine phosphorylation of beta-catenin and plakoglobin enhanced by hepatocyte growth factor and epidermal growth factor in human carcinoma cells
112. Dominant negative inhibition of the association between β-catenin and c-erbB-2 by N-terminally deleted β-catenin suppresses the invasion and metastasis of cancer cells
113. Biosynthesis of the cell-cell adhesion molecule uvomorulin (E-cadherin) in Madin-Darby canine kidney epithelial cells
114. Cadherin sequences that inhibit betacatenin signaling: A study in yeast and mammalian cells
115. A short core region of E-cadherin is essential for catenin binding and is highly phosphorylated
116. Regulation of cell-cell adhesion by Rac andRho small G Proteins in MDCK cells
117. Two cell adhesion molecules, Nectin and Cadherin, interact through their cytoplasmic domain-associated proteins
118. V-SRC kinase shifts the cadherin-based cell adhesion from the strong to the weak state and beta-catenin is not required for the shift
119. Cadherins in embryonic and neural morphogenesis
120. ctn from E-cadherin disrupts strong adhesion
121. Membrane-cytoskeleton interactions with cadherin cell adhesion proteins: Roles of catenins as linker proteins
122. Molecular cloning and characterization of DdCAD-1, a Ca2+-dependent cell-cell adhesion molecule, in Dictyostelium discoideum
123. Identification of cadherin tyrosine residues that are phosphorylated and mediate Shc association
124. Cadherin superfamily genes: Functions, genomic organization, and neurologic diversity
125. ctn
126. The presenilin 1 protein is a component of a high molecular weight intracellular complex that contains β-catenin
127. ctn