Inhibition of Src family tyrosine kinases prevents lipopolysaccharide-induced hyporeactivity in isolated rat tail arteries

Vascular Pharmacology

Volumn 46, Issue 3, 2007, Pages 195-200

  Kox, Matthijs ^a,b   Wijetunge, Sumangali ^a   Pickkers, Peter ^b   Hughes, Alun D ^a  

^a NATIONAL HEART AND LUNG INSTITUTE   (United Kingdom)

^b RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

Lipopolysaccharide; PP1; Src family tyrosine kinases; SU6656; Vascular hyporeactivity

Indexed keywords

2,3 DIHYDRO 2 OXO 3 (4,5,6,7 TETRAHYDRO 1H INDOL 2 YLMETHYLENE) 1H INDOLE 5 SULFONIC ACID DIMETHYLAMIDE; 4 AMINO 7 TERT BUTYL 5 (4 METHYLPHENYL)PYRAZOLO[3,4 D]PYRIMIDINE; INDUCIBLE NITRIC OXIDE SYNTHASE; LIPOPOLYSACCHARIDE; PHENYLEPHRINE; POTASSIUM; PROTEIN TYROSINE KINASE; PROTEIN TYROSINE KINASE INHIBITOR;

ANIMAL TISSUE; ARTERY CONSTRICTION; ARTICLE; BLOOD VESSEL REACTIVITY; CONTROLLED STUDY; DRUG MECHANISM; DRUG TARGETING; IN VITRO STUDY; MALE; MYOGRAPHY; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RAT; SEPTIC SHOCK; TAIL ARTERY; WESTERN BLOTTING;

ANIMALS; ARTERIES; BLOTTING, WESTERN; ENDOTHELIUM, VASCULAR; ENZYME INHIBITORS; INDOLES; LIPOPOLYSACCHARIDES; MALE; MUSCLE CONTRACTION; NITRIC OXIDE SYNTHASE TYPE II; PHENYLEPHRINE; POTASSIUM; PYRAZOLES; PYRIMIDINES; RATS; RATS, WISTAR; SRC-FAMILY KINASES; SULFONAMIDES; TAIL; VASOCONSTRICTION; VASODILATION;

EID: 33846296979     PISSN: 15371891     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.vph.2006.10.004     Document Type: Article

References (39)

1. Akiyama T., Ishida J., Nakagawa S., Ogawara H., Watanabe S., Itoh N., Shibuya M., and Fukami Y. Genistein, a specific inhibitor of tyrosine-specific protein kinases. J. Biol. Chem. 262 (1987) 5592-5595
2. Bain J., McLauchlan H., Elliott M., and Cohen P. The specificities of protein kinase inhibitors: an update. Biochem. J. 371 (2003) 199-204
3. Bermejo A., Zarzuelo A., and Duarte J. In vivo vascular effects of genistein on a rat model of septic shock induced by lipopolysaccharide. J. Cardiovasc. Pharmacol. 42 (2003) 329-338
4. Blake R.A., Broome M.A., Liu X., Wu J., Gishizky M., Sun L., and Courtneidge S.A. SU6656, a selective src family kinase inhibitor, used to probe growth factor signaling. Mol. Cell. Biol. 20 (2000) 9018-9027
5. Brun-Buisson C., Doyon F., Carlet J., Dellamonica P., Gouin F., Lepoutre A., Mercier J.C., Offenstadt G., and Regnier B. Incidence, risk factors, and outcome of severe sepsis and septic shock in adults. A multicenter prospective study in intensive care units. French ICU Group for Severe Sepsis. JAMA 274 (1995) 968-974
6. Fan H., Teti G., Ashton S., Guyton K., Tempel G.E., Halushka P.V., and Cook J.A. Involvement of G(i) proteins and Src tyrosine kinase in TNFalpha production induced by lipopolysaccharide, group B Streptococci and Staphylococcus aureus. Cytokine 22 (2003) 126-133
7. Fatehi M., Anvari K., and Fatehi-Hassanabad Z. The beneficial effects of protein tyrosine kinase inhibition on the circulatory failure induced by endotoxin in the rat. Shock 18 (2002) 450-455
8. Hanke J.H., Gardner J.P., Dow R.L., Changelian P.S., Brissette W.H., Weringer E.J., Pollok B.A., and Connelly P.A. Discovery of a novel, potent, and Src family-selective tyrosine kinase inhibitor. Study of Lck- and FynT-dependent T cell activation. J. Biol. Chem. 271 (1996) 695-701
9. Hernanz R., Alonso M.J., Zibrandtsen H., Alvarez Y., Salaices M., and Simonsen U. Measurements of nitric oxide concentration and hyporeactivity in rat superior mesenteric artery exposed to endotoxin. Cardiovasc. Res. 62 (2004) 202-211
10. Hughes A.D., and Wijetunge S. Role of tyrosine phosphorylation in excitation-contraction coupling in vascular smooth muscle. Acta Physiol. Scand. 164 (1998) 457-469
11. Joly G.A., Ayres M., and Kilbourn R.G. Potent inhibition of inducible nitric oxide synthase by geldanamycin, a tyrosine kinase inhibitor, in endothelial, smooth muscle cells, and in rat aorta. FEBS Lett. 403 (1997) 40-44
12. Julou-Schaeffer G., Gray G.A., Fleming I., Schott C., Parratt J.R., and Stoclet J.C. Loss of vascular responsiveness induced by endotoxin involves L-arginine pathway. Am. J. Physiol. 259 (1990) H1038-H1043
13. 2+ channel isoforms in murine colon: effect of inflammation. Pflugers Arch. 449 (2004) 288-297
14. Kefalas P., Brown T.R., and Brickell P.M. Signalling by the p60c-src family of protein-tyrosine kinases. Int. J. Biochem. Cell Biol. 27 (1995) 551-563
15. Lee J.Y., Lowell C.A., Lemay D.G., Youn H.S., Rhee S.H., Sohn K.H., Jang B., Ye J., Chung J.H., and Hwang D.H. The regulation of the expression of inducible nitric oxide synthase by Src-family tyrosine kinases mediated through MyD88-independent signaling pathways of Toll-like receptor 4. Biochem. Pharmacol. 70 (2005) 1231-1240
16. Lowell C.A., and Berton G. Resistance to endotoxic shock and reduced neutrophil migration in mice deficient for the Src-family kinases Hck and Fgr. Proc. Natl. Acad. Sci. U. S. A. 95 (1998) 7580-7584
17. Marczin N., Papapetropoulos A., and Catravas J.D. Tyrosine kinase inhibitors suppress endotoxin- and IL-1 beta-induced NO synthesis in aortic smooth muscle cells. Am. J. Physiol. 265 (1993) H1014-H1018
18. Mukundan L., Milhorn D.M., Matta B., and Suttles J. CD40-mediated activation of vascular smooth muscle cell chemokine production through a Src-initiated, MAPK-dependent pathway. Cell. Signal. 16 (2004) 375-384
19. Mulvany M.J., and Aalkjaer C. Structure and function of small arteries. Physiol. Rev. 70 (1990) 921-961
20. Mulvany M.J., and Halpern W. Contractile properties of small arterial resistance vessels in spontaneously hypertensive and normotensive rats. Circ. Res. 41 (1977) 19-26
21. Napolitani G., Bortoletto N., Racioppi L., Lanzavecchia A., and D'Oro U. Activation of src-family tyrosine kinases by LPS regulates cytokine production in dendritic cells by controlling AP-1 formation. Eur. J. Immunol. 33 (2003) 2832-2841
22. O'Brien A.J., Wilson A.J., Sibbald R., Singer M., and Clapp L.H. Temporal variation in endotoxin-induced vascular hyporeactivity in a rat mesenteric artery organ culture model. Br. J. Pharmacol. 133 (2001) 351-360
23. O'Brien A.J., Thakur G., Buckley J.F., Singer M., and Clapp L.H. The pore-forming subunit of the K(ATP) channel is an important molecular target for LPS-induced vascular hyporeactivity in vitro. Br. J. Pharmacol. 144 (2005) 367-375
24. Parrillo J.E., Parker M.M., Natanson C., Suffredini A.F., Danner R.L., Cunnion R.E., and Ognibene F.P. Septic shock in humans. Advances in the understanding of pathogenesis, cardiovascular dysfunction, and therapy. Ann. Intern. Med. 113 (1990) 227-242
25. Rosselet A., Feihl F., Markert M., Gnaegi A., Perret C., and Liaudet L. Selective iNOS inhibition is superior to norepinephrine in the treatment of rat endotoxic shock. Am. J. Respir. Crit. Care Med. 157 (1998) 162-170
26. Ruetten H., and Thiemermann C. Effects of tyrphostins and genistein on the circulatory failure and organ dysfunction caused by endotoxin in the rat: a possible role for protein tyrosine kinase. Br. J. Pharmacol. 122 (1997) 59-70
27. Santti R., Makela S., Strauss L., Korkman J., and Kostian M.L. Phytoestrogens: potential endocrine disruptors in males. Toxicol. Ind. Health 14 (1998) 223-237
28. Schwartz D., Brasowski E., Raskin Y., Schwartz I.F., Wolman Y., Blum M., Blantz R.C., and Iaina A. The outcome of non-selective vs selective nitric oxide synthase inhibition in lipopolysaccharide treated rats. J. Nephrol. 14 (2001) 110-114
29. Severgnini M., Takahashi S., Tu P., Perides G., Homer R.J., Jhung J.W., Bhavsar D., Cochran B.H., and Simon A.R. Inhibition of the Src and Jak kinases protects against lipopolysaccharide-induced acute lung injury. Am. J. Respir. Crit. Care Med. 171 (2005) 858-867
30. Soloviev A., Lehen'kyi V., Zelensky S., and Hellstrand P. Nitric oxide relaxes rat tail artery smooth muscle by cyclic GMP-independent decrease in calcium sensitivity of myofilaments. Cell Calcium 36 (2004) 165-173
31. Suba E.A., McKenna T.M., and Williams T.J. In vivo and in vitro effects of endotoxin on vascular responsiveness to norepinephrine and signal transduction in the rat. Circ. Shock 36 (1992) 127-133
32. Waitkus-Edwards K.R., Martinez-Lemus L.A., Wu X., Trzeciakowski J.P., Davis M.J., Davis G.E., and Meininger G.A. alpha(4)beta(1) Integrin activation of L-type calcium channels in vascular smooth muscle causes arteriole vasoconstriction. Circ. Res. 90 (2002) 473-480
33. Whitesell L., Mimnaugh E.G., De C.B., Myers C.E., and Neckers L.M. Inhibition of heat shock protein HSP90-pp60v-src heteroprotein complex formation by benzoquinone ansamycins: essential role for stress proteins in oncogenic transformation. Proc. Natl. Acad. Sci. U. S. A. 91 (1994) 8324-8328
34. Wijetunge S., and Hughes A.D. pp60c-src increases voltage-operated calcium channel currents in vascular smooth muscle cells. Biochem. Biophys. Res. Commun. 217 (1995) 1039-1044
35. Wijetunge S., Lymn J.S., and Hughes A.D. Effects of protein tyrosine kinase inhibitors on voltage-operated calcium channel currents in vascular smooth muscle cells and pp60(c-src) kinase activity. Br. J. Pharmacol. 129 (2000) 1347-1354
36. i) and tyrosine phosphorylation in adhesion of cultured vascular smooth muscle cells to fibrinogen. Cardiovasc. Res. 39 (1998) 475-484
37. + channel activity by tyrosine kinase inhibitors in vascular smooth muscle cell. Eur. J. Pharmacol. 290 (1995) 117-123
38. Yamashita T., Kawashima S., Ohashi Y., Ozaki M., Ueyama T., Ishida T., Inoue N., Hirata K., Akita H., and Yokoyama M. Resistance to endotoxin shock in transgenic mice overexpressing endothelial nitric oxide synthase. Circulation 101 (2000) 931-937
39. Yun B.G., and Matts R.L. Differential effects of Hsp90 inhibition on protein kinases regulating signal transduction pathways required for myoblast differentiation. Exp. Cell Res. 307 (2005) 212-223