Synthesis and surface expression of CD14 by human endothelial cells

Infection and Immunity

Volumn 69, Issue 1, 2001, Pages 479-485

  Jersmann, H P A ^a   Hii, C S T ^a   Hodge, G L ^a   Ferrante, A ^a  

^a WOMEN S AND CHILDREN S HOSPITAL   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

CD14 ANTIGEN; LIPOPOLYSACCHARIDE; LYSOPHOSPHATIDIC ACID; METHIONINE; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY CD14; UNCLASSIFIED DRUG;

ANTIGEN EXPRESSION; ARTICLE; CELL ACTIVATION; CELL SURFACE; CONTROLLED STUDY; ENDOTHELIUM CELL; GRAM NEGATIVE BACTERIUM; HUMAN; HUMAN CELL; MONOCYTE; PRIORITY JOURNAL; PROTEIN SYNTHESIS; SEPSIS; TISSUE CULTURE; UMBILICAL VEIN; VASCULAR ENDOTHELIUM;

ANIMALS; ANTIGENS, CD14; CYCLOHEXIMIDE; ENDOTHELIUM, VASCULAR; HUMANS; LIPOPOLYSACCHARIDES; MICE;

EID: 0035164011     PISSN: 00199567     EISSN: None     Source Type: Journal    
DOI: 10.1128/IAI.69.1.479-485.2001     Document Type: Article

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3. CD14 is a member of the family of leucine-rich proteins and is encoded by a gene syntenic with multiple receptor genes
4. Soluble CD14 participates in the response of cells to lipopolysaccharide
5. Surface expression of human CD14 in Chinese hamster ovary fibroblasts imparts macrophage-like responsiveness to bacterial endotoxin
6. Expression of myeloid differentiation antigens on normal and myeloid cells
7. Endotoxin-neutralizing capacity of soluble CD14 is a highly conserved specific function
8. Lipopolysaccharide (LPS)-binding protein accelerates the binding of LPS to CD14
9. Stimulation of macrophages and neutrophils by complexes of lipopolysaccharide and soluble CD14
10. Resistance to endotoxin shock and reduced dissemination of gram-negative bacteria in CD14-deficient mice
11. Inhibition of stimulus-induced endothelial cell intercellular adhesion molecule-1, E-selectin and vascular cellular adhesion molecule-1 expression by arachidonic acid and its hydroxy and hydroperoxy derivatives
12. Both membrane-bound and soluble forms of CD14 bind to gram-negative bacteria
13. Potent CD14-mediated signalling of human leukocytes by Escherichia coli can be mediated by interaction of whole bacteria and host cells without extensive prior release of endotoxin
14. Molecules from Staphylococcus aureus that bind CD14 and stimulate innate immune responses
15. Transfection of CD14 into 70Z/3 cells dramatically enhances the sensitivity to complexes of lipopolysaccharide (LPS) and LPS binding protein
16. Activation of human endothelial cells by viable or heat-killed gram-negative bacteria requires soluble CD14
17. Anti-CD14 mAb treatment provides therapeutic benefit after in vivo exposure to endotoxin
18. Search for sepsis drugs goes on despite past failures
19. Interferon-gamma (IFN-γ) and tumor necrosis factor-alpha (TNF-α) enhance lipopolysaccharide binding to neutrohils via CD14
20. Moesin functions as a lipopolysaccharide receptor on human monocytes
21. Regulatory functions of the vascular endothelium
22. Specific antimononuclear phagocyte monoclonal antibodies. Application to the purification of dendritic cells and the tissue location of macrophages
23. Sensitive responses of leukocytes to lipopolysaccharide require a protein distinct from CD14 at the cell surface
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25. Multiple receptors for endotoxin
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27. Activation of the adhesive capacity of CR3 on neutrophils by endotoxin: Dependence on lipopolysaccharide binding protein and CD14
28. Toll-like receptor-2 mediates lipopolysaccharide-induced cellular signalling
29. Lipopolysaccharide-binding protein and soluble CD14 catalyze exchange of phospholipids