-
1
-
-
19344364880
-
Effects of chemotherapy and hormonal therapy for early breast cancer on recurrence and 15-year survival: An overview of the randomised trials
-
Effects of chemotherapy and hormonal therapy for early breast cancer on recurrence and 15-year survival: an overview of the randomised trials. Lancet 2005;365:1687-1717.
-
(2005)
Lancet
, vol.365
, pp. 1687-1717
-
-
-
2
-
-
23644456477
-
Preoperative (neoadjuvant) systemic treatment of breast cancer
-
Kaufmann M, von Minckwitz G, Rody A: Preoperative (neoadjuvant) systemic treatment of breast cancer. Breast 2005;14:576-581.
-
(2005)
Breast
, vol.14
, pp. 576-581
-
-
Kaufmann, M.1
von Minckwitz, G.2
Rody, A.3
-
3
-
-
33644973070
-
Prognostic value of pathologic complete response after primary chemotherapy in relation to hormone receptor status and other factors
-
Guarneri V, Broglio K, Kau SW, Cristofanilli M, Buzdar AU, Valero V, Buchholz T, Meric F, Middleton L, Hortobagyi GN, Gonzalez-Angulo AM: Prognostic value of pathologic complete response after primary chemotherapy in relation to hormone receptor status and other factors. J Clin Oncol 2006;24:1037-1044.
-
(2006)
J Clin Oncol
, vol.24
, pp. 1037-1044
-
-
Guarneri, V.1
Broglio, K.2
Kau, S.W.3
Cristofanilli, M.4
Buzdar, A.U.5
Valero, V.6
Buchholz, T.7
Meric, F.8
Middleton, L.9
Hortobagyi, G.N.10
Gonzalez-Angulo, A.M.11
-
4
-
-
33646357786
-
Measuring response in a post-RECIST world: From black and white to shades of grey
-
Michaelis LC, Ratain MJ: Measuring response in a post-RECIST world: from black and white to shades of grey. Nat Rev Cancer 2006;6:409-414.
-
(2006)
Nat Rev Cancer
, vol.6
, pp. 409-414
-
-
Michaelis, L.C.1
Ratain, M.J.2
-
5
-
-
24744448033
-
Prognostic significance of a combined clinicopathologic score for response to primary systemic therapy in locally advanced breast cancer
-
Bertheau P, Lerebours F, Mounier N, de Roquancourt A, Espie M, Clot P, Servant JM, Misset JL, Marty M, Janin A: Prognostic significance of a combined clinicopathologic score for response to primary systemic therapy in locally advanced breast cancer. Oncol Rep 2005;14:513-520.
-
(2005)
Oncol Rep
, vol.14
, pp. 513-520
-
-
Bertheau, P.1
Lerebours, F.2
Mounier, N.3
de Roquancourt, A.4
Espie, M.5
Clot, P.6
Servant, J.M.7
Misset, J.L.8
Marty, M.9
Janin, A.10
-
6
-
-
13644254794
-
Molecular mechanisms of drug resistance
-
Longley DB, Johnston PG: Molecular mechanisms of drug resistance. J Pathol 2005;205:275-292.
-
(2005)
J Pathol
, vol.205
, pp. 275-292
-
-
Longley, D.B.1
Johnston, P.G.2
-
7
-
-
14644407525
-
The role of apoptosis in cancer development and treatment response
-
Brown JM, Attardi LD: The role of apoptosis in cancer development and treatment response. Nat Rev Cancer 2005;5:231-237.
-
(2005)
Nat Rev Cancer
, vol.5
, pp. 231-237
-
-
Brown, J.M.1
Attardi, L.D.2
-
8
-
-
34447543913
-
Cellular senescence in cancer and aging
-
Collado M, Blasco MA, Serrano M: Cellular senescence in cancer and aging. Cell 2007;130:223-233.
-
(2007)
Cell
, vol.130
, pp. 223-233
-
-
Collado, M.1
Blasco, M.A.2
Serrano, M.3
-
9
-
-
33646782954
-
p53 and disease: When the guardian angel fails
-
Royds JA, Iacopetta B: p53 and disease: when the guardian angel fails. Cell Death Differ 2006;13:1017-1026.
-
(2006)
Cell Death Differ
, vol.13
, pp. 1017-1026
-
-
Royds, J.A.1
Iacopetta, B.2
-
10
-
-
0037038699
-
Groups of p53 target genes involved in specific p53 downstream effects cluster into different classes of DNA binding sites
-
Qian H, Wang T, Naumovski L, Lopez CD, Brachmann RK: Groups of p53 target genes involved in specific p53 downstream effects cluster into different classes of DNA binding sites. Oncogene 2002;21:7901-7911.
-
(2002)
Oncogene
, vol.21
, pp. 7901-7911
-
-
Qian, H.1
Wang, T.2
Naumovski, L.3
Lopez, C.D.4
Brachmann, R.K.5
-
11
-
-
0036892060
-
Differential transactivation by the p53 transcription factor is highly dependent on p53 level and promoter target sequence
-
Inga A, Storici F, Darden TA, Resnick MA: Differential transactivation by the p53 transcription factor is highly dependent on p53 level and promoter target sequence. Mol Cell Biol 2002;22:8612-8625.
-
(2002)
Mol Cell Biol
, vol.22
, pp. 8612-8625
-
-
Inga, A.1
Storici, F.2
Darden, T.A.3
Resnick, M.A.4
-
13
-
-
18144416611
-
The transcriptional targets of p53 in apoptosis control
-
Yu J, Zhang L: The transcriptional targets of p53 in apoptosis control. Biochem Biophys Res Commun 2005;331:851-858.
-
(2005)
Biochem Biophys Res Commun
, vol.331
, pp. 851-858
-
-
Yu, J.1
Zhang, L.2
-
15
-
-
35148826938
-
Shaping genetic alterations in human cancer: The p53 mutation paradigm
-
Soussi T, Wiman KG: Shaping genetic alterations in human cancer: the p53 mutation paradigm. Cancer Cell 2007;12:303-312.
-
(2007)
Cancer Cell
, vol.12
, pp. 303-312
-
-
Soussi, T.1
Wiman, K.G.2
-
16
-
-
33845185824
-
Mdm2 is critically and continuously required to suppress lethal p53 activity in vivo
-
Ringshausen I, O'Shea CC, Finch AJ, Swigart LB, Evan GI: Mdm2 is critically and continuously required to suppress lethal p53 activity in vivo. Cancer Cell 2006;10:501-514.
-
(2006)
Cancer Cell
, vol.10
, pp. 501-514
-
-
Ringshausen, I.1
O'Shea, C.C.2
Finch, A.J.3
Swigart, L.B.4
Evan, G.I.5
-
17
-
-
11844293427
-
p53 and prognosis: New insights and further complexity
-
Vousden KH, Prives C: p53 and prognosis: new insights and further complexity. Cell 2005;120:7-10.
-
(2005)
Cell
, vol.120
, pp. 7-10
-
-
Vousden, K.H.1
Prives, C.2
-
18
-
-
33845270990
-
Regulating the p53 pathway: In vitro hypotheses, in vivo veritas
-
Toledo F, Wahl GM: Regulating the p53 pathway: in vitro hypotheses, in vivo veritas. Nat Rev Cancer 2006;6:909-923.
-
(2006)
Nat Rev Cancer
, vol.6
, pp. 909-923
-
-
Toledo, F.1
Wahl, G.M.2
-
19
-
-
0029802591
-
p53 levels, functional domains, and DNA damage determine the extent of the apoptotic response of tumor cells
-
Chen X, Ko LJ, Jayaraman L, Prives C: p53 levels, functional domains, and DNA damage determine the extent of the apoptotic response of tumor cells. Genes Dev 1996;10:2438-2451.
-
(1996)
Genes Dev
, vol.10
, pp. 2438-2451
-
-
Chen, X.1
Ko, L.J.2
Jayaraman, L.3
Prives, C.4
-
20
-
-
33947702646
-
Exquisite sensitivity of TP53 mutant and basal breast cancers to a dosedense epirubicin-cyclophosphamide regimen
-
Bertheau P, Turpin E, Rickman DS, EspiéM, de Reyniès A, Feugeas JP, Plassa LF, Soliman H, Varna M, de Roquancourt A, Lehmann-Che J, Beuzard Y, Marty M, Misset JL, Janin A, de ThéH: Exquisite sensitivity of TP53 mutant and basal breast cancers to a dosedense epirubicin-cyclophosphamide regimen. PLoS Med 2007;4:e90.
-
(2007)
PLoS Med
, vol.4
-
-
Bertheau, P.1
Turpin, E.2
Rickman, D.S.3
EspiéM4
de Reyniès, A.5
Feugeas, J.P.6
Plassa, L.F.7
Soliman, H.8
Varna, M.9
de Roquancourt, A.10
Lehmann-Che, J.11
Beuzard, Y.12
Marty, M.13
Misset, J.L.14
Janin, A.15
de ThéH16
-
21
-
-
34247255527
-
p53 and NF-kappaB crosstalk: IKKalpha tips the balance
-
Tergaonkar V, Perkins ND: p53 and NF-kappaB crosstalk: IKKalpha tips the balance. Mol Cell 2007;26:158-159.
-
(2007)
Mol Cell
, vol.26
, pp. 158-159
-
-
Tergaonkar, V.1
Perkins, N.D.2
-
22
-
-
34547956843
-
hCAS/CSE1L associates with chromatin and regulates expression of select p53 target genes
-
Tanaka T, Ohkubo S, Tatsuno I, Prives C: hCAS/CSE1L associates with chromatin and regulates expression of select p53 target genes. Cell 2007;130:638-650.
-
(2007)
Cell
, vol.130
, pp. 638-650
-
-
Tanaka, T.1
Ohkubo, S.2
Tatsuno, I.3
Prives, C.4
-
23
-
-
34248379012
-
Impact of mutant p53 functional properties on TP53 mutation patterns and tumor phenotype: Lessons from recent developments in the IARC TP53 database
-
Petitjean A, Mathe E, Kato S, Ishioka C, Tavtigian SV, Hainaut P, Olivier M: Impact of mutant p53 functional properties on TP53 mutation patterns and tumor phenotype: lessons from recent developments in the IARC TP53 database. Hum Mutat 2007;28:622-629.
-
(2007)
Hum Mutat
, vol.28
, pp. 622-629
-
-
Petitjean, A.1
Mathe, E.2
Kato, S.3
Ishioka, C.4
Tavtigian, S.V.5
Hainaut, P.6
Olivier, M.7
-
24
-
-
30144433850
-
Locus-specific mutation databases: Pitfalls and good practice based on the p53 experience
-
Soussi T, Ishioka C, Claustres M, Béroud C: Locus-specific mutation databases: pitfalls and good practice based on the p53 experience. Nat Rev Cancer 2006;6:83-90.
-
(2006)
Nat Rev Cancer
, vol.6
, pp. 83-90
-
-
Soussi, T.1
Ishioka, C.2
Claustres, M.3
Béroud, C.4
-
25
-
-
0036674617
-
Live or let die: The cell's response to p53
-
Vousden KH, Lu X: Live or let die: the cell's response to p53. Nat Rev Cancer 2002;2:594-604.
-
(2002)
Nat Rev Cancer
, vol.2
, pp. 594-604
-
-
Vousden, K.H.1
Lu, X.2
-
26
-
-
18644384419
-
-
Turpin E, Bieche I, Bertheau P, Plassa LF, Lerebours F, de Roquancourt A, Olivi M, Espie M, Marty M, Lidereau R, Vidaud M, de The H: Increased incidence of ERBB2 overexpression and TP53 mutation in inflammatory breast cancer. Oncogene 2002;21:7593-7597.
-
Turpin E, Bieche I, Bertheau P, Plassa LF, Lerebours F, de Roquancourt A, Olivi M, Espie M, Marty M, Lidereau R, Vidaud M, de The H: Increased incidence of ERBB2 overexpression and TP53 mutation in inflammatory breast cancer. Oncogene 2002;21:7593-7597.
-
-
-
-
27
-
-
33644772215
-
The clinical value of somatic TP53 gene mutations in 1,794 patients with breast cancer
-
Olivier M, Langerod A, Carrieri P, Bergh J, Klaar S, Eyfjord J, Theillet C, Rodriguez C, Lidereau R, Bieche I, Varley J, Bignon Y, Uhrhammer N, Winqvist R, Jukkola-Vuorinen A, Niederacher D, Kato S, Ishioka C, Hainaut P, Borresen-Dale AL: The clinical value of somatic TP53 gene mutations in 1,794 patients with breast cancer. Clin Cancer Res 2006;12:1157-1167.
-
(2006)
Clin Cancer Res
, vol.12
, pp. 1157-1167
-
-
Olivier, M.1
Langerod, A.2
Carrieri, P.3
Bergh, J.4
Klaar, S.5
Eyfjord, J.6
Theillet, C.7
Rodriguez, C.8
Lidereau, R.9
Bieche, I.10
Varley, J.11
Bignon, Y.12
Uhrhammer, N.13
Winqvist, R.14
Jukkola-Vuorinen, A.15
Niederacher, D.16
Kato, S.17
Ishioka, C.18
Hainaut, P.19
Borresen-Dale, A.L.20
more..
-
28
-
-
1842536849
-
Mutant p53 exerts a dominant negative effect by preventing wild-type p53 from binding to the promoter of its target genes
-
Willis A, Jung EJ, Wakefield T, Chen X: Mutant p53 exerts a dominant negative effect by preventing wild-type p53 from binding to the promoter of its target genes. Oncogene 2004;23:2330-2338.
-
(2004)
Oncogene
, vol.23
, pp. 2330-2338
-
-
Willis, A.1
Jung, E.J.2
Wakefield, T.3
Chen, X.4
-
29
-
-
0029783722
-
A mutant p53 that discriminates between p53-responsive genes cannot induce apoptosis
-
Friedlander P, Haupt Y, Prives C, Oren M: A mutant p53 that discriminates between p53-responsive genes cannot induce apoptosis. Mol Cell Biol 1996;16:4961-4971.
-
(1996)
Mol Cell Biol
, vol.16
, pp. 4961-4971
-
-
Friedlander, P.1
Haupt, Y.2
Prives, C.3
Oren, M.4
-
30
-
-
0030021748
-
Specific loss of apoptotic but not cell-cycle arrest function in a human tumor derived p53 mutant
-
Rowan S, Ludwig RL, Haupt Y, Bates S, Lu X, Oren M, Vousden KH: Specific loss of apoptotic but not cell-cycle arrest function in a human tumor derived p53 mutant. EMBO J 1996;15:827-838.
-
(1996)
EMBO J
, vol.15
, pp. 827-838
-
-
Rowan, S.1
Ludwig, R.L.2
Haupt, Y.3
Bates, S.4
Lu, X.5
Oren, M.6
Vousden, K.H.7
-
31
-
-
34047216406
-
p53 alterations in human cancer: More questions than answers
-
Soussi T: p53 alterations in human cancer: more questions than answers. Oncogene 2007;26:2145-2156.
-
(2007)
Oncogene
, vol.26
, pp. 2145-2156
-
-
Soussi, T.1
-
32
-
-
0031856995
-
Comparison between p53 protein measurements using the luminometric immunoassay and immunohistochemistry with detection of p53 gene mutations using cDNA sequencing in human breast tumors
-
Norberg T, Lennerstrand J, Inganas M, Bergh J: Comparison between p53 protein measurements using the luminometric immunoassay and immunohistochemistry with detection of p53 gene mutations using cDNA sequencing in human breast tumors. Int J Cancer 1998;79:376-383.
-
(1998)
Int J Cancer
, vol.79
, pp. 376-383
-
-
Norberg, T.1
Lennerstrand, J.2
Inganas, M.3
Bergh, J.4
-
33
-
-
0029043805
-
A simple p53 functional assay for screening cell lines, blood, and tumors
-
Flaman JM, Frebourg T, Moreau V, Charbonnier F, Martin C, Chappuis P, Sappino AP, Limacher IM, Bron L, Benhattar J, et al: A simple p53 functional assay for screening cell lines, blood, and tumors. Proc Natl Acad Sci USA 1995;92:3963-3967.
-
(1995)
Proc Natl Acad Sci USA
, vol.92
, pp. 3963-3967
-
-
Flaman, J.M.1
Frebourg, T.2
Moreau, V.3
Charbonnier, F.4
Martin, C.5
Chappuis, P.6
Sappino, A.P.7
Limacher, I.M.8
Bron, L.9
Benhattar, J.10
-
34
-
-
26444546442
-
An expression signature for p53 status in human breast cancer predicts mutation status, transcriptional effects, and patient survival
-
Miller LD, Smeds J, George J, Vega VB, Vergara L, Ploner A, Pawitan Y, Hall P, Klaar S, Liu ET, Bergh J: An expression signature for p53 status in human breast cancer predicts mutation status, transcriptional effects, and patient survival. Proc Natl Acad Sci USA 2005;102:13550-13555.
-
(2005)
Proc Natl Acad Sci USA
, vol.102
, pp. 13550-13555
-
-
Miller, L.D.1
Smeds, J.2
George, J.3
Vega, V.B.4
Vergara, L.5
Ploner, A.6
Pawitan, Y.7
Hall, P.8
Klaar, S.9
Liu, E.T.10
Bergh, J.11
-
35
-
-
12244311223
-
Locally advanced/inflammatory breast cancers treated with intensive epirubicin-based neoadjuvant chemotherapy: Are there molecular markers in the primary tumour that predict for 5-year clinical outcome?
-
Bonnefoi H, Diebold-Berger S, Therasse P, Hamilton A, van de Vijver M, MacGrogan G, Shepherd L, Amaral N, Duval C, Drijkoningen R, Larsimont D, Piccart M: Locally advanced/inflammatory breast cancers treated with intensive epirubicin-based neoadjuvant chemotherapy: are there molecular markers in the primary tumour that predict for 5-year clinical outcome? Ann Oncol 2003;14:406-413.
-
(2003)
Ann Oncol
, vol.14
, pp. 406-413
-
-
Bonnefoi, H.1
Diebold-Berger, S.2
Therasse, P.3
Hamilton, A.4
van de Vijver, M.5
MacGrogan, G.6
Shepherd, L.7
Amaral, N.8
Duval, C.9
Drijkoningen, R.10
Larsimont, D.11
Piccart, M.12
-
36
-
-
0037143098
-
p53 is the strongest predictor of survival in high-risk primary breast cancer patients undergoing high-dose chemotherapy with autologous blood stem cell support
-
Hensel M, Schneeweiss A, Sinn HP, Egerer G, Solomayer E, Haas R, Bastert G, Ho AD: p53 is the strongest predictor of survival in high-risk primary breast cancer patients undergoing high-dose chemotherapy with autologous blood stem cell support. Int J Cancer 2002;100:290-296.
-
(2002)
Int J Cancer
, vol.100
, pp. 290-296
-
-
Hensel, M.1
Schneeweiss, A.2
Sinn, H.P.3
Egerer, G.4
Solomayer, E.5
Haas, R.6
Bastert, G.7
Ho, A.D.8
-
37
-
-
33749628808
-
Evaluation of the prognostic and predictive value of p53 and Bcl-2 in breast cancer patients participating in a randomized study with dose-dense sequential adjuvant chemotherapy
-
Malamou-Mitsi V, Gogas H, Dafni U, Bourli A, Fillipidis T, Sotiropoulou M, Vlachodimitropoulos D, Papadopoulos S, Tzaida O, Kafiri G, Kyriakou V, Markaki S, Papaspyrou I, Karagianni E, Pavlakis K, Toliou T, Scopa C, Papakostas P, Bafaloukos D, Christodoulou C, Fountzilas G: Evaluation of the prognostic and predictive value of p53 and Bcl-2 in breast cancer patients participating in a randomized study with dose-dense sequential adjuvant chemotherapy. Ann Oncol 2006;17:1504-1511.
-
(2006)
Ann Oncol
, vol.17
, pp. 1504-1511
-
-
Malamou-Mitsi, V.1
Gogas, H.2
Dafni, U.3
Bourli, A.4
Fillipidis, T.5
Sotiropoulou, M.6
Vlachodimitropoulos, D.7
Papadopoulos, S.8
Tzaida, O.9
Kafiri, G.10
Kyriakou, V.11
Markaki, S.12
Papaspyrou, I.13
Karagianni, E.14
Pavlakis, K.15
Toliou, T.16
Scopa, C.17
Papakostas, P.18
Bafaloukos, D.19
Christodoulou, C.20
Fountzilas, G.21
more..
-
38
-
-
0029948848
-
Prognostic value of the immunohistochemical expression of p53 in breast carcinomas - a review of the literature involving over 9,000 patients
-
Barbareschi M: Prognostic value of the immunohistochemical expression of p53 in breast carcinomas - a review of the literature involving over 9,000 patients. Appl Immunohistochem 1996;4:106-116.
-
(1996)
Appl Immunohistochem
, vol.4
, pp. 106-116
-
-
Barbareschi, M.1
-
39
-
-
0037221767
-
TP53 and breast cancer
-
Børresen-Dale AL: TP53 and breast cancer. Hum Mutat 2003;21:292-300.
-
(2003)
Hum Mutat
, vol.21
, pp. 292-300
-
-
Børresen-Dale, A.L.1
-
40
-
-
33749030177
-
Pharmacogenomic predictor of sensitivity to preoperative chemotherapy with paclitaxel and fluorouracil, doxorubicin, and cyclophosphamide in breast cancer
-
Hess KR, Anderson K, Symmans WF, Valero V, Ibrahim N, Mejia JA, Booser D, Theriault RL, Buzdar AU, Dempsey PJ, Rouzier R, Sneige N, Ross JS, Vidaurre T, Gomez HL, Hortobagyi GN, Pusztai L: Pharmacogenomic predictor of sensitivity to preoperative chemotherapy with paclitaxel and fluorouracil, doxorubicin, and cyclophosphamide in breast cancer. J Clin Oncol 2006;24:4236-4244.
-
(2006)
J Clin Oncol
, vol.24
, pp. 4236-4244
-
-
Hess, K.R.1
Anderson, K.2
Symmans, W.F.3
Valero, V.4
Ibrahim, N.5
Mejia, J.A.6
Booser, D.7
Theriault, R.L.8
Buzdar, A.U.9
Dempsey, P.J.10
Rouzier, R.11
Sneige, N.12
Ross, J.S.13
Vidaurre, T.14
Gomez, H.L.15
Hortobagyi, G.N.16
Pusztai, L.17
-
41
-
-
39049159199
-
The use of an in vitro adenosine triphosphate-based chemotherapy response assay to predict chemotherapeutic response in breast cancer
-
Kim HA, Yom CK, Moon BI, Choe KJ, Sung SH, Han WS, Choi HY, Kim HK, Park HK, Choi SH, Yoon EJ, Oh SY: The use of an in vitro adenosine triphosphate-based chemotherapy response assay to predict chemotherapeutic response in breast cancer. Breast 2008;17:19-26.
-
(2008)
Breast
, vol.17
, pp. 19-26
-
-
Kim, H.A.1
Yom, C.K.2
Moon, B.I.3
Choe, K.J.4
Sung, S.H.5
Han, W.S.6
Choi, H.Y.7
Kim, H.K.8
Park, H.K.9
Choi, S.H.10
Yoon, E.J.11
Oh, S.Y.12
-
42
-
-
0037139372
-
Prediction of chemotherapeutic response by collagen gel droplet embedded culture-drug sensitivity test in human breast cancers
-
Takamura Y, Kobayashi H, Taguchi T, Motomura K, Inaji H, Noguchi S: Prediction of chemotherapeutic response by collagen gel droplet embedded culture-drug sensitivity test in human breast cancers. Int J Cancer 2002;98:450-455.
-
(2002)
Int J Cancer
, vol.98
, pp. 450-455
-
-
Takamura, Y.1
Kobayashi, H.2
Taguchi, T.3
Motomura, K.4
Inaji, H.5
Noguchi, S.6
-
43
-
-
0035525733
-
Cellular stress response and apoptosis in cancer therapy
-
Herr I, Debatin KM: Cellular stress response and apoptosis in cancer therapy. Blood 2001;98:2603-2614.
-
(2001)
Blood
, vol.98
, pp. 2603-2614
-
-
Herr, I.1
Debatin, K.M.2
-
44
-
-
0027451668
-
p53-dependent apoptosis modulates the cytotoxicity of anticancer agents
-
Lowe SW, Ruley HE, Jacks T, Housman DE: p53-dependent apoptosis modulates the cytotoxicity of anticancer agents. Cell 1993;74:957-967.
-
(1993)
Cell
, vol.74
, pp. 957-967
-
-
Lowe, S.W.1
Ruley, H.E.2
Jacks, T.3
Housman, D.E.4
-
45
-
-
0027944206
-
p53 status and the efficacy of cancer therapy in vivo
-
Lowe SW, Bodis S, McClatchey A, Remington L, Ruley HE, Fisher DE, Housman DE, Jacks T: p53 status and the efficacy of cancer therapy in vivo. Science 1994;266:807-810.
-
(1994)
Science
, vol.266
, pp. 807-810
-
-
Lowe, S.W.1
Bodis, S.2
McClatchey, A.3
Remington, L.4
Ruley, H.E.5
Fisher, D.E.6
Housman, D.E.7
Jacks, T.8
-
46
-
-
0030865104
-
Characterization of the p53 tumor suppressor pathway in cell lines of the National Cancer Institute anticancer drug screen and correlations with the growth-inhibitory potency of 123 anticancer agents
-
O'Connor PM, Jackman J, Bae I, Myers TG, Fan S, Mutoh M, Scudiero DA, Monks A, Sausville EA, Weinstein JN, Friend S, Fornace AJ Jr, Kohn KW: Characterization of the p53 tumor suppressor pathway in cell lines of the National Cancer Institute anticancer drug screen and correlations with the growth-inhibitory potency of 123 anticancer agents. Cancer Res 1997;57:4285-4300.
-
(1997)
Cancer Res
, vol.57
, pp. 4285-4300
-
-
O'Connor, P.M.1
Jackman, J.2
Bae, I.3
Myers, T.G.4
Fan, S.5
Mutoh, M.6
Scudiero, D.A.7
Monks, A.8
Sausville, E.A.9
Weinstein, J.N.10
Friend, S.11
Fornace Jr, A.J.12
Kohn, K.W.13
-
47
-
-
9944221027
-
Meta-analysis of the role of p53 status in isogenic systems tested for sensitivity to cytotoxic antineoplastic drugs
-
Cimoli G, Malacarne D, Ponassi R, Valenti M, Alberti S, Parodi S: Meta-analysis of the role of p53 status in isogenic systems tested for sensitivity to cytotoxic antineoplastic drugs. Biochim Biophys Acta 2004;1705:103-120.
-
(2004)
Biochim Biophys Acta
, vol.1705
, pp. 103-120
-
-
Cimoli, G.1
Malacarne, D.2
Ponassi, R.3
Valenti, M.4
Alberti, S.5
Parodi, S.6
-
48
-
-
0029956081
-
Specific p53 mutations are associated with de novo resistance to doxorubicin in breast cancer patients
-
Aas T, Borresen AL, Geisler S, Smith-Sorensen B, Johnsen H, Varhaug JE, Akslen LA, Lonning PE: Specific p53 mutations are associated with de novo resistance to doxorubicin in breast cancer patients. Nat Med 1996;2:811-814.
-
(1996)
Nat Med
, vol.2
, pp. 811-814
-
-
Aas, T.1
Borresen, A.L.2
Geisler, S.3
Smith-Sorensen, B.4
Johnsen, H.5
Varhaug, J.E.6
Akslen, L.A.7
Lonning, P.E.8
-
49
-
-
0035866772
-
Influence of TP53 gene alterations and c-erbB-2 expression on the response to treatment with doxorubicin in locally advanced breast cancer
-
Geisler S, Lønning PE, Aas T, Johnsen H, Fluge O, Haugen DF, Lillehaug JR, Akslen LA, Børresen-Dale AL: Influence of TP53 gene alterations and c-erbB-2 expression on the response to treatment with doxorubicin in locally advanced breast cancer. Cancer Res 2001;61:2505-2512.
-
(2001)
Cancer Res
, vol.61
, pp. 2505-2512
-
-
Geisler, S.1
Lønning, P.E.2
Aas, T.3
Johnsen, H.4
Fluge, O.5
Haugen, D.F.6
Lillehaug, J.R.7
Akslen, L.A.8
Børresen-Dale, A.L.9
-
50
-
-
17744403009
-
Complete sequencing of TP53 predicts poor response to systemic therapy of advanced breast cancer
-
Berns EM, Foekens JA, Vossen R, Look MP, Devilee P, Henzen-Logmans SC, van Staveren IL, van Putten WL, Inganäs M, Meijervan Gelder ME, Cornelisse C, Claassen CJ, Portengen H, Bakker B, Klijn JG: Complete sequencing of TP53 predicts poor response to systemic therapy of advanced breast cancer. Cancer Res 2000;60:2155-2162.
-
(2000)
Cancer Res
, vol.60
, pp. 2155-2162
-
-
Berns, E.M.1
Foekens, J.A.2
Vossen, R.3
Look, M.P.4
Devilee, P.5
Henzen-Logmans, S.C.6
van Staveren, I.L.7
van Putten, W.L.8
Inganäs, M.9
Meijervan Gelder, M.E.10
Cornelisse, C.11
Claassen, C.J.12
Portengen, H.13
Bakker, B.14
Klijn, J.G.15
-
51
-
-
0037363440
-
A mutant TP53 gene status is associated with a poor prognosis and anthracycline-resistance in breast cancer patients
-
Rahko E, Blanco G, Soini Y, Bloigu R, Jukkola A: A mutant TP53 gene status is associated with a poor prognosis and anthracycline-resistance in breast cancer patients. Eur J Cancer 2003;39:447-453.
-
(2003)
Eur J Cancer
, vol.39
, pp. 447-453
-
-
Rahko, E.1
Blanco, G.2
Soini, Y.3
Bloigu, R.4
Jukkola, A.5
-
52
-
-
10744230945
-
p53 polymorphism influences response in cancer chemotherapy via modulation of p73-dependent apoptosis
-
Bergamaschi D, Gasco M, Hiller L, Sullivan A, Syed N, Trigiante G, Yulug I, Merlano M, Numico G, Comino A, Attard M, Reelfs O, Gusterson B, Bell AK, Heath V, Tavassoli M, Farrell PJ, Smith P, Lu X, Crook T: p53 polymorphism influences response in cancer chemotherapy via modulation of p73-dependent apoptosis. Cancer Cell 2003;3:387-402.
-
(2003)
Cancer Cell
, vol.3
, pp. 387-402
-
-
Bergamaschi, D.1
Gasco, M.2
Hiller, L.3
Sullivan, A.4
Syed, N.5
Trigiante, G.6
Yulug, I.7
Merlano, M.8
Numico, G.9
Comino, A.10
Attard, M.11
Reelfs, O.12
Gusterson, B.13
Bell, A.K.14
Heath, V.15
Tavassoli, M.16
Farrell, P.J.17
Smith, P.18
Lu, X.19
Crook, T.20
more..
-
53
-
-
27144536311
-
p53 codon 72 polymorphism predicts the pathologic response to neoadjuvant chemotherapy in patients with breast cancer
-
Xu Y, Yao L, Ouyang T, Li J, Wang T, Fan Z, Lin B, Lu Y, Xie Y: p53 codon 72 polymorphism predicts the pathologic response to neoadjuvant chemotherapy in patients with breast cancer. Clin Cancer Res 2005;11:7328-7333.
-
(2005)
Clin Cancer Res
, vol.11
, pp. 7328-7333
-
-
Xu, Y.1
Yao, L.2
Ouyang, T.3
Li, J.4
Wang, T.5
Fan, Z.6
Lin, B.7
Lu, Y.8
Xie, Y.9
-
54
-
-
0037077831
-
de Roquancourt A, Marty M, Lerebours F, Beuzard Y, Janin A, de ThéH: Effect of mutated TP53 on response of advanced breast cancers to high-dose chemotherapy
-
Bertheau P, Plassa F, EspiéM, Turpin E, de Roquancourt A, Marty M, Lerebours F, Beuzard Y, Janin A, de ThéH: Effect of mutated TP53 on response of advanced breast cancers to high-dose chemotherapy. Lancet 2002;360:852-854.
-
(2002)
Lancet
, vol.360
, pp. 852-854
-
-
Bertheau, P.1
Plassa, F.2
Espié, M.3
Turpin, E.4
-
55
-
-
0037017816
-
p53 as a potential predictive factor of response to chemotherapy: Feasibility of p53 assessment using a functional test in yeast from trucut biopsies in breast cancer patients
-
Bonnefoi H, Ducraux A, Movarekhi S, Pelte MF, Bongard S, Lurati E, Iggo R: p53 as a potential predictive factor of response to chemotherapy: feasibility of p53 assessment using a functional test in yeast from trucut biopsies in breast cancer patients. Br J Cancer 2002;86:750-755.
-
(2002)
Br J Cancer
, vol.86
, pp. 750-755
-
-
Bonnefoi, H.1
Ducraux, A.2
Movarekhi, S.3
Pelte, M.F.4
Bongard, S.5
Lurati, E.6
Iggo, R.7
-
56
-
-
23844549918
-
Breast cancer molecular subtypes respond differently to preoperative chemotherapy
-
Rouzier R, Perou CM, Symmans WF, Ibrahim N, Cristofanilli M, Anderson K, Hess KR, Stec J, Ayers M, Wagner P, Morandi P, Fan C, Rabiul I, Ross JS, Hortobagyi GN, Pusztai L: Breast cancer molecular subtypes respond differently to preoperative chemotherapy. Clin Cancer Res 2005;11:5678-5685.
-
(2005)
Clin Cancer Res
, vol.11
, pp. 5678-5685
-
-
Rouzier, R.1
Perou, C.M.2
Symmans, W.F.3
Ibrahim, N.4
Cristofanilli, M.5
Anderson, K.6
Hess, K.R.7
Stec, J.8
Ayers, M.9
Wagner, P.10
Morandi, P.11
Fan, C.12
Rabiul, I.13
Ross, J.S.14
Hortobagyi, G.N.15
Pusztai, L.16
-
57
-
-
31544466566
-
Prognostic and predictive effects of immunohistochemical factors in high-risk primary breast cancer patients
-
Kröger N, Milde-Langosch K, Riethdorf S, Schmoor C, Schumacher M, Zander AR, Löning T: Prognostic and predictive effects of immunohistochemical factors in high-risk primary breast cancer patients. Clin Cancer Res 2006;12:159-168.
-
(2006)
Clin Cancer Res
, vol.12
, pp. 159-168
-
-
Kröger, N.1
Milde-Langosch, K.2
Riethdorf, S.3
Schmoor, C.4
Schumacher, M.5
Zander, A.R.6
Löning, T.7
-
58
-
-
0036870714
-
Reduced expression of p53 and p21WAF1/CIP1 sensitizes human breast cancer cells to paclitaxel and its combination with 5-fluorouracil
-
Johnson KR, Fan W: Reduced expression of p53 and p21WAF1/CIP1 sensitizes human breast cancer cells to paclitaxel and its combination with 5-fluorouracil. Anticancer Res 2002;22:3197-3204.
-
(2002)
Anticancer Res
, vol.22
, pp. 3197-3204
-
-
Johnson, K.R.1
Fan, W.2
-
59
-
-
0033971806
-
TP53 mutation and p53 overexpression for prediction of response to neoadjuvant treatment in breast cancer patients
-
Kandioler-Eckersberger D, Ludwig C, Rudas M, Kappel S, Janschek E, Wenzel C, Schlagbauer-Wadl H, Mittlböck M, Gnant M, Steger G, Jakesz R: TP53 mutation and p53 overexpression for prediction of response to neoadjuvant treatment in breast cancer patients. Clin Cancer Res 2000;6:50-56.
-
(2000)
Clin Cancer Res
, vol.6
, pp. 50-56
-
-
Kandioler-Eckersberger, D.1
Ludwig, C.2
Rudas, M.3
Kappel, S.4
Janschek, E.5
Wenzel, C.6
Schlagbauer-Wadl, H.7
Mittlböck, M.8
Gnant, M.9
Steger, G.10
Jakesz, R.11
-
60
-
-
33746604292
-
Predictive factors for response to docetaxel in human breast cancers
-
Noguchi S: Predictive factors for response to docetaxel in human breast cancers. Cancer Sci 2006;97:813-820.
-
(2006)
Cancer Sci
, vol.97
, pp. 813-820
-
-
Noguchi, S.1
-
61
-
-
0344198117
-
TP53 gene mutations predict the response to neoadjuvant treatment with 5-fluorouracil and mitomycin in locally advanced breast cancer
-
Geisler S, Børresen-Dale AL, Johnsen H, Aas T, Geisler J, Akslen LA, Anker G, Lønning PE: TP53 gene mutations predict the response to neoadjuvant treatment with 5-fluorouracil and mitomycin in locally advanced breast cancer. Clin Cancer Res 2003;9:5582-5588.
-
(2003)
Clin Cancer Res
, vol.9
, pp. 5582-5588
-
-
Geisler, S.1
Børresen-Dale, A.L.2
Johnsen, H.3
Aas, T.4
Geisler, J.5
Akslen, L.A.6
Anker, G.7
Lønning, P.E.8
-
62
-
-
20044382813
-
Worse survival for TP53 (p53)-mutated breast cancer patients receiving adjuvant CMF
-
Andersson J, Larsson L, Klaar S, Holmberg L, Nilsson J, Inganäs M, Carlsson G, Ohd J, Rudenstam CM, Gustavsson B, Bergh J: Worse survival for TP53 (p53)-mutated breast cancer patients receiving adjuvant CMF. Ann Oncol 2005;16:743-748.
-
(2005)
Ann Oncol
, vol.16
, pp. 743-748
-
-
Andersson, J.1
Larsson, L.2
Klaar, S.3
Holmberg, L.4
Nilsson, J.5
Inganäs, M.6
Carlsson, G.7
Ohd, J.8
Rudenstam, C.M.9
Gustavsson, B.10
Bergh, J.11
-
63
-
-
0029848257
-
Primary chemotherapy in breast invasive carcinoma: Predictive value of the immunohistochemical detection of hormonal receptors, p53, c-erbB-2, MiB1, pS2 and GST pi
-
MacGrogan G, Mauriac L, Durand M, Bonichon F, Trojani M, de Mascarel I, Coindre JM: Primary chemotherapy in breast invasive carcinoma: predictive value of the immunohistochemical detection of hormonal receptors, p53, c-erbB-2, MiB1, pS2 and GST pi. Br J Cancer 1996;74:1458-1465.
-
(1996)
Br J Cancer
, vol.74
, pp. 1458-1465
-
-
MacGrogan, G.1
Mauriac, L.2
Durand, M.3
Bonichon, F.4
Trojani, M.5
de Mascarel, I.6
Coindre, J.M.7
-
64
-
-
0030847311
-
Predictive value of c-erbB-2, p53, cathepsin-D and histology of the primary tumour in metastatic breast cancer
-
Niskanen E, Blomqvist C, Franssila K, Hietanen P, Wasenius VM: Predictive value of c-erbB-2, p53, cathepsin-D and histology of the primary tumour in metastatic breast cancer. Br J Cancer 1997;76:917-922.
-
(1997)
Br J Cancer
, vol.76
, pp. 917-922
-
-
Niskanen, E.1
Blomqvist, C.2
Franssila, K.3
Hietanen, P.4
Wasenius, V.M.5
-
65
-
-
0033744498
-
The contribution of molecular markers to the prediction of response in the treatment of breast cancer: A review of the literature on HER-2, p53 and BCL-2
-
Hamilton A, Piccart M: The contribution of molecular markers to the prediction of response in the treatment of breast cancer: a review of the literature on HER-2, p53 and BCL-2. Ann Oncol 2000;11:647-663.
-
(2000)
Ann Oncol
, vol.11
, pp. 647-663
-
-
Hamilton, A.1
Piccart, M.2
-
67
-
-
0032702604
-
p53 and cancer therapy: A double-edged sword
-
McGill G, Fisher DE: p53 and cancer therapy: a double-edged sword. J Clin Invest 1999;104:223-225.
-
(1999)
J Clin Invest
, vol.104
, pp. 223-225
-
-
McGill, G.1
Fisher, D.E.2
-
68
-
-
0032701521
-
Disruption of p53 in human cancer cells alters the responses to therapeutic agents
-
Bunz F, Hwang PM, Torrance C, Waldman T, Zhang Y, Dillehay L, Williams J, Lengauer C, Kinzler KW, Vogelstein B: Disruption of p53 in human cancer cells alters the responses to therapeutic agents. J Clin Invest 1999;104:263-269.
-
(1999)
J Clin Invest
, vol.104
, pp. 263-269
-
-
Bunz, F.1
Hwang, P.M.2
Torrance, C.3
Waldman, T.4
Zhang, Y.5
Dillehay, L.6
Williams, J.7
Lengauer, C.8
Kinzler, K.W.9
Vogelstein, B.10
-
69
-
-
2342635919
-
Cell death by mitotic catastrophe: A molecular definition
-
Castedo M, Perfettini JL, Roumier T, Andreau K, Medema R, Kroemer G: Cell death by mitotic catastrophe: a molecular definition. Oncogene 2004;23:2825-2837.
-
(2004)
Oncogene
, vol.23
, pp. 2825-2837
-
-
Castedo, M.1
Perfettini, J.L.2
Roumier, T.3
Andreau, K.4
Medema, R.5
Kroemer, G.6
-
70
-
-
36549089750
-
Evidence that p53-mediated cell-cycle-arrest inhibits chemotherapeutic treatment of ovarian carcinomas
-
Moreno CS, Matyunina L, Dickerson EB, Schubert N, Bowen NJ, Logani S, Benigno BB, McDonald JF: Evidence that p53-mediated cell-cycle-arrest inhibits chemotherapeutic treatment of ovarian carcinomas. PLoS ONE 2007;2:e441.
-
(2007)
PLoS ONE
, vol.2
-
-
Moreno, C.S.1
Matyunina, L.2
Dickerson, E.B.3
Schubert, N.4
Bowen, N.J.5
Logani, S.6
Benigno, B.B.7
McDonald, J.F.8
-
71
-
-
0141987942
-
Alterations in p53 predict response to preoperative high dose chemotherapy in patients with gastric cancer
-
Bataille F, Rümmele P, Dietmaier W, Gaag D, Klebl F, Reichle A, Wild P, Hofstädter F, Hartmann A: Alterations in p53 predict response to preoperative high dose chemotherapy in patients with gastric cancer. Mol Pathol 2003;56:286-292.
-
(2003)
Mol Pathol
, vol.56
, pp. 286-292
-
-
Bataille, F.1
Rümmele, P.2
Dietmaier, W.3
Gaag, D.4
Klebl, F.5
Reichle, A.6
Wild, P.7
Hofstädter, F.8
Hartmann, A.9
-
72
-
-
33750364739
-
Inhibition of p53 response in tumor stroma improves efficacy of anticancer treatment by increasing antiangiogenic effects of chemotherapy and radiotherapy in mice
-
Burdelya LG, Komarova EA, Hill JE, Browder T, Tararova ND, Mavrakis L, DiCorleto PE, Folkman J, Gudkov AV: Inhibition of p53 response in tumor stroma improves efficacy of anticancer treatment by increasing antiangiogenic effects of chemotherapy and radiotherapy in mice. Cancer Res 2006;66:9356-9361.
-
(2006)
Cancer Res
, vol.66
, pp. 9356-9361
-
-
Burdelya, L.G.1
Komarova, E.A.2
Hill, J.E.3
Browder, T.4
Tararova, N.D.5
Mavrakis, L.6
DiCorleto, P.E.7
Folkman, J.8
Gudkov, A.V.9
-
73
-
-
33846899456
-
Restoration of p53 function leads to tumour regression in vivo
-
Ventura A, Kirsch DG, McLaughlin ME, Tuveson DA, Grimm J, Lintault L, Newman J, Reczek EE, Weissleder R, Jacks T: Restoration of p53 function leads to tumour regression in vivo. Nature 2007;445:661-665.
-
(2007)
Nature
, vol.445
, pp. 661-665
-
-
Ventura, A.1
Kirsch, D.G.2
McLaughlin, M.E.3
Tuveson, D.A.4
Grimm, J.5
Lintault, L.6
Newman, J.7
Reczek, E.E.8
Weissleder, R.9
Jacks, T.10
-
74
-
-
34047209861
-
Reactivation of mutant p53: Molecular mechanisms and therapeutic potential
-
Selivanova G, Wiman KG: Reactivation of mutant p53: molecular mechanisms and therapeutic potential. Oncogene 2007;26:2243-2254.
-
(2007)
Oncogene
, vol.26
, pp. 2243-2254
-
-
Selivanova, G.1
Wiman, K.G.2
-
75
-
-
0037317521
-
The role of p53 in determining sensitivity to radiotherapy
-
Gudkov AV, Komarova EA: The role of p53 in determining sensitivity to radiotherapy. Nat Rev Cancer 2003;3:117-129.
-
(2003)
Nat Rev Cancer
, vol.3
, pp. 117-129
-
-
Gudkov, A.V.1
Komarova, E.A.2
|