Development of a physiologically based pharmacokinetic and pharmacodynamic model to determine dosimetry and cholinesterase inhibition for a binary mixture of chlorpyrifos and diazinon in the rat

NeuroToxicology

Volumn 29, Issue 3, 2008, Pages 428-443

  Timchalk, C ^a   Poet, T S ^a  

^a BATTELLE MEMORIAL INSTITUTE   (United States)

Author keywords

Chlorpyrifos; Cholinesterase; Diazinon; Mixtures; Organophosphorus insecticide

Indexed keywords

ARYLDIALKYLPHOSPHATASE 1; CARBOXYLESTERASE; CHLORPYRIFOS; CYTOCHROME P450; DIMPYLATE;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CHOLINESTERASE INHIBITION; CONTROLLED STUDY; DOSIMETRY; ENZYME METABOLISM; EXPERIMENTAL MODEL; IN VITRO STUDY; MAXIMUM PLASMA CONCENTRATION; NONHUMAN; PRIORITY JOURNAL; RAT; SIMULATION; TOXICOKINETICS;

ANIMALS; ARYLDIALKYLPHOSPHATASE; BRAIN; CARDIAC OUTPUT; CHEMISTRY, PHYSICAL; CHLORPYRIFOS; CHOLINESTERASE INHIBITORS; CHOLINESTERASES; CYTOCHROME P-450 ENZYME SYSTEM; DATA INTERPRETATION, STATISTICAL; DIAZINON; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG COMBINATIONS; LIVER; MALE; MICROSOMES, LIVER; MODELS, STATISTICAL; RATS; RATS, SPRAGUE-DAWLEY; TISSUE DISTRIBUTION;

RATTUS; RODENTIA;

EID: 44649149558     PISSN: 0161813X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neuro.2008.02.004     Document Type: Article

References (55)

1. Abu-Quare A.W., Abdel-Rahman A., Brownie C., Kishk A.M., and Abou-Donia M.B. Inhibition of cholinesterase enzymes following a single dermal dose of chlorpyrifos and methyl parathion, alone and in combination, in pregnant rats. J Toxicol Environ Health, Part A 63 (2001) 173-189
2. Amitai G., Moorad D., Adani R., and Doctor B.P. Inhibition of acetylcholinesterase and butyrylcholinesterase by chlorpyrifos-oxon. Biochem Pharmacol 56 (1998) 293-299
3. Andersen M.E., Gargas M.L., Clewell H.J., and Severyn K.M. Quantitative evaluation of the metabolic interaction between trichloroethylene and 1,1-dichloroethylene in vivo using gas uptake methods. Toxicol Appl Pharmacol 89 (1987) 185-205
4. Bradman A., Barr D.B., Claus-Henn B.G., Drumheller T., Curry C., and Eskenazi B. Measurement of pesticides and other toxicants in amniotic fluid as a potential biomarker of prenatal exposure: a validation study. Environ Health Perspect 111 14 (2003) 1779-1782
5. Brown R.P., Delp M.D., Lindstedt S.L., Rhomberg L.R., and Beliles R.P. Physiological parameter values for physiologically based pharmacokinetic models. Toxicol Ind Health 13 (1997) 407-484
6. Buratti F.M., Volpe M.T., Fabrizi L., Meneguz A., Vittozzi L., and Testai E. Kinetic parameters of OPT pesticide desulfation by c-DNA expressed human CYPs. Environ Toxicol Pharmacol 11 (2002) 181-190
7. Buratti F.M., Volpe M.T., Meneguz A., Vittozzi L., and Testai E. CYP-specific bioactivation of four organophosphorothioate pesticides by human liver microsomes. Toxicol Appl Pharmacol 186 (2003) 143-154
8. Calabrese E.J. Comparative metabolism: the principal causes of differential susceptibility to toxic and carcinogenic agents. In: Calabrese E.J. (Ed). Principles of animals extrapolation (1991), Lewis Publishers, Chelsea, MI 203-276
9. Chambers J.E., Carr R.L., Boone S., and Chambers H.W. The metabolism of organophosphorus insecticides. In: Krieger R., Doull J., Ecobichon D., Gammon D., Hodgson E., Reiter L., and Ross J. (Eds). Handbook of pesticide toxicology vol. 2 (2001), Academic Press, San Diego 919-929
10. Chambers J.E., and Chambers H.W. Oxidative desulfuration of chlorpyrifos, chlorpyrifos-methyl, and leptophos by rat brain and liver 4 3 (1989) 201-203
11. Chanda S.M., Mortensen S.R., Moser V.C., and Padilla S. Tissue-specific effects of chlorpyrifos on carboxylesterase and cholinesterase activity in adult rats: an in vitro and in vivo comparison. Fundam Appl Toxicol 38 (1997) 148-157
12. Clement J.G. Role of aliesterase in organophosphate poisoning. Fundam Appl Toxicol 4 (1984) S96-S105
13. el-Masri H.A., Reardon K.F., and Yang R.S. Integrated approaches for the analysis of toxicologic interactions of chemical mixtures. Crit Rev Toxicol 27 2 (1997) 175-197
14. Fabrizi L., Gemma S., Testai E., and Vittozzi L. Identification of the cytochrome P450 isoenzymes involved in the metabolism of diazinon in the rat liver. J Biochem Mol Toxicol 13 1 (1999) 53-61
15. FQPA (1996). Food Quality Protection Act, Public Law No. 104-170.
16. Gearhart J.M., Jepson G.W., Clewell III H.J., Andersen M.E., and Conolly R.B. Physiologically based pharmacokinetic and pharmacodynamic model for the inhibition of acetylcholinesterase by diisopropylfluorophosphate. Toxicol Appl Pharmacol 106 (1990) 295-310
17. Halpert J., Hammond D., and Neal R.A. Inactivation of purified rat liver cytochrome P-450 during the metabolism of parathion (diethyl p-nitrophenyl phosphorothionate). J Biol Chem 255 3 (1980) 1080-1089
18. Hayes A.L., Wise R.A., and Weir F.W. Assessment of occupational exposure to organophosphates in pest control operators. Am Ind Hyg Assoc J 41 8 (1980) 568-575
19. Hodgson E., and Rose R.L. Organophosphorus chemicals: potent inhibitors of the human metabolism of steroid hormones and xenobiotics. Drug Metab Rev 38 1-2 (2006) 149-162
20. Joo H., Choi K., Rose R.L., and Hodgson E. Inhibition of fipronil and nonane metabolism in human liver microsomes and human cytochrome P450 isoforms by chlorpyrifos. J Biochem Mol Toxicol 21 2 (2007) 76-80
21. Karanth S., Liu J., Olivier Jr. K., and Pope C. Interactive toxicity of the organophosphorus insecticide chlorpyrifos and methyl chlorpyrifos in adult rats. Toxicol Appl Pharmacol 196 (2004) 183-190
22. Karanth S., Olivier Jr. K., Liu J., and Pope C. In vivo interaction between chlorpyrifos and parathion in adult rats: sequence of administration can markedly influence toxic. Toxicol Appl Pharmacol 177 (2001) 247-255
23. Kaushik R., Rosenfeld C.A., and Sultatos L.G. Concentration-dependent interactions of the organophosphates chlorpyrifos oxon and methyl paraoxon with human recombinant acetylcholinesterase. Toxicol Sci 221 (2007) 243-250
24. Kousba A.A., Poet T.S., and Timchalk C. Age-related brain cholinesterase inhibition kinetics following in vitro incubation with chlorpyrifos-oxon and diazinon-oxon. Toxicol Sci 95 1 (2007) 147-155
25. Kousba A.A., Sultatos L.G., Poet T.S., and Timchalk C. Comparison of chlorpyrifos-oxon and paraoxon acetylcholinesterase inhibition dynamics: potential role of a peripheral binding site. Toxicol Sci 80 (2004) 239-248
26. Kousba A., Poet T.S., and Timchalk C. Characterization of the in vitro kinetic interaction of chlorpyrifos-oxon with rat salivary cholinesterase: a potential biomonitoring matrix. Toxicology 188 2-3 (2003) 219-232
27. Krishnan K., Haddad S., Béliveau M., and Tardif R. Physiological modeling and extrapolation of pharmacokinetic interactions from binary to more complex chemical mixtures. Environ Health Perspect 110 Suppl. 6 (2002) 989-994
28. Lavy T.L., Mattice J.D., Massey J.H., and Skulman B.W. Measurement of year-long exposure to tree nursery workers using multiple pesticides. Arch Environ Contam Toxicol 24 (1993) 123-144
29. Lowe E.R., Rick D.L., West R.J., and Bartels M.J. The evaluation of quantitative structure property relationship predictions of tissue-blood partition coefficients of high lipophilic chemicals. Drug Metab Rev 38 (2006) 78
30. Lu C., Fenske R.A., Simcox N.J., and Kalman D. Pesticide exposure of children in agricultural community: evidence of household proximity to farmland and take home exposure pathways. Environ Res Sect A 84 (2000) 290-302
31. Ma T., and Chambers J.E. Kinetic parameters of desulfuration and dearylation of parathion and chlorpyrifos by rat liver microcosms. Food Chem Toxicol 32 (1994) 763-767
32. Ma T., and Chambers J.E. A kinetic analysis of hepatic microsomal activation of parathion and chlorpyrifos in control and phenobarbital-treated rats. J Biochem Toxicol 10 (1995) 63-68
33. Marinovich M., Ghilardi F., and Galli C.L. Effect of pesticide mixtures on in vitro nervous cells: comparison with single pesticides. Toxicology 108 (1996) 201-206
34. Maxwell D.M., Lenz D.E., Groff W.A., Kaminskis A., and Froehlich H.L. The effect of blood flow and detoxification on in vivo cholinesterase inhibition by soman in rats. Toxicol Appl Pharmacol 88 (1987) 66-76
35. Mileson B.E., Chambers J.E., Chen W.L., Dettbarn W., Ehrich M., Eldefrawi A.T., Gaylor D.W., Hamernik K., Hodgson E., Karczmar A.G., Padilla S., Pope C.N., Richardson R.J., Saunders D.R., Sheets L.P., Sultatos L.G., and Wallace K.B. Common mechanism of toxicity: a case study of organophosphorus pesticides. Toxicol Sci 41 (1998) 8-20
36. Mortensen S.R., Chanda S.M., Hooper M.J., and Padilla S. Maturational differences in chlorpyrifos-oxonase activity may contribute to age-related sensitivity to chlorpyrifos. J Biochem Toxicol 11 (1996) 279-287
37. Moser V.C., Casey M., Hamm A., Carter Jr. W.H., Simmons J.E., and Gennings C. Neurtoxicological and statistical analyses of a mixture of five organophosphorus pesticides using a ray design. Toxicol Sci 86 1 (2005) 101-115
38. Moser V.C., Simmons J.E., and Gennings C. Neurotoxicological interactions of a five-pesticide mixture in preweanling rats. Toxicol Sci 92 1 (2006) 235-245
39. 14C-labeled diazinon in the rat. J Agric Food Chem 18 (1970) 208-212
40. Nolan R.J., Rick D.L., Freshour N.L., and Saunders J.H. Chlorpyrifos: pharmacokinetics in human volunteers. Toxicol Appl Pharmacol 73 (1984) 8-15
41. Poet T.S., Kousba A.A., Dennison S.L., and Timchalk C. Physiologically based pharmacokinetic/pharmacodynamic model for the organophosphorus pesticide diazinon. NeuroToxicol 25 (2004) 1013-1030
42. Poet T.S., Wu H., Kousba A.A., and Timchalk C. In vitro rat hepatic and enterocyte metabolism of the organophosphate pesticides chlorpyrifos and diazinon. Toxicol Sci 72 (2003) 193-200
43. Poulin P., and Krishnan K. An algorithm for predicting tissue:blood partition coefficients of organic chemicals from n-octonol: water partition coefficient data. J Toxicol Environ Health 46 (1995) 117-129
44. Quandt S.A., Arcury T.A., Rao P., Snively B.M., Camann D.E., Doran A.M., Yau A.Y., Hoppin J.A., and Jackson D.S. Agricultural and residential pesticides in wipe samples from farmworker family residences in North Carolina and Virginia. Environ Health Perspect 112 3 (2004) 382-387
45. Richardson J.R., Chambers H.W., and Chambers J.E. Analysis of the additivity of in vitro inhibition of cholinesterase by mixtures of chlorpyrifos-oxon and azinphos-methyl-oxon. Toxicol Appl Pharmacol 172 (2001) 128-139
46. Sams C., Mason H.J., and Rawbone R. Evidence for the activation of organophosphate pesticides by cytochromes P450 3A4 and 2D6 in human liver microcosms. Toxicol Lett 116 (2000) 217-221
47. Staats D.A., Fisher J.W., and Conolly R.B. Gastrointestinal absorption of xenobiotics in physiologically based pharmacokinetic models. Drug Metab Dispos 19 (1991) 144-148
48. Sultatos L.G., and Murphy S.D. Kinetic analyses of the microsomal biotransformation of the phosphorothioate insecticides chlorpyrifos and parathion. Fundam Appl Toxicol 3 (1983) 16-21
49. Tang J., Cao Y., Rose R.L., Brimfield A.A., Dai D., Goldstein J.A., and Hodgson E. Metabolism of chlorpyrifos by human cytochrome P450 isoforms and human, mouse, and rat liver microsomes. Drug Metab Dispos 29 9 (2001) 1201-1204
50. Timchalk C., Kousba A.A., and Poet T.S. An age-dependent physiologically based pharmacokinetic/pharmacodynamic model for the organophosphorus insecticide chlorpyrifos in the preweanling rat. Toxicol Sci 98 2 (2007) 348-365
51. Timchalk C., Poet T.S., Hinman M.N., Busby A.L., and Kousba A.A. Pharmacokinetic and pharmacodynamic interaction for a binary mixture of chlorpyrifos and diazinon in the rat. Toxicol Appl Pharmacol 205 (2005) 31-42
52. Timchalk C., Nolan R.J., Mendrala A.L., Dittenber D.A., Brzak K.A., and Mattsson J.L. A physiologically based pharmacokinetic and pharmacodynamic (PBPK/PD) model for the organophosphate insecticide chlorpyrifos in rats and humans. Toxicol Sci 66 (2002) 34-53
53. Wacher V.J., Salphati L., and Benet L.Z. Active secretion and enterocytic drug metabolism barriers to drug absorption. Adv Drug Deliv Rev 46 (2001) 89-102
54. Yang R.S., el-Masri H.A., Thomas R.S., and Constan A.A. The use of physiologically-based pharmacokinetic/pharmacodynamic dosimetry models for chemical mixtures. Toxicol Lett 82-82 (1995) 497-504
55. Zhang Y., and Benet L.Z. The gut as a barrier to drug absorption combined role of cytochrome CYP 3A and p-glycoprotein. Clin Pharmacokinet 40 (2001) 159-168