-
1
-
-
0001372176
-
Guidelines for the health risk assessment of chemical mixtures
-
U.S. Environmental Protection Agency
-
U.S. Environmental Protection Agency. Guidelines for the health risk assessment of chemical mixtures. Fed Reg 51(185):3401-34025 (1986).
-
(1986)
Fed. Reg.
, vol.51
, Issue.185
, pp. 34014-34025
-
-
-
2
-
-
0003526589
-
Supplementary guidance for conducting health risk assessment of chemical mixtures
-
U.S. Environmental Protection Agency. EPA630R00002. Washington, D.C: U.S. EPA
-
U.S. Environmental Protection Agency. Supplementary guidance for conducting health risk assessment of chemical mixtures. EPA630R00002. Washington, D.C: U.S. EPA, 2000.
-
(2000)
-
-
-
3
-
-
0001989984
-
Toxicological consequences of combined exposure to environmental pollutants
-
Krishnan K., Brodeur J. Toxicological consequences of combined exposure to environmental pollutants. Arch Complex Environ Stud 3:1-106 (1991).
-
(1991)
Arch. Complex Environ. Stud.
, vol.3
, pp. 1-106
-
-
Krishnan, K.1
Brodeur, J.2
-
4
-
-
0028558984
-
Toxic interactions among environmental pollutants: Corroborating laboratory observations with human experience
-
Krishnan K, Brodeur J. Toxic interactions among environmental pollutants: corroborating laboratory observations with human experience. Environ Health Perspect 102:11-17 (1994).
-
(1994)
Environ. Health Perspect.
, vol.102
, pp. 11-17
-
-
Krishnan, K.1
Brodeur, J.2
-
5
-
-
0023195488
-
Quantitative evaluation of the metabolic interactions between trichloroethylene and 1,1-dicholoethylene in vivo using gas uptake methods
-
Andersen ME, Gargas ML, Clewell HJ, Severyn KM. Quantitative evaluation of the metabolic interactions between trichloroethylene and 1,1-dicholoethylene in vivo using gas uptake methods. Toxicol Appl Pharmacol 89:149-157(1987).
-
(1987)
Toxicol. Appl. Pharmacol.
, vol.89
, pp. 149-157
-
-
Andersen, M.E.1
Gargas, M.L.2
Clewell, H.J.3
Severyn, K.M.4
-
6
-
-
0030297476
-
Physiologically-based pharmacodynamic modeling of an interaction threshold between trichloroethylene and 1,1-dichloroethylene in Fischer 344 rats
-
El- Masri HA, Constan AA, Ramsdell HS, Yang RSH. Physiologically-based pharmacodynamic modeling of an interaction threshold between trichloroethylene and 1,1-dichloroethylene in Fischer 344 rats. Toxicol Appl Pharmacol 141:124-132 (1996).
-
(1996)
Toxicol. Appl. Pharmacol.
, vol.141
, pp. 124-132
-
-
El- Masri, H.A.1
Constan, A.A.2
Ramsdell, H.S.3
Yang, R.S.H.4
-
7
-
-
0025290203
-
In vivo metabolic interactions of benzene and tolune
-
Purcell KJ, Cason GH, Gargas ML, Andersen ME, Travis CC. In vivo metabolic interactions of benzene and tolune. Toxicol Lett 52:141-152 (1990).
-
(1990)
Toxicol. Lett.
, vol.52
, pp. 141-152
-
-
Purcell, K.J.1
Cason, G.H.2
Gargas, M.L.3
Andersen, M.E.4
Travis, C.C.5
-
8
-
-
0025764834
-
PBPK derived metabolic constants, hepatotoxicity, and lethality of BRCCI, in rats pretreated with clordecone, phenobarbital or mirex
-
Thakore KN, Gargas ML, Andersen ME, Methandale HM. PBPK derived metabolic constants, hepatotoxicity, and lethality of BRCCI, in rats pretreated with clordecone, phenobarbital or mirex. Toxicol Appl Pharmacol 109:514-528 (1991).
-
(1991)
Toxicol. Appl. Pharmacol.
, vol.109
, pp. 514-528
-
-
Thakore, K.N.1
Gargas, M.L.2
Andersen, M.E.3
Methandale, H.M.4
-
9
-
-
0002252728
-
Physiologically-based pharmacokinetic modeling of chemical mixtures
-
(Yang RSH, ed). New York:Academic Press
-
Krishnan K, Clewell HJ III, Andersen ME, Yang RSH. Physiologically-based pharmacokinetic modeling of chemical mixtures. In: Toxicology of Complex Mixtures (Yang RSH, ed). New York:Academic Press, 1994;399-437.
-
(1994)
Toxicology of Complex Mixtures
, pp. 399-437
-
-
Krishnan, K.1
Clewell H.J. III2
Andersen, M.E.3
Yang, R.S.H.4
-
10
-
-
0000581605
-
Physiologically based pharmacokinetic modeling in toxicology
-
(Hayes AW, ed). Philadelphia:Taylor & Francis
-
Krishnan K, Andersen ME. Physiologically based pharmacokinetic modeling in toxicology. In: Principles and Methods of Toxicology (Hayes AW, ed). Philadelphia:Taylor & Francis, 2001;193-241.
-
(2001)
Principles and Methods of Toxicology
, pp. 193-241
-
-
Krishnan, K.1
Andersen, M.E.2
-
11
-
-
0031080471
-
Assessing the relevance of rodent data on chemical interactions for health risk assessment purposes: A case study with dichloromethane-toluene mixture
-
Pelekis ML, Krishnan K. Assessing the relevance of rodent data on chemical interactions for health risk assessment purposes: a case study with dichloromethane-toluene mixture. Reg Toxicol Pharmacol 25:79-86 (1997).
-
(1997)
Reg. Toxicol. Pharmacol.
, vol.25
, pp. 79-86
-
-
Pelekis, M.L.1
Krishnan, K.2
-
12
-
-
0029016437
-
Physiòlogically-based pharmacokinetic modeling of a mixture of toluene and xylene in humans
-
Tardif R, Laparé S, Brodeur J. Krishnan K. Physiòlogically-based pharmacokinetic modeling of a mixture of toluene and xylene in humans. Risk Anal 15:335-342 (1995).
-
(1995)
Risk Anal.
, vol.15
, pp. 335-342
-
-
Tardif, R.1
Laparé, S.2
Brodeur, J.3
Krishnan, K.4
-
13
-
-
0027319124
-
Physiologically based modeling of the toxicokinetic interaction between toluene and m-xylene in the rat
-
Tardif R, Lapare S, Krishnan K, Breuder J. Physiologically based modeling of the toxicokinetic interaction between toluene and m-xylene in the rat. Toxicol Appl Pharmacol 120:226-273 (1993).
-
(1993)
Toxicol. Appl. Pharmacol.
, vol.120
, pp. 226-273
-
-
Tardif, R.1
Lapare, S.2
Krishnan, K.3
Breuder, J.4
-
14
-
-
0031149782
-
Physiologically based pharmacokkinetic modeling of a ternary mixture of alkyl benzenes in rats and humans
-
Tardif R, Charest-Tardif G, Brodeur J, Krishnan K. physiologically based pharmacokkinetic modeling of a ternary mixture of alkyl benzenes in rats and humans. Toxicol Appl Pharmacol 144:120-134 (1997).
-
(1997)
Toxicol. Appl. Pharmacol.
, vol.144
, pp. 120-134
-
-
Tardif, R.1
Charest-Tardif, G.2
Brodeur, J.3
Krishnan, K.4
-
15
-
-
0033572851
-
Physiological modeling of pharmacokinetic interactions in a quaternary mixture of hydrocarbons
-
Haddad S, Tardif R, Charest-Tardif G, Krishnan K. Physiological modeling of pharmacokinetic interactions in a quaternary mixture of hydrocarbons. Toxicol Appl Pharmacol 161:249-257 (1999).
-
(1999)
Toxicol. Appl. Pharmacol.
, vol.161
, pp. 249-257
-
-
Haddad, S.1
Tardif, R.2
Charest-Tardif, G.3
Krishnan, K.4
-
16
-
-
0034665623
-
Validation of a physiological modeling framework for simulating toxicokinetic interactions in chemical mixtures
-
Haddad S, Charest-Tardif G, Tardif R, Krishnan K. Validation of a physiological modeling framework for simulating toxicokinetic interactions in chemical mixtures. Toxicol Appl Pharmacol 167:199-209 (2000).
-
(2000)
Toxicol. Appl. Pharmacol.
, vol.167
, pp. 199-209
-
-
Haddad, S.1
Charest-Tardif, G.2
Tardif, R.3
Krishnan, K.4
-
17
-
-
12244254319
-
Physiologically based modeling of the maximal effect of metabolic interactions on the kinetics oof components of complex chemical mixtures
-
Haddad S, Charest-Tardif G, Krishnan K. Physiologically based modeling of the maximal effect of metabolic interactions on the kinetics oof components of complex chemical mixtures. J Toxicol Environ Health 60:101-113 (2000).
-
(2000)
J. Toxicol. Environ. Health
, vol.60
, pp. 101-113
-
-
Haddad, S.1
Charest-Tardif, G.2
Krishnan, K.3
-
18
-
-
0032847264
-
A modeling approach for predicting the biological hazard index of chemical mixtures
-
Haddad S, Tardif R, Viau C, Krishnan K. A modeling approach for predicting the biological hazard index of chemical mixtures. Toxicol Lett 108:303-308 (1999).
-
(1999)
Toxicol. Lett.
, vol.108
, pp. 303-308
-
-
Haddad, S.1
Tardif, R.2
Viau, C.3
Krishnan, K.4
-
19
-
-
0034874732
-
A PBPK modeling-based approach to account for interactions in the health risk assessment of chemical mixtures
-
Haddad S, Bélieau M, Tardif R, Krishnan K. A PBPK modeling-based approach to account for interactions in the health risk assessment of chemical mixtures. Toxicol Sci. 63:125-131 (2001).
-
(2001)
Toxicol. Sci.
, vol.63
, pp. 125-131
-
-
Haddad, S.1
Bélieau, M.2
Tardif, R.3
Krishnan, K.4
|