Physiologically based pharmacokinetic/pharmacodynamic model for the organophosphorus pesticide diazinon

NeuroToxicology

Volumn 25, Issue 6, 2004, Pages 1013-1030

  Poet, T S ^a   Kousba, A A ^a   Dennison, S L ^a   Timchalk, C ^a  

^a BATTELLE MEMORIAL INSTITUTE   (United States)

Author keywords

Cholinesterase inhibition; Organophosphate pesticide; PBPK PD

Indexed keywords

4 HYDROXY 2 ISOPROPYL 6 METHYLPYRIMIDINE; ACETYLCHOLINESTERASE; CHOLINESTERASE; DIMPYLATE; ORGANOPHOSPHATE PESTICIDE; PYRIMIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; BRAIN; CONTROLLED STUDY; DIAPHRAGM; DOSIMETRY; ENZYME INHIBITION; ERYTHROCYTE; FEMALE; NONHUMAN; PLASMA; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; RAT; TARGET ORGAN; TOXICITY; URINE; VALIDATION PROCESS;

ANIMALS; BRAIN; DIAZINON; INSECTICIDES; LIVER; MALE; MODELS, BIOLOGICAL; ORGANOPHOSPHORUS COMPOUNDS; RATS; RATS, SPRAGUE-DAWLEY;

EID: 5044234937     PISSN: 0161813X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neuro.2004.03.002     Document Type: Article

References (50)

1. Aldridge W.N. The nature of the reaction of organophosphorus compounds and carbamates with esterases. Bull. World Health Organ. 44:1971;25-30
2. Amitai G., Moorad D., Adani R., Doctor B.P. Inhibition of acetylcholinesterase and butyrylcholinesterase by chlorpyrifos-oxon. Biochem. Pharmacol. 56:1998;293-299
3. Bakke J.E., Feil V.J., Price C.E. Rat urinary metabolites from O,O-diethyl-O-(3,5,6-trichloro-2-pyridyl) phosphorothioate. J. Environ. Sci. Health B. 11:1976;225-230
4. Barton H.A., Deisinger P.J., English J.C., Gearhart J.N., Faber W.D., Tyler T.R., Banton M.I., Teeguarden J., Andersen M.E. Family approach for estimating reference concentrations/doses for series of related organic chemicals. Toxicol. Sci. 54:2000;251-261
5. Braeckman R.A., Audenaert F., Willems J.L., Belpaire F.M., Bogaert M.G. Toxicokinetics of methyl parathion and parathion in the dog after intravenous and oral administration. Arch Toxicol. 54:1983;71-82
6. Brown R.P., Delp M.D., Lindstedt S.L., Rhomberg L.R., Beliles R.P. Physiologicaly parameter values for physiologically based pharmacokinetic models. Toxicol Indust Health. 13:1997;407-484
7. Butte W., Heinzow B. Pollutants in house dust as indicators of indoor contamination. Rev. Environ. Contam Toxicol. 175:2002;1-46
8. Carr R.L., Chambers J.E. Acute effects of the organophosphate paraoxon on schedule- controlled behavior and esterase-activity in rats - dose- response relationships. Pharmacol Biochem Behavior. 40:1991;929-936
9. Chambers J.E., Chambers H.W. Oxidative desulfuration of chlorpyrifos, chlorpyrifos-methyl, and leptophos by rat brain and liver. J Biochem Toxicol. 4:1989;201-203
10. Clark A.G., Shamaan N.A., Sinclair M.D., Dauterman W.C. Insecticide metabolism by multiple glutathione S-transferases in 2 strains of the housefly, Musca-Domestica. Pesticide Biochem. Physiol. 25:2003;169-175
11. Domoradzki J.Y., Marty M.S., Hansen S.C., Timchalk C., Mattsson J.L. Effect of different dosing paradigms on the body burden of chlorpyrifos in neonatal Sprague-dawley rats. Toxicologist. 78:2004;104
12. Ding J.L., Yeo L.C. Conjugation of diazinon with glutathione, and gamma-glutamyl-transferase actibivities in Pilularia-Americana. Compar. Biochem. Physiol. C. 85:1986;413-417
13. Ellman G.L., Courtney K.D., Andres V. Jr., Feather-Stone R.M. A new and rapid colorimetric determination of acetylcholinesterase activity. Biochem Pharmacol. 7:1961;88-95
14. Fabrizi L., Gemma S., Testai E., Vittozzi L. Identification of the cytochrome P450 isoenzymes involved in the metabolism of diazinon in the rat liver. J. Biochem. Mol. Toxicol. 13:1999;53-61
15. Franklin C.A. Estimation of dermal exposure to pesticides and its use in risk assessment. Can. J. Physiol Pharmacol. 62:1984;1037-1039
16. Garfitt S.J., Jones K., Mason H.J., Cocker J. Exposure to the organophosphate diazinon: data from a human volunteer study with oral and dermal doses. Toxicol. Lett. 134:2002;105-113
17. Gearhart J.M., Jepson G.W., Clewell H.J. III, Andersen M.E., Conolly R.B. Physiologically based pharmacokinetic and pharmacodynamic model for the inhibition of acetylcholinesterase by diisopropylfluorophosphate. Toxicol. Appl. Pharmacol. 106:1990;295-310
18. Griffin P., Mason H., Heywood K., Cocker J. Oral and dermal absorption of chlorpyrifos: a human volunteer study. Occ. Environ. Med. 56:1999;10-13
19. Hackathorn D.R., Brinkman W.J., Hathaway T.R., Talbott T.D., Thompson L.R. Validation of A Whole-Blood Method for Cholinesterase Monitoring. Am Indust Hygiene Assoc J. 44:1983;547-551
20. Imaizumi H., Nagamatsu K., Hasegawa A., Ohno Y., Takanaka A. Metabolism and toxicity of acid phsphate-esters, metabolites of organophosphorous insecticides, in rat. Jpn. J Cancer Res. 39:1993;566-571
21. Iverson F., Grant D.L., Lacroix J. Diazinon metabolism in the dog. Bull. Environ. Contam Toxicol. 13:1975;611-618
22. Jepson G.W., McDougal J.N. Physiologically based modeling of nonsteady state dermal absorption of halogenated methanes from an aqueous solution. Toxicol Appl Pharmacol. 144:1997;315-324
23. Kousba A.A., Poet T.S., Timchalk C. Characterization of the in vitro kinetic interaction of chlorpyrifos-oxon with rat salivary cholinesterase: a potential biomonitoring matrix. Toxicology. 188:2003;219-232
24. Lanning C.L., Fine R.L., Sachs C.W., Rao U.S., Corcoran J.J., Abou-Donia M.B. Chlorpyrifos oxon interacts with the mammalian multidrug resistance protein, P-glycoprotein. J. Toxicol. Environ. Health. 47:1996;395-407
25. Lassiter T.L., Barone S. Jr., Padilla S. Ontogenetic differences in the regional and cellular acetylcholinesterase and butyrylcholinesterase activity in the rat brain. Brain Res. Dev. Brain Res. 105:1998;109-123
26. Lewis R.G., Fortune C.R., Blanchard F.T., Camann D.E. Movement and deposition of two organophosphorus pesticides within a residence after interior and exterior applications. J. Air Waste Manag. Assoc. 51:2001;339-351
27. Lotti M. Clinical toxicology of anitcholinesterase agents in humans. In: Krieger R, editor. Handbook of pesticide toxicology, vol. 2, 2001. p. 1043-85.
28. Ma T., Chambers J.E. Kinetic parameters of desulfuration and dearylation of parathion and chlorpyrifos by rat liver microsomes. Food Chem. Toxicol. 32:1994;763-767
29. MacIntosh D.L., Kabiru C.W., Ryan P.B. Longitudinal investigation of dietary exposure to selected pesticides. Environ. Health Perspect. 109:2001;145-150
30. Maxwell D., Brecht K., Eberle M. Correlation of invitro acetylcholinesterase (AChE) inhibition with invivo toxicity of organophosphorus agents. Abstr Papers of the Am Chem Soc. 194:1987;173
31. Mortensen S.R., Chanda S.M., Hooper M.J., Padilla S. Maturational differences in chlorpyrifos-oxonase activity may contribute to age-related sensitivity to chlorpyrifos. J Biochem Toxicol. 11:1996;279-287
32. Mucke W., Alt K.O., Esser H.O. Degradation of 14 C-labeled Diazinon in the rat. J. Agric. Food Chem. 18:1970;208-212
33. Nolan R.J., Rick D.L., Freshour N.L., Saunders J.H. Chlorpyrifos: pharmacokinetics in human volunteers. Toxicol. Appl. Pharmacol. 73:1984;8-15
34. Poet T.S., Thrall K.D., Corley R.A., Hui X., Edwards J.A., Weitz K.K., Maibach H.I., Wester R.C. Utility of real time breath analysis and physiologically based pharmacokinetic modeling to determine the percutaneous absorption of methyl chloroform in rats and humans. Toxicol Sci. 54:2000;42-51
35. Poet T.S., Wu H., Kousba A.A., Timchalk C. In vitro rat hepatic and intestinal metabolism of the organophosphate pesticides chlorpyrifos and diazinon. Toxicol. Sci. 72:2003;193-200
36. Poulin P., Krishnan K. A tissue composition-based algorithm for predicting tissue:air partition coefficients of organic chemicals. Toxicol. Appl. Pharmacol. 136:1996;126-130
37. Ramsey J.C., Andersen M.E. A physiologically based description of the inhalation pharmacokinetics of styrene in rats and humans. Toxicol. Appl. Pharmacol. 73:1984;159-175
38. Staats D.A., Fisher J.W., Conolly R.B. Gastrointestinal absorption of xenobiotics in physiologically based pharmacokinetic models. A two-compartment description. Drug Metab. Dispos. 19:1991;144-148
39. Takahashi H., Kojima T., Ikeda T., Tsuda S., Shirasu Y. Differences in the mode of lethality produced through intravenous and oral administration of organophosphorus insecticides in rats. Fundam. Appl. Toxicol. 16:1991;459-468
40. Taylor P., Radic Z., Hosea N.A., Camp S., Marchot P., Berman H.A. Structural bases for the specificity of cholinesterase catalysis and inhibition. Toxicol. Lett. 82-83:1995;453-458
41. Timchalk C., Kousba A., Poet T. Monte Carlo analysis of the human chlorpyrifos-oxonase (PON1) polymorphism using a physiologically based pharmacokinetic and pharmacodynamic (PBPK/PD) model. Toxicol. Lett. 135:2002a;51
42. Timchalk C., Nolan R.J., Mendrala A.L., Dittenber D.A., Brzak K.A., Mattsson J.L. A Physiologically based pharmacokinetic and pharmacodynamic (PBPK/PD) model for the organophosphate insecticide chlorpyrifos in rats and humans. Toxicol. Sci. 66:2002;34-53
43. Tomokuni K., Hasegawa T., Hirai Y., Koga N. The tissue distribution of diazinon and the inhibition of blood cholinesterase activities in rats and mice receiving a single intraperitoneal dose of diazinon. Toxicology. 37:1985;91-98
44. USEPA. Dermal exposure assessment: Principles and applications. 1992; EPA/600/8-91/011B, United States Environmental.
45. Van Tellingen O. The importance of drug-transporting p-glycoproteins in toxicology. Toxicol Lett. 120:2001;31-41
46. Wester R.C., Maibach H.I., Bucks D.A.W., Guy R.H. Malathion percutaneous-absorption after repeated administration to man. Toxicol. Appl. Pharmacol. 68:1983;116-119
47. Wester R.C., Sedik L., Melendres J., Logan F., Maibach H.I., Russell I. Percutaneous absorption of diazinon in humans. Food Chem. Toxicol. 31:1993;569-572
48. Wilson BW. Cholinesterases. In: Krieger R, editor. Handbook of pesticide toxicology, vol 2. Academic Press; 2001. p. 967-86.
49. Wu H.X., Evreux-Gros C., Descotes J. Diazinon toxicokinetics, tissue distribution and anticholinesterase activity in the rat. Biomed. Environ. Sci. 9:1996;359-369
50. Yang R.S., Hodgson E., Dauterman W.C. Metabolism in vitro of diazinon and diazoxon in rat liver. J. Agric. Food Chem. 19:1971;10-13