Pharmacokinetic and pharmacodynamic interaction for a binary mixture of chlorpyrifos and diazinon in the rat

Toxicology and Applied Pharmacology

Volumn 205, Issue 1, 2005, Pages 31-42

  Timchalk, C ^a   Poet, T S ^a   Hinman, M N ^b   Busby, A L ^c   Kousba, A A ^d  

^a BATTELLE MEMORIAL INSTITUTE   (United States)

^b Whitworth College   (United States)

^c TRINITY WESTERN UNIVERSITY   (Canada)

^d TargeGen Inc   (United States)

Author keywords

Chlorpyrifos; Cholinesterase; Diazinon; Mixtures; Organophosphorus insecticide

Indexed keywords

ACETYLCHOLINESTERASE; CHLORPYRIFOS; CHOLINESTERASE; DIMPYLATE; INSECTICIDE; ORGANOPHOSPHORUS COMPOUND; PYRIMIDINE DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BLOOD ANALYSIS; BRAIN TISSUE; COMPETITION; DOSE RESPONSE; DRUG CLEARANCE; DRUG STRUCTURE; ENVIRONMENTAL EXPOSURE; ENZYME INHIBITION; ERYTHROCYTE; MALE; MEASUREMENT; METABOLISM; NEUROTOXICITY; NONHUMAN; OCCUPATIONAL EXPOSURE; QUANTITATIVE ANALYSIS; RAT; RISK ASSESSMENT; TISSUE LEVEL; URINALYSIS;

ADMINISTRATION, ORAL; ANIMALS; AREA UNDER CURVE; BRAIN; CHLORPYRIFOS; CHOLINESTERASE INHIBITORS; CHOLINESTERASES; DIAZINON; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG ADMINISTRATION SCHEDULE; DRUG EVALUATION, PRECLINICAL; DRUG SYNERGISM; ERYTHROCYTES; INTUBATION, GASTROINTESTINAL; MALE; METABOLIC CLEARANCE RATE; PYRIDONES; PYRIMIDINES; RATS; RATS, SPRAGUE-DAWLEY;

EID: 18844407501     PISSN: 0041008X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.taap.2004.09.004     Document Type: Article

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