Augmentation of CTLA-4 expression by wortmannin: Involvement of lysosomal sorting properties of CTLA-4

International Immunology

Volumn 11, Issue 9, 1999, Pages 1563-1571

  Oki, Shinji ^a   Kohsaka, Takao ^a   Azuma, Miyuki ^a  

^a NATIONAL RESEARCH INSTITUTE FOR CHILD HEALTH AND DEVELOPMENT   (Japan)

Author keywords

CTLA 4 expression; Endocytosis; Lysosomal trafficking; Post translational regulation

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; CELL PROTEIN; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; ENZYME INHIBITOR; MEMBRANE ANTIGEN; PHOSPHATIDYLINOSITOL 3 KINASE; WORTMANNIN;

ANIMAL CELL; ANTIGEN EXPRESSION; ARTICLE; CANCER CELL CULTURE; CONTROLLED STUDY; ENDOCYTOSIS; ENZYME ACTIVITY; IMMUNOFLUORESCENCE MICROSCOPY; MASTOCYTOMA; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN TARGETING; PROTEIN TRANSPORT; T LYMPHOCYTE ACTIVATION;

AMMONIUM CHLORIDE; ANDROSTADIENES; ANIMALS; ANTIGENS, CD; ANTIGENS, DIFFERENTIATION; CELL LINE, TRANSFORMED; CELL MEMBRANE; CHROMONES; DOWN-REGULATION; ENDOCYTOSIS; HUMANS; IMMUNOCONJUGATES; IMMUNOSUPPRESSIVE AGENTS; LEUKOCYTES, MONONUCLEAR; LYSOSOMES; MICE; MONENSIN; MORPHOLINES; RNA, MESSENGER; TRANSFECTION;

EID: 0032870207     PISSN: 09538178     EISSN: None     Source Type: Journal    
DOI: 10.1093/intimm/11.9.1563     Document Type: Article

References (50)

1. Linsley, P. S., Clark, E. A. and Ledbetter, J. A. 1990. T-cell antigen CD28 mediates adhesion with B cells by interacting with activation antigen B7/BB-1. Proc. Natl Acad. Sci. USA 87:5031.
2. Azuma, M., Ito, D., Yagita, H., Okumura, K., Phillips, J. H., Lanier, L. L. and Somoza, C. 1993. B70 antigen is a second ligand for CTLA-4 and CD28. Nature 366:76.
3. Krummel, M. F. and Allison, J. P. 1995. CD28 and CTLA-4 have opposing effects on the response of T cells to stimulation. J. Exp. Med. 182:459.
4. Krummel, M. F. and Allison, J. P. 1996. CTLA-4 engagement inhibits IL-2 accumulation and cell cycle progression upon activation of resting T cells. J. Exp. Med. 183:2533.
5. Walunas, T. L., Lenschow, D. J., Bakker, C. Y., Linsley, P. S., Freeman, G. J., Green, J. M., Thompson, C. B. and Bluestone, J. A. 1994. CTLA-4 can function as a negative regulator of T cell activation. Immunity 1:405.
6. Walunas, T. L., Bakker, C. Y. and Bluestone, J. A. 1996. CTLA-4 ligation blocks CD28-dependent T cell activation. J. Exp. Med. 183:2541.
7. Thompson, C. B. and Allison, J. P. 1997. The emerging role of CTLA-4 as an immune attenuator. Immunity 7:445.
8. Perez, V L., Van, P. L., Biuckians, A., Zheng, X. X., Strom, T. B. and Abbas, A. K. 1997. Induction of peripheral T cell tolerance in vivo requires CTLA-4 engagement. Immunity 6:411.
9. Bluestone, J. A. 1997. Is CTLA-4 a master switch for peripheral T cell tolerance? J. Immunol. 158:1989.
10. Perkins, D., Wang, Z., Donovan, C., He, H., Mark, D., Guan, G., Wang, Y., Walunas, T., Bluestone, J., Listman, J., et al. 1996. Regulation of CTLA-4 expression during T cell activation. J. Immunol. 156:4154.
11. Lindsten, T., Lee, K. P., Harris, E. S., Petryniak, B., Craighead, N., Reynolds, P. J., Lombard, D. B., Freeman, G. J., Nadler, L. M., Gray, G. S., et al. 1993. Characterization of CTLA-4 structure and expression on human T cells. J. Immunol. 151:3489.
12. Leung, H. T., Bradshaw, J., Cleaveland, J. S. and Linsley, P. S. 1995. Cytotoxic T lymphocyte-associated molecule-4, a highavidity receptor for CD80 and CD86, contains an intracellular localization motif in its cytoplasmic tail. J. Biol. Chem. 270:25107.
13. Linsley, P. S., Bradshaw, J., Greene, J., Peach, R., Bennett, K. L. and Mittler, R. S. 1996. Intracellular trafficking of CTLA-4 and focal localization towards sites of TCR engagement. Immunity 4:535.
14. Chuang, E., Alegre, M. L., Duckett, C. S., Noel, P. J., Vander, H. M. and Thompson, C. B. 1997. Interaction of CTLA-4 with the clathrin-associated protein AP50 results in ligand-independent endocytosis that limits cell surface expression. J. Immunol. 159:144.
15. Shiratori, T., Miyatake, S., Ohno, H., Nakaseko, C., Isono, K., Bonifacino, J. S. and Saito, T. 1997. Tyrosine phosphorylation controls internalization of CTLA-4 by regulating its interaction with clathrin-associated adaptor complex AP-2. Immunity 6:583.
16. Zhang, Y. and Allison, J. P. 1997. Interaction of CTLA-4 with AP50, a clathrin-coated pit adaptor protein. Proc. Natl Acad. Sci. USA 94:9273.
17. Marengere, L. E., Waterhouse, P., Duncan, G. S., Mittrucker, H. W., Feng, G. S. and Mak, T. W. 1996. Regulation of T cell receptor signaling by tyrosine phosphatase SYP association with CTLA-4. Science 272:1170.
18. Schneider, H., Prasad, K. V., Shoelson, S. E. and Rudd, C. E. 1995. CTLA-4 binding to the lipid kinase phosphatidylinositol 3-kinase in T cells. J. Exp. Med. 181:351.
19. Prasad, K. V., Cai, Y. C., Raab, M., Duckworth, B., Cantley, L., Shoelson, S. E. and Rudd, C. E. 1994. T-cell antigen CD28 interacts with the lipid kinase phosphatidylinositol 3-kinase by a cytoplasmic Tyr(P)-Met-Xaa-Met motif Proc. Natl Acad. Sci. USA 91:2834.
20. Pages, F., Ragueneau, M., Rottapel, R., Truneh, A., Nunes, J., Imbert, J. and Olive, D. 1994. Binding of phosphatidylinositol-3-OH kinase to CD28 is required for T-cell signalling. Nature 369:327.
21. Cai, Y. C., Cefai, D., Schneider, H., Raab, M., Nabavi, N. and Rudd, C. E. 1995. Selective CD28pYMNM mutations implicate phosphatidylinositol 3-kinase in CD86-CD28-mediated costimulation. Immunity 3:417.
22. Joly, M., Kazlauskas, A., Fay, F. S. and Corvera, S. 1994. Disruption of PDGF receptor trafficking by mutation of its Pl-3 kinase binding sites. Science 263:684.
23. Joly, M., Kazlauskas, A. and Corvera, S. 1995. Phosphatidylinositol 3-kinase activity is required at a postendocytic step in platelet-derived growth factor receptor trafficking. J. Biol. Chem. 270:13225.
24. Schu, P. V., Takegawa, K., Fry, M. J., Stack, J. H., Waterfield, M. D. and Emr, S. D. 1993. Phosphatidylinositol 3-kinase encoded by yeast VPS34 gene essential for protein sorting. Science 260:88.
25. Shepherd, P. R., Nave, B. T. and O'Rahilly, S. 1996. The role of phosphoinositide 3-kinase in insulin signalling. J. Mol. Endocrinol. 17:175.
26. Karasuyama, H. and Melchers, F. 1988. Establishment of mouse cell lines which constitutively secrete large quantities of interleukin 2, 3, 4 or 5, using modified cDNA expression vectors. Eur. J. Immunol. 18:97.
27. Lin, A. Y., Devaux, B., Green, A., Sagerstrom, C., Elliott, J. F. and Davis, M. M. 1990. Expression of T cell antigen receptor heterodimers in a lipid-linked form. Science 249:677.
28. Azuma, M., Cayabyab, M., Buck, D., Phillips, J. H. and Lanier, L. L. 1992. CD28 interaction with 87 costimulates primary allogeneic proliferative responses and cytotoxicity mediated by small, resting T lymphocytes. J. Exp. Med. 175:353.
29. Nakanishi, S., Kakita, S., Takahashi, I., Kawahara, K., Tsukuda, E., Sano, T., Yamada, K., Yoshida, M., Kase, H. and Matsuda, Y. 1992. Wortmannin, a microbial product inhibitor of myosin light chain kinase. J. Biol. Chem. 267:2157.
30. Vlahos, C. J., Matter, W. F., Hui, K. Y. and Brown, R. F. 1994. A specific inhibitor of phosphatidylinositol 3-kinase, 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002). J. Biol. Chem. 269:5241.
31. Lu, Y., Rodriguez, R., Bjorndahl, J., Phillips, C. A. and Trevillyan, J. M. 1996. CD28-dependent killing by human YT cells requires phosphatidylinositol 3-kinase activation. Eur. J. Immunol. 26:1278.
32. Teng, J. M. C., Liu, X., Wills, G. B. and Dupont, B. 1996. CD28-mediated cytotoxicity by the human leukemic NK cell line YT involves tyrosine phosphorylation, activation of phosphatidylinositol 3-kinase, and protein kinase C. J. Immunol. 156:3222.
33. Chen, J. W., Murphy, T. L., Willingham, M. C., Pastan, I. and August, J. T. 1985. Identification of two lysosomal membrane glycoproteins. J. Cell Biol. 101:85.
34. Cefai, D., Schneider, H., Matangkasombut, O., Kang, H., Brody, J. and Rudd, C. E. 1998. CD28 receptor endocytosis is targeted by mutations that disrupt phosphatidylinositol 3-kinase binding and costimulation. J. Immunol 160:2223.
35. Meyers, R. and Cantley, L. C. 1997, Cloning and characterization of a wortmannin-sensitive human phosphatidylinositol 4-kinase. J. Biol. Chem. 272:4384.
36. Nakanishi, S., Catt, K. J. and Balla, T. 1995. A wortmannin-sensitive phosphatidylinositol 4-kinase that regulates hormone-sensitive pools of inositolphospholipids. Proc. Natl Acad. Sci. USA 92:5317.
37. Cross, M. J., Stewart, A., Hodgkin, M. N., Kerr, D. J. and Wakelam, M. J. 1995. Wortmannin and its structural analogue demethoxyviridin inhibit stimulated phospholipase A2 activity in Swiss 3T3 cells. Wortmannin is not a specific inhibitor of phosphatidylinositol 3-kinase. J. Biol. Chem. 270:25352.
38. Bonser, R. W., Thompson, N. T., Randall, R. W., Tateson, J. E., Spacey, G. D., Hodson, H. F. and Garland, L. G. 1989. Demethoxyviridin and wortmannin block phospholipase C and D activation in the human neutrophil. Br. J. Pharmacol. 264:617.
39. Jones, S. M. and Howell, K. E. 1997, Phosphatidylinositol 3-kinase is required for the formation of constitutive transport vesicles from the TGN. J. Cell Biol. 139:339.
40. Martys, J. L., Wjasow, C., Gangi, D. M., Kielian, M. C., McGraw, T. E. and Backer, J. M. 1996. Wortmannin-sensitive trafficking pathways in Chinese hamster ovary cells. Differential effects on endocytosis and lysosomal sorting. J. Biol. Chem. 271:10953
41. Robinson, M. S. 1994. The role of clathrin, adaptors and dynamin in endocytosis. Curr. Opin. Cell Biol. 6:538.
42. Cowles, C. R., Odorizzi, G., Payne, G S. and Emr, S. D. 1997. The AP-3 adaptor complex is essential for cargo-selective transport to the yeast vacuole. Cell 91:109.
43. Stepp, J. D., Huang, K. and Lemmon, S. K. 1997. The yeast adaptor protein complex, AP-3, is essential for the efficient delivery of alkaline phosphatase by the alternate pathway to the vacuole. J. Cell Biol. 139:1761.
44. Ward, S. G., Wilson, A., Turner, L., Westwick, J. and Sansom, D. M. 1995. Inhibition of CD28-mediated T cell costimulation by the phosphoinositide 3-kinase inhibitor wortmannin. Eur. J. Immunol 25:526.
45. Crooks, M. E., Littman, D. R., Carter, R. H., Fearon, D. T., Weiss, A. and Stein, P. H. 1995. CD28-mediated costimulation in the absence of phosphatidylinositol 3-kinase association and activation. Mol. Cell. Biol. 15:6820.
46. Lu, Y., Phillips, C. A. and Trevillyan, J. M. 1995. Phosphatidylinositol 3-kinase activity is not essential for CD28 costimulatory activity in Jurkat T cells: studies with a selective inhibitor, wortmannin. Eur. J. Immunol. 25:533.
47. Ni, H. T., Deeths, M. J. and Mescher M. F. 1996. Phosphatidylinositol 3 kinase activity is not essential for B7-1-mediated costimulation of proliferation or development of cytotoxicity in murine T cells. J. Immunol. 157:2243.
48. Truitt, K. E., Shi, J., Gibson, S., Segal, L. G., Mills, G. B. and Imboden, J. B. 1995. CD28 delivers costimulatory signals independently of its association with phosphatidylinositol 3-kinase. J. Immunol. 155:4702.
49. Taub, D. D., Murphy, W. J., Asai, O., Fenton, R. G., Peltz, G., Key, M. L., Turcovski, C. S. and Longo, D. L. 1997. Induction of alloantigen-specific T cell tolerance through the treatment of human T lymphocytes with wortmannin. J Immunol. 158:2745.
50. Wilson, A., Sansom, D., Parry, R., Westwick, J, and Ward, S. 1995. The phosphoinositide 3-kinase inhibitor wortmannin inhibits CD28-mediated T cell co-stimulation Biochem. Soc Trans. 23:282.