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Volumn 4, Issue 3, 2004, Pages 297-308

Undermining tumor angiogenesis by gene therapy: An emerging field

Author keywords

Angiogenesis; Cancer gene therapy; Endostatin; Interferon; Viral vector

Indexed keywords

ALPHA2 INTERFERON; ANGIOGENESIS INHIBITOR; ANGIOSTATIN; BETA INTERFERON; ENDOSTATIN; GAMMA INTERFERON; GAMMA INTERFERON INDUCIBLE PROTEIN 10; INTERLEUKIN 12; THROMBOCYTE FACTOR 4; THROMBOSPONDIN 1; TISSUE INHIBITOR OF METALLOPROTEINASE 1; TISSUE INHIBITOR OF METALLOPROTEINASE 2; VASCULOTROPIN RECEPTOR 1; VASCULOTROPIN RECEPTOR 2; VIRUS VECTOR;

EID: 4444296585     PISSN: 15665232     EISSN: None     Source Type: Journal    
DOI: 10.2174/1566523043346363     Document Type: Review
Times cited : (24)

References (123)
  • 3
    • 0032904888 scopus 로고    scopus 로고
    • Transfer of the murine interleukin-12 gene in vivo by a Semliki Forest virus vector induces B16 tumor regression through inhibition of tumor blood vessel formation monitored by Doppler ultrasonography
    • Asselin-Paturel, C., Lassau, N., Guinebretiere, J. M., Zhang, J., Gay, F., Bex, F., Hallez, S., Leclere, J., Peronneau, P., Mami-Chouaib, F., and Chouaib, S. (1999) Transfer of the murine interleukin-12 gene in vivo by a Semliki Forest virus vector induces B16 tumor regression through inhibition of tumor blood vessel formation monitored by Doppler ultrasonography. Gene Ther., 6: 606-615.
    • (1999) Gene Ther. , vol.6 , pp. 606-615
    • Asselin-Paturel, C.1    Lassau, N.2    Guinebretiere, J.M.3    Zhang, J.4    Gay, F.5    Bex, F.6    Hallez, S.7    Leclere, J.8    Peronneau, P.9    Mami-Chouaib, F.10    Chouaib, S.11
  • 5
    • 0011276415 scopus 로고    scopus 로고
    • Retroviral Vector Design for Cancer Gene Therapy
    • Eds. Lattime E.C. & Gerson S.L., Academic Press, San Diego
    • Baum, C., Ostertag, W., Stocking, C., and Von Laer, D. (2002) Retroviral Vector Design for Cancer Gene Therapy. In: Gene therapy of Cancer, Eds. Lattime E.C. & Gerson S.L., Academic Press, San Diego, pp. 3-29.
    • (2002) Gene Therapy of Cancer , pp. 3-29
    • Baum, C.1    Ostertag, W.2    Stocking, C.3    Von Laer, D.4
  • 7
    • 0032952010 scopus 로고    scopus 로고
    • Selective ablation of immature blood vessels in established human tumors follows vascular endothelial growth factor withdrawal
    • Benjamin, L. E., Golijanin, D., Itin, A., Pode, D., and Keshet, E. (1999) Selective ablation of immature blood vessels in established human tumors follows vascular endothelial growth factor withdrawal. J Clin. Invest., 103: 159-165.
    • (1999) J. Clin. Invest. , vol.103 , pp. 159-165
    • Benjamin, L.E.1    Golijanin, D.2    Itin, A.3    Pode, D.4    Keshet, E.5
  • 8
    • 0034575632 scopus 로고    scopus 로고
    • The angiogenesis inhibitor endostatin impairs blood vessel maturation during wound healing
    • Bloch, W., Huggel, K., Sasaki, T., Grose, R., Bugnon, P., Addicks, K., Timpl, R., and Werner, S. (2000) The angiogenesis inhibitor endostatin impairs blood vessel maturation during wound healing. FASEB J., 14: 2373-2376.
    • (2000) FASEB J. , vol.14 , pp. 2373-2376
    • Bloch, W.1    Huggel, K.2    Sasaki, T.3    Grose, R.4    Bugnon, P.5    Addicks, K.6    Timpl, R.7    Werner, S.8
  • 9
    • 0031469819 scopus 로고    scopus 로고
    • Antiangiogenic therapy of experimental cancer does not induce acquired drug resistance
    • Boehm, T., Folkman, J., Browder, T., and O'Reilly, M. S. (1997) Antiangiogenic therapy of experimental cancer does not induce acquired drug resistance. Nature, 390: 404-407.
    • (1997) Nature , vol.390 , pp. 404-407
    • Boehm, T.1    Folkman, J.2    Browder, T.3    O'Reilly, M.S.4
  • 11
    • 0010712792 scopus 로고    scopus 로고
    • Disruption of angiogenesis by PEX, a noncatalytic metalloproteinase fragment with integrin binding activity
    • Brooks, P. C., Silletti, S., von Schalscha, T. L., Friedlander, M., and Cheresh, D. A. (1998) Disruption of angiogenesis by PEX, a noncatalytic metalloproteinase fragment with integrin binding activity. Cell, 92: 391-400.
    • (1998) Cell , vol.92 , pp. 391-400
    • Brooks, P.C.1    Silletti, S.2    von Schalscha, T.L.3    Friedlander, M.4    Cheresh, D.A.5
  • 12
    • 0037099521 scopus 로고    scopus 로고
    • Adenovirus-mediated endostatin delivery results in inhibition of mammary gland tumor growth in C3(1)/SV40 T-antigen transgenic mice
    • Calvo, A., Feldman, A. L., Libutti, S. K., and Green, J. E. (2002) Adenovirus-mediated endostatin delivery results in inhibition of mammary gland tumor growth in C3(1)/SV40 T-antigen transgenic mice. Cancer Res., 62: 3934-3938.
    • (2002) Cancer Res. , vol.62 , pp. 3934-3938
    • Calvo, A.1    Feldman, A.L.2    Libutti, S.K.3    Green, J.E.4
  • 14
    • 0033565645 scopus 로고    scopus 로고
    • Liposomes complexed to plasmids encoding angiostatin and endostatin inhibit breast cancer in nude mice
    • Chen, Q. R., Kumar, D., Stass, S. A., and Mixson, A. J. (1999) Liposomes complexed to plasmids encoding angiostatin and endostatin inhibit breast cancer in nude mice. Cancer Res., 59: 3308-3312.
    • (1999) Cancer Res. , vol.59 , pp. 3308-3312
    • Chen, Q.R.1    Kumar, D.2    Stass, S.A.3    Mixson, A.J.4
  • 15
    • 0031197176 scopus 로고    scopus 로고
    • Controlling mammalian gene expression with small molecules
    • Clackson, T. (1997) Controlling mammalian gene expression with small molecules. Curr. Opin. Chem. Biol., 1: 210-218.
    • (1997) Curr. Opin. Chem. Biol. , vol.1 , pp. 210-218
    • Clackson, T.1
  • 16
    • 0029071065 scopus 로고
    • Activation of mitogen-activated protein kinases by vascular endothelial growth factor and basic fibroblast growth factor in capillary endothelial cells is inhibited by the antiangiogenic factor 16-kDa N- terminal fragment of prolactin
    • D'Angelo, G., Struman, I., Martial, J., and Weiner, R. I. (1995) Activation of mitogen-activated protein kinases by vascular endothelial growth factor and basic fibroblast growth factor in capillary endothelial cells is inhibited by the antiangiogenic factor 16-kDa N- terminal fragment of prolactin. Proc. Natl. Acad. Sci. USA, 92: 6374-6378.
    • (1995) Proc. Natl. Acad. Sci. USA , vol.92 , pp. 6374-6378
    • D'Angelo, G.1    Struman, I.2    Martial, J.3    Weiner, R.I.4
  • 17
    • 0037942860 scopus 로고    scopus 로고
    • Antiangiogenic therapy against experimental glioblastoma using genetically engineered cells producing interferon-alpha, angiostatin, or endostatin
    • De Bouard, S., Guillamo, J.S., Christov, C., Lefevre, N., Brugieres, P., Gola, E., Devanz, P., Indraccolo, S., and Peschanski, M. (2003) Antiangiogenic therapy against experimental glioblastoma using genetically engineered cells producing interferon-alpha, angiostatin, or endostatin. Hum. Gene Ther., 14: 883-895.
    • (2003) Hum. Gene Ther. , vol.14 , pp. 883-895
    • De Bouard, S.1    Guillamo, J.S.2    Christov, C.3    Lefevre, N.4    Brugieres, P.5    Gola, E.6    Devanz, P.7    Indraccolo, S.8    Peschanski, M.9
  • 18
    • 0038644403 scopus 로고    scopus 로고
    • Targeting exogenous genes to tumor angiogenesis by transplantation of genetically modified hematopoietic stem cells
    • De Palma, M., Venneri, M.A., Roca, C., and Naldini, L. (2003) Targeting exogenous genes to tumor angiogenesis by transplantation of genetically modified hematopoietic stem cells. Nat. Med., 9: 789-795.
    • (2003) Nat. Med. , vol.9 , pp. 789-795
    • De Palma, M.1    Venneri, M.A.2    Roca, C.3    Naldini, L.4
  • 19
    • 0032519590 scopus 로고    scopus 로고
    • Inhibition of basic fibroblast growth factor expression, angiogenesis, and growth of human bladder carcinoma in mice by systemic interferon- Alpha administration
    • Dinney, C. P., Bielenberg, D. R., Perrotte, P., Reich, R., Eve, B. Y., Bucana, C. D., and Fidler, I. J. (1998) Inhibition of basic fibroblast growth factor expression, angiogenesis, and growth of human bladder carcinoma in mice by systemic interferon- alpha administration. Cancer Res., 58: 808-814.
    • (1998) Cancer Res. , vol.58 , pp. 808-814
    • Dinney, C.P.1    Bielenberg, D.R.2    Perrotte, P.3    Reich, R.4    Eve, B.Y.5    Bucana, C.D.6    Fidler, I.J.7
  • 20
    • 0033557916 scopus 로고    scopus 로고
    • Suppression of angiogenesis, tumorigenicity, and metastasis by human prostate cancer cells engineered to produce interferon-beta
    • Dong, Z., Greene, G., Pettaway, C., Dinney, C. P., Eue, I., Lu, W., Bucana, C. D., Balbay, M. D., Bielenberg, D., and Fidler, I. J. (1999) Suppression of angiogenesis, tumorigenicity, and metastasis by human prostate cancer cells engineered to produce interferon-beta. Cancer Res., 59: 872-879.
    • (1999) Cancer Res. , vol.59 , pp. 872-879
    • Dong, Z.1    Greene, G.2    Pettaway, C.3    Dinney, C.P.4    Eue, I.5    Lu, W.6    Bucana, C.D.7    Balbay, M.D.8    Bielenberg, D.9    Fidler, I.J.10
  • 21
    • 0033504699 scopus 로고    scopus 로고
    • Toxicity profile of interferon alfa-2b in children: A prospective evaluation
    • Dubois, J., Hershon, L., Carmant, L., Belanger, S., Leclerc, J. M., and David, M. (1999) Toxicity profile of interferon alfa-2b in children: A prospective evaluation. J. Pediatr., 135: 782-785.
    • (1999) J. Pediatr. , vol.135 , pp. 782-785
    • Dubois, J.1    Hershon, L.2    Carmant, L.3    Belanger, S.4    Leclerc, J.M.5    David, M.6
  • 22
    • 0034161989 scopus 로고    scopus 로고
    • Heterogeneity of angiogenesis and blood vessel maturation in human tumors: Implications for antiangiogenic tumor therapies
    • Eberhard, A., Kahlert, S., Goede, V., Hemmerlein, B., Plate, K. H., and Augustin, H. G. (2000) Heterogeneity of angiogenesis and blood vessel maturation in human tumors: implications for antiangiogenic tumor therapies. Cancer Res., 60: 1388-1393.
    • (2000) Cancer Res. , vol.60 , pp. 1388-1393
    • Eberhard, A.1    Kahlert, S.2    Goede, V.3    Hemmerlein, B.4    Plate, K.H.5    Augustin, H.G.6
  • 23
    • 0036222328 scopus 로고    scopus 로고
    • Unfulfilled promise of endostatin in a gene therapy-xenotransplant model of human acute lymphocytic leukemia
    • Eisterer, W., Jiang, X., Bachelot, T., Pawliuk, R., Abramovich, C., Leboulch, P., Hogge, D., and Eaves, C. (2002) Unfulfilled promise of endostatin in a gene therapy-xenotransplant model of human acute lymphocytic leukemia. Mol. Ther., 5: 352-359.
    • (2002) Mol. Ther. , vol.5 , pp. 352-359
    • Eisterer, W.1    Jiang, X.2    Bachelot, T.3    Pawliuk, R.4    Abramovich, C.5    Leboulch, P.6    Hogge, D.7    Eaves, C.8
  • 26
    • 0034666258 scopus 로고    scopus 로고
    • Progress in antiangiogenic gene therapy of cancer
    • Feldman, A. L., and Libutti, S. K. (2000) Progress in antiangiogenic gene therapy of cancer. Cancer, 89: 1181-1194.
    • (2000) Cancer , vol.89 , pp. 1181-1194
    • Feldman, A.L.1    Libutti, S.K.2
  • 27
    • 0034654555 scopus 로고    scopus 로고
    • Antiangiogenic gene therapy of cancer utilizing a recombinant adenovirus to elevate systemic endostatin levels in mice
    • Feldman, A. L., Restifo, N. P., Alexander, H. R., Bartlett, D. L., Hwu, P., Seth, P., and Libutti, S. K. (2000) Antiangiogenic gene therapy of cancer utilizing a recombinant adenovirus to elevate systemic endostatin levels in mice. Cancer Res., 60: 1503-1506.
    • (2000) Cancer Res. , vol.60 , pp. 1503-1506
    • Feldman, A.L.1    Restifo, N.P.2    Alexander, H.R.3    Bartlett, D.L.4    Hwu, P.5    Seth, P.6    Libutti, S.K.7
  • 28
    • 0033941331 scopus 로고    scopus 로고
    • Gene therapy of cancer with interferon: Lessons from tumor models and perspectives for clinical applications
    • Ferrantini, M., and Belardelli, F. (2000) Gene therapy of cancer with interferon: lessons from tumor models and perspectives for clinical applications. Semin. Cancer Biol., 10: 145-157.
    • (2000) Semin. Cancer Biol. , vol.10 , pp. 145-157
    • Ferrantini, M.1    Belardelli, F.2
  • 29
    • 0025141337 scopus 로고
    • What is the evidence that tumors are angiogenesis dependent?
    • Folkman, J. (1990) What is the evidence that tumors are angiogenesis dependent? J. Natl. Cancer Inst., 82: 4-6.
    • (1990) J. Natl. Cancer Inst. , vol.82 , pp. 4-6
    • Folkman, J.1
  • 30
    • 0028929803 scopus 로고
    • Angiogenesis in cancer, vascular, rheumatoid and other disease
    • Folkman, J. (1995a) Angiogenesis in cancer, vascular, rheumatoid and other disease. Nat. Med., 1: 27-31.
    • (1995) Nat. Med. , vol.1 , pp. 27-31
    • Folkman, J.1
  • 31
    • 84975525035 scopus 로고
    • Seminars in Medicine of the Beth Israel Hospital Boston. Clinical applications of research on angiogenesis
    • Folkman, J. (1995b) Seminars in Medicine of the Beth Israel Hospital, Boston. Clinical applications of research on angiogenesis. N. Engl. J. Med., 333: 1757-1763.
    • (1995) N. Engl. J. Med. , vol.333 , pp. 1757-1763
    • Folkman, J.1
  • 32
    • 0032482939 scopus 로고    scopus 로고
    • Antiangiogenic gene therapy
    • Folkman, J. (1998) Antiangiogenic gene therapy. Proc. Natl. Acad. Sci. USA 95: 9064-9066.
    • (1998) Proc. Natl. Acad. Sci. USA , vol.95 , pp. 9064-9066
    • Folkman, J.1
  • 33
    • 0029085337 scopus 로고
    • Peripheral blood T lymphocytes and lymphocytes infiltrating human cancers express vascular endothelial growth factor: A potential role for T cells in angiogenesis
    • Freeman, M. R., Schneck, F. X., Gagnon, M. L., Corless, C., Soker, S., Niknejad, K., Peoples, G. E., and Klagsbrun, M. (1995) Peripheral blood T lymphocytes and lymphocytes infiltrating human cancers express vascular endothelial growth factor: a potential role for T cells in angiogenesis. Cancer Res., 55: 4140-4145.
    • (1995) Cancer Res. , vol.55 , pp. 4140-4145
    • Freeman, M.R.1    Schneck, F.X.2    Gagnon, M.L.3    Corless, C.4    Soker, S.5    Niknejad, K.6    Peoples, G.E.7    Klagsbrun, M.8
  • 34
    • 0023118633 scopus 로고
    • Inhibition of endothelial cell proliferation by gamma-interferon
    • Friesel, R., Komoriya, A., and Maciag, T. (1987) Inhibition of endothelial cell proliferation by gamma-interferon. J. Cell Biol., 104: 689-696.
    • (1987) J. Cell Biol. , vol.104 , pp. 689-696
    • Friesel, R.1    Komoriya, A.2    Maciag, T.3
  • 36
    • 0032568632 scopus 로고    scopus 로고
    • Angiostatin gene transfer: Inhibition of tumor growth in vivo by blockage of endothelial cell proliferation associated with a mitosis arrest
    • Griscelli, F., Li, H., Bennaceur-Griscelli, A., Soria, J., Opolon, P., Soria, C., Perricaudet, M., Yeh, P., and Lu, H. (1998) Angiostatin gene transfer: inhibition of tumor growth in vivo by blockage of endothelial cell proliferation associated with a mitosis arrest. Proc. Natl. Acad. Sci. USA, 95: 6367-6372.
    • (1998) Proc. Natl. Acad. Sci. USA , vol.95 , pp. 6367-6372
    • Griscelli, F.1    Li, H.2    Bennaceur-Griscelli, A.3    Soria, J.4    Opolon, P.5    Soria, C.6    Perricaudet, M.7    Yeh, P.8    Lu, H.9
  • 38
    • 0035873073 scopus 로고    scopus 로고
    • Combined treatment of a murine breast cancer model with type 5 adenovirus vectors expressing murine angiostatin and IL-12: A role for combined anti-angiogenesis and immunotherapy
    • Gyorffy, S., Palmer, K., Podor, T. J., Hitt, M., and Gauldie, J. (2001) Combined treatment of a murine breast cancer model with type 5 adenovirus vectors expressing murine angiostatin and IL-12: a role for combined anti-angiogenesis and immunotherapy. J. Immunol., 166: 6212-6217.
    • (2001) J. Immunol. , vol.166 , pp. 6212-6217
    • Gyorffy, S.1    Palmer, K.2    Podor, T.J.3    Hitt, M.4    Gauldie, J.5
  • 39
    • 0036194917 scopus 로고    scopus 로고
    • Enhancement of the antitumor activity of interleukin-12 by targeted delivery to neovasculature
    • Halin, C., Rondini S., Nilsson, F., Berndt, A., Kosmehl, H., Zardi, L., and Neri, D. (2002) Enhancement of the antitumor activity of interleukin-12 by targeted delivery to neovasculature. Nat. Biotechnol., 20: 264-269.
    • (2002) Nat. Biotechnol. , vol.20 , pp. 264-269
    • Halin, C.1    Rondini, S.2    Nilsson, F.3    Berndt, A.4    Kosmehl, H.5    Zardi, L.6    Neri, D.7
  • 41
    • 0034802845 scopus 로고    scopus 로고
    • Therapeutic effects of viral vector-mediated antiangiogenic gene transfer in malignant ascites
    • Hampl, M., Tanaka, T., Albert, P. S., Lee, J., Ferrari, N., and Fine, H. A. (2001) Therapeutic effects of viral vector-mediated antiangiogenic gene transfer in malignant ascites. Hum. Gene Ther., 12: 1713-1729.
    • (2001) Hum. Gene Ther. , vol.12 , pp. 1713-1729
    • Hampl, M.1    Tanaka, T.2    Albert, P.S.3    Lee, J.4    Ferrari, N.5    Fine, H.A.6
  • 45
    • 0030443062 scopus 로고    scopus 로고
    • Interleukin 10 suppresses tumor growth and metastasis of human melanoma cells: Potential inhibition of angiogenesis
    • Huang, S., Xie, K., Bucana, C. D., Ullrich, S. E., and Bar-Eli, M. (1996) Interleukin 10 suppresses tumor growth and metastasis of human melanoma cells: potential inhibition of angiogenesis. Clin. Cancer Res., 2: 1969-1979.
    • (1996) Clin. Cancer Res. , vol.2 , pp. 1969-1979
    • Huang, S.1    Xie, K.2    Bucana, C.D.3    Ullrich, S.E.4    Bar-Eli, M.5
  • 51
    • 0036554710 scopus 로고    scopus 로고
    • Inhibition of tumorigenicity and metastasis of human bladder cancer growing in athymic mice by interferon-beta gene therapy results partially from various antiangiogenic effects including endothelial cell apoptosis
    • Izawa, J. I., Sweeney, P., Perrotte, P., Kedar, D., Dong, Z., Slaton, J. W., Karashima, T., Inoue, K., Benedict, W. F., and Dinney, C. P. (2002) Inhibition of tumorigenicity and metastasis of human bladder cancer growing in athymic mice by interferon-beta gene therapy results partially from various antiangiogenic effects including endothelial cell apoptosis. Clin. Cancer Res., 8: 1258-1270.
    • (2002) Clin. Cancer Res. , vol.8 , pp. 1258-1270
    • Izawa, J.I.1    Sweeney, P.2    Perrotte, P.3    Kedar, D.4    Dong, Z.5    Slaton, J.W.6    Karashima, T.7    Inoue, K.8    Benedict, W.F.9    Dinney, C.P.10
  • 54
    • 0030582384 scopus 로고    scopus 로고
    • Identification of a natural soluble form of the vascular endothelial growth factor receptor, FLT-1, and its heterodimerization with KDR
    • Kendall, R. L., Wang, G., and Thomas, K. A. (1996) Identification of a natural soluble form of the vascular endothelial growth factor receptor, FLT-1, and its heterodimerization with KDR. Biochem. Biophys. Res. Commun., 226: 324-328.
    • (1996) Biochem. Biophys. Res. Commun. , vol.226 , pp. 324-328
    • Kendall, R.L.1    Wang, G.2    Thomas, K.A.3
  • 55
    • 0036780251 scopus 로고    scopus 로고
    • Clinical translation of angiogenesis inhibitors
    • Kerbel, R., and Folkman, J. (2002) Clinical translation of angiogenesis inhibitors. Nat. Rev. Cancer, 2: 727-739.
    • (2002) Nat. Rev. Cancer , vol.2 , pp. 727-739
    • Kerbel, R.1    Folkman, J.2
  • 56
    • 0032410157 scopus 로고    scopus 로고
    • Orthotopic models are necessary to predict therapy of transplantable tumors in mice
    • Killion, J. J., Radinsky, R., and Fidler, I. J. (1998) Orthotopic models are necessary to predict therapy of transplantable tumors in mice. Cancer Metastasis Rev., 17: 279-284.
    • (1998) Cancer Metastasis Rev. , vol.17 , pp. 279-284
    • Killion, J.J.1    Radinsky, R.2    Fidler, I.J.3
  • 57
    • 0035806482 scopus 로고    scopus 로고
    • Gene therapy for antiangiogenesis
    • Kleinman, H. K., and Liau, G. (2001) Gene therapy for antiangiogenesis. J Natl. Cancer Inst., 93: 965-967.
    • (2001) J. Natl. Cancer Inst. , vol.93 , pp. 965-967
    • Kleinman, H.K.1    Liau, G.2
  • 59
    • 0032542528 scopus 로고    scopus 로고
    • Gene therapy strategies for tumor antiangiogenesis
    • Kong, H. L., and Crystal, R. G. (1998) Gene therapy strategies for tumor antiangiogenesis. J. Natl. Cancer Inst., 90: 273-286.
    • (1998) J. Natl. Cancer Inst. , vol.90 , pp. 273-286
    • Kong, H.L.1    Crystal, R.G.2
  • 60
    • 0035884609 scopus 로고    scopus 로고
    • Inhibition of glioma angiogenesis and growth in vivo by systemic treatment with a monoclonal antibody against vascular endothelial growth factor receptor-2
    • Kunkel, P., Ulbricht, U., Bohlen, P., Brockmann, M. A., Fillbrandt, R., Stavrou, D., Westphal, M., and Lamszus, K. (2001) Inhibition of glioma angiogenesis and growth in vivo by systemic treatment with a monoclonal antibody against vascular endothelial growth factor receptor-2. Cancer Res., 61: 6624-6628.
    • (2001) Cancer Res. , vol.61 , pp. 6624-6628
    • Kunkel, P.1    Ulbricht, U.2    Bohlen, P.3    Brockmann, M.A.4    Fillbrandt, R.5    Stavrou, D.6    Westphal, M.7    Lamszus, K.8
  • 62
    • 0030692665 scopus 로고    scopus 로고
    • Human angiostatin inhibits murine hemangioendothelioma tumor growth in vivo
    • Lannutti, B. J., Gately, S. T., Quevedo, M. E., Soff, G. A., and Paller, A. S. (1997) Human angiostatin inhibits murine hemangioendothelioma tumor growth in vivo. Cancer Res., 57: 5277-5280.
    • (1997) Cancer Res. , vol.57 , pp. 5277-5280
    • Lannutti, B.J.1    Gately, S.T.2    Quevedo, M.E.3    Soff, G.A.4    Paller, A.S.5
  • 63
    • 0035399244 scopus 로고    scopus 로고
    • Clinical efforts to modulate angiogenesis in the adult: Gene therapy versus conventional approaches
    • Liau, G., Su, E. J., and Dixon, K. D. (2001) Clinical efforts to modulate angiogenesis in the adult: gene therapy versus conventional approaches. Drug Discov. Today, 6: 689-697.
    • (2001) Drug Discov. Today , vol.6 , pp. 689-697
    • Liau, G.1    Su, E.J.2    Dixon, K.D.3
  • 64
    • 0033532052 scopus 로고    scopus 로고
    • Systemic gene delivery expands the repertoire of effective antiangiogenic agents
    • Liu, Y., Thor, A., Shtivelman, E., Cao, Y., Tu, G., Heath, T. D., and Debs, R. J. (1999) Systemic gene delivery expands the repertoire of effective antiangiogenic agents. J. Biol. Chem., 274: 13338-13344.
    • (1999) J. Biol. Chem. , vol.274 , pp. 13338-13344
    • Liu, Y.1    Thor, A.2    Shtivelman, E.3    Cao, Y.4    Tu, G.5    Heath, T.D.6    Debs, R.J.7
  • 66
    • 7344268645 scopus 로고    scopus 로고
    • Targeted chemotherapy by intratumor injection of encapsulated cells engineered to produce CYP2B1, an ifosfamide activating cytochrome P450
    • Lohr, M., Muller, P., Karle, P., Stange, J., Mitzner, S., Jesnowski, R., Nizze, H., Nebe, B., Liebe, S., Salmons, B., and Gunzburg, W. H. (1998) Targeted chemotherapy by intratumor injection of encapsulated cells engineered to produce CYP2B1, an ifosfamide activating cytochrome P450. Gene Ther., 5: 1070-1078.
    • (1998) Gene Ther. , vol.5 , pp. 1070-1078
    • Lohr, M.1    Muller, P.2    Karle, P.3    Stange, J.4    Mitzner, S.5    Jesnowski, R.6    Nizze, H.7    Nebe, B.8    Liebe, S.9    Salmons, B.10    Gunzburg, W.H.11
  • 67
    • 0036468564 scopus 로고    scopus 로고
    • Suppression of intracranial human glioma growth after intramuscular administration of an adeno-associated viral vector expressing angiostatin
    • Ma, H. I., Guo, P., Li, J., Lin, S. Z., Chiang, Y. H., Xiao, X., and Cheng, S. Y. (2002) Suppression of intracranial human glioma growth after intramuscular administration of an adeno-associated viral vector expressing angiostatin. Cancer Res., 62: 756-763.
    • (2002) Cancer Res. , vol.62 , pp. 756-763
    • Ma, H.I.1    Guo, P.2    Li, J.3    Lin, S.Z.4    Chiang, Y.H.5    Xiao, X.6    Cheng, S.Y.7
  • 72
    • 0028174337 scopus 로고
    • Glioblastoma growth inhibited in vivo by a dominant-negative Flk-1 mutant
    • Millauer, B., Shawver, L. K., Plate, K. H., Risau, W., and Ullrich, A. (1994) Glioblastoma growth inhibited in vivo by a dominant-negative Flk-1 mutant. Nature, 367: 576-579.
    • (1994) Nature , vol.367 , pp. 576-579
    • Millauer, B.1    Shawver, L.K.2    Plate, K.H.3    Risau, W.4    Ullrich, A.5
  • 73
    • 0030996011 scopus 로고    scopus 로고
    • Progress in transcriptionally targeted and regulatable vectors for genetic therapy
    • Miller, N., and Whelan, J. (1997) Progress in transcriptionally targeted and regulatable vectors for genetic therapy. Hum. Gene Ther., 8: 803-815.
    • (1997) Hum. Gene Ther. , vol.8 , pp. 803-815
    • Miller, N.1    Whelan, J.2
  • 74
    • 0033761804 scopus 로고    scopus 로고
    • Adeno-associated virus vectors for gene therapy: More pros than cons?
    • Monahan, P.E., and Samulski, R.J. (2000) Adeno-associated virus vectors for gene therapy: more pros than cons? Mol. Med. Today, 6: 433-440.
    • (2000) Mol. Med. Today , vol.6 , pp. 433-440
    • Monahan, P.E.1    Samulski, R.J.2
  • 75
    • 0026644693 scopus 로고
    • Isolation and characterization of an inhibitor of neovascularization from scapular chondrocytes
    • Moses, M. A., Sudhalter, J., and Langer, R. (1992) Isolation and characterization of an inhibitor of neovascularization from scapular chondrocytes. J. Cell Biol., 119: 475-482.
    • (1992) J. Cell Biol. , vol.119 , pp. 475-482
    • Moses, M.A.1    Sudhalter, J.2    Langer, R.3
  • 76
    • 0033999308 scopus 로고    scopus 로고
    • Matrix metalloproteinases: Biologic activity and clinical implications
    • Nelson, A. R., Fingleton, B., Rothenberg, M. L., and Matrisian, L. M. (2000) Matrix metalloproteinases: biologic activity and clinical implications. J. Clin. Oncol., 18: 1135-1149.
    • (2000) J. Clin. Oncol. , vol.18 , pp. 1135-1149
    • Nelson, A.R.1    Fingleton, B.2    Rothenberg, M.L.3    Matrisian, L.M.4
  • 77
    • 0032535405 scopus 로고    scopus 로고
    • Adeno-associated virus-mediated delivery of antiangiogenic factors as an antitumor strategy
    • Nguyen, J. T., Wu, P., Clouse, M. E., Hlatky, L., and Terwilliger, E. F. (1999) Adeno-associated virus-mediated delivery of antiangiogenic factors as an antitumor strategy. Cancer Res., 58: 5673-5677.
    • (1999) Cancer Res. , vol.58 , pp. 5673-5677
    • Nguyen, J.T.1    Wu, P.2    Clouse, M.E.3    Hlatky, L.4    Terwilliger, E.F.5
  • 78
    • 0035863566 scopus 로고    scopus 로고
    • Targeted delivery of tissue factor to the ED-B domain of fibronectin, a marker of angiogenesis, mediates the infarction of solid tumors in mice
    • Nilsson, F., Kosmehl, H., Zardi, L., and Neri, D. (2001) Targeted delivery of tissue factor to the ED-B domain of fibronectin, a marker of angiogenesis, mediates the infarction of solid tumors in mice. Cancer Res., 61: 711-716.
    • (2001) Cancer Res. , vol.61 , pp. 711-716
    • Nilsson, F.1    Kosmehl, H.2    Zardi, L.3    Neri, D.4
  • 79
    • 0026756731 scopus 로고
    • Downregulation of interleukin 8 gene expression in human fibroblasts: Unique mechanism of transcriptional inhibition by interferon
    • Oliveira, I. C., Sciavolino, P. J., Lee, T. H., and Vilcek, J. (1992) Downregulation of interleukin 8 gene expression in human fibroblasts: unique mechanism of transcriptional inhibition by interferon. Proc. Natl. Acad. Sci. USA, 89: 9049-9053.
    • (1992) Proc. Natl. Acad. Sci. USA , vol.89 , pp. 9049-9053
    • Oliveira, I.C.1    Sciavolino, P.J.2    Lee, T.H.3    Vilcek, J.4
  • 81
    • 0027970092 scopus 로고
    • Angiostatin: A novel angiogenesis inhibitor that mediates the suppression of metastases by a Lewis lung carcinoma
    • O'Reilly, M. S., Holmgren, L., Shing, Y., Chen, C., Rosenthal, R. A., Moses, M., Lane, W. S., Cao, Y., Sage, E. H., and Folkman, J. (1994) Angiostatin: a novel angiogenesis inhibitor that mediates the suppression of metastases by a Lewis lung carcinoma. Cell, 79: 315-328.
    • (1994) Cell , vol.79 , pp. 315-328
    • O'Reilly, M.S.1    Holmgren, L.2    Shing, Y.3    Chen, C.4    Rosenthal, R.A.5    Moses, M.6    Lane, W.S.7    Cao, Y.8    Sage, E.H.9    Folkman, J.10
  • 82
    • 0033578910 scopus 로고    scopus 로고
    • Antiangiogenic activity of the cleaved conformation of the serpin antithrombin
    • O'Reilly, M. S., Pirie-Shepherd, S., Lane, W. S., and Folkman, J. (1999) Antiangiogenic activity of the cleaved conformation of the serpin antithrombin. Science, 285: 1926-1928.
    • (1999) Science , vol.285 , pp. 1926-1928
    • O'Reilly, M.S.1    Pirie-Shepherd, S.2    Lane, W.S.3    Folkman, J.4
  • 83
    • 0036222277 scopus 로고    scopus 로고
    • Continuous intravascular secretion of endostatin in mice from transduced hematopoietic stem cells
    • Pawliuk, R., Bachelot, T., Zurkiya, O., Eriksson, A., Cao, Y., and Leboulch, P. (2002) Continuous intravascular secretion of endostatin in mice from transduced hematopoietic stem cells. Mol. Ther., 5: 345-351.
    • (2002) Mol. Ther. , vol.5 , pp. 345-351
    • Pawliuk, R.1    Bachelot, T.2    Zurkiya, O.3    Eriksson, A.4    Cao, Y.5    Leboulch, P.6
  • 84
    • 0034710883 scopus 로고    scopus 로고
    • Suppression of angiogenesis by lentiviral delivery of PEX, a noncatalytic fragment of matrix metalloproteinase 2
    • Pfeifer, A., Kessler, T., Silletti, S., Cheresh, D. A., and Verma, I. M. (2000) Suppression of angiogenesis by lentiviral delivery of PEX, a noncatalytic fragment of matrix metalloproteinase 2. Proc. Natl. Acad. Sci. USA, 97: 12227-12232.
    • (2000) Proc. Natl. Acad. Sci. USA , vol.97 , pp. 12227-12232
    • Pfeifer, A.1    Kessler, T.2    Silletti, S.3    Cheresh, D.A.4    Verma, I.M.5
  • 85
    • 0034700090 scopus 로고    scopus 로고
    • Delivery of a stringent dimerizer-regulated gene expression system in a single retroviral vector
    • Pollock, R., Issner, R., Zoller, K., Natesan, S., Rivera, V. M., and Clackson, T. (2000) Delivery of a stringent dimerizer-regulated gene expression system in a single retroviral vector. Proc. Natl. Acad. Sci. USA, 97: 13221-13226.
    • (2000) Proc. Natl. Acad. Sci. USA , vol.97 , pp. 13221-13226
    • Pollock, R.1    Issner, R.2    Zoller, K.3    Natesan, S.4    Rivera, V.M.5    Clackson, T.6
  • 86
    • 0032564480 scopus 로고    scopus 로고
    • Interferon-beta gene therapy inhibits tumor formation and causes regression of established tumors in immune-deficient mice
    • Qin, X. Q., Tao, N., Dergay, A., Moy, P., Fawell, S., Davis, A., Wilson, J. M., and Barsoum, J. (1998) Interferon-beta gene therapy inhibits tumor formation and causes regression of established tumors in immune-deficient mice. Proc. Natl. Acad. Sci. USA, 95: 14411-14116.
    • (1998) Proc. Natl. Acad. Sci. USA , vol.95 , pp. 14116-14411
    • Qin, X.Q.1    Tao, N.2    Dergay, A.3    Moy, P.4    Fawell, S.5    Davis, A.6    Wilson, J.M.7    Barsoum, J.8
  • 89
    • 0035183055 scopus 로고    scopus 로고
    • Adenoviral delivery of TIMP1 or TIMP2 can modify the invasive behavior of pancreatic cancer and can have a significant antitumor effect in vivo
    • Rigg, A. S., and Lemoine, N. R. (2001) Adenoviral delivery of TIMP1 or TIMP2 can modify the invasive behavior of pancreatic cancer and can have a significant antitumor effect in vivo. Cancer Gene Ther., 8: 869-878.
    • (2001) Cancer Gene Ther. , vol.8 , pp. 869-878
    • Rigg, A.S.1    Lemoine, N.R.2
  • 90
    • 0030952289 scopus 로고    scopus 로고
    • Mechanisms of angiogenesis
    • Risau, W. (1997) Mechanisms of angiogenesis. Nature, 386: 671-674.
    • (1997) Nature , vol.386 , pp. 671-674
    • Risau, W.1
  • 92
    • 0032929390 scopus 로고    scopus 로고
    • Interferon (IFN)-beta gene transfer into TS/A adenocarcinoma cells and comparison with IFN-alpha: Differential effects on tumorigenicity and host response
    • Rozera, C., Carlei, D., Lollini, P. L., De Giovanni, C., Musiani, P., Di Carlo, E., Belardelli, F., and Ferrantini, M. (1999) Interferon (IFN)-beta gene transfer into TS/A adenocarcinoma cells and comparison with IFN-alpha: differential effects on tumorigenicity and host response. Am. J. Pathol., 154: 1211-1222.
    • (1999) Am. J. Pathol. , vol.154 , pp. 1211-1222
    • Rozera, C.1    Carlei, D.2    Lollini, P.L.3    De Giovanni, C.4    Musiani, P.5    Di Carlo, E.6    Belardelli, F.7    Ferrantini, M.8
  • 93
    • 0034657404 scopus 로고    scopus 로고
    • Liposome-delivered angiostatin strongly inhibits tumor growth and metastatization in a transgenic model of spontaneous breast cancer
    • Sacco, M. G., Caniatti, M., Cato, E. M., Frattini, A., Chiesa, G., Ceruti, R., Adorni, F., Zecca, L., Scanziani, E., and Vezzoni, P. (2000) Liposome-delivered angiostatin strongly inhibits tumor growth and metastatization in a transgenic model of spontaneous breast cancer. Cancer Res., 60: 2660-2665.
    • (2000) Cancer Res. , vol.60 , pp. 2660-2665
    • Sacco, M.G.1    Caniatti, M.2    Cato, E.M.3    Frattini, A.4    Chiesa, G.5    Ceruti, R.6    Adorni, F.7    Zecca, L.8    Scanziani, E.9    Vezzoni, P.10
  • 94
    • 0035134335 scopus 로고    scopus 로고
    • Systemic gene therapy with anti-angiogenic factors inhibits spontaneous breast tumor growth and metastasis in MMTVneu transgenic mice
    • Sacco, M. G., Cato, E. M., Ceruti, R., Soldati, S., Indraccolo, S., Caniatti, M., Scanziani, E., and Vezzoni, P. (2001) Systemic gene therapy with anti-angiogenic factors inhibits spontaneous breast tumor growth and metastasis in MMTVneu transgenic mice. Gene Ther., 8: 67-70.
    • (2001) Gene Ther. , vol.8 , pp. 67-70
    • Sacco, M.G.1    Cato, E.M.2    Ceruti, R.3    Soldati, S.4    Indraccolo, S.5    Caniatti, M.6    Scanziani, E.7    Vezzoni, P.8
  • 95
    • 0036791554 scopus 로고    scopus 로고
    • Combined effects on tumor growth and metastasis by anti-estrogenic and antiangiogenic therapies in MMTVneu mice
    • Sacco, M. G., Soldati, S., Mira Cato, E., Cattaneo, L., Pratesi, G., Scanziani, E., and Vezzoni, P. (2002) Combined effects on tumor growth and metastasis by anti-estrogenic and antiangiogenic therapies in MMTVneu mice. Gene Ther., 9: 1338-1341.
    • (2002) Gene Ther. , vol.9 , pp. 1338-1341
    • Sacco, M.G.1    Soldati, S.2    Mira Cato, E.3    Cattaneo, L.4    Pratesi, G.5    Scanziani, E.6    Vezzoni, P.7
  • 96
    • 0012336076 scopus 로고    scopus 로고
    • The Advent of Lentiviral Vectors: Prospects for Cancer Therapy. Gene therapy of Cancer Gene
    • Eds. Lattime E.C. & Gerson S.L., Academic Press, San Diego
    • Sadelain, M., and Riviere, I. (2002) The Advent of Lentiviral Vectors: Prospects for Cancer Therapy. Gene therapy of Cancer. In: Gene therapy of Cancer, Eds. Lattime E.C. & Gerson S.L., Academic Press, San Diego, pp109-124.
    • (2002) Therapy of Cancer , pp. 109-124
    • Sadelain, M.1    Riviere, I.2
  • 98
    • 0034712958 scopus 로고    scopus 로고
    • Adenovirus-mediated gene transfer of endostatin in vivo results in high level of transgene expression and inhibition of tumor growth and metastases
    • Sauter, B. V., Martinet, O., Zhang, W. J., Mandeli, J., and Woo, S. L. (2000) Adenovirus-mediated gene transfer of endostatin in vivo results in high level of transgene expression and inhibition of tumor growth and metastases. Proc. Natl. Acad. Sci. USA, 97: 4802-4807.
    • (2000) Proc. Natl. Acad. Sci. USA , vol.97 , pp. 4802-4807
    • Sauter, B.V.1    Martinet, O.2    Zhang, W.J.3    Mandeli, J.4    Woo, S.L.5
  • 99
    • 0037106374 scopus 로고    scopus 로고
    • Mechanisms and future directions for angiogenesis-based cancer therapies
    • Scappaticci, F. A. (2002) Mechanisms and future directions for angiogenesis-based cancer therapies. J. Clin. Oncol, 20: 3906-3927.
    • (2002) J. Clin. Oncol. , vol.20 , pp. 3906-3927
    • Scappaticci, F.A.1
  • 100
    • 0034984653 scopus 로고    scopus 로고
    • Combination angiostatin and endostatin gene transfer induces synergistic antiangiogenic activity in vitro and antitumor efficacy in leukemia and solid tumors in mice
    • Scappaticci, F. A., Smith, R., Pathak, A., Schloss, D., Lum, B., Cao, Y., Johnson, F., Engleman, E. G., and Nolan, G. P. (2001) Combination angiostatin and endostatin gene transfer induces synergistic antiangiogenic activity in vitro and antitumor efficacy in leukemia and solid tumors in mice. Mol. Ther., 3: 186-196.
    • (2001) Mol. Ther. , vol.3 , pp. 186-196
    • Scappaticci, F.A.1    Smith, R.2    Pathak, A.3    Schloss, D.4    Lum, B.5    Cao, Y.6    Johnson, F.7    Engleman, E.G.8    Nolan, G.P.9
  • 102
    • 0029922177 scopus 로고    scopus 로고
    • Inhibition of angiogenesis by interleukin-12 is mediated by the interferon-inducible protein 10
    • Sgadari, C., Angiolillo, A. L., and Tosato, G. (1996b) Inhibition of angiogenesis by interleukin-12 is mediated by the interferon-inducible protein 10. Blood, 87: 3877-3882.
    • (1996) Blood , vol.87 , pp. 3877-3882
    • Sgadari, C.1    Angiolillo, A.L.2    Tosato, G.3
  • 104
    • 0036275675 scopus 로고    scopus 로고
    • Adeno-associated virus-mediated gene transfer of endostatin inhibits angiogenesis and tumor growth in vivo
    • Shi, W., Teschendorf, C., Muzyczka, N., and Siemann, D. W. (2002) Adeno-associated virus-mediated gene transfer of endostatin inhibits angiogenesis and tumor growth in vivo. Cancer Gene Ther., 9: 513-521.
    • (2002) Cancer Gene Ther. , vol.9 , pp. 513-521
    • Shi, W.1    Teschendorf, C.2    Muzyczka, N.3    Siemann, D.W.4
  • 105
    • 12244252749 scopus 로고    scopus 로고
    • Gene therapy delivery of endostatin enhances the treatment efficacy of radiation
    • Shi, W., Teschendorf, C., Muzyczka, N., and Siemann, D. W. (2003) Gene therapy delivery of endostatin enhances the treatment efficacy of radiation. Radiother. Oncol., 66: 1-9.
    • (2003) Radiother. Oncol. , vol.66 , pp. 1-9
    • Shi, W.1    Teschendorf, C.2    Muzyczka, N.3    Siemann, D.W.4
  • 107
    • 0023160237 scopus 로고
    • Inhibition of angiogenesis by interferons: Effects on tumor- and lymphocyte-induced vascular responses
    • Sidky, Y. A., and Borden, E. C. (1987) Inhibition of angiogenesis by interferons: effects on tumor- and lymphocyte-induced vascular responses. Cancer Res., 47: 5155-5161.
    • (1987) Cancer Res. , vol.47 , pp. 5155-5161
    • Sidky, Y.A.1    Borden, E.C.2
  • 108
    • 0029075603 scopus 로고
    • Interferons alpha and beta down-regulate the expression of basic fibroblast growth factor in human carcinomas
    • Singh, R. K., Gutman, M., Bucana, C. D., Sanchez, R., Llansa, N., and Fidler, I. J. (1995) Interferons alpha and beta down-regulate the expression of basic fibroblast growth factor in human carcinomas. Proc. Natl. Acad. Sci. USA, 92: 4562-4566.
    • (1995) Proc. Natl. Acad. Sci. USA , vol.92 , pp. 4562-4566
    • Singh, R.K.1    Gutman, M.2    Bucana, C.D.3    Sanchez, R.4    Llansa, N.5    Fidler, I.J.6
  • 109
    • 0033573994 scopus 로고    scopus 로고
    • Opposing actions of intact and N-terminal fragments of the human prolactin/growth hormone family members on angiogenesis: An efficient mechanism for the regulation of angiogenesis
    • Struman, I., Bentzien, F., Lee, H., Mainfroid, V., D'Angelo, G., Goffin, V., Weiner, R. I., and Martial, J. A. (1999) Opposing actions of intact and N-terminal fragments of the human prolactin/growth hormone family members on angiogenesis: an efficient mechanism for the regulation of angiogenesis. Proc. Natl. Acad. Sci. USA, 96: 1246-1251.
    • (1999) Proc. Natl. Acad. Sci. USA , vol.96 , pp. 1246-1251
    • Struman, I.1    Bentzien, F.2    Lee, H.3    Mainfroid, V.4    D'Angelo, G.5    Goffin, V.6    Weiner, R.I.7    Martial, J.A.8
  • 111
    • 0030937456 scopus 로고    scopus 로고
    • Viral vector-mediated transduction of a modified platelet factor 4 cDNA inhibits angiogenesis and tumor growth
    • Tanaka, T., Manome, Y., Wen, P., Kufe, D. W., and Fine, H. A. (1997) Viral vector-mediated transduction of a modified platelet factor 4 cDNA inhibits angiogenesis and tumor growth. Nat. Med., 3: 437-442.
    • (1997) Nat. Med. , vol.3 , pp. 437-442
    • Tanaka, T.1    Manome, Y.2    Wen, P.3    Kufe, D.W.4    Fine, H.A.5
  • 112
    • 9844239373 scopus 로고    scopus 로고
    • Interferon-alpha gene therapy for cancer: Retroviral transduction of fibroblasts and particle-mediated transfection of tumor cells are both effective strategies for gene delivery in murine tumor models
    • Tuting, T., Gambotto, A., Baar, J., Davis, I. D., Storkus, W. J., Zavodny, P. J., Narula, S., Tahara, H., Robbins, P. D., and Lotze, M. T. (1997) Interferon-alpha gene therapy for cancer: retroviral transduction of fibroblasts and particle-mediated transfection of tumor cells are both effective strategies for gene delivery in murine tumor models. Gene Ther., 4: 1053-1060.
    • (1997) Gene Ther. , vol.4 , pp. 1053-1060
    • Tuting, T.1    Gambotto, A.2    Baar, J.3    Davis, I.D.4    Storkus, W.J.5    Zavodny, P.J.6    Narula, S.7    Tahara, H.8    Robbins, P.D.9    Lotze, M.T.10
  • 117
    • 0035119250 scopus 로고    scopus 로고
    • Adenovirus-mediated human endostatin gene delivery demonstrates strain-specific antitumor activity and acute dose-dependent toxicity in mice
    • Wen, X. Y., Bai, Y., and Stewart, A. K. (2001) Adenovirus-mediated human endostatin gene delivery demonstrates strain-specific antitumor activity and acute dose-dependent toxicity in mice. Hum. Gene Ther., 12: 347-358.
    • (2001) Hum. Gene Ther. , vol.12 , pp. 347-358
    • Wen, X.Y.1    Bai, Y.2    Stewart, A.K.3
  • 118
    • 0035342191 scopus 로고    scopus 로고
    • Cancer gene therapy by adenovirus-mediated gene transfer
    • Wu, Q., Moyana, T., and Xiang, J. (2001) Cancer gene therapy by adenovirus-mediated gene transfer. Curr. Gene Ther., 1: 101-122.
    • (2001) Curr. Gene Ther. , vol.1 , pp. 101-122
    • Wu, Q.1    Moyana, T.2    Xiang, J.3
  • 119
    • 0031685633 scopus 로고    scopus 로고
    • Gene therapy with p53 and a fragment of thrombospondin I inhibits human breast cancer in vivo
    • Xu, M., Kumar, D., Stass, S. A., and Mixson, A. J. (1998) Gene therapy with p53 and a fragment of thrombospondin I inhibits human breast cancer in vivo. Mol. Genet. Metab., 63: 103-109.
    • (1998) Mol. Genet. Metab. , vol.63 , pp. 103-109
    • Xu, M.1    Kumar, D.2    Stass, S.A.3    Mixson, A.J.4
  • 120
    • 0034775286 scopus 로고    scopus 로고
    • Induction of therapeutic antitumor antiangiogenesis by intratumoral injection of genetically engineered endostatin-producing Semliki Forest virus
    • Yamanaka, R., Zullo, S. A., Ramsey, J., Onodera, M., Tanaka, R., Blaese, M., and Xanthopoulos, K. G. (2001) Induction of therapeutic antitumor antiangiogenesis by intratumoral injection of genetically engineered endostatin-producing Semliki Forest virus. Cancer Gene Ther., 8: 796-802.
    • (2001) Cancer Gene Ther. , vol.8 , pp. 796-802
    • Yamanaka, R.1    Zullo, S.A.2    Ramsey, J.3    Onodera, M.4    Tanaka, R.5    Blaese, M.6    Xanthopoulos, K.G.7
  • 121
    • 0035503609 scopus 로고    scopus 로고
    • sFlt-1 gene-transfected fibroblasts: A wound-specific gene therapy inhibits local cancer recurrence
    • Yang, W., Arii, S., Mori, A., Furumoto, K., Nakao, T., Isobe, N., Murata, T., Onodera, H., and Imamura, M. (2001) sFlt-1 gene-transfected fibroblasts: a wound-specific gene therapy inhibits local cancer recurrence. Cancer Res., 61: 7840-7845.
    • (2001) Cancer Res. , vol.61 , pp. 7840-7845
    • Yang, W.1    Arii, S.2    Mori, A.3    Furumoto, K.4    Nakao, T.5    Isobe, N.6    Murata, T.7    Onodera, H.8    Imamura, M.9
  • 122
    • 0037154738 scopus 로고    scopus 로고
    • Effect of p53 status on tumor response to antiangiogenic therapy
    • Yu, J. L., Rak, J. W., Coomber, B. L., Hicklin, D. J., and Kerbel, R. S. (2002) Effect of p53 status on tumor response to antiangiogenic therapy. Science, 295: 1526-1528.
    • (2002) Science , vol.295 , pp. 1526-1528
    • Yu, J.L.1    Rak, J.W.2    Coomber, B.L.3    Hicklin, D.J.4    Kerbel, R.S.5
  • 123
    • 0029685931 scopus 로고    scopus 로고
    • Gene therapy with an adeno-associated virus carrying an interferon gene results in tumor growth suppression and regression
    • Zhang, J. F., Hu, C., Geng, Y., Blatt, L. M., and Taylor, M. W. (1996) Gene therapy with an adeno-associated virus carrying an interferon gene results in tumor growth suppression and regression. Cancer Gene Ther., 3: 31-38.
    • (1996) Cancer Gene Ther. , vol.3 , pp. 31-38
    • Zhang, J.F.1    Hu, C.2    Geng, Y.3    Blatt, L.M.4    Taylor, M.W.5


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