Continuous intravascular secretion of endostatin in mice from transduced hematopoietic stem cells

Molecular Therapy

Volumn 5, Issue 4, 2002, Pages 345-351

  Pawliuk, Robert ^a,b   Bachelot, Thomas ^a   Zurkiya, Omar ^a   Eriksson, Anna ^c   Cao, Yihai ^c   Leboulch, Philippe ^a,b,d  

^a MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^b Genetix Pharmaceuticals Inc   (United States)

^c KAROLINSKA INSTITUTE   (Sweden)

^d BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

Anti angiogenesis; Bone marrow transplantation; Endostatin; Hematopoietic stem cells; Retroviral vector

Indexed keywords

ANGIOGENESIS INHIBITOR; COLLAGEN; ENDOSTATIN;

ANGIOGENESIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ARTICLE; BLOOD VESSEL; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; DISEASE MODEL; DRUG POTENCY; ESCHERICHIA COLI; GENE TARGETING; GENE THERAPY; GENETIC TRANSDUCTION; HEMATOPOIETIC STEM CELL; IN VIVO STUDY; INHIBITION KINETICS; MOUSE; NONHUMAN; PROTEIN SECRETION; PROTEIN SYNTHESIS; RETROVIRUS; TUMOR REGRESSION;

ANIMALIA; ESCHERICHIA COLI; MURINAE; UNIDENTIFIED RETROVIRUS;

EID: 0036222277     PISSN: 15250016     EISSN: None     Source Type: Journal    
DOI: 10.1006/mthe.2002.0572     Document Type: Article

References (42)

1. Tumor angiogenesis: Therapeutic implications
2. The hallmarks of cancer
3. Endogenous angiogenesis inhibitors: Angiostatin, endostatin, and other proteolytic fragments
4. Endostatin: An endogenous inhibitor of angiogenesis and tumor growth
5. Antiangiogenic therapy of experimental cancer does not induce acquired drug resistance
6. Reality testing in cancer treatment: The phase I trial of endostatin
7. Tumor development under angiogenic signaling: A dynamical theory of tumor growth, treatment response, and postvascular dormancy
8. Zinc-binding of endostatin is essential for its antiangiogenic activity
9. Endostatin: Yeast production, mutants, and antitumor effect in renal cell carcinoma
10. Structure, function and tissue forms of the C-terminal globular domain of collagen XVIII containing the angiogenesis inhibitor endostatin
11. Effects of angiogenesis inhibitors on multistage carcinogenesis in mice
12. Cloning, expression, and in vitro activity of human endostatin
13. Behind the headlines of endostatin's ups and downs
14. Systemic inhibition of tumor growth and tumor metastases by intramuscular administration of the endostatin gene
15. Liposomes complexed to plasmids encoding angiostatin and endostatin inhibit breast cancer in nude mice
16. Mouse endostatin inhibits the formation of lung and liver metastases
17. Combination angiostatin and endostatin gene transfer induces synergistic antiangiogenic activity in vitro and antitumor efficacy in leukemia and solid tumors in mice
18. Effect of retroviral endostatin gene transfer on subcutaneous and intraperitoneal growth of murine tumors
19. Intra-tumoral administration of naked plasmid DNA encoding mouse endostatin inhibits renal carcinoma growth
20. Anticancer treatment of endostatin gene therapy by targeting tumor neovasculature in C57/BL mice
21. Systemin gene therapy with anti-angiogenic factors inhibits spontaneous breast tumor growth and metastases in MMTVneu transgenic mice
22. Adenovirus-mediated human endostatin gene delivery demonstrates strain-specific antitumor activity and acute dose-dependent toxicity in mice
23. Antiangiogenic gene therapy for cancer via systemic administration of adenoviral vectors expressing secretable endostatin
24. Antiangiogenic gene therapy of cancer utilizing a recombinant adenovirus to elevate systemic endostatin levels in mice
25. Adenovirus-mediated gene transfer of endostatin in vivo results in high level of transgene expression and inhibition of tumor growth and metastases
26. Comparative evaluation of the antitumor activity of antiangiogenic proteins delivered by gene transfer
27. Endostatin binds to blood vessels in situ independent of heparan sulfate and does not compete for fibroblast growth factor-2 binding
28. Selection of retrovirally transduced hematopoietic cells using CD24 as a marker of gene transfer
29. Lack of antitumor activity of recombinant endostatin in a human neuroblastoma xenograft model
30. gro-β, a -C-X-C- chemokine, is an angiogenesis inhibitor that suppresses the growth of Lewis lung carcinoma in mice
31. Specific prolongation of skin graft survival following retroviral transduction of bone marrow with an allogeneic major histocompatibility complex gene
32. Unfulfilled promise of endostatin in a gene therapy-xeno-transplant model of human acute lymphocytic leukemia
33. Endostatin inhibits VEGF-induced endothelial cell migration and tumor growth independently of zinc binding
34. Endostatin induces endothelial cell apoptosis
35. Isolation and sequencing of cDNAs for proteins with multiple domains of Gly-Xaa-Yaa repeats identify a distinct family of collagenous proteins
36. Versatile retroviral vectors for potential use in gene therapy
37. Role of the hepatitis B virus posttranscriptional regulatory element in export of intronless transcripts
38. Production of high-titer helper-free retroviruses by transient transfection
39. Long-term culture of capillary endothelial cells
40. Long-term cure of the photosensitivity of murine erythropoietic protoporphyria by pre-selective gene therapy
41. Analyzing glycoproteins separated by two-dimensional gel electrophoresis