Antiangiogenic gene therapy of cancer utilizing a recombinant adenovirus to elevate systemic endostatin levels in mice

Cancer Research

Volumn 60, Issue 6, 2000, Pages 1503-1506

  Feldman, Andrew L ^a   Restifo, Nicholas P ^a   Alexander, H Richard ^a   Bartlett, David L ^a   Hwu, Patrick ^a   Seth, Prem ^b   Libutti, Steven K ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

^b Iowa Cancer Research Foundation   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOCARCINOMA; ANIMAL CELL; ARTICLE; GENE TARGETING; GENE THERAPY; MOUSE; NONHUMAN; PRIORITY JOURNAL; TISSUE SPECIFICITY; TUMOR BLOOD FLOW;

ADENOVIRIDAE; ANGIOGENESIS INHIBITORS; ANIMALS; ANTINEOPLASTIC AGENTS; CELL DIVISION; CELL LINE; COLLAGEN; ENDOSTATINS; FEMALE; GENE THERAPY; HUMANS; INJECTIONS, INTRAVENOUS; MICE; MICE, INBRED C57BL; MICE, NUDE; NEOPLASMS, EXPERIMENTAL; PEPTIDE FRAGMENTS; RECOMBINANT FUSION PROTEINS; TIME FACTORS; TUMOR CELLS, CULTURED;

EID: 0034654555     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (17)

1. Folkman, J. Angiogenesis in cancer, vascular, rheumatoid and other disease. Nat. Med., 1: 27-31, 1995.
2. Crystal, R. G. The body as a manufacturer of endostatin. Nat. Biotechnol., 17: 336-337, 1999.
3. Folkman, J. Antiangiogenic gene therapy. Proc. Natl. Acad Sci. USA, 95: 9064-9066, 1998.
4. Kong, H-L., and Crystal, R. G. Gene therapy strategies for tumor antiangiogenesis. J. Natl. Cancer Inst., 90: 273-286, 1998.
5. Lin, P., Buxton, J. A., Acheson, A., Radziejewski, C., Maisonpierre, P. C., Yancopoulos, G. D., Channon, K. M., Hale, L. P., Dewhirst, M. W., George, S. E., and Peters, K. G. Antiangiogenic gene therapy targeting the endothelium-specific receptor lyrosine kinase Tie2. Proc. Natl. Acad. Sci. USA, 95: 8829-8834, 1998.
6. Katayose, D., Gudas, J., Nygeun, H., Cowan, K., and Seth, P. Cytotoxic effects of adenovirus-mediated wild type p53 protein expression in normal and tumor mammary epithelial cells. Clin. Cancer Res., 1: 889-898, 1995.
7. Katayose, D., Wersto, R., Cowan, K., and Seth, P. Effects of a recombinant adenovirus expressing WAF/Cip1 on cell growth, cell cycle, and apoptosis. Cell Growth Differ., 6: 1207-1212, 1995.
8. Blezinger, P., Wang, J., Gondo, M., Quezada, A., Mehrens, D., French, M., Singhal, A., Sullivan, S. Rolland, A., Ralston, R., and Min, W. Systemic inhibition of tumor growth and tumor metastases by intramuscular administration of the endostatin gene. Nat. Biotech., 17: 343-348, 1999.
9. Cao, Y. Endogenous angiogenesis inhibitors: angiostatin, endostatin, and other proteolytic fragments. Prog. Mol. Subcell. Biol., 20: 161-176, 1998.
10. O'Reilly, M. S., Boehm, T., Shing, Y., Fukai, N., Vasios, G., Lane, W. S., Flynn, E., Birkhead, J. R., Olsen, B. R., and Folkman, J. Endostatin: an endogenous inhibitor of angiogenesis and tumor growth. Cell, 88: 277-285, 1997.
11. Chen, Q-R., Kumar, D., Stass, S. A., and Mixson A. J. Liposomes complexed to plasmids encoding angiostatin and endostatin inhibit breast cancer in nude mice. Cancer Res., 59: 3308-3312, 1999.
12. Feldman, A. L., and Libutti, S. K. Correspondence re: Q-R. Chen, et al., Liposomes complexed to plasmids encoding angiostatin and endostatin inhibit breast cancer in nude mice. Cancer Res., 60: 1463, 2000.
13. Mauceri, H. J., Hanna, N. N., Beckett, M. A., Gorski, D. H., Staba, M. J., Stellato, K. A., Bigelow, K., Heimann, R., Gately, S. Dhanabal, M., Soff, G. A., Sukhatme, V. P., Kufe, D. W., and Weichselbaum, R. R. Combined effects of angiostatin and ionizing radiation in antitumour therapy. Nature (Lond.), 394: 287-291, 1998.
14. Ferry, N., and Heard, J. Liver-directed gene transfer vectors. Hum. Gene. Ther., 9: 1975-1981, 1998.
15. Tomko, R., Xu, R., and Philipson, L. HCAR and MCAR: the human and mouse cellular receptors for subgroup C adenoviruses and group B Coxsackieviruses. Proc. Natl. Acad. Sci. USA, 94: 3352-3354, 1997.
16. Persson, H., Jornvall, H., and Zabielski, J. Multiple mRNA species for the precursor to an adenovirus-encoded glycoprotein: identification and structure of the signal sequence. Proc. Natl. Acad. Sci. USA, 77: 6349-6353, 1980.
17. Hogaboam, C. M., Simpson, K. J., Chensue, S. W., Steinhauser, M. L., Lukacs, N. W., Gauldie, J., Stricter, R. M., and Kunkel, S. L. Macrophage inflammatory protein-2 gene therapy attenuates adenovirus-and acetaminophen-mediated hepatic injury. Gene Ther., 6: 573-584, 1999.