Colorectal hyperplasia and dysplasia due to human carcinoembryonic antigen (CEA) family member expression in transgenic mice

PLoS ONE

Volumn 2, Issue 12, 2007, Pages

  Chan, Carlos H F ^a   Camacho Leal, Pilar ^a   Stanners, Clifford P ^a  

^a MCGILL UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CARCINOEMBRYONIC ANTIGEN; CARCINOEMBRYONIC ANTIGEN RELATED CELL ADHESION MOLECULE 6; CD51 ANTIGEN; IMMUNOGLOBULIN; PROTEIN KINASE B; INTEGRIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANOIKIS; ANTIGEN EXPRESSION; APOPTOSIS; ARTICLE; CARCINOGENESIS; CELL DIFFERENTIATION; CELL PROLIFERATION; COLORECTAL HYPERPLASIA; CONTROLLED STUDY; ENZYME ACTIVATION; GASTROINTESTINAL DYSPLASIA; HUMAN GENOME; HYPERPLASIA; IN VITRO STUDY; IN VIVO STUDY; INTESTINE CELL; INTESTINE CRYPT; MATING; NONHUMAN; TRANSGENIC MOUSE; UPREGULATION; ANIMAL; CELL FRACTIONATION; COLON; GENETICS; HUMAN; IMMUNOLOGY; METABOLISM; MOUSE; PATHOLOGY; RECTUM;

MUS MUSCULUS;

ANIMALS; CARCINOEMBRYONIC ANTIGEN; COLON; HUMANS; INTEGRINS; MICE; MICE, TRANSGENIC; RECTUM; SUBCELLULAR FRACTIONS;

EID: 44349171174     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0001353     Document Type: Article

References (57)

1. Hammarstrom S, Olsen A, Teglund S, Baranov V (1998) The nature and expression of the human CEA family. In: Stanners CP, ed. Cell Adhesion and Communication Mediated by the CEA Family: Basic and Clinical Perspectives. Amsterdam, The Netherlands: Harwood Academic Publishers. pp 1-30.
2. Chevinsky AH (1991) CEA in tumors of other than colorectal origin. Semin Surg Oncol 7: 162-166.
3. Allard WJ, Neaman IE, Elting JJ, Barnett TR, Yoshimura H, et al. (1994) Nonspecific cross-reacting antigen 50/90 is elevated in patients with breast, lung, and colon cancer. Cancer Res 54: 1227-1234.
4. Scholzel S, Zimmermann W, Schwarzkopf G, Crunert F, Rogaczewski B, et al. (2000) Carcinoembryonic antigen family members CEACAM6 and CEACAM7 are differentially expressed in normal tissues and oppositely deregulated in hyperplastic colorectal polyps and early adenomas. Am J Pathol 156: 595-605.
5. Ballesta AM, Molina R, Filella X, Jo J, Gimenez N (1995) Carcinoembryonic antigen in staging and follow-up of patients with solid tumors. Tumour Biol 16: 32-41.
6. Maxwell P (1999) Carcinoembryonic antigen: cell adhesion molecule and useful diagnostic marker. Br J Biomed Sci 56: 209-214.
7. Jantscheff P, Terracciano L, Lowy A, Glatz-Krieger K, Grunert F, et al. (2003) Expression of CEACAM6 in resectable colorectal cancer: a factor of independent prognostic significance. J Clin Oncol 21: 3638-3646.
8. Ilantzis C, Jothy S, Alpert LC, Draber P, Stanners CP (1997) Cell-surface levels of human carcinoembryonic antigen are inversely correlated with colonocyte differentiation in colon carcinogenesis. Lab Invest 76: 703-716.
9. Eidelman FJ, Fuks A, DeMarte L, Taheri M, Stanners CP (1993) Human carcinoembryonic antigen, an intercellular adhesion molecule, blocks fusion and differentiation of rat myoblasts. J Cell Biol 123: 467-475.
10. Ilantzis C, DeMarte L, Screaton RA, Stanners CP (2002) Deregulated expression of the human tumor marker CEA and CEA family member CEACAM6 disrupts tissue architecture and blocks colonocyte differentiation. Neoplasia 4: 151-163.
11. Rojas M, DeMarte L, Screaton RA, Stanners CP (1996) Radical differences in functions of closely related members of the human carcinoembryonic antigen gene family. Cell Growth Differentiation 7: 655-662.
12. Duxbury MS, Ito H, Zinner MJ, Ashley SW, Whang EE (2004) CEACAM6 gene silencing impairs anoikis resistance and in vivo metastatic ability of pancreatic adenocarcinoma cells. Oncogene 23: 465-473.
13. Wirth T, Soeth E, Czubayko F, Juhl H (2002) Inhibition of endogenous carcinoembryonic antigen (CEA) increases the apoptotic rate of colon cancer cells and inhibits metastatic tumor growth. Clin Exp Metastasis 19: 155-160.
14. Soeth E, Wirth T, List HJ, Kumbhani S, Petersen A, et al. (2001) Controlled ribozyme targeting demonstrates an antiapoptotic effect of carcinoembryonic antigen in HT29 colon cancer cells. Clin Cancer Res 7: 2022-2030.
15. Ordonez C, Screaton RA, Ilantzis C, Stanners CP (2000) Human carcinoembryonic antigen functions as a general inhibitor of anoikis. Cancer Res 60: 3419-3424.
16. Screaton RA, Penn LZ, Stanners CP (1997) Carcinoembryonic antigen, a human tumor marker, cooperates with Myc and Bcl-2 in cellular transformation. J Cell Biol 137: 939-952.
17. Screaton RA, DeMarte L, Draber P, Stanners CP (2000) The specificity for the differentiation blocking activity of carcinoembryonic antigen resides in its glycophosphatidyl-inositol anchor. J Cell Biol 150: 613-626.
18. Taheri M, Saragovi HU, Stanners CP (2003) The adhesion and differentiation-inhibitory activities of the immunoglobulin superfamily member, carcinoembryonic antigen, can be independently blocked. J Biol Chem 278: 14632-14639.
19. Nicholson TB, Stanners CP (2006) Specific inhibition of GPI-anchored protein function by homing and self-association of specific GPI anchors. J Cell Biol 175: 647-659.
20. Giancotti FG, Ruoslahti E (1999) Integrin signaling. Science 285: 1028-1032,
21. Camacho-Leal P, Zhai AB, Stanners CP (2007) A co-clustering model involving alpha5beta1 integrin for the biological effects of GPI-anchored human Carcinoembryonic Antigen (CEA). J Cell Physiol 211: 791-802.
22. Duxbury MS, Ito H, Ashley SW, Whang EE (2004) c-Src-dependent cross-talk between CEACAM6 and alplhavbeta3 integrin enhances pancreatic adenocarcinoma cell adhesion to extracellular matrix components. Biochem Biophys Res Comm 317: 133-141.
23. Stupack DG, Cheresh DA (2002) Get a ligand, get a life: integrins, signaling and cell survival. J Cell Sci 115: 3729-3738.
24. Reddig PJ, Juliano RL (2005) Clinging to life: cell to matrix adhesion and cell survival. Cancer Metastasis Rev 24: 425-439.
25. Guo W, Giancotti FG (2004) Integrin signalling during tumour progression. Nature Rev Mol Cell Biol 5: 816-826.
26. Zimmermann W (1998) The nature and expression of the rodent CEA families: Evolutionary considerations. In: Stanners CP, ed. Cell Adhesion and Communication Mediated by the CEA Family: Basic and Clinical Perspectives. Amsterdam, The Netherlands: Harwood Academic Publishers. pp 31-56.
27. Eades-Perner AM, van der Putten H, Hirth A, Thompson J, Neumaier M, et al. (1994) Mice transgenic for the human carcinoembryonic antigen gene maintain its spatiotemporal expression pattern. Cancer Res 54: 4169-4176.
28. Clarke P, Mann J, Simpson JF, Rickard-Dickson K, Primus FJ (1998) Mice transgenic for human carcincembryonic antigen as a model for immunotherapy. Cancer Res 58: 1469-1477.
29. Thompson JA, Eades-Perner AM, Ditter M, Muller WJ, Zimmermann W (1997) Expression of transgenic carcinoembryonic antigen (CEA) in tumor-prone mice: an animal model for CEA-directed tumor immunotherapy. Int J Cancer 72: 197-202.
30. Chan CH, Scanners CP (2004) Novel mouse model for carcinoembryonic antigen-based therapy. Mol Therapy 9: 775-785.
31. Mandir N, FitzGerald AJ, Goodlad RA (2005) Differences in the effects of age on intestinal proliferation, crypt fission and apoptosis on the small intestine and the colon of the rat. Int J Exp Pathol 86: 125-130.
32. Cory S, Adams JM (2002) The Bcl2 family: regulators of the cellular life-or-death switch. Nature Rev Cancer 2: 647-656.
33. Scanners CP (1998) Contributions of the human CEA family to malignant transformation. In: Stanners CP, ed. Cell Adhesion and Communication Mediated by the CEA Family: Basic and Clinical Perspectives. Amsterdam, The Netherlands: harwood Academic Publishers. pp 141-154.
34. Ginsberg MH, Partridge A, Shattil SJ (2005) Integrin regulation. Carr Opin Cell Biol 17: 509-516.
35. Hynes RO (2002) Integrins: bidirectional, allosteric signaling machines. Cell 110: 673-687.
36. Park CC, Zhang H, Pallavicini M, Gray JW, Bachner F, et al. (2006) Beta1 integrin inhibitory antibody induces apoptosis of breast cancer cells, inhibits growth, and distinguishes malignant from normal phenotype in three dimensional cultures and in vivo. Cancer Res 66: 1526-1535.
37. Janes SM, Watt FM (2006) New roles for integrins in squamous-cell carcinoma. Nature Rev Cancer 6: 175-183.
38. Ordonez C, Zhai AB, Camacho-Leal P, DeMarte L, Fan MM, et al. (2007) GPI-anchored CEA family glycoproteins CEA and CEACAM6 mediate their biological effects through enhanced integrin alpha5beta1-fibronectin interaction. J Cell Physiol 210: 757-765.
39. Rijkers T, Peetz A, Ruther U (1994) Insertional mutagenesis in transgenic mice. Transgenic Res 3: 203-215.
40. Leconte A, Garambois V, Ychou M, Robert B, Pourquier D, et al. (1999) Involvement or circulating CEA in liver metastases from colorectal cancers re-examined in a new experimental model. Br J Cancer 80: 1373-1379.
41. Chan CH, Cook D, Stanners CP (2006) Increased colon tumor susceptibility in azoxymethane treated CEABAC transgenic mice. Carcinogenesis 27: 1909-1916.
42. Caswell PT, Norman JC (2006) Integrin trafficking and the control of cell migration. Traffic 7: 14-21.
43. Bretscher MS (1992) Circulating integrins: alpha 5 beta 1, alpha 6 beta 4 and Mac-1, but not alpha 3 beta 1, alpha 4 beta 1 or LFA-1. EMBO J 11: 405-410.
44. Velcich A, Yang W, Heyer J, Fragale A, Nicholas C, et al. (2002) Colorectal cancer in mice genetically deficient in the mucin Muc2. Science 295: 1726-1729.
45. Goldstein NS (2006) Serrated pathway and APC (conventional)-type colorectal polyps: molecular-morphologic correlations, genetic pathways, and implications for classification. Am J Clin Pathol 125: 146-153.
46. Jass JR, Whitehall VL, Young J, Leggett BA (2002) Emerging concepts in colorectal neoplasia. Gastroenterol 123: 862-876.
47. Jass JR, Filipe MI, Abbas S, Falcon CA, Wilson Y, et al. (1984) A morphologic and histochemical study of metaplastic polyps of the colorectum. Cancer 53: 510-515.
48. Baker K, Zhang Y, Jin C, Jass JR (2004) Proximal versus distal hyperplastic polyps of the colorectum: different lesions or a biological spectrum? J Clin Pathol 57: 1089-1093.
49. Giles RH, van Es JH, Clevers H (2003) Caught up in a Wnt storm: Wnt signaling in cancer. Biochim Biophys Acta 1653: 1-24.
50. Kinzler KW, Vogelstein B (1996) Lessons from hereditary colorectal cancer. Cell 87: 159-170.
51. Predow TP, Roukhadze EV, O'Riordan MA, Chan JC, Amini SB, et al. (1994) Carcinoembryonic antigen in human colonic aberrant crypt foci. Gastroenterol 107: 1719-1725.
52. Duxbury MS, Matros E, Ito H, Zinner MJ, Ashley SW, et al. (2004) Systemic siRNA-mediated gene silencing: a new approach to targeted therapy of cancer. Ann Surg 2440: 667-674.
53. Duxbury MS, Ito H, Benoit E, Waseem T, Ashley SW, et al. (2004) A novel role for carcinoembryonic antigen-related cell adhesion molecule 6 as a determinant of gemcitabine chemoresistance in pancreatic adenocarcinoma cells. Cancer Res 64: 3987-3993.
54. Zhou H, Stanners CP, Fuks A (1993) Specificity of anti-carcinoembryonic antigen monoclonal antibodies and their effects on CEA-mediated adhesion. Cancer Res 53: 3817-3822.
55. Spector DL, Goldman RD, Leinwand LA (1998) Cells: A Laboratory Manual. Plainview: Cold Spring Harbor laboratory Press.
56. Grossmann J, Walther K, Artinger M, Kiessling S, Scholmerich J (2001) Apoptotic signaling during initiation of detachment-induced apoptosis ("anoikis") of primary human intestinal epithelial cells. Cell Growth Differentiation 12: 147-155.
57. Lynch MJ, Raphael SS, Mellor LD, Spare PD, Inwood MJH (1969) Medical Laboratory Technology and Clinical Pathology. Philadephia: W. B. Saunders Company.