Proximal versus distal hyperplastic polyps of the colorectum: Different lesions or a biological spectrum?

Journal of Clinical Pathology

Volumn 57, Issue 10, 2004, Pages 1089-1093

  Baker, K ^a   Zhang, Y ^a   Jin, C ^a   Jass, J R ^a  

^a MCGILL UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CARCINOEMBRYONIC ANTIGEN; TUMOR MARKER;

ADULT; AGE; ARTICLE; ASCENDING COLON; CELL DIFFERENTIATION; CELL PROLIFERATION; CLINICAL ARTICLE; COLON ADENOMA; COLORECTAL CANCER; CONTROLLED STUDY; DESCENDING COLON; FEMALE; GROWTH REGULATION; HISTOCHEMISTRY; HUMAN; HUMAN CELL; HUMAN TISSUE; HYPERPLASTIC POLYP; IMMUNOHISTOCHEMISTRY; MALE; METHYLATION; MICROSATELLITE INSTABILITY; POLYP; PRIORITY JOURNAL; SESSILE SERRATED ADENOMA; TUMOR DIFFERENTIATION;

AGE FACTORS; AGED; BIOLOGICAL MARKERS; COLON; COLON, ASCENDING; COLON, DESCENDING; COLONIC POLYPS; FEMALE; HUMANS; HYPERPLASIA; IMMUNOHISTOCHEMISTRY; MALE; MIDDLE AGED;

EID: 4944253882     PISSN: 00219746     EISSN: None     Source Type: Journal    
DOI: 10.1136/jcp.2004.016600     Document Type: Article

References (44)

1. Vogelstein B, Fearon ER, Hamilton SR, et al. Genetic alterations during colorectal-tumor development. N Engl J Med 1988;319:525-32.
2. Goldstein NS, Bhanot P, Odish E, et al. Hyperplastic-like colon polyps that preceded microsatellite unstable adenocarcinomas. Am J Clin Pathol 2003;119:778-96.
3. Smyrk TC, Watson P, Kaul K, et al. Tumor-infiltrating lymphocytes are a marker for microsatellite instability in colorectal carcinoma. Cancer 2001;91:2417-22.
4. Lindor NM, Burgart U, Leontovich O, et al. Immunohistochemistry versus microsatellite instability testing in phenotyping colorectal tumors. J Clin Oncol 2002;20:1043-8.
5. Biemer-Hüttmann A-E, Walsh MD, McGuckin MA, et al. Mucin core protein expression in colorectal cancers with high levels of microsatellite instability indicates a novel pathway of morphogenesis. Clin Cancer Res 2000;6:1909-16.
6. Higuchi T, Jass JR. My approach to serrated polyps of the colorectum. J Clin Pathol 2004;57:682-6.
7. Whitehall VLJ, Wynter CVA, Walsh MD, et al. Morphological and molecular heterogeneity within nonmicrosatellite instability-high colorectal cancer. Cancer Res 2002;62:6011-14.
8. Iino H, Jass JR, Simms LA, et al. DNA microsatellite instability in hyperplastic polyps, serrated adenomas, and mixed polyps: a mild mutator pathway for colorectal cancer? J Clin Pathol 1999;52:5-9.
9. Jass JR. Serrated route to colorectal cancer: back street or super highway? J Pathol 2001;193:283-5.
10. Jass JR, Iino H, Ruszkiewicz A, et al. Neoplastic progression occurs through mutator pathways in hyperplastic polyposis of the colorectum. Gut 2000;47:43-9.
11. Mori Y, Selaru FM, Sato F, et al. The impact of microsatellite instability on the molecular phenotype of colorectal tumors. Cancer Res 2003;63:4577-82.
12. Calin GA, Gafa R, Tibiletti MG, et al. Genetic progression in microsatellite instability high (MSI-H) colon cancer correlates with clinico-pathological parameters: a study of the TGFbRII, BAX, HMSH3, HMSH6, IGFRII and BLM genes. Int J Cancer 2000;89:230-5.
13. Kane MF, Loda M, Gaida GM, et al. Methylation of the hMLH1 promoter correlates with lack of expression of hMLH1 in sporadic colon tumors and mismatch repair-defective human tumor cell lines. Cancer Res 1997;57:808-11.
14. Jass JR. Hyperplastic-like polyps as precursors of microsatellite- unstable colorectal cancer. Am J Clin Pathol 2003;119:773-5.
15. Hawkins NJ, Ward RL. Sporadic colorectal cancers with microsatellite instability and their possible origins in hyperplastic polyps and serrated adenomas. J Natl Cancer Inst 2001;93:1307-13.
16. Jass JR. Hyperplastic polyps of the colorectum-innocent or guilty? Dis Colon Rectum 2001;44:163-6.
17. Takayama T, Katsuki S, Takahashi Y, et al. Aberrant crypt foci of the colon as precursors of adenoma and cancer. N Engl J Med 1998;339:1277-84.
18. Torlakovic E, Skovlund E, Snover DC, et al. Morphologic reappraisal of serrated colorectal polyps. Am J Surg Pathol 2003;27:65-81.
19. Jass JR, Filipe MI, Abbas S, et al. A morphologic and histochemical study of metaplastic polyps of the colorectum. Cancer 1984;53:510-15.
20. Piyathilake CJ, Johanning GL, Frost AR, et al. Immunohistochemical evaluation of global DNA methylation: comparison with in vitro radiolabeled methyl incorporation assay. Biotech Histochem 2000;75:251-8.
21. Arthur JF. Structure and significance of metaplastic nodules in the rectal mucosa. J Clin Pathol 1968;21:735-43.
22. Togo G. Relationship between grade of microsatellite instability and target genes of mismatch repair pathways in sporadic colorectal carcinoma. Dig Dis Sci 2001;46:1615-22.
23. Jass JR. Glycoprotein histochemistry and the histogenesis of colorectal cancer. In: Tahara E, ed. Molecular pathology of gastraenterological cancer: application to clinical practice. Tokyo: Springer-Verlag, 1997:129-46.
24. Jass JR, Allison LM, Edgar S. Monoclonal antibody TKH2 to the cancer-associated epitope sialosyl Tn shows cross reactivity with variants of normal colorectal goblet cell mucin. Pathology 1994;26:418-22.
25. Jass JP, Allison LM, Edgar SG. Distribution of sialosyl Tn and Tn antigens within normal and malignant colorectal epithelium. J Pathol 1995;176:143-9.
26. Jass JR, Smith M. Sialic acid and epithelial differentiation in colorectal polyps and cancer-a morphological, mucin and lectin histochemical study. Pathology 1992;24:233-42.
27. Sugihara K, Jass JR. Colorectal goblet cell sialomucin heterogeneity: its relation to malignant disease. J Clin Pathol 1986;39:1088-95.
28. Schölzel S, Zimmerman W, Schwarzkopf G, et al. Carcinoembryonic antigen family members CEACAM6 and CEACAM7 are differentially expressed in normal tissues and oppositely deregulated in hyperplastic colorectal polyps and early adenomas. Am J Pathol 2000;156:595-605.
29. Salem RR, Wolf BC, Sears HF, et al. Expression of colorectal carcinoma-associated antigens in colonic polyps. J Surg Res 1993;55:249-55.
30. Datta SR, Dudek H, Tao X, et al. Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery. Cell 1997;91:231-41.
31. Erhardt P, Schremser EJ, Cooper GM. B-Raf inhibits programmed cell death downstream of cytochrome c release from mitochondria by activating the MEK/Erk pathway. Mol Cell Biol 1999;19:5308-15.
32. Kambara T, Simms LA, Whitehall VU, et al. BRAF mutation and CpG island methylation: an alternative pathway to colorectal cancer. Gut 2004;53:1137-44.
33. Arnold CN, Goel A, Boland CR. Role of hMLH1 promoter hypermethylation in drug resistance to 5-fluorouracil in colorectal cancer cell lines. Int J Cancer 2003;106:66-73.
34. Eads CA, Danenberg KD, Kawakami K, et al. CpG island hypermethylation in human colorectal tumors is not associated with DNA methyltransferase overexpression. Cancer Res 1999;59:2302-6.
35. Kang Y-H, Bae SI, Kim WH. Comprehensive analysis of promoter methylation and altered expression of hMLH1 in gastric cancer cell lines with microsatellite instability. J Cancer Res Clin Oncol 2002;128:119-24.
36. Kim HC, Kim CN, Yu CS, et al. Methylation of the hMLH1 and hMSH2 promoter in early-onset sporadic colorectal carcinomas with microsatellite instability. Int J Colorectal Dis 2003;18:196-202.
37. 6-methylguanine-DNA methyltransferase promoter may predict nonrecurrence after chemotherapy in colorectal cancer cases. Clin Cancer Res 2003;9:5306-12.
38. Ballestar E, Esteller M. The impact of chromatin in human cancer: linking DNA methylation to gene silencing. Carcinogenesis 2002;23:1103-9.
39. Bariol C, Suter C, Cheong K, et al. The relationship between hypomethylation and CpG island methylation in colorectal neoplasia. Am J Pathol 2003;162:1361-71.
40. Butler LM, Dobrovic A, Bianco T, et al. Promoter region methylation does not account for the frequent loss of expression of the Fas gene in colorectal carcinoma. Br J Cancer 2000;82:131-5.
41. Costello JF, Frühwald MC, Smiraglia DJ, et al. Aberrant CpG-island methylation has non-random and tumor-type-specific patterns. Nat Genet 2000;25:132-8.
42. Ehrlich M. DNA methylation in cancer: too much, but also too little. Oncogene 2002;21:5400-13.
43. Piyathilake CJ, Frost AR, Bell WC, et al. Altered global methylation of DNA: an epigenetic difference in susceptibility for lung cancer is associated with its progression. Hum Pathol 2001;32:856-62.
44. James SJ, Pogribney IP, Pogribna M, et al. Mechanisms of DNA damage, DNA hypomethylation, and tumor progression in the folate/methyl-deficient rat model of hepatocarcinogenesis. J Nutr 2003;133:3740S-47S.