Radical differences in functions of closely related members of the human carcinoembryonic antigen gene family

Cell Growth and Differentiation

Volumn 7, Issue 5, 1996, Pages 655-662

  Rojas, Mercedes ^a   Demarte, Luisa ^a   Screaton, Robert A ^a   Stanners, Clifford P ^a  

^a MCGILL UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATE; CALCIUM; CARCINOEMBRYONIC ANTIGEN; CELL ADHESION MOLECULE; CROSS REACTING ANTIGEN; GLYCOPROTEIN; GLYCOSYLPHOSPHATIDYLINOSITOL; MAGNESIUM;

ANIMAL CELL; ARTICLE; CELL ADHESION; CELL DIFFERENTIATION; CHO CELL; CONTROLLED STUDY; HUMAN; MOLECULAR INTERACTION; MUSCLE DEVELOPMENT; MYOBLAST; NONHUMAN; PRIORITY JOURNAL; RAT; TEMPERATURE DEPENDENCE;

ADENOSINE TRIPHOSPHATE; ANIMALS; ANTIGENS, CD; ANTIGENS, NEOPLASM; CALCIUM; CARCINOEMBRYONIC ANTIGEN; CELL ADHESION; CELL ADHESION MOLECULES; CELL DIFFERENTIATION; CHO CELLS; CRICETINAE; GLYCOPROTEINS; HUMANS; MAGNESIUM; MEMBRANE GLYCOPROTEINS; PROTEIN BINDING;

ANIMALIA; PRIMATES; RODENTIA;

EID: 0029845137     PISSN: 10449523     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (50)

1. Thompson, J. A., Zimmermann, W., Osthus-Bugat, P., Schleussner, C., Eades-Perner, A. M., Bamert, S., von Kleist, S., Willcocks, T., Tyran, C. K., Olsen, A., and Mohrensweiser, H. Long-range chromosomal mapping of the carcinoembryonic antigen (CEA) gene family cluster. Genomics, 12: 761-772, 1992.
2. Khan, W. N., Frängsmyr, L., Teglund, S., Israelsson, A., Bremer, K., and Hammarström, S. Identification of three new genes and estimation of the size of the carcinoembryonic antigen family. Genomics, 14: 384-390, 1992.
3. Paxton, R. J., Mooser, G., Pande, H., Lee, T. D., and Shively, J. E. Sequence analysis of carcinoembryonic antigen: identification of glycosylation sites and homology with immunoglobulin supergene family. Proc. Natl. Acad. Sci. USA, 84: 920-924, 1987.
4. Beauchemin, N., Benchimol, S., Cournoyer, D., Fuks, A., and Stanners, C. P. Isolation and characterization of full-length functional cDNA clones for human carcinoembryonic antigen. Mol. Cell. Biol., 7: 3221-3230, 1987.
5. Oikawa, S., Nakazato, H., and Kosaki, G. Primary structure of human carcinoembryonic antigen (CEA) deduced from cDNA sequence. Biochem. Biophys. Res. Commun., 142: 511-518, 1987.
6. Zimmermann, W., Ortlieb, B., Friedrich, R., and von Kleist, S. Isolation and characterization of cDNA clones encoding the human carcinoembryonic antigen reveal a highly conserved repeating structure. Proc. Natl. Acad. Sci. USA, 84: 2960-2964, 1987.
7. Tawaragi, Y., Oikawa, S., Matsuoka, Y., Kosaki, G., and Nakazato, H. Primary structure of nonspecific cross-reacting antigen (NCA), a member of carcinoembryonic antigen (CEA) gene family, deduced from cDNA sequence. Biochem. Biophys. Res. Commun., 150: 89-96, 1988.
8. Barnett, T., Goebel, S. J., Nothdurft, M. A., and Elting, J. J. Carcinoembryonic antigen family: characterization of cDNAs coding for NCA and CEA and suggestion of non-random sequence variation in their conserved loop-domains. Genomics, 3: 59-66, 1988.
9. Neumaier, M., Zimmermann, W., Shively, L., Hinoda, Y., Riggs, A. D., and Shively, J. E. Characterization of a cDNA clone for the nonspecific cross-reacting antigen (NCA) and a comparison of NCA and carcinoembryonic antigen. J. Biol. Chem., 263: 3202-3207, 1988.
10. Hefta, S. A., Hefta, L. J. F., Lee, T. D., Paxton, R. J., and Shively, J. E. Carcinoembryonic antigen is anchored to membranes by covalent attachment to a glycosylphosphatidylinositol moiety: identification of the ethanolamine linkage site. Proc. Natl. Acad. Sci. USA, 85: 4648-4652, 1988.
11. Kolbinger, F., Schwarz, K., Brombacher, F., von Kleist, S., and Grunert, F. Expression of an NCA cDNA in NIH-3T3 cells yields a 110k glycoprotein, which is anchored into the membrane via glycosylphosphatidylinositol. Biochem. Biophys. Res. Commun., 161: 1126-1134, 1989.
12. Takami, N., Misumi, Y., Kuroki, M., Matsuoka, Y., and Ikehara, Y. Evidence for carboxyl-terminal processing and glycolipid-anchoring of human carcinoembryonic antigen. J. Biol. Chem., 263: 12716-12720, 1988.
13. Barnett, T., Kretschmer, A., Austen, D. A., Goebel, S. J., Hart, J. T., Elting, J. J., and Kamarck, M. E. Carcinoembryonic antigens: alternative splicing accounts for the multiple mRNAs that code for novel members of the carcinoembryonic antigen family. J. Cell. Biol., 108: 267-276, 1989.
14. Hinoda, Y., Neumaier, M., Hefta, S. A., Drzeniek, Z., Wagener, C., Shively, J. E., and Paxton, R. J. Molecular cloning of a cDNA coding biliary glycoprotein. I. Primary structure of a glycoprotein immunologically cross-reactive with carcinoembryonic antigen. Proc. Natl. Acad. Sci. USA, 85: 6959-6963, 1988.
15. Thompson, J. A., Grunert, F., and Zimmermann, W. Carcinoembryonic antigen gene family: molecular biology and clinical perspectives. J. Clin. Lab. Anal., 5: 344-366, 1991.
16. Stanners, C. P., Rojas, M., Zhou, H., Fuks, A., and Beauchemin, N. The CEA family: a system in transitional evolution? Int. J. Biol. Markers, 7: 137-142, 1992.
17. Tobi, M., Memon, M., Kithier, K., and Clapp, N. A putative CEA moiety is shared by the cotton-top tamarin (Saguinus oedipus) and humans. Cancer Lett., 77: 7-13, 1994.
18. Nédellec, P., Turbide, C., and Beauchemin, N. Characterization and transcriptional activity of the mouse biliary glycoprotein 1 gene, a carcinoembryonic antigen-related gene. Eur. J. Biochem., 231: 104-114, 1995.
19. Nédellec, P., Dveksler, G. S., Daniels, E., Turbide, C., Chow, B., Basile, A. A., Holmes, K. V., and Beauchemin, N. Bgp2, a new member of the carcinoembryonic antigen-related gene family, encodes an alternative receptor for mouse hepatitis viruses. J. Virol., 68: 4525-4537, 1994.
20. Gold, P., and Freedman, S. O. Demonstration of tumour-specific antigens in human colonic carcinomata by immunological tolerance and absorption techniques. J. Exp. Med., 121: 439-462, 1965.
21. Benchimol, S., Fuks, A., Jothy, S., Beauchemin, N., Shirota, K., and Stanners, C. P. Carcinoembryonic antigen, a human tumor marker, functions as an intercellular adhesion molecule. Cell, 57: 327-334, 1989.
22. Oikawa, S., Inuzuka, C., Kuroki, M., Matsuoka, Y., Kosaki, G., and Nakazato, H. Cell adhesion of non-specific cross-reacting antigen (NCA) and carcinoembryonic antigen (CEA) expressed on CHO cell surface: homophilic and heterophilic adhesion. Biochem. Biophys. Res. Commun., 164: 39-45, 1989.
23. Zhou, H., Fuks, A., and Stanners, C. P. Specificity of intercellular adhesion mediated by various members of the immunoglobulin supergene family. Cell Growth & Differ., 1: 209-215, 1990.
24. 2+-dependent intercellular adhesion molecule. Cell Growth & Differ., 1: 527-533, 1990.
25. Oikawa, S., Inuzuka, C., Kuroki, M., Arakawa, F., Matsuoka, Y., Kosaki, G., and Nakazato, H. A specific heterotypic cell adhesion between members of carcinoembryonic antigen family, W272 and NCA, is mediated by N-domains. J. Biol. Chem., 266: 7995-8001, 1991.
26. Frixen, U. H., Behrens, J., Sachs, M., Eberle, G., Voss, B., Warda, A., Löchner, D., and Birchmeier, W. E-cadherin-mediated cell-cell adhesion prevents invasiveness of human carcinoma cells. J. Cell Biol., 113: 173-185, 1991.
27. Johnson, J. P., Stade B. G., Holzmann, B., Schwäble, W., and Riethmüller, G. De novo expression of intercellular-adhesion molecule 1 in melanoma correlates with increased risk of metastasis. Proc. Natl. Acad. Sci. USA, 86: 641-644, 1989.
28. Eidelman, F. J., Fuks, A., DeMarte, L., Taheri, M., and Stanners, C. P. Human carcinoembryonic antigen, an intercellular adhesion molecule, blocks fusion and differentiation of rat myoblasts. J. Cell Biol., 123: 467-475, 1993.
29. Boucher, D., Cournoyer, D., Stanners, C. P., and Fuks, A. Studies on the control of gene expression of the carcinoembryonic antigen family in human tissue. Cancer Res., 49: 847-852, 1989.
30. Hinoda, Y., Takahashi, H., Higashide, T., Nakano, T., Arimura, Y., Yoshimoto, M., Tsujisaki, M., Imai, K., and Yachi, A. Correlated expression of mRNAs of carcinoembryonic antigen and non-specific cross-reacting antigen genes in malignant and nonmalignant tissues of the colon. Jpn J. Clin. Oncol., 21: 75-81, 1991.
31. Neumaier, M., Paululat, S., Chan, A., Matthaes, P., and Wagener, C. Biliary glycoprotein, a potential human cell adhesion molecule, is down-regulated in colorectal carcinomas. Proc. Natl. Acad. Sci. USA, 90: 10744-10748, 1993.
32. Hinoda, Y., Imai, K., Nakagawa, N., Ibayashi, Y., Nakano, T., Paxton, R. J., Shively, J. E., and Yachi, A. Transcription of biliary glycoprotein I gene in malignant and non-malignant human liver tissues. Int. J. Cancer, 45: 875-878, 1990.
33. Hsieh, J. T., Luo, W., Song, W., Wang, Y., Kleinerman, D. I., Van, N. T., and Lin, S. H. Tumor suppressive role of an androgen-regulated epithelial cell adhesion molecule (C-CAM) in prostate carcinoma cell revealed by sense and antisense approaches. Cancer Res., 55: 190-197, 1995.
34. Kunath, T., Ordoñez, C., Turbide, C., and Beauchemin, N. Inhibition of colonic tumor cell growth by biliary glycoprotein. Oncogene, 11: 2375-2382, 1995.
35. Zhou, H., Fuks, A., Alcaraz, G., Boiling, T. J., and Stanners, C. P. Homophilic adhesion between Ig superfamily carcinoembryonic antigen molecules involves double reciprocal bonds. J. Cell Biol., 122: 951-960, 1993.
36. Stanners, C. P., DeMarte, L., Rojas, M., Gold, P., and Fuks, A. Opposite functions for two classes of genes of the human carcinoembryonic antigen family. Tumor Biol., 16: 23-31, 1995.
37. ++ independent cell adhesion activities of biliary glycoprotein, a member of carcinoembryonic antigen family, expressed on CHO cell surface. Biochem. Biophys. Res. Commun., 186: 881-887, 1992.
38. Teixeira, A. M., Fawcett, J., Simmons, D. L., and Watt, S. M. The N-domain of the biliary glycoprotein (BGP) adhesion molecule mediates homotypic binding: domain interactions and epitope analysis of BGPc. Blood, 84: 211-219, 1994.
39. Ehrlich, Y. H., Davis, T. B., Bock, E., Komecki, E., and Lenox, R. H. Ecto-protein kinase activity on the external surface of neural cells. Nature (Lond.), 320: 67-70, 1986.
40. Lin, S. H., and Guidotti, G. Cloning and expression of a cDNA coding for a rat liver plasma membrane ecto-ATPase: the primary structure of the ecto-ATPase is similar to that of the human biliary glycoprotein I. J. Biol. Chem., 264: 14408-14414, 1989.
41. Takeichi, M. Cadherins: a molecular family essential for selective cell-cell adhesion and animal morphogenesis. Trends Genet., 3: 213-217, 1987.
42. Afar, D. E. H., Stanners, C. P., and Bell, J. C. Tyrosine phosphorylation of biliary glycoprotein, a cell adhesion molecule related to carcinoembryonic antigen. Biochim. Biophys. Acta, 1134: 46-52, 1992.
43. Skubitz, K. M., Ducker, T. P., Skubitz, A. P. N., and Goueli, S. A. Antiserum to carcinoembryonic antigen recognizes a phosphotyrosine-containing protein in human colon cancer cell lines. FEBS Lett., 318: 200-204, 1993.
44. Eades-Perner, A. M. Van der Putten, H., Hirth, A., Thompson, J., Neumaier, M., von Kleist, S., and Zimmermann, W. Mice transgenic for the human carcinoembryonic antigen gene maintain its spatiotemporal expression pattern. Cancer Res., 54: 4169-4176, 1994.
45. Hasegawa, T., Isobe, K., Tsuchiya, Y., Oikawa, S., Nakazato, H., Ikezawa, H., Nakashima, I., and Shimokata, K. Establishment and characterization of human carcinoembryonic antigen transgenic mice. Br. J. Cancer, 64: 710-714, 1991.
46. Pollard, J. W., and Stanners, C. P. Characterization of cell lines showing growth control isolated from both the wild type and leucyl-tRNA synthetase mutant of Chinese hamster ovary cells. J. Cell. Physiol., 98: 571-586, 1989.
47. Stanners, C. P., Elicieri, G. L., and Green, H. Two types of ribosomes in mouse-hamster hybrid cells. Nature (Lond.), 230: 52-54, 1971.
48. Barnett, T. R., Drake, L., and Pickle, W., II. Human biliary glycoprotein gene: characterization of a family of novel alternatively spliced RNAs and their expressed proteins. Mol. Cell. Biol., 13: 1273-1282, 1993.
49. Southern, P. J., and Berg, P. Transformation of mammalian cells to antibiotic resistance with a bacterial gene under control of the SV40 early region promoter. J. Mol. Appl. Genet., 1: 327-341, 1982.
50. De Giovanni, C., Lollini, P. L., Dolcetti, R., Landuzzi, L., Nicoletti, G., D'Andrea, E., Scotland, K., and Nanni, P. Uncoupling of growth inhibition and differentiation in dexamethasone-treated human rhabdomyosarcoma cells. Br. J. Cancer, 67: 674-679, 1993.