Involvement of circulating CEA in liver metastases from colorectal cancers re-examined in a new experimental model

British Journal of Cancer

Volumn 80, Issue 9, 1999, Pages 1373-1379

  Leconte, A ^a   Garambois, V ^a   Ychou, M ^a   Robert, B ^a   Pourquier, D ^a   Terskikh, A ^b   Mach, J P ^b   Pelegrin A ^a  

^a CENTRE VAL D AURELLE   (France)

^b UNIVERSITY OF LAUSANNE   (Switzerland)

Author keywords

Colon cancer; Experimental model; Liver metastases; Serum CEA

Indexed keywords

CARCINOEMBRYONIC ANTIGEN; COMPLEMENTARY DNA; MEMBRANE ANTIGEN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD LEVEL; CANCER CELL CULTURE; COLON CARCINOMA; COLORECTAL CANCER; CONTROLLED STUDY; DNA TRANSFECTION; EXPERIMENTAL MODEL; FEMALE; HUMAN; HUMAN CELL; LIVER METASTASIS; MOUSE; NONHUMAN; PRIORITY JOURNAL; TUMOR VOLUME; TUMOR XENOGRAFT;

ANIMALS; CARCINOEMBRYONIC ANTIGEN; COLORECTAL NEOPLASMS; FEMALE; HUMANS; LIVER NEOPLASMS, EXPERIMENTAL; MICE; MICE, INBRED BALB C; MICE, NUDE; TRANSFECTION; TUMOR CELLS, CULTURED;

EID: 0032987243     PISSN: 00070920     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjc.6690531     Document Type: Article

References (27)

1. Benchimol S, Fuks A, Jothy S, Beauchemin N, Shirota K, Stanners CP (1989) Carcinoembryonic antigen, a human tumor marker, functions as an intercellular adhesion molecule. Cell 57: 327-334
2. Buchegger F, Mach JP, Pèlegrin A, Gillet M, Vogel CA, Buelin T, Ryser JE, Delaloye B and Bischof Delaloye A (1995) Radiolabeled chimeric anti-CEA monoclonal antibody compared with the original mouse monoclonal antibody for surgically treated colorectal carcinoma. J Nucl Med 36: 420-429
3. Carrel S, Sordat B and Merenda C (1976) Establishment of a cell line (CO115) from a human colon carcinoma transplanted into nude mice. Cancer Res 36: 3978-3984
4. Edmiston KH, Gangopadhyay A, Shoji Y, Nachman AP, Thomas P and Jessup JM (1977) In vivo induction of murine cytokine production by carcinoembryonic antigen. Cancer Res 57: 4432-4436
5. Folli S, Pèlegrin A, Chalandon Y, Yo X, Buchegger F, Lejeune F and Mach J-P (1993) Tumor Necrosis Factor can enhance radio-antibody uptake in human colon carcinoma xenografts by selective increase of vascular permeability. Int J Cancer 53: 829-836
6. Gangopadhyay A, Bajenova O, Kelly TM and Thomas P (1996) Carcinoembryonic antigen induces cytokine expression in kupffer cells: implications for hepatic metastasis from colorectal cancer. Cancer Res 56: 4805-4810
7. Giavazzi R, Campbell DE, Jessup JM, Cleary K and Fidler IJ (1986) Metastatic behaviour of tumor cells isolated from primary and metastatic human colorectal carcinomas implanted into different sites in nude mice. Cancer Res 46: 1928-1933
8. Hammarstrom S, Shively JE, Paxton RJ, Beatty BG, Larson A, Ghosh R, Bormer O, Buchegger F, Mach J-P, Burtin P, Seguin P, Darbouret B, Degorce F, Sertour J, Jolu J-P, Fuks A, Kalthoff H, Schmiegel W, Arndt R, Kloppel G, von Kleist S, Grunert F, Schwarz K, Matsuoka Y, Kuroki M, Wagener C, Weber T, Yachi A, Imai K, Hishikawa N and Tsujisaki M (1989) Antigenic sites in carcinoembryonic antigen. Cancer Res 49: 4852-4858
9. Hardman N, Lee Gill L, de Winter RFJ, Wagner K, Hollis M, Businger F, Ammaturo D, Buchegger F, Mach J-P and Heusser C (1989) Generation of a recombinant human-mouse chimaeric monoclonal antibody directed against human carcinoembryonic antigen. Int J Cancer 44: 424-433
10. Hashino J, Fukuda Y, Oikawa S, Nakazato H and Nakanishi T (1994) Metastatic potential in nude mice of Chinese hamster ovary cells expressing human carcinoembryonic antigen. Biochem Biophys Res Commun 200: 1748-1753
11. Hostetter RB, Augustus LB, Mankarious R, Chi KF, Fan D, Toth C, Thomas P and Jessup JM (1990) Carcinoembryonic antigen as a selective enhancer of colorectal cancer metastasis. J Natl Cancer Inst 82: 380-385
12. Jessup JM, Petrick AT, Toth CA, Ford R, Meterissian S, O'Hara CJ, Steele G Jr, and Thomas P (1993a) Carcinoembryonic antigen: enhancement of liver colonization through retention of human colorectal carcinoma cells. Br J Cancer 67: 464-470
13. Jessup JM, Kim JC, Thomas P, Ishii S, Ford R, Shively JE, Durbin H, Stanners CP, Fuks A, Zhou H, Hansen HJ, Goldenberg DM and Steele G Jr (1993b) Adhesion to carcinoembryonic antigen by human colorectal carcinoma cells involves at least two epitopes. Int J Cancer 55: 262-268
14. Kozlowski JM, Fidler IJ, Campbell D, Xu Z, Kaighn ME and Hart IR (1984) Metastatic behavior of human tumor cells lines grown in the nude mouse. Cancer Res 44: 3522-3529
15. Landuzzi L, Frabetti F, Rossi I, Griffoni C, De Giovanni C, Nicoletti G, Nanni P, Miniero R, Palmieri G, Santoni A and Lollini PL (1996) Expression of transduced carcinoembryonic antigen gene in human rhabdomyosarcoma inhibits metastasis. Cancer Res 56: 4503-4508
16. Liotta LA, Saidel MG and Kleinerman J (1976) The significance of hematogenous tumor cell clumps in the metastatic process. Cancer Res 36: 889-894
17. Lucha PA Jr, Rosen L, Olenwine JA, Reed JF 3rd, Riether RD, Stasik JJ Jr and Khubchandani IT (1997) Value of carcinoembryonic antigen monitoring in curative surgery for recurrent colorectal carcinoma. Dis Colon Rectum 40: 145-149
18. Mach J-P, Carrel S, Merenda C, Sordat B and Cerottini JC (1974) In vivo localisation of radiolabelled antibodies to carcinoembryonic antigen in human colon carcinoma grafted into nude mice. Nature 248: 704-706
19. Oikawa S, Inuzuka C, Kuroki M, Matsuoka Y, Kosaki G and Nakazato H (1989) Cell adhesion activity of non-specific cross-reacting antigen (NCA) and carcinoembryonic antigen (CEA) expressed on cho cell surface: homophilic and heterophilic adhesion. Biochem Biophys Res Commun 164: 39-45
20. Pèlegrin A, Terskikh A, Hayoz D, Chalandon Y, Olsson NO, Folli S, Buchegger F, Kromer B, Schwarz K, Martin M, Martin F and Mach J-P (1992) Human carcinoembryonic antigen cDNA expressed in rat carcinoma cells can function as target antigen for tumor localisation of antibodies in nude rats and as rejection antigen in syngeneic rats. Int J Cancer 52: 110-119
21. Pignatelli M, Durbin H and Bodmer WF (1990) Carcinoembryonic antigen functions as an accessory adhesion molecule mediating colon epithelial cell-collagen interactions. Proc Natl Acad Sci USA 87: 1541-1545
22. Terskikh A, Mach JP and Pèlegrin A (1993) Marked increase in the secretion of a fully antigenic recombinant carcinoembryonic antigen obtained by deletion of its hydrophobic tail. Mol Immunol 30: 921-927
23. Thomas P, Gangopadhyay A, Steele G Jr, Andrews C, Nakazato H, Oikawa S and Jessup JM (1995) The effect of transfection of the CEA gene on the metastatic behavior of the human colorectal cancer cell line MIP-101. Cancer Lett 92: 59-66
24. Tibbetts LM, Doremus CM, Tzanakakis GN and Vezeridis MP (1993) Liver metastases with 10 human colon carcinoma cell lines in nude mice and association with carcinoembryonic antigen production. Cancer 71: 315-321
25. Toth CA and Thomas P (1992) Liver endocytosis and Kupffer cells. Hepatology 16: 255-266
26. Zhou H, Fuks A and Stanners CP (1990) Specificity of intercellular adhesion mediated by various members of the immunoglobulin supergene family. Cell Growth Differ 1: 209-215
27. Zhou H, Fuks A, Alcaraz G, Bolling TJ, Stanners CP (1993) Homophilic adhesion between Ig superfamily carcinoembryonic antigen molecule involves double reciprocal bonds. J Cell Biol 122: 951-960