Pathophysiology and treatment of neuropathic pain associated with syringomyelia

Veterinary Journal

Volumn 175, Issue 2, 2008, Pages 164-172

  Rusbridge, Clare ^a   Jeffery, Nick D ^b  

^a Stone Lion Veterinary Centre   (United Kingdom)

^b UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

Allodynia; Cavalier King Charles Spaniel; Dysaesthesia; Neuropathic pain; Spinal cord dorsal horn

Indexed keywords

AMITRIPTYLINE; ANTICONVULSIVE AGENT; CALCIUM CHANNEL BLOCKING AGENT; CARBAMAZEPINE; CARPROFEN; CORTICOSTEROID; DERACOXIB; DEXTROMETHORPHAN; FENTANYL; FIBROCOXIB; GABAPENTIN; KETAMINE; LIDOCAINE; MELOXICAM; METHADONE; METHYLPREDNISOLONE; MEXILETINE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT; NONSTEROID ANTIINFLAMMATORY AGENT; OMEGA CONOTOXIN MVIIA; OPIATE; OPIATE DERIVATIVE; OXCARBAZEPINE; PHENYTOIN; PREDNICARE; PREDNISOLONE; PREGABALIN; PREVICOX; PROSTAGLANDIN SYNTHASE INHIBITOR; SODIUM CHANNEL BLOCKING AGENT; UNINDEXED DRUG; VETERINARY DRUG;

ANALGESIA; ARNOLD CHIARI MALFORMATION; DECOMPRESSION SURGERY; DISEASE ASSOCIATION; DISEASE COURSE; DIZZINESS; DOG DISEASE; DRUG BIOAVAILABILITY; DRUG CLEARANCE; DRUG EFFICACY; DRUG HALF LIFE; DRUG MECHANISM; DRUG MEGADOSE; DRUG RESPONSE; DRUG SAFETY; DRUG TOLERABILITY; ELECTROENCEPHALOGRAPHY; EVOKED SOMATOSENSORY RESPONSE; HEART ARRHYTHMIA; HUMAN; INFLAMMATION; NERVE INJURY; NEUROANATOMY; NEUROPATHIC PAIN; NEUROSURGERY; NEUROTRANSMISSION; NOCICEPTION; NONHUMAN; PATHOPHYSIOLOGY; PSYCHOSIS; REVIEW; SENSORY NERVE CONDUCTION; SIDE EFFECT; SOMATOSENSORY STIMULATION; SOMNOLENCE; SPINAL CORD DORSAL HORN; SPINAL CORD INJURY; SYRINGOMYELIA; UNSPECIFIED SIDE EFFECT; WEIGHT GAIN;

ANIMALS; DOG DISEASES; DOGS; PAIN; SYRINGOMYELIA;

CANIS FAMILIARIS;

EID: 44249104476     PISSN: 10900233     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tvjl.2006.12.007     Document Type: Review

References (91)

1. Ackerman L.L., Follett K.A., and Rosenquist R.W. Long-term outcomes during treatment of chronic pain with intrathecal clonidine or clonidine/opioid combinations. Journal of Pain and Symptom Management 26 (2003) 668-677
2. Adler, J.E., 2003. Cytokines and Neuropathic pain in Syringomyelia, July 2003. (accessed 11.06.06).
3. Amir R., Argoff C.E., Bennett G.J., Cummins T.R., Durieux M.E., Gerner P., Gold M.S., Porreca F., and Strichartz G.R. The role of sodium channels in chronic inflammatory and neuropathic pain. The Journal of Pain 7 5 Suppl. 3 (2006) S1-S29
4. Andersson S., and Lundeberg T. Acupuncture - from empiricism to science: functional background to acupuncture effects in pain and disease. Medical Hypotheses 45 (1995) 271-281
5. Ansel G.M., Coyne K., Arnold S., and Nelson S.D. Mechanisms of ventricular arrhythmia during amitriptyline toxicity. Journal of Cardiovascular Pharmacology 22 (1993) 798-803
6. Attal N., Brasseur L., Parker F., Chauvin M., and Bouhassira D. Effects of gabapentin on the different components of peripheral and central neuropathic pain syndromes: a pilot study. European Neurology 40 (1998) 191-200
7. Barnes P.J. Anti-inflammatory actions of glucocorticoids: molecular mechanisms. Clinical Science 94 (1998) 557-572
8. Baron R. Peripheral neuropathic pain: from mechanisms to symptoms. The Clinical Journal of Pain 16 2 Suppl. (2000) S12-S20
9. Berg, D., 2001. PainOnline (accessed May 2005).
10. Bergh M.-S., and Budsberg S.C. The Coxib NSAIDs: potential clinical and pharmacological importance in veterinary medicine. Journal of Veterinary Internal Medicine 19 (2005) 633-643
11. Beric A., Dimitrijevic M.R., and Lindblom U. Central dysesthesia syndrome in spinal cord injury patients. Pain 34 (1988) 109-116
12. Brearley J.C., and Brearley M.J. Chronic pain in animals. In: Flecknell P.A., and Waterman-Pearson A. (Eds). Pain Management in Animals (2000), W.B. Saunders, London 147-160
13. Broom D.C., Samad T.A., Kohno T., Tegeder I., Geisslinger G., and Woolf C.J. Cyclooxygenase 2 expression in the spared nerve injury model of neuropathic pain. Neuroscience 124 (2004) 891-900
14. Christensen M.D., and Hulsebosch C.E. Spinal cord injury and anti-NGF treatment results in changes in CGRP density and distribution in the dorsal horn in the rat. Experimental Neurology 147 (1997) 463-475
15. Coderre T.J., Kumar N., Lefebvre C.D., and Yu J.S. Evidence that gabapentin reduces neuropathic pain by inhibiting the spinal release of glutamate. Journal of Neurochemistry 94 (2005) 1131-1139
16. Cohen S.P., and DeJesus M. Ketamine patient-controlled analgesia for dysesthetic central pain. Spinal Cord 42 (2004) 425-428
17. Colpaert F.C., Tarayre J.P., Koek W., Pauwels P.J., Bardin L., Xu X.J., Wiesenfeld-Hallin Z., Cosi C., Carilla-Durand E., Assie M.B., and Vacher B. Large-amplitude 5-HT1A receptor activation: a new mechanism of profound, central analgesia. Neuropharmacology 43 (2002) 945-958
18. Colpaert F.C., Wu W.P., Hao J.X., Royer I., Sautel F., Wiesenfeld-Hallin Z., and Xu X.J. High-efficacy 5-HT1A receptor activation causes a curative-like action on allodynia in rats with spinal cord injury. European Journal of Pharmacology 497 (2004) 29-33
19. Costigan M., and Woolf C.J. Pain: molecular mechanisms. The Journal of Pain 1 3 Suppl. (2000) 35-44
20. Cronin J.N., Bradbury E.J., and Lidierth M. Laminar distribution of GABAA- and glycine-receptor mediated tonic inhibition in the dorsal horn of the rat lumbar spinal cord: effects of picrotoxin and strychnine on expression of Fos-like immunoreactivity. Pain 112 (2004) 156-163
21. DeLeo J.A., and Yezierski R.P. The role of neuroinflammation and neuroimmune activation in persistent pain. Pain 90 (2001) 1-6
22. Dembo G., Park S.B., and Kharasch E.D. Central nervous system concentrations of cyclooxygenase-2 inhibitors in humans. Anesthesiology 102 (2005) 409-415
23. Dewey C.W., Berg J.M., Barone G., Marino D.J., and Stefanacci J.D. Foramen magnum decompression for treatment of caudal occipital malformation syndrome in dogs. Journal of the American Veterinary Medical Association 227 (2005) 1270-1275
24. Ducreux D., Attal N., Parker F., and Bouhassira D. Mechanisms of central neuropathic pain: a combined psychophysical and fMRI study in syringomyelia. Brain 129 (2006) 963-976
25. Eaton, M.J., 2003. Pre-Clinical Development of GABA Cell Therapy for Chronic Pain after Spinal Cord Injury, July 2003 (accessed 11.06.06).
26. Eaton M.J. Cell and molecular approaches to the attenuation of pain after spinal cord injury. Journal of Neurotrauma 23 (2006) 549-559
27. Finnerup N.B., and Jensen T.S. Spinal cord injury pain - mechanisms and treatment. European Journal of Neurology 11 (2004) 73-82
28. Frey H.H., and Loscher W. Pharmacokinetics of carbamazepine in the dog. Archives Internationales de Pharmacodynamie et de Thérapie 243 (1980) 180-191
29. Gellman H. Reflex sympathetic dystrophy: alternative modalities for pain management. Instructional Course Lectures 49 (2000) 549-557
30. Gilron I., and Flatters S.J. Gabapentin and pregabalin for the treatment of neuropathic pain: A review of laboratory and clinical evidence. Pain Research and Management 11 Suppl. A (2006) 16A-29A
31. Hains B.C., Klein J.P., Saab C.Y., Craner M.J., Black J.A., and Waxman S.G. Upregulation of sodium channel Nav1.3 and functional involvement in neuronal hyperexcitability associated with central neuropathic pain after spinal cord injury. The Journal of Neuroscience 23 (2003) 8881-8892
32. Hamandi K., and Sander J.W. Pregabalin: A new antiepileptic drug for refractory epilepsy. Seizure 15 (2006) 73-78
33. Hassenbusch S.J., Gunes S., Wachsman S., and Willis K.D. Intrathecal clonidine in the treatment of intractable pain: a phase I/II study. Pain Medicine 3 (2002) 85-91
34. Kakigi R., Shibasaki H., Kuroda Y., Neshige R., Endo C., Tabuchi K., and Kishikawa T. Pain-related somatosensory evoked potentials in syringomyelia. Brain 114 (1991) 1871-1889
35. Kalso E. Sodium channel blockers in neuropathic pain. Current Pharmaceutical Design 11 (2005) 3005-3011
36. Kukanich B., and Papich M.G. Plasma profile and pharmacokinetics of dextromethorphan after intravenous and oral administration in healthy dogs. Journal of Veterinary Pharmacology and Therapeutics 27 (2004) 337-341
37. Lalwani K., Shoham A., Koh J.L., and McGraw T. Use of oxcarbazepine to treat a pediatric patient with resistant complex regional pain syndrome. The Journal of Pain 6 (2005) 704-706
38. Li X., and Eisenach J.C. Alpha2A-adrenoceptor stimulation reduces capsaicin-induced glutamate release from spinal cord synaptosomes. The Journal of Pharmacology and Experimental Therapeutics 299 (2001) 939-944
39. Lynch M.E., Clark A.J., Sawynok J., and Sullivan M.J. amitriptyline and ketamine in neuropathic pain syndromes: an open-label study. The Journal of Pain 6 (2005) 644-649
40. Mao J., Price D.D., and Mayer D.J. Mechanisms of hyperalgesia and morphine tolerance: a current view of their possible interactions. Pain 62 (1995) 353-364
41. Martin, T.J., Kim, S.A., Eisenach, J.C., 2006. Clonidine maintains intrathecal self-administration in rats following spinal nerve ligation. Pain 23 [Epub ahead of print].
42. Matthews E.A., and Dickenson A.H. Effects of spinally delivered N- and P-type voltage-dependent calcium channel antagonists on dorsal horn neuronal responses in a rat model of neuropathy. Pain 92 (2001) 235-246
43. Meadows J., Kraut M., Guarnieri M., Haroun R.I., and Carson B.S. Asymptomatic Chiari Type I malformations identified on magnetic resonance imaging. Journal of Neurosurgery 92 (2000) 920-926
44. Medow, J., Sansone, J., Iskandar, B.J., in press. Syringomyelia and hydromyelia. In: Albright, A.L., Pollack, A.F., Adelson, P.D. (Eds.), Principles and Practice of Pediatric Neurosurgery, 2nd ed. Thieme Medical Publishers, ISBN 1-58890-395-8.
45. Meurs K.M., Spier A.W., Wright N.A., Atkins C.E., DeFrancesco T.C., Gordon S.G., Hamlin R.L., Keene B.W., Miller M.W., and Moise N.S. Comparison of the effects of four antiarrhythmic treatments for familial ventricular arrhythmias in Boxers. Journal of the American Veterinary Medical Association 221 (2002) 522-527
46. Milhorat T.H., Kotzen R.M., Mu H.T., Capocelli Jr. A.L., and Milhorat R.H. Dysesthetic pain in patients with syringomyelia. Neurosurgery 38 (1996) 940-946
47. Milhorat T.H., Mu H.T., LaMotte C.C., and Milhorat A.T. Distribution of substance P in the spinal cord of patients with syringomyelia. Journal of Neurosurgery 84 (1996) 992-998
48. Milhorat T.H., Chou M.W., Trinidad E.M., Kula R.W., Mandell M., Wolpert C., and Speer M.C. Chiari I malformation redefined: clinical and radiographic findings for 364 symptomatic patients. Neurosurgery 44 (1999) 1005-1017
49. Mochizucki D. Serotonin and noradrenaline reuptake inhibitors in animal models of pain. Human Psychopharmacology 19 Suppl. 1 (2004) S15-S19
50. Moulin D.E., Palma D., Watling C., and Schulz V. Methadone in the management of intractable neuropathic noncancer pain. The Canadian Journal of Neurological Sciences 32 (2005) 340-343
51. Nakamura M., Chiba K., Nishizawa T., Maruiwa H., Matsumoto M., and Toyama Y. Retrospective study of surgery-related outcomes in patients with syringomyelia associated with Chiari I malformation: clinical significance of changes in the size and localization of syrinx on pain relief. Journal of Neurosurgery 100 3 Suppl. Spine (2004) 241-244
52. Neumann S., Doubell T.P., Leslie T., and Woolf C.J. Inflammatory pain hypersensitivity mediated by phenotypic switch in myelinated primary sensory neurons. Nature 384 (1996) 360-364
53. Nolan A.M. Pharmacology of analgesic drugs. In: Flecknell P.A., and Waterman-Pearson A. (Eds). Pain Management in Animals (2000), W.B. Saunders, London 21-52
54. Nurmikko T.J. Mechanisms of central pain. The Clinical Journal of Pain 16 2 Suppl. (2000) S21-S25
55. O'Hagan B.J. Neuropathic pain in a cat post-amputation. Australian Veterinary Journal 84 (2006) 83-86
56. Ohtori S., Takahashi K., Ino H., Chiba T., Yamagata M., Sameda H., and Moriya H. Up-regulation of substance P and NMDA receptor mRNA in dorsal horn and preganglionic sympathetic neurons during adjuvant-induced noxious stimulation in rats. Annals of Anatomy 184 (2002) 71-76
57. Olaizola I., Ellger T., Young P., Bösebeck F., Ever S., and Kellinghaus C. Pregabalin-associated acute psychosis and epileptiform EEG-Changes. Seizure 15 (2006) 208-210
58. Overduin L.M., van Gogh H., Mol J.A., and van Nes J.J. Pharmacokinetics of three formulations of diphenylhydantoin in the dog. Research in Veterinary Science 46 (1989) 271-273
59. Pancrazio J.J., Kamatchi G.L., Roscoe A.K., and Lynch III C. Inhibition of neuronal Na+ channels by antidepressant drugs. The Journal of Pharmacology and Experimental Therapeutics 284 (1998) 208-214
60. Rexed B. The cytoarchitectonic organization of the spinal cord in the cat. Journal of Comparative Neurology 96 (1952) 415-466
61. Rusbridge C., MacSweeny J.E., Davies J.V., Chandler K.E., Fitzmaurice S.N., Dennis R., Cappello R., and Wheeler S.J. Syringomyelia in Cavalier King Charles Spaniels. Journal of the American Animal Hospital Association 36 (2000) 34-41
62. Rusbridge C., Greitz D., and Iskander B.J. Syringomyelia: current concepts in pathogenesis, diagnosis and treatment. Journal of Veterinary Internal Medicine 20 (2007) 469-479
63. Rusbridge, C., 2007. Chiari-like malformation with syringomyelia in the cavalier King Charles spaniel: long term follow up after surgical management. Veterinary Surgery, in press.
64. Rusbridge, C., Curruthers, H., Dube, M.-P., Holmes, M., Jeffery, N.D., 2007. Syringomyelia in cavalier King Charles spaniels: the relationship between syrinx dimensions and pain. JSAP, in press.
65. Schicht S., Wigger D., and Frey H.H. Pharmacokinetics of oxcarbazepine in the dog. Journal of Veterinary Pharmacology and Therapeutics 19 (1996) 27-31
66. Schnoebel R., Wolff M., Peters S.C., Brau M.E., Scholz A., Hempelmann G., Olschewski H., and Olschewski A. Ketamine impairs excitability in superficial dorsal horn neurones by blocking sodium and voltage-gated potassium currents. British Journal of Pharmacology 146 (2005) 826-833
67. Shneker B.F., and McAuley J.W. Pregabalin: a new neuromodulator with broad therapeutic indications. The Annals of Pharmacotherapy 39 (2005) 2029-2037
68. Skerrit, G.C., Hughes, D., 1998. A syndrome of syringomyelia in the cavalier King Charles spaniel, and its treatment by syringo-subarachnoid shunting. In: Proceedings from the 12th Annual Symposium of the European Society of Veterinary Neurology, Vienna, pp. 23.
69. Snutch T.P. Targeting chronic and neuropathic pain: the N-type calcium channel comes of age. NeuroRx: The Journal of the American Society for Experimental NeuroTherapeutics 2 (2005) 662-670
70. Takahashi M., Kawaguchi M., Shimada K., Nakashima T., and Furuya H. Systemic meloxicam reduces tactile allodynia development after L5 single spinal nerve injury in rats. Regional Anesthesia and Pain Medicine 30 (2005) 351-355
71. Taylor F.R., and Larkins M.V. Headache and Chiari I malformation: clinical presentation, diagnosis, and controversies in management. Current Pain and Headache Reports 6 (2002) 331-337
72. Thimineur M., Kitaj M., Kravitz E., Kalizewski T., and Sood P. Functional abnormalities of the cervical cord and lower medulla and their effect on pain: observations in chronic pain patients with incidental mild Chiari I malformation and moderate to severe cervical cord compression. Clinical Journal of Pain 18 (2002) 171-179
73. Todd A.J. Anatomy of primary afferents and projection neurones in the rat spinal dorsal horn with particular emphasis on substance P and the neurokinin 1 receptor. Experimental Physiology 87 (2002) B245-B249
74. Todd A.J., and Spike R.C. The localization of classical transmitters and neuropeptides within neurons in laminae I-III of the mammalian spinal dorsal horn. Progress in Neurobiology 41 (1993) 609-645
75. Todor D.R., Harrison T.M., and Milhorat T.H. Pain and syringomyelia: a review. Neurosurgical Focus [electronic resource] 8 (2000) 1-6
76. Vermeersch K., Van Ham L., Caemaert J., Tshamala M., Taeymans O., Bhatti S., and Polis I. Suboccipital craniectomy, dorsal laminectomy of C1, durotomy and dural graft placement as a treatment for syringohydromyelia with cerebellar tonsil herniation in Cavalier King Charles Spaniels. Veterinary Surgery 33 (2004) 355-360
77. Virga V., Houpt K.A., and Scarlett J.M. Efficacy of amitriptyline as a pharmacological adjunct to behavioral modification in the management of aggressive behaviors in dogs. Journal of the American Animal Hospital Association 37 (2001) 325-330
78. Vranken J.H., Troost D., Wegener J.T., Kruis M.R., and van der Vegt M.H. Neuropathological findings after continuous intrathecal administration of S(+)-ketamine for the management of neuropathic cancer pain. Pain 117 (2005) 231-235
79. Wang C.Z., and Chi C.W. Conus peptides - a rich pharmaceutical treasure. Acta Biochimica et Biophysica Sinica 36 (2004) 713-723
80. Wang G.K., Russell C., and Wang S.Y. State-dependent block of voltage-gated Na+ channels by amitriptyline via the local anaesthetic receptor and its implication for neuropathic pain. Pain 110 (2004) 166-174
81. Wiese A.J., Muir III W.W., and Wittum T.E. Characteristics of pain and response to analgesic treatment in dogs and cats examined at a veterinary teaching hospital emergency service. Journal of the American Veterinary Medical Association 226 (2005) 2004-2009
82. Wong H.K., and Tan K.J. Effects of corticosteroids on nerve root recovery after spinal nerve root compression. Clinical Orthopaedics 403 (2002) 248-252
83. Wood J.N., Boorman J.P., Okuse K., and Baker M.D. Voltage-gated sodium channels and pain pathways. Journal of Neurobiology 61 (2004) 55-71
84. Woolf C.J. Dissecting out mechanisms responsible for peripheral neuropathic pain: implications for diagnosis and therapy. Life Sciences 74 (2004) 2605-2610
85. Woolf C.J., and Mannion R.J. Neuropathic pain: aetiology, symptoms, mechanisms, and management. Lancet 353 (1999) 1959-1964
86. Woolf C.J., and Salter M.W. Neuronal plasticity: increasing the gain in pain. Science 288 (2000) 1765-1788
87. Yaksh T.L. Behavioral and anatomic correlates of the tactile-evoked allodynia produced by spinal glycine inhibition: effects of modulatory receptor systems and excitatory amino acid antagonists. Pain 37 (1989) 111-123
88. Yezierski R.P., Liu S., Ruenes G.L., Kajander K.J., and Brewer K.L. Excitotoxic spinal cord injury: behavioral and morphological characteristics of a central pain model. Pain 75 (1998) 41-55
89. You H.J., Colpaert F.C., and Arendt-Nielsen L. The novel analgesic and high-efficacy 5-HT1A receptor agonist F 13640 inhibits nociceptive responses, wind-up, and after-discharges in spinal neurons and withdrawal reflexes. Experimental Neurology 191 (2005) 174-183
90. Zhang A.L., Hao J.X., Seiger A., Xu X.J., Wiesenfeld-Hallin Z., Grant G., and Aldskogius H. Decreased GABA immunoreactivity in spinal cord dorsal horn neurons after transient spinal cord ischemia in the rat. Brain Research 656 (1994) 187-190
91. Zou X., Lin Q., and Willis W.D. The effects of sympathectomy on capsaicin-evoked fos expression of spinal dorsal horn GABAergic neurons. Brain Research 958 (2002) 322-329