Long-term outcomes during treatment of chronic pain with intrathecal clonidine or clonidine/opioid combinations

Journal of Pain and Symptom Management

Volumn 26, Issue 1, 2003, Pages 668-677

  Ackerman, Laurie L ^a   Follett, Kenneth A ^a   Rosenquist, Richard W ^a  

^a UNIVERSITY OF IOWA HOSPITALS AND CLINICS   (United States)

Author keywords

Chronic pain; Clonidine; Intrathecal; Opioids; Polyanalgesia

Indexed keywords

CLONIDINE; FENTANYL; HYDROMORPHONE; MORPHINE; OPIATE;

ADULT; AGED; ARTICLE; CANCER PAIN; CHRONIC PAIN; CLINICAL ARTICLE; CONFUSION; CONSTIPATION; CONTINUOUS INFUSION; CONTROLLED STUDY; DEATH; DRUG EFFICACY; DRUG UTILIZATION; FEMALE; HEADACHE; HUMAN; HYPOTENSION; LONG TERM CARE; LUMBAR PUNCTURE; MALE; MEDICAL AUDIT; MEDICAL RECORD; MONOTHERAPY; NAUSEA; NEUROPATHIC PAIN; PAIN; PAIN ASSESSMENT; PRURITUS; RADICULOPATHY; RETROSPECTIVE STUDY; SCORING SYSTEM; SEDATION; SHORT COURSE THERAPY; SIDE EFFECT; SINGLE DRUG DOSE; SPINAL ANESTHESIA; TREATMENT FAILURE; TREATMENT OUTCOME; VISUAL ANALOG SCALE;

EID: 0037674939     PISSN: 08853924     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0885-3924(03)00144-1     Document Type: Article

References (32)

1. Yaksh T. Pharmacology of spinal adrenergic systems which modulate spinal cord nociceptive processing. Pharmacol Biochem Behav. 22:1985;323-330.
2. Rainov N.G., Heidecke V., Burkert W. Long-term intrathecal infusion of drug combinations for chronic back and leg pain. J Pain Symptom Manage. 22:(4):2001;862-871.
3. Osenbach R.K., Harvey S. Neuraxial infusion in patients with chronic intractable cancer and noncancer pain. Curr Pain Headache Rep. 5:(3):2001;241-249.
4. Hassenbusch S.J., Garber J., Buchser E., Du Pen S. Alternative intrathecal agents for the treatment of pain. Neuromodulation. 2:1999;85-91.
5. Tallarida R.J., Stone D.J. Jr., McCary J.D., Raffa R.B. Response surface analysis of synergism between morphine and clonidine. J Pharmacol Exp Ther. 289:(1):1999;8-13.
6. Plummer J.L., Cmielewski P.L., Gourlay G.K., et al. Antinociceptive and motor effects of intrathecal morphine combined with intrathecal clonidine, noradrenaline, carbachol or midazolam in rats. Pain. 49:(1):1992;145-152.
7. Siddall P.J., Molloy A.R., Walker S., et al. The efficacy of intrathecal morphine and clonidine in the treatment of pain after spinal cord injury. Anesth Analg. 91:(6):2000;1493-1498.
8. Eisenach J.C., DuPen S., Dubois M., et al. Epidural clonidine analgesia for intractable cancer pain. The Epidural Clonidine Study Group. Pain. 61:(3):1995;391-399.
9. Eisenach J., Lysak S.Z., Viscomi C.M., Epidural clonidine analgesia following surgery: phase I. Anesthesiology. 71:(5):1989;640-646.
10. Filos K.S., Goudas L.C., Patroni O., Polyzou V. Hemodynamic and analgesic profile after intrathecal clonidine in humans. A dose-response study. Anesthesiology. 81:(3):1994;591-601. discussion 27A-28A.
11. Rauck R., Eisenach J.C., Jackson K., Young L.D. Epidural clonidine treatment for refractory reflex sympathetic dystrophy. Anestheiology. 79:(6):1993;1163-1169.
12. Eisenach J.C., Hood D.D., Tuttle R., et al. Computer-controlled epidural infusion to targeted cerebrospinal fluid concentrations in humans. Clonidine. Anesthesiology. 83:(1):1995;33-47.
13. Eisenach J.C., Rauck R.L., Buzzanell C., Lysak S.Z. Epidural clonidine analgesia for intractable cancer pain: phase I. Anesthesiology. 71:(5):1989;647-652.
14. Glynn C.J., Jamous M.A., Teddy P.J., et al. Role of spinal noradrenergic system in transmission of pain in patients with spinal cord injury. Lancet. 2:(8518):1986;1249-1250.
15. Grace D., Bunting H., Milligan K.R., Fee J.P.H. Postoperative analgesia after co-administration of clonidine and morphine by the intrathecal route in patients undergoing hip replacement. Anesth Analg. 80:1995;86-91.
16. van Essen E.J., Bovill J.G., Ploeger E.J., Beerman H. Intrathecal morphine and clonidine for control of intractable cancer pain. A case report. Acta Anaesthesiol Belg. 39:(2):1988;109-112.
17. Tumber P.S., Fitzgibbon D.R. The control of severe cancer pain by continuous intrathecal infusion and patient controlled intrathecal analgesia with morphine, bupivacaine and clonidine. Pain. 78:(3):1998;217-220.
18. Coombs D.W., Saunders R.L., Fratkin J.D., et al. Continuous intrathecal hydromorphone and clonidine for intractable cancer pain. J Neurosurg. 64:(6):1986;890-894.
19. Coombs D.W., Saunders R.L., Lachance D., et al. Intrathecal morphine tolerance: use of intrathecal clonidine, DADLE, and intraventricular morphine. Anesthesiology. 62:(3):1985;358-363.
20. Mercadante S., Serretta R., Sapio M., et al. When all else fails: stepwise multiple solutions for a complex cancer pain syndrome. Support Care Cancer. 7:(1):1999;47-50.
21. Borg P.A., Krijnen H.J. Long-term intrathecal administration of midazolam and clonidine. Clin J Pain. 12:(1):1996;63-68.
22. Middleton J.W., Siddall P.J., Walker S., et al. Intrathecal clonidine and baclofen in the management of spasticity and neuropathic pain following spinal cord injury: a case study. Arch Phys Med Rehabil. 77:(8):1996;824-826.
23. Siddall P.J., Gray M., Rutkowski S., Cousins M.J. Intrathecal morphine and clonidine in the management of spinal cord injury pain: a case report. Pain. 59:(1):1994;147-148.
24. Kumar K., Kelly M., Pirlot T. Continuous intrathecal morphine treatment for chronic pain of nonmalignant etiology: long-term benefits and efficacy. Surg Neurol. 55:(2):2001;79-86. discussion 86-88.
25. Hardy P.A., Wells J.C. Pain after spinal intrathecal clonidine. An adverse interaction with tricyclic antidepressants? Anaesthesia. 43:(12):1988;1026-1027.
26. Eisenach J.C., Hood D.D., Curry R. Relative potency of epidural to intrathecal clonidine differs between acute thermal pain and capsaicin-induced allodynia. Pain. 84:(1):2000;57-64.
27. Bennett G., Serafini M., Burchiel K., et al. Evidence-based review of the literature on intrathecal delivery of pain medication. J Pain Symptom Manage. 20:(2):2000;S12-36.
28. Eisenach J., Detwiler D., Hood D. Hemodynamic and analgesic actions of epidurally administered clonidine. Anesthesiology. 78:(2):1993;277-287.
29. Nance P., Meythaler J. Intrathecal drug therapy. Phys Med Rehabil Clin N Am. 10:(2):1999;385-401. viii-ix.
30. Coffey R.J., Burchiel K. Inflammatory mass lesions associated with intrathecal drug infusion catheters: report and observations on 41 patients. Neurosurgery. 50:(1):2002;78-87.
31. Hassenbusch S.J., Portenoy R.K. Current practices in intraspinal therapy - a survey of clinical trends and decision making. J Pain Symptom Manage. 20:(2):2000;S4-S11.
32. Bennett G., Burchiel K., Buchser E., et al. Clinical guidelines for intraspinal infusion: report of an expert panel. PolyAnalgesic Consensus Conference 2000. J Pain Symptom Manage. 20:(2):2000;S37-S43.