A new acycloguanosine-specific supermutant of herpes simplex virus type 1 thymidine kinase suitable for PET imaging and suicide gene therapy for potential use in patients treated with pyrimidine-based cytotoxic drugs

Journal of Nuclear Medicine

Volumn 49, Issue 5, 2008, Pages 713-720

  Likar, Yury ^a   Dobrenkov, Konstantin ^a   Olszewska, Malgorzata ^a   Vider, Elena ^a   Shenker, Larissa ^a   Cai, Shangde ^a   Pillarsetty, Nagavarakishore ^a   Hricak, Hedvig ^a   Ponomarev, Vladimir ^a  

^a MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

Author keywords

18F FHBG; FEAU; HSV1 tk; Molecular imaging; PET; Reporter gene

Indexed keywords

5 (2 BROMOVINYL) 2' DEOXYURIDINE; 9 [4 FLUORO 3 (HYDROXYMETHYL)BUTYL]GUANINE F 18; ACICLOVIR; ALANINE; CLEVUDINE F 18; CLEVUDINE H 3; CYTOTOXIC AGENT; ENZYME; GREEN FLUORESCENT PROTEIN; PENCYCLOVIR H 3; PYRIMIDINE; PYRIMIDINE DERIVATIVE; RADIOPHARMACEUTICAL AGENT; THYMIDINE KINASE; TYROSINE;

AMINO ACID SUBSTITUTION; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG SENSITIVITY; ENZYME ACTIVITY; FLUORESCENCE ACTIVATED CELL SORTING; GENE EXPRESSION; HERPES SIMPLEX VIRUS 1; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MOUSE; MUTANT; NONHUMAN; PHOSPHORYLATION; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; REPORTER GENE; SUICIDE GENE THERAPY; TUMOR; WILD TYPE; XENOGRAFT;

ACYCLOVIR; ANIMALS; ANTIVIRAL AGENTS; CELL LINE, TUMOR; CYTOTOXINS; GANCICLOVIR; GENE EXPRESSION REGULATION, VIRAL; GENE THERAPY; GENES, REPORTER; GUANINE; HERPESVIRUS 1, HUMAN; HUMANS; MICE; MUTATION; PHOSPHORYLATION; POSITRON-EMISSION TOMOGRAPHY; PYRIMIDINES; SUBSTRATE SPECIFICITY; THYMIDINE KINASE;

EID: 44149101969     PISSN: 01615505     EISSN: None     Source Type: Journal    
DOI: 10.2967/jnumed.107.046425     Document Type: Article

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