A new transgene reporter for in vivo magnetic resonance imaging

Nature Medicine

Volumn 11, Issue 4, 2005, Pages 450-454

  Genove, Guillem ^a   DeMarco, Ulrike ^a   Xu, Hongyan ^a   Goins, William F ^b   Ahrens, Eric T ^a  

^a CARNEGIE MELLON UNIVERSITY   (United States)

^b UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOVIRUS VECTOR; CONTRAST MEDIUM; FERRITIN; IRON; METAL COMPLEX; METALLOPROTEIN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN; CONTROLLED STUDY; FEMALE; GENE DELIVERY SYSTEM; GENE EXPRESSION; GENETIC TRANSDUCTION; GLIA; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; IRON TRANSPORT; NERVE CELL; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; PRIORITY JOURNAL; PROTEIN FAMILY; REPORTER GENE; TECHNOLOGY; TRANSGENE;

ADENOVIRIDAE; ANIMALS; BRAIN; CELLS, CULTURED; DEFECTIVE VIRUSES; FERRITINS; GENE EXPRESSION; GENES, REPORTER; GENETIC VECTORS; IRON; MAGNETIC RESONANCE IMAGING; MICE; MICE, INBRED C57BL; TRANSDUCTION, GENETIC; TRANSGENES;

ADENOVIRIDAE; ANIMALIA;

EID: 17644394164     PISSN: 10788956     EISSN: None     Source Type: Journal    
DOI: 10.1038/nm1208     Document Type: Article

References (25)

1. Contag, C.H. & Bachmann, M.H. Advances in in vivo bioluminescence imaging of gene expression. Annu. Rev. Biomed. Eng. 4, 235-260 (2002).
2. Gambhir, S.S. et al. Imaging adenoviral-directed reporter gene expression in living animals with positron emission tomography. Proc. Natl. Acad. Sci. USA 96, 2333-2338 (1999).
3. Louie, A.Y. et al. In vivo visualization of gene expression using magnetic resonance imaging. Nat. Biotechnol. 18, 321-325 (2000).
4. Weissleder, R. et al. In vivo magnetic resonance imaging of transgene expression. Nat. Med. 6, 351-355 (2000).
5. Koretsky, A.P., Brosnan, M.J., Chen, L.H., Chen, J.D. & Vandyke, T. NMR detection of creatine-kinase expressed in liver of transgenic mice - determination of free ADP levels. Proc. Natl. Acad. Sci. USA 87, 3112-3116 (1990).
6. Walter, G., Barton, E.R. & Sweeney, H.L. Noninvasive measurement of gene expression in skeletal muscle. Proc. Natl. Acad. Sci. USA 197, 5151-5155 (2000).
7. Stolz, J.F., Chang, S.B.R. & Kirschvink, J.L. Magnetotactic bacteria and single-domain magnetite in hemipelagic sediments. Nature 321, 849-851 (1986).
8. Bulte, J.W. et al. Magnetoferritin: characterization of a novel superparamagnetic MR contrast agent. J. Magn. Reson. Imag. 4, 497-505 (1994).
9. Gottesfeld, Z. & Neeman, M. Ferritin effect on the transverse relaxation of water: NMR microscopy at 9.4 T. Magn. Reson. Med. 35, 514-520 (1996).
10. Vymazal, J., Zak, O., Bulte, J.W.M., Aisen, P. & Brooks, R.A. T1 and T2 of ferritin solutions: effect of loading factor. Magn. Reson. Med. 36, 61-65 (1996).
11. Vymazal, J., Brooks, R.A., Bulte, J.W.M., Gordon, D. & Aisen, P. Iron uptake by ferritin: NMR relaxometry studies at low iron loads. J. Inorg. Biochem. T1, 153-157 (1998).
12. Welch, S. Transferrin: The Iron Carrier (CRC Press, Boca Raton, Florida, 1992).
13. Vymazal, J. et al. The relation between brain iron and NMR relaxation times: an in vitro study. Magn. Reson. Med. 35, 56-61 (1996).
14. Dhenain, M., Michot, J.L., Volk, A., Picq, J.L. & Boller, F. T2-weighted MRI studies of mouse lemurs: a primate model of brain aging. Neurobiol. Aging 18, 517-521 (1997).
15. Okon, E. et al. Biodegradation of magnetite dextran nanoparticles in the rat - a histologic and biophysical study. Lab. Invest. 71, 895-903 (1994).
16. Yeh, T.C., Zhang, W.G., Ildstad, S.T. & Ho, C. Intracellular labeling of T-cells with superparamagnetic contrast agents. Magn. Reson. Med. 30, 617-625 (1993).
17. Ahrens, E.T., Feili-Hariri, M., Genove, G. & Morel, P.A. Receptor-mediated endocytosis of iron-oxide particles provides efficient labeling of dendritic cells for in vivo MR imaging. Magn. Reson. Med. 46, 1006-1013 (2003).
18. Kircher, M.F. et al. In vivo high resolution three-dimensional imaging of antigen-specific cytotoxic T-lymphocyte trafficking to tumors. Cancer Res. 63, 6838-6846 (2003).
19. Bulte, J.W.M., Arbab, A.S., Douglas, T. & Frank, J.A. Preparation of magnetically labeled cells for cell tracking by magnetic resonance imaging. Meth. Enzymol. 386, 275-299 (2004).
20. Epsztejn, S. et al. H-ferritin subunit overexpression in erythroid cells reduces the oxidative stress response and induces multidrug resistance properties. Blood 94, 3593-3603 (1999).
21. Corsi, B. et al. Transient overexpression of human H- and L-ferritin chains in COS cells. Biochem. J. 330, 315-320 (1998).
22. Cozzi, A. et al. Overexpression of wild type and mutated human ferritin H-chain in HeLa cells - in vivo role of ferritin ferroxidase activity. J. Biol. Chem. 275, 25122-25129 (2000).
23. Santambrogio, P. et al. Production and characterization of recombinant heteropolymers of human ferritin Hchain and L-chain. J. Biol. Chem. 268, 12744-12748 (1993).
24. Levi, S. et al. Evidence that Hchains and L-chains have cooperative roles in the iron-uptake mechanism of human ferritin. Biochem. J, 288, 591-596 (1992).
25. Klausner, R.D. et al. Receptor-mediated endocytosis of transferrin in K562 cells. J. Biol. Chem. 258, 4715-4724 (1983).