The A167Y mutation converts the herpes simplex virus type 1 thymidine kinase into a guanosine analogue kinase

Biochemistry

Volumn 41, Issue 20, 2002, Pages 6517-6524

  Balzarini, Jan ^a   Liekens, Sandra ^a   Esnouf, Robert ^b   De Clercq, Erik ^a  

^a REGA INSTITUTE FOR MEDICAL RESEARCH   (Belgium)

^b UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING AFFINITY;

DISEASES; ENZYME KINETICS; MUTAGENESIS; PHOSPHORUS; SUBSTITUTION REACTIONS; SUBSTRATES;

BIOCHEMICAL ENGINEERING;

9 [1,2 BIS(HYDROXYMETHYL)CYCLOPROPYLMETHYL]GUANINE; ACICLOVIR; ANTIVIRUS AGENT; DEOXYCYTIDINE KINASE; GANCICLOVIR; GUANOSINE DERIVATIVE; LOBUCAVIR; PENCICLOVIR; PHOSPHOTRANSFERASE; PYRIMIDINE DERIVATIVE; THYMIDINE KINASE;

ARTICLE; BINDING AFFINITY; COMPUTER MODEL; CONTROLLED STUDY; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME SPECIFICITY; GENE MUTATION; HERPES SIMPLEX VIRUS 1; MOLECULAR RECOGNITION; NONHUMAN; PHOSPHORYLATION; PRIORITY JOURNAL; VIRUS INHIBITION;

ALANINE; AMINO ACID SUBSTITUTION; ANTINEOPLASTIC AGENTS; ANTIVIRAL AGENTS; ENZYME INHIBITORS; HERPESVIRUS 1, HUMAN; KINETICS; MUTAGENESIS, SITE-DIRECTED; PHOSPHORYLATION; PHOSPHOTRANSFERASES (ALCOHOL GROUP ACCEPTOR); PURINE NUCLEOSIDES; PURINE NUCLEOTIDES; PYRIMIDINE NUCLEOSIDES; SUBSTRATE SPECIFICITY; THYMIDINE KINASE; TYROSINE;

HUMAN HERPESVIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS 1; LEUCISCUS IDUS; SIMPLEXVIRUS;

EID: 0037150096     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi0255930     Document Type: Article

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