Monitoring gene therapy with herpes simplex virus thymidine kinase in hepatoma cells: Uptake of specific substrates

Journal of Nuclear Medicine

Volumn 38, Issue 2, 1997, Pages 287-294

  Haberkorn, Uwe ^a   Altmann, Annette ^a   Morr, Iris ^a   Knopf, Karl Werner ^a   Germann, Christine ^a   Haeckel, Roland ^a   Oberdorfer, Franz ^a   Van Kaick, Gerhard ^a  

^a GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

Author keywords

ganciclovir; gene therapy; HSV thymidine kinase; PET

Indexed keywords

FLUCYTOSINE DEOXYRIBOSIDE; GANCICLOVIR; THYMIDINE; THYMIDINE KINASE;

ANIMAL CELL; ARTICLE; DNA SYNTHESIS; ENZYME ACTIVITY; GENE THERAPY; HEPATOMA CELL; HERPES SIMPLEX VIRUS; MOLECULAR CLONING; NONHUMAN; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; RAT;

ANIMALS; ANTIVIRAL AGENTS; CELL SURVIVAL; CLONING, MOLECULAR; DEOXYCYTIDINE MONOPHOSPHATE; DNA; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; FLUORESCENT ANTIBODY TECHNIQUE; GANCICLOVIR; GENE THERAPY; GENES, VIRAL; LIVER NEOPLASMS, EXPERIMENTAL; SCINTILLATION COUNTING; SIMPLEXVIRUS; SUBSTRATE SPECIFICITY; THYMIDINE KINASE; TOMOGRAPHY, EMISSION-COMPUTED; TRITIUM; TUMOR CELLS, CULTURED; VIRAL PROTEINS;

EID: 0031039313     PISSN: 01615505     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (32)

1. Kasahara N, Dozy AM, Kan YW. Tissue-specific targeting of retroviral vectors through ligand-receptor interactions. Science 1994;266:1373-1376.
2. Huber BE, Richards CA, Krenitsky TA. Retroviral-mediated gene therapy for the treatment of hepatocellular carcinoma: an innovative approach for cancer therapy. Proc Natl Acad Sci USA 1991;88:8039-8043.
3. Vile RG, Hart IR. Use of tissue-specific expression of the herpes simplex virus thymidine kinase gene to inhibit growth of established murine melanomas following direct intratumoral injection of DNA. Cancer Res 1993;53:3860-3864.
4. Chen SH, Shine HD, Goodman JC, Grossman RG, Woo SLC. Gene therapy for brain tumors: regression of experimental gliomas by adenovirus-mediated gene transfer in vivo. Proc Natl Acad Sci USA 1994;91:3054-3057.
5. Moolten FL. Tumor chemosensitivity conferred by inserted herpes thymidine kinase genes: paradigm for a prospective cancer control strategy. Cancer Res 1986;46:5276-5281.
6. Caruso M, Panis Y, Gagandeep S, Houssin D, Salzmann JL, Klatzman D. Regression of established macroscopic liver metastases after in situ transduction of a suicide gene. Proc Natl Acad Sci USA 1993;90:7024-7028.
7. Oldfield EH, Ram Z, Culver KW, Blaese RM, DeVroom HL, Anderson WF. Gene therapy for the treatment of brain tumors using intra-tumoral transduction with the thymidine kinase gene and intravenous ganciclovir. Hum Gene Ther 19931:39-69.
8. Culver KW, Ram Z, Walbridge S, et al. In vivo gene transfer with retroviral vector-producer cells for treatment of experimental brain tumors. Science 1992;256: 1550-1552.
9. Ram Z, Culver WK, Walbridge S, et al. In situ retroviral-mediated gene transfer for the treatment of brain tumors in rats. Cancer Res 1993;53:83-88.
10. Keller PM, Fyfe JA, Beauchamp L, et al. Enzymatic phosphorylation of acyclic nucleoside analogs and correlations with antiherpetic activities. Biochem Pharmacol 1981;30:3071-3077.
11. Miller AD, Rosman GJ. Improved retroviral vectors for gene transfer and expression. Bio Techniques 1989;7:980-990.
12. Zimmerman TP, Mahony WB, Prus KL. 3′-azido-3′deoxythymidine. An unusual nucleoside analogue that permeates the membrane of human erythrocytes and lymphocytes by nonfacilitated diffusion. J Biol Chem 1987;262:5748-5754.
13. Sachs L. Angewandte Statistik. Berlin. Springer; 1984:329-333.
14. Haberkorn U, Oberdorfer F, Klenner T, et al. Metabolic and transcriptional changes in osteosarcoma cells treated with chemotherapeutic drugs. Nucl Med Biol 1994;21:835-845.
15. Higashi K, Clavo AC, Wahl RL. In vitro assessment of 2-fluoro-2-deoxy-D-glucose, L-methionine and thymidine as agents to monitor the early response of a human adenocarcinoma cell line to radiotherapy. J Nucl Med 1993;34:773-779.
16. Shields AF, Coonrod DV, Quackenbush RC, Crowley JJ. Cellular sources of thymidine nucleotides: studies for PET. J Nucl Med 1987;28:1435-1440.
17. Shields AF, Lim K, Grierson J, Link J, Krohn KA. Utilization of labeled thymidine in DNA synthesis: studies for PET. J Nucl Med 1990;1990:31:337-342.
18. Balzarini J, Bohman C, Walker RT, DeClerqu E. Comparative cytostatic activity of different antiherpetic drugs against herpes simplex virus thymidine kinase genetransfected tumor cells. Mol Pharmacol 1994;45:1253-1258.
19. Wohlrab F, Jamieson AT, Hay J, Mengel R, Guschlbauer W. The effect of 2′-fluoro-2′-deoxycytidine on herpes virus growth. Biochim Biophys Acta 1985;824: 233-242.
20. 18F)fluoro-3-hydroxy-2-propoxy)methyl) guanine. J Label Comp Radiopharm 1995;37:193-195.
21. Tjuvajev JG, Stockhammer G, Desai R, et al. Imaging the expression of transfected genes in vivo. Cancer Res 1995;55:6126-6132.
22. Bi WL, Parysk LM, Warnick R, Stambrook PJ. In vitro evidence that metabolic cooperation is responsible for the bystander effect observed with HSV-tk retroviral gene therapy. Hum Gene Ther 1993;4:725-731.
23. Freeman SM, Abbond CN, Whartenby KA, et al. The "bystander effect": tumor regression when a fraction of tumor mass is genetically modified. Cancer Res 1993;53:5274-5283.
24. Chen CY, Chang YN, Ryan P, Linscott M, McGarrity GJ, Chiang YL. Effect of herpes simplex virus thymidine kinase expression levels on ganciclovir-mediated cytotoxicity and the "bystander effect". Hum Gene Ther 1995;6:1467-1476.
25. Plagemann PGW, Richey DP. Transport of nucleosides, nucleic acid bases, choline and glucose by animal cells in culture. Biochem Biophys Acta 1974;344:263-305.
26. Belt JA, Marina NM, Phelps DA, Crawford CR. Nucleoside transport in normal and neoplastic cells. Advan Enzyme Regul 1993;33:235-252.
27. Huang QQ, Yao SYM, Ritzel MWL, Paterson ARP, Cass CE, Young JD. Cloning and functional expression of a complementary DNA encoding a mammalian nucleoside transport protein. J Biol Chem 1994;269:17757-17760.
28. Mahony WB, Domin BA, McConnel RT, Zimmerman TP. Acyclovir transport into human erythrocytes. J Biol Chem 1988;263:9285-9291.
29. Gati WP, Misra HK, Knaus EE, Wiebe LI. Structural modifications at the 2′ and 3′ positions of some pyrimidine nucleosides as determinants of their interaction with the mouse erythrocyte nucleoside transporter. Biochem Pharmacol 1984;33:3325-3331.
30. Mahony WB, Domin BA, Zimmerman TP. Ganciclovir permeation of the human erythrocyte membrane. Biochem Pharmacol 1991;41:263-271.
31. Domin BA, Mahony WB, Zimmerman TP. Membrane permeation mechanisms of 2′,3′-dideoxynucleosides. Biochem Pharmacol 1993;46:725-729.
32. 3H-5-fluorocytosine. J Nucl Med 1996;37:87-94.