Serial in vivo imaging of the lung metastases model and gene therapy using HSV1-tk and ganciclovir

Journal of Nuclear Medicine

Volumn 47, Issue 5, 2006, Pages 877-884

  Deng, Win Ping ^a   Wu, Cheng Chia ^a   Lee, Chien Chih ^a   Yang, Wen K ^b   Wang, Hsin Ell ^c   Liu, Ren Shyan ^d   Wei, Hon Jian ^a   Gelovani, Juri G ^e   Hwang, Jeng Jong ^c   Yang, Den Mei ^b   Fu, Ying Kai ^f   Wu, Cheng Wen ^g  

^a TAIPEI MEDICAL UNIVERSITY   (Taiwan)

^b CHINA MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

^c NATIONAL YANG MING UNIVERSITY   (Taiwan)

^d TAIPEI VETERANS GENERAL HOSPITAL   (Taiwan)

^e UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

^f INSTITUTE OF NUCLEAR ENERGY RESEARCH   (Taiwan)

^g NATIONAL HEALTH RESEARCH INSTITUTES   (Taiwan)

Author keywords

131I FIAU; Ganciclovir; Gene therapy; Herpes simplex virus thymidine kinase; Lung metastases model; Noninvasive imaging; Reporter gene

Indexed keywords

FIALURIDINE; GANCICLOVIR; IODINE 131; THYMIDINE KINASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER GENE THERAPY; CANCER REGRESSION; CONTROLLED STUDY; DISEASE MODEL; FEMALE; GENE EXPRESSION; HERPES SIMPLEX VIRUS 1; IN VIVO STUDY; LUNG METASTASIS; MOUSE; NONHUMAN; PRIORITY JOURNAL; ANIMAL; GENE THERAPY; GENE TRANSFER; GENETICS; IMAGE PROCESSING; LUNG TUMOR; METASTASIS; METHODOLOGY; REPORTER GENE; SCINTISCANNING; TISSUE DISTRIBUTION;

ANIMALS; GANCICLOVIR; GENE THERAPY; GENE TRANSFER TECHNIQUES; GENES, REPORTER; HERPESVIRUS 1, HUMAN; IMAGE PROCESSING, COMPUTER-ASSISTED; LUNG NEOPLASMS; MICE; NEOPLASM METASTASIS; THYMIDINE KINASE; TISSUE DISTRIBUTION;

EID: 33745552227     PISSN: 01615505     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (35)

1. Yamamoto N, Yang M, Jiang P, et al. Real-time GFP imaging of spontaneous HT-1080 fibrosarcoma lung metastases. Clin Exp Metastasis. 2003;20:181-185.
2. Yazawa K, Fisher WE, Brunicardi FC. Current progress in suicide gene therapy for cancer. World J Surg. 2002;26:783-789.
3. Cameron MD, Schmidt EE, Kerkvliet N, et al. Temporal progression of metastasis in lung: cell survival, dormancy, and location dependence of metastatic inefficiency. Cancer Res. 2000;60:2541-2546.
4. Nogawa M, Yuasa T, Kimura S, et al. Monitoring luciferase-labeled cancer cell growth and metastasis in different in vivo models. Cancer Lett. 2005;217:243-253.
5. Greco O, Dachs GU. Gene directed enzyme/prodrug therapy of cancer: historical appraisal and future prospectives. J Cell Physiol. 2001;187:22-36.
6. Marsee DK, Shen DH, MacDonald LR, et al. Imaging of metastatic pulmonary tumors following NIS gene transfer using single photon emission computed tomography. Cancer Gene Ther. 2004;11:121-127.
7. Tjuvajev JG, Chen SH, Joshi A, et al. Imaging adenoviral-mediated herpes virus thymidine kinase gene transfer and expression in vivo. Cancer Res. 1999;59:5186-5193.
8. Blasberg RG, Tjuvajev JG. Molecular-genetic imaging: current and future perspectives. J Clin Invest. 2003;111:1620-1629.
9. Deng WP, Yang WK, Lai WF, et al. Non-invasive in vivo imaging with radiolabelled FIAU for monitoring cancer gene therapy using herpes simplex virus type 1 thymidine kinase and ganciclovir. Eur J Nucl Med Mol Imaging. 2004;31:99-109.
10. Wei SJ, Chao Y, Shih YL, Yang DM, Hung YM, Yang WK. Involvement of Fas (CD95/APO-1) and Fas ligand in apoptosis induced by ganciclovir treatment of tumor cells transduced with herpes simplex virus thymidine kinase. Gene Ther. 1999;6:420-431.
11. Mar EC, Chiou JF, Cheng YC, Huang ES. Inhibition of cellular DNA polymerase alpha and human cytomegalovirus-induced DNA polymerase by the triphosphates of 9-(2-hydroxyethoxymethyl)guanine and 9-(1,3-dihydroxy-2- propoxymethyl) guanine. J Virol. 1985;53:776-780.
12. Ilsley DD, Lee SH, Miller WH, Kuchta RD. Acyclic guanosine analogs inhibit DNA polymerases alpha, delta, and epsilon with very different potencies and have unique mechanisms of action. Biochemistry. 1995;34:2504-2510.
13. Freeman SM, Abboud CN, Whartenby KA, et al. The "bystander effect": tumor regression when a fraction of the tumor mass is genetically modified. Cancer Res. 1993;53:5274-5283.
14. Pope IM, Poston GJ, Kinsella AR. The role of the bystander effect in suicide gene therapy. Eur J Cancer. 1997;33:1005-1016.
15. Samejima Y, Meruelo D. 'Bystander killing' induces apoptosis and is inhibited by forskolin. Gene Ther. 1995;2:50-58.
16. Wei SJ, Chao Y, Hung YM, et al. S- and G2-phase cell cycle arrests and apoptosis induced by ganciclovir in murine melanoma cells transduced with herpes simplex virus thymidine kinase. Exp Cell Res. 1998;241:66-75.
17. Mesnil M, Yamasaki H. Bystander effect in herpes simplex virus-thymidine kinase/ganciclovir cancer gene therapy: role of gap-junctional intercellular communication. Cancer Res. 2000;60:3989-3999.
18. Yang WK, Ch'ang LY, Koh CK, Myer FE, Yang MD. Mouse endogenous retroviral long-terminal-repeat (LTR) elements and environmental carcinogenesis. Prog Nucleic Acid Res Mol Biol. 1989;36:247-266.
19. Rosenthal MS, Cullom J, Hawkins W, Moore SC, Tsui BM, Yester M. Quantitative SPECT imaging: a review and recommendations by the Focus Committee of the Society of Nuclear Medicine Computer and Instrumentation Council. J Nucl Med. 1995;36:1489-1513.
20. Koehne G, Doubrovin M, Doubrovina E, et al. Serial in vivo imaging of the targeted migration of human HSV-TK-transduced antigen-specific lymphocytes. Nat Biotechnol. 2003;21:405-413.
21. Nagamachi Y, Tani M, Shimizu K, Yoshida T, Yokota J. Suicidal gene therapy for pleural metastasis of lung cancer by liposome-mediated transfer of herpes simplex virus thymidine kinase gene. Cancer Gene Ther. 1999;6:546-553.
22. Shibata MA, Morimoto J, Otsuki Y. Suppression of murine mammary carcinoma growth and metastasis by HSVtk/GCV gene therapy using in vivo electroporation. Cancer Gene Ther. 2002;9:16-27.
23. Garcia-Castro J, Martinez-Palacio J, Lillo R, et al. Tumor cells as cellular vehicles to deliver gene therapies to metastatic tumors. Cancer Gene Ther. 2005;12:341-349.
24. Haubner R, Avril N, Hantzopoulos PA, Gansbacher B, Schwaiger M. In vivo imaging of herpes simplex virus type 1 thymidine kinase gene expression: early kinetics of radiolabelled FIAU. Eur J Nucl Med. 2000;27:283-291.
25. Hung SC, Deng WP, Yang WK, et al. Mesenchymal stem cell targeting of microscopic tumors and tumor stroma development monitored by noninvasive in vivo positron emission tomography imaging. Clin Cancer Res. 2005;11:7749-7756.
26. 211At]astato-1-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl) uracil by a halodestannylation reaction. Nucl Med Biol. 1998;25:487-496.
27. Chung JK. Sodium iodide symporter: its role in nuclear medicine. J Nucl Med. 2002;43:1188-1200.
28. Dingli D, Russell SJ, Morris JC 3rd. In vivo imaging and tumor therapy with the sodium iodide symporter. J Cell Biochem. 2003;90:1079-1086.
29. Massoud TF, Gambhir SS. Molecular imaging in living subjects: seeing fundamental biological processes in a new light. Genes Dev. 2003;17:545-580.
30. Cherry SR, Gambhir SS. Use of positron emission tomography in animal research. ILAR J. 2001;42:219-232.
31. Chatziioannou A, Tai YC, Doshi N, Cherry SR. Detector development for microPET II: a 1 microl resolution PET scanner for small animal imaging. Phys Med Biol. 2001;46:2899-2910.
32. Freytag SO, Khil M, Stricker H, et al. Phase I study of replication-competent adenovirus-mediated double suicide gene therapy for the treatment of locally recurrent prostate cancer. Cancer Res. 2002;62:4968-4976.
33. Germano IM, Fable J, Gultekin SH, Silvers A. Adenovirus/herpes simplex-thymidine kinase/ganciclovir complex: preliminary results of a phase I trial in patients with recurrent malignant gliomas. J Neurooncol. 2003;65:279-289.
34. Prados MD, McDermott M, Chang SM, et al. Treatment of progressive or recurrent glioblastoma multiforme in adults with herpes simplex virus thymidine kinase gene vector-producer cells followed by intravenous ganciclovir administration: a phase I/II multi-institutional trial. J Neurooncol. 2003;65:269-278.
35. Hasenburg A, Fischer DC, Tong XW, et al. Histologic and immunohistochemical analysis of tissue response to adenovirus-mediated herpes simplex thymidine kinase gene therapy of ovarian cancer. Int J Gynecol Cancer. 2002;12:66-73.