Imaging of adenoviral-directed herpes simplex virus type 1 thymidine kinase reporter gene expression in mice with radiolabeled ganciclovir

Journal of Nuclear Medicine

Volumn 39, Issue 11, 1998, Pages 2003-2011

  Gambhir, Sanjiv S ^a   Barrio, Jorge R ^b   Wu, Lily ^b   Iyer, Meera ^b   Namavari, Mohammad ^b   Satyamurthy, Nagichettiar ^b   Bauer, Eileen ^b   Parrish, Capella ^b   MacLaren, Duncan C ^b   Borghei, Ali R ^b   Green, Leeta A ^b   Sharfstein, Susan ^b   Berk, Arnold J ^b   Cherry, Simon R ^b   Phelps, Michael E ^b   Herschman, Harvey R ^b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b NONE

Author keywords

Gene expression; Imaging; PET; Reporter gene; Thymidine kinase

Indexed keywords

GANCICLOVIR; THYMIDINE KINASE;

ARTICLE; AUTORADIOGRAPHY; BIOACCUMULATION; CELL CULTURE; GENE EXPRESSION; GENE TARGETING; HERPES SIMPLEX VIRUS 1; IMAGE ANALYSIS; ISOTOPE LABELING; NONHUMAN; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; REPORTER GENE; TISSUE LEVEL;

ADENOVIRIDAE; ANIMALS; ANTIVIRAL AGENTS; AUTORADIOGRAPHY; CELLS, CULTURED; FEASIBILITY STUDIES; GANCICLOVIR; GENE EXPRESSION; GENES, REPORTER; GENES, VIRAL; HERPESVIRUS 1, HUMAN; HUMANS; LIVER; MICE; RATS; THYMIDINE KINASE; TISSUE DISTRIBUTION; TOMOGRAPHY, EMISSION-COMPUTED;

EID: 0031742514     PISSN: 01615505     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (39)

1. Chalfie M, Tu Y, Euskirchen W, Ward W, Prasher DC. Green fluorescent protein as a marker for gene expression. Science 1994;263:802-805.
2. Jacobs WR, Barletta RG, Udani R, et al. Rapid assessment of drug susceptibilities of Mycobacterium tuberculosis by means of luciferase reporter phages. Science 1993: 260:819-822.
3. Morin KW, Atrazheva ED, Knaus EE, Wiebe LI. Synthesis and cellular uptake of 2′-substituted analogues of (E)-5-(2-[125I]Iodovinyl)-2′-deoxyuridine in tumor cells transduced with the herpes simplex type-1 thymidine kinase gene. Evaluation as probes for monitoring gene therapy. J Med Chem 1997;40:2184-2190.
4. De Clercq E. Biochemical aspects of the selective antiherpes activity of nucleoside analogues. Biochem Pharmacol 1984;33:2159-2169.
5. Watanabe K, Reichman U, Hirota K, Lopez C, Fox J. Nucleosides synthesis and anitherpes virus activity of some 2′-fluoro-2′deoxy-arabinofuranosyl-pyrimidine nucleosides. J Med Chem 1979;22:21-24.
6. Tjuvajev JG, Stockhammer G, Desai R, et al. Imaging the expression of transfected genes in vivo. Cancer Res 1995;55:6126-6132.
7. Tjuvajev JG, Finn R, Watanabe K, et al. Noninvasive imaging of herpes virus thymidine kinase gene transfer and expression: a potential method for monitoring clinical gene therapy. Cancer Res 1996;56:4087-4096.
8. Tjuvajev J, Avrill N, Safer M, et al. Quantitative PET imaging of HSV1-TK gene expression with [I-124]FIAU [Abstract]. J Nucl Med 1997;38:239P.
9. Srinivasan A, Gambhir SS, Green LA, et al. A PET reporter gene (PRG)/PET reporter probe (PRP) technology for repeatedly imaging gene expression in living animals [Abstract]. J Nucl Med 1996;37:107P.
10. Haberkorn U, Altmann A, Morr I, et al. Monitoring gene therapy with herpes simplex virus thymidine kinase in hepatoma cells: uptake of specific substrates. J Nucl Med 1997;38:287-294.
11. Haberkorn U, Oberdorfer F, Gebert J, et al. Monitoring of gene therapy with cytosine deaminase: in vitro studies using 3H-5-fluorocytosine. J Nucl Med 1996;37:87-94.
12. Herschman HR, Sharfstein S, Gambhir SS, et al. In vivo imaging of gene expression associated with cell replication [Abstract]. J Nucl Med 1997;38:250P.
13. O'Brien JJ, Campoli-Richards DM. Acyclovir. An updated review of its antiviral activity, pharmacokinetic properties and therapeutic efficacy. Drugs 1989;37:233-309.
14. Faulds D, Heel RC. Ganciclovir. A review of its antiviral activity, pharmacokinetic properties and therapeutic efficacy in cytomegalovirus infections. Drugs 1990;39:597-638.
15. Mahony WB, Domin BA, McConnell RT, Zimmerman TP. Acyclovir transport into human erythrocytes. J Biol Chem 1988;263:9285-9291.
16. Mahony WB, Domin BA, Zimmerman TP. Ganciclovir permeation of the human erythrocyte membrane. Biochem Pharm 1991;41:263-271.
17. Elion GB. Mechanism of action and selectivity of acyclovir. Am J Med 1982;73:7-13.
18. Balzarini J, Bohman C, De Clercq E. Differential mechanism of cytostatic effect of (E)-5-(2-bromovinyl)-2′-deoxyuridine, 9-(1,3-dihydroxy-2-propoxymethyl) guanine, and other antiherpetic drugs on tumor cells transfected by the thymidine kinase gene of herpes simplex virus type 1 or type 2. J Biol Chem 1993;268:6332-6337.
19. de Miranda P, Krasny HC, Page DA, Elion GB. The disposition of acyclovir in different species. J Pharmacol Exp Ther 1981;219:309-315.
20. Barrio JR, Namavari M, Phelps ME, Satyamurthy N. Regioselective fluorination of substituted guanines with dilute F2: a facile entry to 8-fluoroguanine derivatives. J Org Chem 1996;61:6084-6085.
21. Barrio JR, Namavari M, Phelps ME, Satymamurthy N. Elemental fluorine to 8-fluoropurines in one step. J Am Chem Soc 1996;118:10408-10411.
22. Barrio JR, Namavari M, Srinivasan A, et al. Carbon-8 radiofluorination of purines: a general approach to probe design for gene therapy in humans. XIIth International Symposium on Radiopharmaceutical Chemistry 1997:348.
23. Monclus M, Luxen A, Cool V, Damhaut P, Velu T, Goldman S. Development of a positron emission tomography radiopharmaceutical for imaging thymidine kinase gene expression: synthesis and in vitro evaluation of 9-{(3-[F-18]fluoro-1-hydroxy-2-propoxy)methyl}guanine. Bioorg Med Chem Lett 1997;7:1879-1882.
24. 18F]-fluoro-1-hydroxy-2-propoxy)methyl]guanine ([18F]-FHPG): a potential imaging agent of viral infection and gene therapy using PET. Nuc Med Biol 1996;23:787-792.
25. Bading JR, Alauddin MM, Fissekis JH, Kirkman E, Raman RK, Conti PS. Pharmacokinetics of F-18 fluorohydroxypropoxymethylguanine (FHPG) in primates [Abstract]. J Nucl Med 1997;38:43P.
26. Herz J Girard RD. Adenovirus-mediated transfer of low density lipoprotein receptor gene acutely accelerates cholesterol clearance in normal mice. Proc Nat Acad Sci USA 1993;90:2812-2816.
27. Cherry SR, Shao Y, Silverman RW, et al. microPET: a high resolution PET scanner for imaging small animals. IEEE Transactions on Nucl Sci 1997;44:1161-1166.
28. Smith GN, Ludwig DP, Wright KC, Bauriedel WR. Simple apparatus for combustion of samples containing C14-labeled pesticides for residue analysis. Agricul Food Chem 1964;12:172-175.
29. Gomez-Foix AM, Coats WS, Baques S, Alam T, Girard RD, Newgard CB. Adenovirus-mediated transfer of the muscle glycogen phosphorylase gene into hepatocytes confers altered regulation of glycogen metabolism. J Biol Chem 1992;267:25129-134.
30. Jones N, Shenk T. Isolation of adenovirus type 5 host range deletion mutants defective for transformation of rat embryo cells. Cell 1979;17:683-689.
31. Grodzicker T, Klessig DF. Expression of unselected adenovirus genes in human cells co-transformed with the HSV-1tk gene and adenovirus 2 DNA. Cell 1980;21:453-463.
32. Bradford MM. A Rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of proteint-dye binding. Anal Biochem 1976;72:248-254.
33. Hruby DE, Ball AL. Cell-free synthesis of enzymatically active vaccinia virus thymidine kinase. Virology 1981;113:594-601.
34. TM procedure for isolation of RNA from polysaccharide-and proteoglycan-rich sources. BioTechniques 1995;19:942-945.
35. Kawamoto T, Shimizu M. A method for preparing whole-body sections suitable for autoradiographic, histological, and histochemical studies. Stain Technol 1986;61:169-183.
36. Lear JL. Principles of single and multiple radionuclide autoradiography, Chapter 5. In: Positron emission tomography and autoradiogaphy: principles and applications for the brain and heart. New York: Raven Press; 1986:197-235.
37. Brewster ME, Raghavan K, Pop E, Bodor N. Enhanced delivery of ganciclovir to the brain through the use of redox targeting. Antimicrobial Agents and Chemotherapy 1994;38:817-823.
38. Che M, Gatmaitan Z, Arias IM. Ectonucleotidases, purine nucleoside transporter, and function of the bile canalicular plasma membrane of the hepatocyte. FASEB J 1997;11:101-108.
39. Moolten FL. Suicide genes for cancer therapy. Science and Medicine 1997;4:16-25.