Carbon-deuterium bonds as probes of dihydrofolate reductase

Journal of the American Chemical Society

Volumn 130, Issue 20, 2008, Pages 6597-6603

  Thielges, Megan C ^a   Case, David A ^a   Romesberg, Floyd E ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ABSORPTION; BOND STRENGTH (CHEMICAL); CATALYST ACTIVITY; COMPUTATIONAL METHODS; ELECTROSTATICS;

ABSORPTION FREQUENCY; DIHYDROFOLATE REDUCTASE; PROTEIN FUNCTION;

ENZYMES;

CARBON; DEUTERIUM; DIHYDROFOLATE REDUCTASE; METHIONINE;

ARTICLE; CATALYSIS; CHEMICAL BOND; DIELECTRIC CONSTANT; ENZYME ANALYSIS; ENZYME MECHANISM; LIGAND BINDING; MULTIPLE CHEMICAL SENSITIVITY; PROTEIN FUNCTION;

CRYSTALLOGRAPHY, X-RAY; DEUTERIUM; ELECTROSTATICS; LIGANDS; METHIONINE; MODELS, MOLECULAR; NADP; SPECTROSCOPY, FOURIER TRANSFORM INFRARED; TETRAHYDROFOLATE DEHYDROGENASE;

EID: 43949094162     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja0779607     Document Type: Article

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