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Volumn 153, Issue 4, 2008, Pages 1115-1125

Targeted silencing of TrkA expression in rat forebrain neurons via the p75 receptor

Author keywords

fusogenic; immunogene; immunoporter; karyophilic; MC192; shRNA

Indexed keywords

GREEN FLUORESCENT PROTEIN; HEMAGGLUTININ; HEMAGGLUTININ 2; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY MC192; NEUROTROPHIN RECEPTOR P75; POLYLYSINE; PROTEIN TYROSINE KINASE A; PROTEIN VP1;

EID: 43949091758     PISSN: 03064522     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neuroscience.2008.03.025     Document Type: Article
Times cited : (8)

References (54)
  • 1
    • 15044354554 scopus 로고    scopus 로고
    • RNAi-induced gene silencing by local electroporation in targeting brain region
    • Akaneya Y., Jiang B., and Tsumoto T. RNAi-induced gene silencing by local electroporation in targeting brain region. J Neurophysiol 93 (2005) 594-602
    • (2005) J Neurophysiol , vol.93 , pp. 594-602
    • Akaneya, Y.1    Jiang, B.2    Tsumoto, T.3
  • 2
    • 0035076610 scopus 로고    scopus 로고
    • Neurotrophins differentially enhance acetylcholine release, acetylcholine content and choline acetyltransferase activity in basal forebrain neurons
    • Auld D.S., Mennicken F., Day J.C., and Quirion R. Neurotrophins differentially enhance acetylcholine release, acetylcholine content and choline acetyltransferase activity in basal forebrain neurons. J Neurochem 77 (2001) 253-262
    • (2001) J Neurochem , vol.77 , pp. 253-262
    • Auld, D.S.1    Mennicken, F.2    Day, J.C.3    Quirion, R.4
  • 4
    • 0033393303 scopus 로고    scopus 로고
    • The generation of reactive-oxygen species associated with long-lasting pulse-induced electropermeabilisation of mammalian cells is based on a non-destructive alteration of the plasma membrane
    • Bonnafous P., Vernhes M., Teissie J., and Gabriel B. The generation of reactive-oxygen species associated with long-lasting pulse-induced electropermeabilisation of mammalian cells is based on a non-destructive alteration of the plasma membrane. Biochim Biophys Acta 1461 (1999) 123-134
    • (1999) Biochim Biophys Acta , vol.1461 , pp. 123-134
    • Bonnafous, P.1    Vernhes, M.2    Teissie, J.3    Gabriel, B.4
  • 5
    • 0021152619 scopus 로고
    • A monoclonal antibody modulates the interaction of nerve growth factor with PC12 cells
    • Chandler C.E., Parsons L.M., Hosang M., and Shooter E.M. A monoclonal antibody modulates the interaction of nerve growth factor with PC12 cells. J Biol Chem 259 (1984) 6882-6889
    • (1984) J Biol Chem , vol.259 , pp. 6882-6889
    • Chandler, C.E.1    Parsons, L.M.2    Hosang, M.3    Shooter, E.M.4
  • 7
    • 8544231403 scopus 로고    scopus 로고
    • Highly efficient small interfering RNA delivery to primary mammalian neurons induces microRNA-like effects before mRNA degradation [erratum appears in J Neurosci 2005 25(5):1311]
    • Davidson T.J., Harel S., Arboleda V.A., Prunell G.F., Shelanski M.L., Greene L.A., and Troy C.M. Highly efficient small interfering RNA delivery to primary mammalian neurons induces microRNA-like effects before mRNA degradation [erratum appears in J Neurosci 2005 25(5):1311]. J Neurosci 24 (2004) 10040-10046
    • (2004) J Neurosci , vol.24 , pp. 10040-10046
    • Davidson, T.J.1    Harel, S.2    Arboleda, V.A.3    Prunell, G.F.4    Shelanski, M.L.5    Greene, L.A.6    Troy, C.M.7
  • 8
    • 0030761205 scopus 로고    scopus 로고
    • A role for TrkA during maturation of striatal and basal forebrain cholinergic neurons in vivo
    • Fagan A.M., Garber M., Barbacid M., Silos-Santiago I., and Holtzman D.M. A role for TrkA during maturation of striatal and basal forebrain cholinergic neurons in vivo. J Neurosci 17 (1997) 7644-7654
    • (1997) J Neurosci , vol.17 , pp. 7644-7654
    • Fagan, A.M.1    Garber, M.2    Barbacid, M.3    Silos-Santiago, I.4    Holtzman, D.M.5
  • 9
    • 0032545933 scopus 로고    scopus 로고
    • Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans
    • Fire A., Xu S., Montgomery M.K., Kostas S.A., Driver S.E., and Mello C.C. Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans. Nature 391 (1998) 806-811
    • (1998) Nature , vol.391 , pp. 806-811
    • Fire, A.1    Xu, S.2    Montgomery, M.K.3    Kostas, S.A.4    Driver, S.E.5    Mello, C.C.6
  • 10
    • 0037081834 scopus 로고    scopus 로고
    • Vascular reactions to in vivo electroporation: characterization and consequences for drug and gene delivery
    • Gehl J., Skovsgaard T., and Mir L.M. Vascular reactions to in vivo electroporation: characterization and consequences for drug and gene delivery. Biochim Biophys Acta 1569 (2002) 51-58
    • (2002) Biochim Biophys Acta , vol.1569 , pp. 51-58
    • Gehl, J.1    Skovsgaard, T.2    Mir, L.M.3
  • 11
    • 0025200076 scopus 로고
    • Use of maleimide-thiol coupling chemistry for efficient syntheses of oligonucleotide-enzyme conjugate hybridization probes
    • Ghosh S.S., Kao P.M., McCue A.W., and Chappelle H.L. Use of maleimide-thiol coupling chemistry for efficient syntheses of oligonucleotide-enzyme conjugate hybridization probes. Bioconjug Chem 1 (1990) 71-76
    • (1990) Bioconjug Chem , vol.1 , pp. 71-76
    • Ghosh, S.S.1    Kao, P.M.2    McCue, A.W.3    Chappelle, H.L.4
  • 12
    • 0027958125 scopus 로고
    • In situ hybridization detection of trkA mRNA in brain: distribution, colocalization with p75NGFR and up-regulation by nerve growth factor
    • Gibbs R.B., and Pfaff D.W. In situ hybridization detection of trkA mRNA in brain: distribution, colocalization with p75NGFR and up-regulation by nerve growth factor. J Comp Neurol 341 (1994) 324-339
    • (1994) J Comp Neurol , vol.341 , pp. 324-339
    • Gibbs, R.B.1    Pfaff, D.W.2
  • 13
    • 30644477580 scopus 로고    scopus 로고
    • Supraspinal brain-derived neurotrophic factor signaling: a novel mechanism for descending pain facilitation
    • Guo W., Robbins M.T., Wei F., Zou S., Dubner R., and Ren K. Supraspinal brain-derived neurotrophic factor signaling: a novel mechanism for descending pain facilitation. J Neurosci 26 (2006) 126-137
    • (2006) J Neurosci , vol.26 , pp. 126-137
    • Guo, W.1    Robbins, M.T.2    Wei, F.3    Zou, S.4    Dubner, R.5    Ren, K.6
  • 14
    • 0037062951 scopus 로고    scopus 로고
    • RNA interference
    • Hannon G.J. RNA interference. Nature 418 (2002) 244-251
    • (2002) Nature , vol.418 , pp. 244-251
    • Hannon, G.J.1
  • 15
    • 25144505839 scopus 로고    scopus 로고
    • Plasmid-based RNA interference: construction of small-hairpin RNA expression vectors
    • Harper S.Q., and Davidson B.L. Plasmid-based RNA interference: construction of small-hairpin RNA expression vectors. Methods Mol Biol 309 (2005) 219-235
    • (2005) Methods Mol Biol , vol.309 , pp. 219-235
    • Harper, S.Q.1    Davidson, B.L.2
  • 17
    • 0346216853 scopus 로고    scopus 로고
    • Local gene knockdown in the brain using viral-mediated RNA interference
    • Hommel J.D., Sears R.M., Georgescu D., Simmons D.L., and DiLeone R.J. Local gene knockdown in the brain using viral-mediated RNA interference. Nat Med 9 (2003) 1539-1544
    • (2003) Nat Med , vol.9 , pp. 1539-1544
    • Hommel, J.D.1    Sears, R.M.2    Georgescu, D.3    Simmons, D.L.4    DiLeone, R.J.5
  • 18
    • 0141888360 scopus 로고    scopus 로고
    • Lack of efficacy of 'naked' small interfering RNA applied directly to rat brain
    • Isacson R., Kull B., Salmi P., and Wahlestedt C. Lack of efficacy of 'naked' small interfering RNA applied directly to rat brain. Acta Physiol Scand 179 (2003) 173-177
    • (2003) Acta Physiol Scand , vol.179 , pp. 173-177
    • Isacson, R.1    Kull, B.2    Salmi, P.3    Wahlestedt, C.4
  • 19
    • 0030025980 scopus 로고    scopus 로고
    • Analysis of a nuclear localization signal of simian virus 40 major capsid protein Vp1
    • Ishii N., Minami N., Chen E.Y., Medina A.L., Chico M.M., and Kasamatsu H. Analysis of a nuclear localization signal of simian virus 40 major capsid protein Vp1. J Virol 70 (1996) 1317-1322
    • (1996) J Virol , vol.70 , pp. 1317-1322
    • Ishii, N.1    Minami, N.2    Chen, E.Y.3    Medina, A.L.4    Chico, M.M.5    Kasamatsu, H.6
  • 21
    • 0037015041 scopus 로고    scopus 로고
    • RNAi functions in cultured mammalian neurons
    • Krichevsky A.M., and Kosik K.S. RNAi functions in cultured mammalian neurons. Proc Natl Acad Sci U S A 99 (2002) 11926-11929
    • (2002) Proc Natl Acad Sci U S A , vol.99 , pp. 11926-11929
    • Krichevsky, A.M.1    Kosik, K.S.2
  • 22
  • 23
    • 0025944524 scopus 로고
    • trkC, A new member of the trk family of tyrosine protein kinases, is a receptor for neurotrophin-3
    • Lamballe F., Klein R., and Barbacid M. trkC, A new member of the trk family of tyrosine protein kinases, is a receptor for neurotrophin-3. Cell 66 (1991) 967-979
    • (1991) Cell , vol.66 , pp. 967-979
    • Lamballe, F.1    Klein, R.2    Barbacid, M.3
  • 24
    • 3042520525 scopus 로고    scopus 로고
    • Immunotoxins and neuropeptide-toxin conjugates experimental applications
    • Lappi D.A., and Wiley R.G. Immunotoxins and neuropeptide-toxin conjugates experimental applications. Mini Rev Med Chem 4 (2004) 585-595
    • (2004) Mini Rev Med Chem , vol.4 , pp. 585-595
    • Lappi, D.A.1    Wiley, R.G.2
  • 25
    • 0028920679 scopus 로고
    • Regulation of TrkA and ChAT expression in developing rat basal forebrain: evidence that both exogenous and endogenous NGF regulate differentiation of cholinergic neurons
    • Li Y., Holtzman D.M., Kromer L.F., Kaplan D.R., Chua-Couzens J., Clary D.O., Knusel B., and Mobley W.C. Regulation of TrkA and ChAT expression in developing rat basal forebrain: evidence that both exogenous and endogenous NGF regulate differentiation of cholinergic neurons. J Neurosci 15 (1995) 2888-2905
    • (1995) J Neurosci , vol.15 , pp. 2888-2905
    • Li, Y.1    Holtzman, D.M.2    Kromer, L.F.3    Kaplan, D.R.4    Chua-Couzens, J.5    Clary, D.O.6    Knusel, B.7    Mobley, W.C.8
  • 26
    • 1342302829 scopus 로고    scopus 로고
    • Transfection of 'naked' siRNA results in endosomal uptake and metabolic impairment in cultured neurons
    • Lingor P., Michel U., Scholl U., Bahr M., and Kugler S. Transfection of 'naked' siRNA results in endosomal uptake and metabolic impairment in cultured neurons. Biochem Biophys Res Commun 315 (2004) 1126-1133
    • (2004) Biochem Biophys Res Commun , vol.315 , pp. 1126-1133
    • Lingor, P.1    Michel, U.2    Scholl, U.3    Bahr, M.4    Kugler, S.5
  • 27
    • 0037038758 scopus 로고    scopus 로고
    • Reducing hypothalamic AGRP by RNA interference increases metabolic rate and decreases body weight without influencing food intake
    • Makimura H., Mizuno T.M., Mastaitis J.W., Agami R., and Mobbs C.V. Reducing hypothalamic AGRP by RNA interference increases metabolic rate and decreases body weight without influencing food intake. BMC Neurosci 3 (2002) 3-9
    • (2002) BMC Neurosci , vol.3 , pp. 3-9
    • Makimura, H.1    Mizuno, T.M.2    Mastaitis, J.W.3    Agami, R.4    Mobbs, C.V.5
  • 28
    • 17244380473 scopus 로고    scopus 로고
    • Progenitors resume generating neurons after temporary inhibition of neurogenesis by Notch activation in the mammalian cerebral cortex
    • Mizutani K., and Saito T. Progenitors resume generating neurons after temporary inhibition of neurogenesis by Notch activation in the mammalian cerebral cortex. Development 132 (2005) 1295-1304
    • (2005) Development , vol.132 , pp. 1295-1304
    • Mizutani, K.1    Saito, T.2
  • 29
    • 0019957779 scopus 로고
    • Place navigation impaired in rats with hippocampal lesions
    • Morris R.G., Garrud P., Rawlins J.N., and O'Keefe J. Place navigation impaired in rats with hippocampal lesions. Nature 297 (1982) 681-683
    • (1982) Nature , vol.297 , pp. 681-683
    • Morris, R.G.1    Garrud, P.2    Rawlins, J.N.3    O'Keefe, J.4
  • 30
    • 0347914568 scopus 로고    scopus 로고
    • Human cholinergic basal forebrain: chemoanatomy and neurologic dysfunction
    • Mufson E.J., Ginsberg S.D., Ikonomovic M.D., and DeKosky S.T. Human cholinergic basal forebrain: chemoanatomy and neurologic dysfunction. J Chem Neuroanat 26 (2003) 233-242
    • (2003) J Chem Neuroanat , vol.26 , pp. 233-242
    • Mufson, E.J.1    Ginsberg, S.D.2    Ikonomovic, M.D.3    DeKosky, S.T.4
  • 31
    • 33745907268 scopus 로고    scopus 로고
    • RNAi-mediated silencing of estrogen receptor {alpha} in the ventromedial nucleus of hypothalamus abolishes female sexual behaviors
    • Musatov S., Chen W., Pfaff D.W., Kaplitt M.G., and Ogawa S. RNAi-mediated silencing of estrogen receptor {alpha} in the ventromedial nucleus of hypothalamus abolishes female sexual behaviors. Proc Natl Acad Sci U S A 103 (2006) 10456-10460
    • (2006) Proc Natl Acad Sci U S A , vol.103 , pp. 10456-10460
    • Musatov, S.1    Chen, W.2    Pfaff, D.W.3    Kaplitt, M.G.4    Ogawa, S.5
  • 34
    • 0021867618 scopus 로고
    • Bregma, lambda and the interaural midpoint in stereotaxic surgery with rats of different sex, strain and weight
    • Paxinos G., Watson C., Pennisi M., and Topple A. Bregma, lambda and the interaural midpoint in stereotaxic surgery with rats of different sex, strain and weight. J Neurosci Methods 13 (1985) 139-143
    • (1985) J Neurosci Methods , vol.13 , pp. 139-143
    • Paxinos, G.1    Watson, C.2    Pennisi, M.3    Topple, A.4
  • 35
    • 0347623204 scopus 로고    scopus 로고
    • Nonspecific, concentration-dependent stimulation and repression of mammalian gene expression by small interfering RNAs (siRNAs)
    • Persengiev S.P., Zhu X., and Green M.R. Nonspecific, concentration-dependent stimulation and repression of mammalian gene expression by small interfering RNAs (siRNAs). RNA 10 (2004) 12-18
    • (2004) RNA , vol.10 , pp. 12-18
    • Persengiev, S.P.1    Zhu, X.2    Green, M.R.3
  • 36
    • 0030029764 scopus 로고    scopus 로고
    • Differential effects of nerve growth factor on expression of choline acetyltransferase and sodium-coupled choline transport in basal forebrain cholinergic neurons in culture
    • Pongrac J.L., and Rylett R.J. Differential effects of nerve growth factor on expression of choline acetyltransferase and sodium-coupled choline transport in basal forebrain cholinergic neurons in culture. J Neurochem 66 (1996) 804-810
    • (1996) J Neurochem , vol.66 , pp. 804-810
    • Pongrac, J.L.1    Rylett, R.J.2
  • 38
    • 17644383664 scopus 로고    scopus 로고
    • Lentiviral-mediated silencing of SOD1 through RNA interference retards disease onset and progression in a mouse model of ALS
    • Raoul C., Abbas-Terki T., Bensadoun J.C., Guillot S., Haase G., Szulc J., Henderson C.E., and Aebischer P. Lentiviral-mediated silencing of SOD1 through RNA interference retards disease onset and progression in a mouse model of ALS. Nat Med 11 (2005) 423-428
    • (2005) Nat Med , vol.11 , pp. 423-428
    • Raoul, C.1    Abbas-Terki, T.2    Bensadoun, J.C.3    Guillot, S.4    Haase, G.5    Szulc, J.6    Henderson, C.E.7    Aebischer, P.8
  • 39
    • 33845201282 scopus 로고    scopus 로고
    • Local knockdown of genes in the brain using small interfering RNA: a phenotypic comparison with knockout animals
    • Salahpour A., Medvedev I.O., Beaulieu J.M., Gainetdinov R.R., and Caron M.G. Local knockdown of genes in the brain using small interfering RNA: a phenotypic comparison with knockout animals. Biol Psychiatry 61 (2007) 65-69
    • (2007) Biol Psychiatry , vol.61 , pp. 65-69
    • Salahpour, A.1    Medvedev, I.O.2    Beaulieu, J.M.3    Gainetdinov, R.R.4    Caron, M.G.5
  • 40
    • 28844454312 scopus 로고    scopus 로고
    • Progression of age-associated cognitive impairment correlates with quantitative and qualitative loss of TrkA receptor protein in nucleus basalis and cortex
    • Saragovi H.U. Progression of age-associated cognitive impairment correlates with quantitative and qualitative loss of TrkA receptor protein in nucleus basalis and cortex. J Neurochem 95 (2005) 1472-1480
    • (2005) J Neurochem , vol.95 , pp. 1472-1480
    • Saragovi, H.U.1
  • 41
    • 0031037811 scopus 로고    scopus 로고
    • Reduced acetylcholinesterase (AChE) activity in adrenal medulla and loss of sympathetic preganglionic neurons in TrkA-deficient, but not TrkB-deficient, mice
    • Schober A., Minichiello L., Keller M., Huber K., Layer P.G., Roig-Lopez J.L., Garcia-Arraras J.E., Klein R., and Unsicker K. Reduced acetylcholinesterase (AChE) activity in adrenal medulla and loss of sympathetic preganglionic neurons in TrkA-deficient, but not TrkB-deficient, mice. J Neurosci 17 (1997) 891-903
    • (1997) J Neurosci , vol.17 , pp. 891-903
    • Schober, A.1    Minichiello, L.2    Keller, M.3    Huber, K.4    Layer, P.G.5    Roig-Lopez, J.L.6    Garcia-Arraras, J.E.7    Klein, R.8    Unsicker, K.9
  • 42
    • 8444249644 scopus 로고    scopus 로고
    • Attenuation of alpha2A-adrenergic receptor expression in neonatal rat brain by RNA interference or antisense oligonucleotide reduced anxiety in adulthood
    • Shishkina G.T., Kalinina T.S., and Dygalo N.N. Attenuation of alpha2A-adrenergic receptor expression in neonatal rat brain by RNA interference or antisense oligonucleotide reduced anxiety in adulthood. Neuroscience 129 (2004) 521-528
    • (2004) Neuroscience , vol.129 , pp. 521-528
    • Shishkina, G.T.1    Kalinina, T.S.2    Dygalo, N.N.3
  • 43
    • 0027938821 scopus 로고
    • TrkA-immunoreactive profiles in the central nervous system: colocalization with neurons containing p75 nerve growth factor receptor, choline acetyltransferase, and serotonin
    • Sobreviela T., Clary D.O., Reichardt L.F., Brandabur M.M., Kordower J.H., and Mufson E.J. TrkA-immunoreactive profiles in the central nervous system: colocalization with neurons containing p75 nerve growth factor receptor, choline acetyltransferase, and serotonin. J Comp Neurol 350 (1994) 587-611
    • (1994) J Comp Neurol , vol.350 , pp. 587-611
    • Sobreviela, T.1    Clary, D.O.2    Reichardt, L.F.3    Brandabur, M.M.4    Kordower, J.H.5    Mufson, E.J.6
  • 44
    • 10344228801 scopus 로고    scopus 로고
    • Neurochemical and behavioral consequences of widespread gene knockdown in the adult mouse brain by using nonviral RNA interference
    • Thakker D.R., Natt F., Husken D., Maier R., Muller M., van der Putten H., Hoyer D., and Cryan J.F. Neurochemical and behavioral consequences of widespread gene knockdown in the adult mouse brain by using nonviral RNA interference. Proc Natl Acad Sci U S A 101 (2004) 17270-17275
    • (2004) Proc Natl Acad Sci U S A , vol.101 , pp. 17270-17275
    • Thakker, D.R.1    Natt, F.2    Husken, D.3    Maier, R.4    Muller, M.5    van der Putten, H.6    Hoyer, D.7    Cryan, J.F.8
  • 47
    • 19444366758 scopus 로고    scopus 로고
    • Pincher-mediated macroendocytosis underlies retrograde signaling by neurotrophin receptors
    • Valdez G., Akmentin W., Philippidou P., Kuruvilla R., Ginty D.D., and Halegoua S. Pincher-mediated macroendocytosis underlies retrograde signaling by neurotrophin receptors. J Neurosci 25 (2005) 5236-5247
    • (2005) J Neurosci , vol.25 , pp. 5236-5247
    • Valdez, G.1    Akmentin, W.2    Philippidou, P.3    Kuruvilla, R.4    Ginty, D.D.5    Halegoua, S.6
  • 48
    • 0026655684 scopus 로고
    • Influenza virus hemagglutinin HA-2 N-terminal fusogenic peptides augment gene transfer by transferrin-polylysine-DNA complexes: toward a synthetic virus-like gene-transfer vehicle
    • Wagner E., Plank C., Zatloukal K., Cotten M., and Birnstiel M.L. Influenza virus hemagglutinin HA-2 N-terminal fusogenic peptides augment gene transfer by transferrin-polylysine-DNA complexes: toward a synthetic virus-like gene-transfer vehicle. Proc Natl Acad Sci U S A 89 (1992) 7934-7938
    • (1992) Proc Natl Acad Sci U S A , vol.89 , pp. 7934-7938
    • Wagner, E.1    Plank, C.2    Zatloukal, K.3    Cotten, M.4    Birnstiel, M.L.5
  • 49
    • 0029437811 scopus 로고
    • Electroporation theory. Concepts and mechanisms
    • Weaver J.C. Electroporation theory. Concepts and mechanisms. Methods Mol Biol 55 (1995) 3-28
    • (1995) Methods Mol Biol , vol.55 , pp. 3-28
    • Weaver, J.C.1
  • 50
    • 2642614501 scopus 로고    scopus 로고
    • Responses of young and aged rat CNS to partial cholinergic immunolesions and NGF treatment
    • Wortwein G., Yu J., Toliver-Kinsky T., and Perez-Polo J.R. Responses of young and aged rat CNS to partial cholinergic immunolesions and NGF treatment. J Neurosci Res 52 (1998) 322-333
    • (1998) J Neurosci Res , vol.52 , pp. 322-333
    • Wortwein, G.1    Yu, J.2    Toliver-Kinsky, T.3    Perez-Polo, J.R.4
  • 52
    • 0036787671 scopus 로고    scopus 로고
    • siRNA-mediated gene silencing in vitro and in vivo
    • Xia H., Mao Q., Paulson H.L., and Davidson B.L. siRNA-mediated gene silencing in vitro and in vivo. Nat Biotechnol 20 (2002) 1006-1010
    • (2002) Nat Biotechnol , vol.20 , pp. 1006-1010
    • Xia, H.1    Mao, Q.2    Paulson, H.L.3    Davidson, B.L.4
  • 53
    • 1942523210 scopus 로고    scopus 로고
    • In vivo knockdown of gene expression in brain cancer with intravenous RNAi in adult rats
    • Zhang Y., Boado R.J., and Pardridge W.M. In vivo knockdown of gene expression in brain cancer with intravenous RNAi in adult rats. J Gene Med 5 (2003) 1039-1045
    • (2003) J Gene Med , vol.5 , pp. 1039-1045
    • Zhang, Y.1    Boado, R.J.2    Pardridge, W.M.3
  • 54
    • 0036518450 scopus 로고    scopus 로고
    • Receptor-mediated delivery of an antisense gene to human brain cancer cells
    • Zhang Y., Jeong Lee H., Boado R.J., and Pardridge W.M. Receptor-mediated delivery of an antisense gene to human brain cancer cells. J Gene Med 4 (2002) 183-194
    • (2002) J Gene Med , vol.4 , pp. 183-194
    • Zhang, Y.1    Jeong Lee, H.2    Boado, R.J.3    Pardridge, W.M.4


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