Regulation of APP processing: Potential for the therapeutical reduction of brain amyloid burden

Annals of the New York Academy of Sciences

Volumn 777, Issue , 1996, Pages 175-182

  Nitsch, R M ^a,b,c   Wurtman, R J ^a   Growdon, J H ^b  

^a MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^b MASSACHUSETTS GENERAL HOSPITAL   (United States)

^c UNIVERSITY MEDICAL CENTER HAMBURG EPPENDORF   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID; AMYLOID PRECURSOR PROTEIN; BRADYKININ RECEPTOR; BRADYKININ RECEPTOR AGONIST; CELL SURFACE RECEPTOR; GLUTAMATE RECEPTOR; GLUTAMATE RECEPTOR AGONIST; MUSCARINIC AGENT; MUSCARINIC M1 RECEPTOR; MUSCARINIC M3 RECEPTOR; RECEPTOR SUBTYPE; SEROTONIN 2 AGONIST; SEROTONIN 2A RECEPTOR; VASOPRESSIN RECEPTOR;

ALZHEIMER DISEASE; CONFERENCE PAPER; DRUG DESIGN; HUMAN; HUMAN TISSUE; PATHOGENESIS; PROTEIN PROCESSING; RECEPTOR BINDING;

EID: 0029936426     PISSN: 00778923     EISSN: None     Source Type: Book Series    
DOI: 10.1111/j.1749-6632.1996.tb34416.x     Document Type: Article

References (28)

1. HYMAN, B. T. & R. D. TERRY. 1994. Apolipoprotein E, Aβ, and Alzheimer's disease. An editorial comment. J. Neuropathol. Exp. Neurol. 53:427-428.
2. ROSES, A. D. 1994. Apolipoprotein E affects the rate of Alzheimer's disease expression: β-amyloid burden is a secondary consequence dependent on APOE genotype and duration of disease. J. Neuropathol. Exp. Neurol. 53:429-437.
3. SELKOE, D. J. 1994. Alzheimer's disease: A central role for amyloid. J. Neuropathol. Exp. Neurol. 53:438-447.
4. CITRON, M., T. OLTERSDORF, C. HAASS, et al. 1992. Mutation of the β-amyloid precursor protein in familial Alzheimer's disease increases β-protein production. Nature 360:672-674.
5. CAI, X.-D., T. E. GOLDE & S. G. YOUNKIN. 1993. Release of excess amyloid β-protein from a mutant amyloid β-protein precursor. Science 259:514-516.
6. CITRON, M., C. VIGO-PELFREY, D. B. TEPLOW, et al. 1994. Excessive production of amyloid β-protein by peripheral cells of symptomatic and presymptomatic patients carrying the Swedish familial Alzheimer's disease mutation. Proc. Natl. Acad. Sci. USA 91:11993-11997.
7. JARRETT, J. T. & P. T. LANSBURY, JR. 1993. Seeding "one-dimensional crystallization" of amyloid: A pathogenic mechanism in Alzheimer's disease and scrapie. Cell 73:1055-1058.
8. SUZUKI, N., T. T. CHEUNG, X.-D. CAI, et al. 1994. An increased percentage of long amyloid β protein secreted by familial amyloid β protein precursor (βAPP717) mutants. Science 264:1336-1340.
9. JARRETT, J. T., E. P. BERGER & P. T. LANDSBURY, JR. 1993. The carboxyterminus of the beta amyloid protein is critical for the seeding of amyloid formation: Implications for the pathogenesis of Alzheimer's disease. Biochemistry 32: 4693-4697.
10. HAASS, C., A. Y. HUNG, D. J. SELKOE & D. B. TEPLOW. 1994. Mutations associated with a locus for familial Alzheimer's disease result in alternative processing of amyloid β-protein precursor. J. Biol. Chem. 269:1-8.
11. LEVY, E., M. D. CARMAN, I. J. FERNANDEZ-MARID, et al. 1990. Mutation of Alzheimer's disease amyloid gene in hereditary cerebral hemorrhage, Dutchtype. Science 248:1124-1126.
12. SUZUKI, N., T. T. CHEUNG, X.-D. CAI, et al. 1994. Factors affecting production of secreted amyloid β-protein (Aβ) ending at Aβ42,43. Soc. Neuroscience Abstr. 20:437.
13. MOYA, K. L., L. I. BENOWITZ, G. E. SCHNEIDER & B. ALLINQUANT. 1994. The amyloid precursor protein is developmentally regulated and correlated with synaptogenesis. Dev. Biol. 161:597-603.
14. MILWARD, E. A., R. PAPADOPOULOS, S. J. FULLER, et al. 1992. The amyloid protein precursor of Alzheimer's disease is a mediator of the effects of nerve growth factor on neurite outgrowth. Neuron 9:129-137.
15. KOO, E. H., L. PARK & D. J. SELKOE. 1993. Amyloid β-protein as a substrate interacts with extracellular matrix to promote neurite outgrowth. Proc. Natl. Acad. Sci. USA 90:4748-4752.
16. SCHUBERT, D., L.-W. JIN, T. SAITOH & G. COLE. 1989. The regulation of amyloid β protein precursor secretion and its modulatory role in cell adhesion. Neuron 3:689-694.
17. MATTSON, M., B. CHENG, A. CULWELL, F. ESCH, I. LIEBERBURG & R. RYDEL. 1993. Evidence for excitoprotective and intraneuronal calcium-regulating roles for secreted forms of the β-amyloid precursor protein. Neuron 10:243-254.
18. MÜLLER, U., N. CRISTINA, Z.-W. LI, et al. 1994. Behavioral and anatomical deficits in mice homologous for a modified β-amyloid precursor protein gene. Cell 79:755-765.
19. HUNG, A. Y., C. HAASS, R. M. NITSCH, et al. 1993. Activation of protein kinase C inhibits cellular production of the amyloid β-protein. J. Biol. Chem. 268:22959-22962.
20. BUXBAUM, J. D., S. E. GANDY, P. CICCHETTI, et al. 1990. Processing of Alzheimer β/A4 amyloid precursor protein: modulation by agents that regulate protein phosphorylation. Proc. Natl. Acad. Sci. USA 87:6003-6006.
21. NITSCH, R. M. & J. H. GROWDON. 1994. Role of neurotransmission in the regulation of amyloid β-protein precursor processing. Biochem. Pharmacol. 47: 1275-1284.
22. NITSCH, R. M., B. E. SLACK, R. J. WURTMAN & J. H. GROWDON. 1992. Release of Alzheimer amyloid precursor derivatives stimulated by activation of muscarinic acetylcholine receptors. Science 258:304-307.
23. BUXBAUM, J. D., M. OISHI, H. I. CHEN, et al. 1992. Cholinergic agonists and interleukin 1 regulate processing and secretion of the Alzheimer β/A4 amyloid protein precursor. Proc. Natl. Acad. Sci. USA 89:10075-10078.
24. NITSCH, R. M., S. A. FARBER, J. H. GROWDON & R. J. WURTMAN. 1993. Release of amyloid β-protein precursor derivatives from hippocampal slices by electrical depolarization. Proc. Natl. Acad. Sci. USA 90:5191-5193.
25. FARBER, S. A., J. G. SCHULZ, R. J. WURTMAN & R. M. NITSCH. 1995. Regulation of amyloid β-protein precursor secretion in rat brain. J. Neurosci. In press.
26. HAASS, C., A. Y. HUNG, M. SCHLOSSMACHER, D. B. TEPLOW & D. J. SELKOE. 1993. β-amyloid peptide and a 3-kDa fragment are derived by distinct cellular mechanisms. J. Biol. Chem. 268:3021-3024.
27. SHERRINGTON, R., E.I. ROGAEV, Y. LIANG, et al. 1995. Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease. Nature 375:754-760.
28. LEVY-LAHAD, E., W. WASCO, P. POORKAJ, et al. 1995. Candidate gene for the chromosome 1 familial Alzheimer's disease locus. Science 269:973-977.