메뉴 건너뛰기




Volumn 53, Issue 4, 2004, Pages 1003-1009

Small molecules that regulate lifespan: Evidence for xenohormesis

Author keywords

[No Author keywords available]

Indexed keywords

SILENT INFORMATION REGULATOR PROTEIN 2; SIRTUIN;

EID: 4344590155     PISSN: 0950382X     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1365-2958.2004.04209.x     Document Type: Short Survey
Times cited : (206)

References (42)
  • 1
    • 0038329323 scopus 로고    scopus 로고
    • Nicotinamide and Pnc1 govern lifespan extension by calorie restriction in S. cerevisiae
    • Anderson, R.M., Bitterman, K.J., Wood, J.G., Medvedik, O., and Sinclair, D.A. (2003a) Nicotinamide and Pnc1 govern lifespan extension by calorie restriction in S. cerevisiae. Nature 423: 181-185.
    • (2003) Nature , vol.423 , pp. 181-185
    • Anderson, R.M.1    Bitterman, K.J.2    Wood, J.G.3    Medvedik, O.4    Sinclair, D.A.5
  • 2
    • 0345731468 scopus 로고    scopus 로고
    • Yeast life-span extension by calorie restriction is independent of NAD fluctuation
    • Anderson, R.M., Latorre-Esteves, M., Neves, A.R., Lavu, S., Medvedik, O., Taylor, C., et al. (2003b) Yeast life-span extension by calorie restriction is independent of NAD fluctuation. Science 302: 2124-2126.
    • (2003) Science , vol.302 , pp. 2124-2126
    • Anderson, R.M.1    Latorre-Esteves, M.2    Neves, A.R.3    Lavu, S.4    Medvedik, O.5    Taylor, C.6
  • 3
    • 0033870805 scopus 로고    scopus 로고
    • Sip2p and its partner snf1p kinase affect aging in S. cerevisiae
    • Ashrafi, K., Lin, S.S., Manchester, J.K., and Gordon, J.I. (2000) Sip2p and its partner snf1p kinase affect aging in S. cerevisiae. Genes Dev 14: 1872-1885.
    • (2000) Genes Dev , vol.14 , pp. 1872-1885
    • Ashrafi, K.1    Lin, S.S.2    Manchester, J.K.3    Gordon, J.I.4
  • 5
    • 0141781063 scopus 로고    scopus 로고
    • NAD+-dependent deacetylase Hst1p controls biosynthesis and cellular NAD+ levels in Saccharomyces cerevisiae
    • Bedalov, A., Hirao, M., Posakony, J., Nelson, M., and Simon, J.A. (2003) NAD+-dependent deacetylase Hst1p controls biosynthesis and cellular NAD+ levels in Saccharomyces cerevisiae. Mol Cell Biol 23: 7044-7054.
    • (2003) Mol Cell Biol , vol.23 , pp. 7044-7054
    • Bedalov, A.1    Hirao, M.2    Posakony, J.3    Nelson, M.4    Simon, J.A.5
  • 6
    • 0037160097 scopus 로고    scopus 로고
    • Inhibition of silencing and accelerated aging by nicotinamide, a putative negative regulator of yeast sir2 and human SIRT1
    • Bitterman, K.J., Anderson, R.M., Cohen, H.Y., Latorre-Esteves, M., and Sinclair, D.A. (2002) Inhibition of silencing and accelerated aging by nicotinamide, a putative negative regulator of yeast sir2 and human SIRT1. J Biol Chem 277: 45099-45107.
    • (2002) J Biol Chem , vol.277 , pp. 45099-45107
    • Bitterman, K.J.1    Anderson, R.M.2    Cohen, H.Y.3    Latorre-Esteves, M.4    Sinclair, D.A.5
  • 7
    • 0141677687 scopus 로고    scopus 로고
    • Longevity regulation in Saccharomyces cerevisiae: Linking metabolism, genome stability, and heterochromatin
    • table of contents
    • Bitterman, K.J., Medvedik, O., and Sinclair, O.A. (2003) Longevity regulation in Saccharomyces cerevisiae: linking metabolism, genome stability, and heterochromatin. Microbiol Mol Biol Rev 67: 376-399. table of contents.
    • (2003) Microbiol Mol Biol Rev , vol.67 , pp. 376-399
    • Bitterman, K.J.1    Medvedik, O.2    Sinclair, O.A.3
  • 8
    • 1642270307 scopus 로고    scopus 로고
    • Rtg2 protein links metabolism and genome stability in yeast longevity
    • Borghouts, C., Benguria, A., Wawryn, J., and Jazwinski, S.M. (2004) Rtg2 protein links metabolism and genome stability in yeast longevity. Genetics 166: 765-777.
    • (2004) Genetics , vol.166 , pp. 765-777
    • Borghouts, C.1    Benguria, A.2    Wawryn, J.3    Jazwinski, S.M.4
  • 9
    • 12144290563 scopus 로고    scopus 로고
    • Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase
    • Brunet, A., Sweeney, L.B., Sturgill, J.F., Chua, K.F., Greer, P.L., Lin, Y., et al. (2004) Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase. Science 303: 2011-2015.
    • (2004) Science , vol.303 , pp. 2011-2015
    • Brunet, A.1    Sweeney, L.B.2    Sturgill, J.F.3    Chua, K.F.4    Greer, P.L.5    Lin, Y.6
  • 10
    • 0033120871 scopus 로고    scopus 로고
    • Elimination of replication block protein Fob1 extends the life span of yeast mother cells
    • Defossez, P.A., Prusty, R., Kaeberlein, M., Lin, S.J., Ferrigno, P., Silver, P.A., et al. (1999) Elimination of replication block protein Fob1 extends the life span of yeast mother cells. Mol Cell 3: 447-455.
    • (1999) Mol Cell , vol.3 , pp. 447-455
    • Defossez, P.A.1    Prusty, R.2    Kaeberlein, M.3    Lin, S.J.4    Ferrigno, P.5    Silver, P.A.6
  • 11
    • 0037221445 scopus 로고    scopus 로고
    • Linking chromatin function with metabolic networks: Sir2 family of NAD(+)-dependent deacetylases
    • Denu, J.M. (2003) Linking chromatin function with metabolic networks: Sir2 family of NAD(+)-dependent deacetylases. Trends Biochem Sci 28: 41-48.
    • (2003) Trends Biochem Sci , vol.28 , pp. 41-48
    • Denu, J.M.1
  • 12
    • 0142149194 scopus 로고    scopus 로고
    • Plasmid accumulation reduces life span in Saccharomyces cerevisiae
    • Falcon, A.A., and Aris, J.P. (2003) Plasmid accumulation reduces life span in Saccharomyces cerevisiae. J Biol Chem 278: 41607-41617.
    • (2003) J Biol Chem , vol.278 , pp. 41607-41617
    • Falcon, A.A.1    Aris, J.P.2
  • 13
    • 1642580758 scopus 로고    scopus 로고
    • Nicotinamide clearance by Pnc1 directly regulates Sir2-mediated silencing and longevity
    • Gallo, C.M., Smith, D.L, Jr, and Smith, J.S. (2004) Nicotinamide clearance by Pnc1 directly regulates Sir2-mediated silencing and longevity. Mol Cell Biol 24: 1301-1312.
    • (2004) Mol Cell Biol , vol.24 , pp. 1301-1312
    • Gallo, C.M.1    Smith Jr., D.L.2    Smith, J.S.3
  • 14
    • 0242556798 scopus 로고    scopus 로고
    • A chromosomal SIR2 homologue with both histone NAD-dependent ADP-ribosyltransferase and deacetylase activities is involved in DNA repair in Trypanosoma brucei
    • Garcia-Salcedo, J.A., Gijon, P., Nolan, D.P., Tebabi, P., and Pays, E. (2003) A chromosomal SIR2 homologue with both histone NAD-dependent ADP-ribosyltransferase and deacetylase activities is involved in DNA repair in Trypanosoma brucei. EMBO J 22: 5851-5862.
    • (2003) EMBO J , vol.22 , pp. 5851-5862
    • Garcia-Salcedo, J.A.1    Gijon, P.2    Nolan, D.P.3    Tebabi, P.4    Pays, E.5
  • 15
    • 0035914304 scopus 로고    scopus 로고
    • Identification of a class of small molecule inhibitors of the sirtuin family of NAD-dependent deacetylases by phenotypic screening
    • Grozinger, C.C.E., Blackwell, H.E., Moazed, D., and Schreiber, S.L. (2001) Identification of a class of small molecule inhibitors of the sirtuin family of NAD-dependent deacetylases by phenotypic screening. J Biol Chem 276: 38837-38843.
    • (2001) J Biol Chem , vol.276 , pp. 38837-38843
    • Grozinger, C.C.E.1    Blackwell, H.E.2    Moazed, D.3    Schreiber, S.L.4
  • 16
    • 0037470539 scopus 로고    scopus 로고
    • Genetics and the specificity of the aging process
    • Hekimi, S., and Guarente, L. (2003) Genetics and the specificity of the aging process. Science 299: 1351-1354.
    • (2003) Science , vol.299 , pp. 1351-1354
    • Hekimi, S.1    Guarente, L.2
  • 17
    • 0141719702 scopus 로고    scopus 로고
    • Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan
    • Howitz, K.T., Bitterman, K.J., Cohen, H.Y., Lamming, D.W., Lavu, S., Wood, J.G., et al. (2003) Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan. Nature 425: 191-196.
    • (2003) Nature , vol.425 , pp. 191-196
    • Howitz, K.T.1    Bitterman, K.J.2    Cohen, H.Y.3    Lamming, D.W.4    Lavu, S.5    Wood, J.G.6
  • 18
    • 0042822279 scopus 로고    scopus 로고
    • Association of the RENT complex with nontranscribed and coding regions of rDNA and a regional requirement for the replication fork block protein Fob1 in rDNA silencing
    • Huang, J., and Moazed, D. (2003) Association of the RENT complex with nontranscribed and coding regions of rDNA and a regional requirement for the replication fork block protein Fob1 in rDNA silencing. Genes Dev 17: 2162-2176.
    • (2003) Genes Dev , vol.17 , pp. 2162-2176
    • Huang, J.1    Moazed, D.2
  • 19
    • 0034677535 scopus 로고    scopus 로고
    • Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase
    • Imai, S., Armstrong, C.M., Kaeberlein, M., and Guarente, L. (2000) Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase. Nature 403: 795-800.
    • (2000) Nature , vol.403 , pp. 795-800
    • Imai, S.1    Armstrong, C.M.2    Kaeberlein, M.3    Guarente, L.4
  • 20
    • 0033738362 scopus 로고    scopus 로고
    • An intervention resembling caloric restriction prolongs life span and retards aging in yeast
    • Jiang, J.C., Jaruga, E., Repnevskaya, M.V., and Jazwinski, S.M. (2000) An intervention resembling caloric restriction prolongs life span and retards aging in yeast. FASEB J 14: 2135-2137.
    • (2000) FASEB J , vol.14 , pp. 2135-2137
    • Jiang, J.C.1    Jaruga, E.2    Repnevskaya, M.V.3    Jazwinski, S.M.4
  • 21
    • 0033214237 scopus 로고    scopus 로고
    • The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms
    • Kaeberlein, M., McVey, M., and Guarente, L. (1999) The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms. Genes Dev 13: 2570-2580.
    • (1999) Genes Dev , vol.13 , pp. 2570-2580
    • Kaeberlein, M.1    McVey, M.2    Guarente, L.3
  • 22
    • 0034523495 scopus 로고    scopus 로고
    • Evolution, stress, and longevity
    • Kirkwood, T.L., Kapahi, P., and Shanley, D.P. (2000) Evolution, stress, and longevity. J Anat 197: 587-590.
    • (2000) J Anat , vol.197 , pp. 587-590
    • Kirkwood, T.L.1    Kapahi, P.2    Shanley, D.P.3
  • 23
    • 0037312020 scopus 로고    scopus 로고
    • How does calorie restriction work?
    • Koubova, J., and Guarente, L. (2003) How does calorie restriction work? Genes Dev 17: 313-321.
    • (2003) Genes Dev , vol.17 , pp. 313-321
    • Koubova, J.1    Guarente, L.2
  • 24
    • 0034735990 scopus 로고    scopus 로고
    • Role of NAD(+) in the deacetylase activity of the SIR2-like proteins
    • Landry, J., Slama, J.T., and Sternglanz, R. (2000) Role of NAD(+) in the deacetylase activity of the SIR2-like proteins. Biochem Biophys Res Commun 278: 685-690.
    • (2000) Biochem Biophys Res Commun , vol.278 , pp. 685-690
    • Landry, J.1    Slama, J.T.2    Sternglanz, R.3
  • 25
    • 0027524176 scopus 로고
    • RTG1 and RTG2: Two yeast genes required for a novel path of communication from mitochondria to the nucleus
    • Liao, X., and Butow, R.A. (1993) RTG1 and RTG2: two yeast genes required for a novel path of communication from mitochondria to the nucleus. Cell 72: 61-71.
    • (1993) Cell , vol.72 , pp. 61-71
    • Liao, X.1    Butow, R.A.2
  • 26
    • 0034703217 scopus 로고    scopus 로고
    • Requirement of NAD and SIR2 for life-span extension by calorie restriction in Saccharomyces cerevisiae
    • Lin, S.J., Defossez, P.A., and Guarente, L. (2000) Requirement of NAD and SIR2 for life-span extension by calorie restriction in Saccharomyces cerevisiae. Science 289: 2126-2128.
    • (2000) Science , vol.289 , pp. 2126-2128
    • Lin, S.J.1    Defossez, P.A.2    Guarente, L.3
  • 27
    • 0347128279 scopus 로고    scopus 로고
    • Calorie restriction extends yeast life span by lowering the level of NADH
    • Lin, S.J., Ford, E., Haigis, M., Liszt, G., and Guarente, L. (2004) Calorie restriction extends yeast life span by lowering the level of NADH. Genes Dev 18: 12-16.
    • (2004) Genes Dev , vol.18 , pp. 12-16
    • Lin, S.J.1    Ford, E.2    Haigis, M.3    Liszt, G.4    Guarente, L.5
  • 28
    • 0037130175 scopus 로고    scopus 로고
    • Calorie restriction extends Saccharomyces cerevisiae lifespan by increasing respiration
    • Lin, S.J., Kaeberlein, M., Andalis, A.A., Sturtz, L.A., Defossez, P.A., Culotta, V.C., et al. (2002) Calorie restriction extends Saccharomyces cerevisiae lifespan by increasing respiration. Nature 418: 344-348.
    • (2002) Nature , vol.418 , pp. 344-348
    • Lin, S.J.1    Kaeberlein, M.2    Andalis, A.A.3    Sturtz, L.A.4    Defossez, P.A.5    Culotta, V.C.6
  • 29
    • 0037470488 scopus 로고    scopus 로고
    • Evolutionary medicine: From dwarf model systems to healthy centenarians?
    • Longo, V.D., and Finch, C.E. (2003) Evolutionary medicine: from dwarf model systems to healthy centenarians? Science 299: 1342-1346.
    • (2003) Science , vol.299 , pp. 1342-1346
    • Longo, V.D.1    Finch, C.E.2
  • 30
    • 0033134233 scopus 로고    scopus 로고
    • Mitochondrial superoxide decreases yeast survival in stationary phase
    • Longo, V.D., Liou, L.L., Valentine, J.S., and Gralla, E.B. (1999) Mitochondrial superoxide decreases yeast survival in stationary phase. Arch Biochem Biophys 365: 131-142.
    • (1999) Arch Biochem Biophys , vol.365 , pp. 131-142
    • Longo, V.D.1    Liou, L.L.2    Valentine, J.S.3    Gralla, E.B.4
  • 31
    • 0034033586 scopus 로고    scopus 로고
    • Caloric restriction and aging: An update
    • Masoro, E.J. (2000) Caloric restriction and aging: an update. Exp Gerontol 35: 299-305.
    • (2000) Exp Gerontol , vol.35 , pp. 299-305
    • Masoro, E.J.1
  • 32
    • 1342264308 scopus 로고    scopus 로고
    • Mammalian SIRT1 represses forkhead transcription factors
    • Motta, M.C., Direcha, N., Lemieux, M., Kamel, C., Chen, D., Gu, W., et al. (2004) Mammalian SIRT1 represses forkhead transcription factors. Cell 116: 551-563.
    • (2004) Cell , vol.116 , pp. 551-563
    • Motta, M.C.1    Direcha, N.2    Lemieux, M.3    Kamel, C.4    Chen, D.5    Gu, W.6
  • 34
    • 0037198057 scopus 로고    scopus 로고
    • Paradigms and pitfalls of yeast longevity research
    • Sinclair, D.A. (2002) Paradigms and pitfalls of yeast longevity research. Mech Ageing Dev 123: 857-867.
    • (2002) Mech Ageing Dev , vol.123 , pp. 857-867
    • Sinclair, D.A.1
  • 35
    • 0031459980 scopus 로고    scopus 로고
    • Extrachromosomal rDNA circles - A cause of aging in yeast
    • Sinclair, D.A., and Guarente, L. (1997) Extrachromosomal rDNA circles - a cause of aging in yeast. Cell 91: 1033-1042.
    • (1997) Cell , vol.91 , pp. 1033-1042
    • Sinclair, D.A.1    Guarente, L.2
  • 36
    • 0030820491 scopus 로고    scopus 로고
    • Accelerated aging and nucleolar fragmentation in yeast sgs1 mutants
    • Sinclair, D.A., Mills, K., and Guarente, L. (1997) Accelerated aging and nucleolar fragmentation in yeast sgs1 mutants. Science 277: 1313-1316.
    • (1997) Science , vol.277 , pp. 1313-1316
    • Sinclair, D.A.1    Mills, K.2    Guarente, L.3
  • 37
    • 27244461732 scopus 로고    scopus 로고
    • Efficiency and mechanism of the antioxidant action of transresveratrol and its analogues in the radical liposome oxidation
    • Stojanovic, S., Sprinz, H., and Brede, O. (2001) Efficiency and mechanism of the antioxidant action of transresveratrol and its analogues in the radical liposome oxidation. Arch Biochem Biophys 391: 79-89.
    • (2001) Arch Biochem Biophys , vol.391 , pp. 79-89
    • Stojanovic, S.1    Sprinz, H.2    Brede, O.3
  • 38
    • 0037945379 scopus 로고    scopus 로고
    • Longevity research. Single signal unites treatments that prolong life
    • Strauss, E. (2003) Longevity research. Single signal unites treatments that prolong life. Science 300: 881-883.
    • (2003) Science , vol.300 , pp. 881-883
    • Strauss, E.1
  • 39
    • 0034567810 scopus 로고    scopus 로고
    • Effect of stress on the life span of the yeast Saccharomyces cerevisiae
    • Swiecilo, A., Krawiec, Z., Wawryn, J., Bartosz, G., and Bilinski, T. (2000) Effect of stress on the life span of the yeast Saccharomyces cerevisiae. Acta Biochim Pol 47: 355-364.
    • (2000) Acta Biochim Pol , vol.47 , pp. 355-364
    • Swiecilo, A.1    Krawiec, Z.2    Wawryn, J.3    Bartosz, G.4    Bilinski, T.5
  • 40
    • 0033598942 scopus 로고    scopus 로고
    • An enzymatic activity in the yeast Sir2 protein that is essential for gene silencing
    • Tanny, J.C., Dowd, G.J., Huang, J., Hilz, H., and Moazed, D. (1999) An enzymatic activity in the yeast Sir2 protein that is essential for gene silencing. Cell 99: 735-745.
    • (1999) Cell , vol.99 , pp. 735-745
    • Tanny, J.C.1    Dowd, G.J.2    Huang, J.3    Hilz, H.4    Moazed, D.5
  • 41
    • 0035826271 scopus 로고    scopus 로고
    • Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans
    • Tissenbaum, H.A., and Guarente, L. (2001) Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans. Nature 410: 227-230.
    • (2001) Nature , vol.410 , pp. 227-230
    • Tissenbaum, H.A.1    Guarente, L.2
  • 42
    • 3943071801 scopus 로고    scopus 로고
    • Sirtuin activators extend lifespan in metazoans by mimicking calorie restriction
    • doi: 10.1038/nature02789
    • Wood, J.G., Rogina, B., Lavu, S., Helfand, S.L., Tatar, M., and Sinclair, D.A. (2004) Sirtuin activators extend lifespan in metazoans by mimicking calorie restriction. Nature doi: 10.1038/nature02789/.
    • (2004) Nature
    • Wood, J.G.1    Rogina, B.2    Lavu, S.3    Helfand, S.L.4    Tatar, M.5    Sinclair, D.A.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.