메뉴 건너뛰기




Volumn 17, Issue 3, 2004, Pages 112-119

Dementia with Lewy bodies: Molecular pathogenesis and implications for classification

Author keywords

Dementia with Lewy bodies; Molecular pathogenesis

Indexed keywords

BEHAVIOR DISORDER; BRAIN CORTEX; CELL DAMAGE; COGNITIVE DEFECT; CORRELATION ANALYSIS; CYTOPLASM; DEGENERATIVE DISEASE; DEMENTIA; DEPRESSION; DISEASE ASSOCIATION; DISEASE CLASSIFICATION; DISEASE SEVERITY; HUMAN; LEWY BODY; NERVE DEGENERATION; PARKINSON DISEASE; PARKINSONISM; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN DEFECT; PROTEIN FOLDING; PSYCHOSIS; REM SLEEP; REVIEW; VISUAL HALLUCINATION;

EID: 4344560385     PISSN: 08919887     EISSN: None     Source Type: Journal    
DOI: 10.1177/0891988704267473     Document Type: Review
Times cited : (34)

References (55)
  • 1
    • 0242363670 scopus 로고    scopus 로고
    • Molecular pathways of neurodegeneration in Parkinson's disease
    • Dawson TM, Dawson VL. Molecular pathways of neurodegeneration in Parkinson's disease. Science 2003; 302:819-822.
    • (2003) Science , vol.302 , pp. 819-822
    • Dawson, T.M.1    Dawson, V.L.2
  • 2
    • 84940364788 scopus 로고    scopus 로고
    • A-synuclein and the Lewy body disorders
    • Dickson D. A-synuclein and the Lewy body disorders. Curr Opin Neurol 2001; 14:423-432.
    • (2001) Curr Opin Neurol , vol.14 , pp. 423-432
    • Dickson, D.1
  • 3
    • 0035947372 scopus 로고    scopus 로고
    • Impairment of the ubiquitin-proteasome system by protein aggregation
    • Bence NF, Sampat RM, Kopito RR. Impairment of the ubiquitin-proteasome system by protein aggregation. Science 2001; 292:1552-1555.
    • (2001) Science , vol.292 , pp. 1552-1555
    • Bence, N.F.1    Sampat, R.M.2    Kopito, R.R.3
  • 4
    • 0036884733 scopus 로고    scopus 로고
    • Pathogenesis of Parkinson's disease: Dopamine, vesicles and alpha-synuclein
    • Lotharius J, Brundin P. Pathogenesis of Parkinson's disease: dopamine, vesicles and alpha-synuclein. Nat Rev 2002; 3:1-11.
    • (2002) Nat Rev , vol.3 , pp. 1-11
    • Lotharius, J.1    Brundin, P.2
  • 5
    • 0042344905 scopus 로고    scopus 로고
    • Towards a molecular neuropsychiatry of neurodegenerative diseases
    • Cummings JL. Towards a molecular neuropsychiatry of neurodegenerative diseases. Ann Neurol 2003; 54:147-154.
    • (2003) Ann Neurol , vol.54 , pp. 147-154
    • Cummings, J.L.1
  • 6
    • 0032491408 scopus 로고    scopus 로고
    • Genetic classification of primary neurodegenerative disease
    • Hardy J, Gwinn-Hardy K. Genetic classification of primary neurodegenerative disease. Science 1998; 282:1075-1079.
    • (1998) Science , vol.282 , pp. 1075-1079
    • Hardy, J.1    Gwinn-Hardy, K.2
  • 7
    • 0032491507 scopus 로고    scopus 로고
    • Experimental therapeutics of neurodegenerative disorders: Unmet needs
    • Shoulson I. Experimental therapeutics of neurodegenerative disorders: unmet needs. Science 1998; 282:1072-1074.
    • (1998) Science , vol.282 , pp. 1072-1074
    • Shoulson, I.1
  • 8
    • 4344599272 scopus 로고    scopus 로고
    • Molecular neurobiology
    • Jameson LJ, ed. Totowa, NJ: Humana Press
    • Martin JB, Longo FM. Molecular neurobiology. In: Jameson LJ, ed. Principles of molecular medicine. Totowa, NJ: Humana Press, 1998:871-890.
    • (1998) Principles of Molecular Medicine , pp. 871-890
    • Martin, J.B.1    Longo, F.M.2
  • 9
    • 0037077040 scopus 로고    scopus 로고
    • Toxic proteins in neurodegenerative disease
    • Taylor JP, Hardy J, Fischbeck KH. Toxic proteins in neurodegenerative disease. Science 2002; 296:1991-1995.
    • (2002) Science , vol.296 , pp. 1991-1995
    • Taylor, J.P.1    Hardy, J.2    Fischbeck, K.H.3
  • 10
    • 0034513218 scopus 로고    scopus 로고
    • "Fatal attractions" of proteins. A comprehensive hypothetical mechanism underlying Alzheimer's disease and other neurodegenerative disorders
    • Trojanowski JQ, Lee VM-Y. "Fatal attractions" of proteins. A comprehensive hypothetical mechanism underlying Alzheimer's disease and other neurodegenerative disorders. Ann N Y Acad Sci 2000; 924:62-67.
    • (2000) Ann N Y Acad Sci , vol.924 , pp. 62-67
    • Trojanowski, J.Q.1    Lee, V.M.-Y.2
  • 11
    • 0036157895 scopus 로고    scopus 로고
    • Protein aggregates and dementia: Is there a common toxicity?
    • Lovestone S, McLoughlin DM. Protein aggregates and dementia: is there a common toxicity? J Neurol Neurosurg Psychiatry 2002; 72:152-161.
    • (2002) J Neurol Neurosurg Psychiatry , vol.72 , pp. 152-161
    • Lovestone, S.1    McLoughlin, D.M.2
  • 13
    • 18444366477 scopus 로고    scopus 로고
    • Genotype-phenotype correlations for EPM2A mutations in Lafora's progressive myoclonus epilepsy: Exon 1 mutations associate with an early-onset cognitive deficit subphenotype
    • Ganesh S, Delgado-Escueta AV, Suzuki T, et al. Genotype-phenotype correlations for EPM2A mutations in Lafora's progressive myoclonus epilepsy: exon 1 mutations associate with an early-onset cognitive deficit subphenotype. Hum Mol Genet 2002; 11:1263-1271.
    • (2002) Hum Mol Genet , vol.11 , pp. 1263-1271
    • Ganesh, S.1    Delgado-Escueta, A.V.2    Suzuki, T.3
  • 14
    • 0041920559 scopus 로고    scopus 로고
    • Adult Alexander disease with autosomal dominant transmission: A distinct entity caused by mutation in the glial fibrillary acid protein gene
    • Stumpf E, Masson H, Duquette A, et al. Adult Alexander disease with autosomal dominant transmission: a distinct entity caused by mutation in the glial fibrillary acid protein gene. Arch Neurol 2003; 60:1307-1312.
    • (2003) Arch Neurol , vol.60 , pp. 1307-1312
    • Stumpf, E.1    Masson, H.2    Duquette, A.3
  • 15
  • 16
    • 0037988748 scopus 로고    scopus 로고
    • Adult polyglucosan body disease associated with Lewy bodies and tremor
    • Trivedi JR, Wolfe GI, Nations SP, et al. Adult polyglucosan body disease associated with Lewy bodies and tremor. Arch Neurol 2003; 60:764-766.
    • (2003) Arch Neurol , vol.60 , pp. 764-766
    • Trivedi, J.R.1    Wolfe, G.I.2    Nations, S.P.3
  • 17
    • 0034857852 scopus 로고    scopus 로고
    • Cognitive deficits associated with a recently reported familial neurodegenerative disease
    • Bradshaw CB, Davis RL, Shrimpton AE, et al. Cognitive deficits associated with a recently reported familial neurodegenerative disease. Arch Neurol 2001; 58:1429-1434.
    • (2001) Arch Neurol , vol.58 , pp. 1429-1434
    • Bradshaw, C.B.1    Davis, R.L.2    Shrimpton, A.E.3
  • 18
    • 0033598346 scopus 로고    scopus 로고
    • Familial dementia caused by polymerization of mutant neuroserpin
    • Davis RL, Shrimpton AE, Holohan PD, et al. Familial dementia caused by polymerization of mutant neuroserpin. Nature 1999; 401:376-379.
    • (1999) Nature , vol.401 , pp. 376-379
    • Davis, R.L.1    Shrimpton, A.E.2    Holohan, P.D.3
  • 19
    • 0036789017 scopus 로고    scopus 로고
    • Serpinopathies and the conformational dementias
    • Lomas DA, Carrell RW. Serpinopathies and the conformational dementias. Nat Rev Genet 2002; 3:759-768.
    • (2002) Nat Rev Genet , vol.3 , pp. 759-768
    • Lomas, D.A.1    Carrell, R.W.2
  • 20
    • 0036715016 scopus 로고    scopus 로고
    • Niemann-Pick type C disease: Accelerated neurofibrillary tangle formation and amyloid beta deposition associated with apolipoprotein E epsilon 4 homozygosity
    • Saito Y, Suzuki K, Nanba E, et al. Niemann-Pick type C disease: accelerated neurofibrillary tangle formation and amyloid beta deposition associated with apolipoprotein E epsilon 4 homozygosity. Ann Neurol 2002; 52:351-355.
    • (2002) Ann Neurol , vol.52 , pp. 351-355
    • Saito, Y.1    Suzuki, K.2    Nanba, E.3
  • 21
    • 0037317334 scopus 로고    scopus 로고
    • Protein folding and disease: A view from the first Horizon Symposium
    • Dobson CM. Protein folding and disease: a view from the first Horizon Symposium. Nat Rev Drug Discov 2003; 2:154-160.
    • (2003) Nat Rev Drug Discov , vol.2 , pp. 154-160
    • Dobson, C.M.1
  • 22
    • 0034123691 scopus 로고    scopus 로고
    • Mechanisms of neurodegenerative disorders part 1: Protein aggregates
    • Wolozin B, Behl C. Mechanisms of neurodegenerative disorders part 1: protein aggregates. Arch Neurol 2000; 57:793-796.
    • (2000) Arch Neurol , vol.57 , pp. 793-796
    • Wolozin, B.1    Behl, C.2
  • 23
    • 0034051284 scopus 로고    scopus 로고
    • Mechanisms of neurodegenerative disorders part 2: Control of cell death
    • Wolozin B, Behl C. Mechanisms of neurodegenerative disorders part 2: control of cell death. Arch Neurol 2000; 57:801-804.
    • (2000) Arch Neurol , vol.57 , pp. 801-804
    • Wolozin, B.1    Behl, C.2
  • 24
    • 0037041420 scopus 로고    scopus 로고
    • Inherent toxicity of aggregates implies a common mechanism for protein misfolding diseases
    • Bucciantini M, Giannoni E, Chiti F, et al. Inherent toxicity of aggregates implies a common mechanism for protein misfolding diseases. Nature 2002; 416:507-511.
    • (2002) Nature , vol.416 , pp. 507-511
    • Bucciantini, M.1    Giannoni, E.2    Chiti, F.3
  • 25
    • 0037157540 scopus 로고    scopus 로고
    • Neurodegeneration in the age of molecular biology
    • Golbe LI. Neurodegeneration in the age of molecular biology. Br Med J 2002; 324:1467-1468.
    • (2002) Br Med J , vol.324 , pp. 1467-1468
    • Golbe, L.I.1
  • 26
    • 0028074993 scopus 로고
    • Synuclein proteins and Alzheimer's disease
    • Brookes AJ, St Clair D. Synuclein proteins and Alzheimer's disease. Trends Neurosci 1994; 17:404-405.
    • (1994) Trends Neurosci , vol.17 , pp. 404-405
    • Brookes, A.J.1    St. Clair, D.2
  • 27
    • 0034759869 scopus 로고    scopus 로고
    • Alpha-synuclein in familial Alzheimer disease: Epitope mapping parallels dementia with Lewy bodies and Parkinson disease
    • Lippa CF, Schmidt ML, Lee VM, et al. Alpha-synuclein in familial Alzheimer disease: epitope mapping parallels dementia with Lewy bodies and Parkinson disease. Arch Neurol 2001; 58:1817-1820.
    • (2001) Arch Neurol , vol.58 , pp. 1817-1820
    • Lippa, C.F.1    Schmidt, M.L.2    Lee, V.M.3
  • 28
    • 0032990543 scopus 로고    scopus 로고
    • Antibodies to alpha-synuclein detect Lewy bodies in many Down's syndrome brains with Alzheimer's disease
    • Lippa CF, Schmidt ML, Lee VM, et al. Antibodies to alpha-synuclein detect Lewy bodies in many Down's syndrome brains with Alzheimer's disease. Ann Neurol 1999; 45:353-357.
    • (1999) Ann Neurol , vol.45 , pp. 353-357
    • Lippa, C.F.1    Schmidt, M.L.2    Lee, V.M.3
  • 29
    • 0006164301 scopus 로고    scopus 로고
    • Consensus guidelines for the clinical and pathologic diagnosis of dementia with Lewy bodies (DLB): Report of the consortium on DLB international workshop
    • McKeith IG, Galasko D, Kosaka K, et al. Consensus guidelines for the clinical and pathologic diagnosis of dementia with Lewy bodies (DLB): report of the consortium on DLB international workshop. Neurology 1996; 47:1113-1124.
    • (1996) Neurology , vol.47 , pp. 1113-1124
    • McKeith, I.G.1    Galasko, D.2    Kosaka, K.3
  • 30
    • 0035834076 scopus 로고    scopus 로고
    • Beta-amyloid peptides enhance alpha-synuclein accumulation and neuronal deficits in a transgenic mouse model linking Alzheimer's disease and Parkinson's disease
    • Masliah E, Rockenstein E, Veinbergs I, et al. Beta-amyloid peptides enhance alpha-synuclein accumulation and neuronal deficits in a transgenic mouse model linking Alzheimer's disease and Parkinson's disease. Proc Natl Acad Sci USA 2001; 98:12245-12250.
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 12245-12250
    • Masliah, E.1    Rockenstein, E.2    Veinbergs, I.3
  • 31
    • 0037466656 scopus 로고    scopus 로고
    • Initiation and synergistic fibrillization of tau and alpha-synuclein
    • Giasson BI, Forman MS, Higuchi M, et al. Initiation and synergistic fibrillization of tau and alpha-synuclein. Science 2003; 300:636-640.
    • (2003) Science , vol.300 , pp. 636-640
    • Giasson, B.I.1    Forman, M.S.2    Higuchi, M.3
  • 32
    • 0344845132 scopus 로고    scopus 로고
    • Amyloid deposition precedes tangle formation in a triple transgenic model of Alzheimer's disease
    • Oddo S, Caccarno A, Kitazawa M, et al. Amyloid deposition precedes tangle formation in a triple transgenic model of Alzheimer's disease. Neurobiol Aging 2003; 24:1063-1070.
    • (2003) Neurobiol Aging , vol.24 , pp. 1063-1070
    • Oddo, S.1    Caccarno, A.2    Kitazawa, M.3
  • 33
    • 0037333666 scopus 로고    scopus 로고
    • Staging of brain pathology related to sporadic Parkinson's disease
    • Braak H, De Tredici K, Rub U, et al. Staging of brain pathology related to sporadic Parkinson's disease. Neurobiol Aging 2003; 24:197-211.
    • (2003) Neurobiol Aging , vol.24 , pp. 197-211
    • Braak, H.1    De Tredici, K.2    Rub, U.3
  • 34
    • 0037042299 scopus 로고    scopus 로고
    • Alzheimer's disease
    • Cummings JL, Cole G. Alzheimer's disease. JAMA 2002; 287:2335-2338.
    • (2002) JAMA , vol.287 , pp. 2335-2338
    • Cummings, J.L.1    Cole, G.2
  • 35
    • 0033595485 scopus 로고    scopus 로고
    • Report of the second dementia with Lewy body international workshop: Diagnosis and treatment
    • McKeith IG, Perry EK, Perry RH. Report of the second dementia with Lewy body international workshop: Diagnosis and treatment. Neurology 1999; 53:902-905.
    • (1999) Neurology , vol.53 , pp. 902-905
    • McKeith, I.G.1    Perry, E.K.2    Perry, R.H.3
  • 36
    • 4344697392 scopus 로고    scopus 로고
    • Conference summary: Third International Workshop on Dementia with Lewy Bodies and Parkinson's Disease Dementia
    • in press
    • Cummings JL. Conference summary: Third International Workshop on Dementia with Lewy Bodies and Parkinson's Disease Dementia. Reviews in Neurological Disease, in press.
    • Reviews in Neurological Disease
    • Cummings, J.L.1
  • 37
    • 0036322266 scopus 로고    scopus 로고
    • Novel antibodies to synuclein show abundant striatal pathology in Lewy body diseases
    • Duda JE, Giasson BI, Mabon ME, et al. Novel antibodies to synuclein show abundant striatal pathology in Lewy body diseases. Ann Neurol 2002; 52:205-210.
    • (2002) Ann Neurol , vol.52 , pp. 205-210
    • Duda, J.E.1    Giasson, B.I.2    Mabon, M.E.3
  • 38
    • 0036171907 scopus 로고    scopus 로고
    • Parkinson's disease: The thalamic components of the limbic loop are severely impaired by alpha-synuclein immunopositive inclusion body pathology
    • Rub U, Del Tredici K, Schultz C, et al. Parkinson's disease: the thalamic components of the limbic loop are severely impaired by alpha-synuclein immunopositive inclusion body pathology. Neurobiol Aging 2002; 23:245-254.
    • (2002) Neurobiol Aging , vol.23 , pp. 245-254
    • Rub, U.1    Del Tredici, K.2    Schultz, C.3
  • 40
    • 0031910093 scopus 로고    scopus 로고
    • Aggregation of neurofilament and alpha-synuclein proteins in Lewy bodies: Implications for the pathogenesis of Parkinson disease and Lewy body dementia
    • Trojanowski JQ, Lee VM. Aggregation of neurofilament and alpha-synuclein proteins in Lewy bodies: implications for the pathogenesis of Parkinson disease and Lewy body dementia. Arch Neurol 1998; 55:151-152.
    • (1998) Arch Neurol , vol.55 , pp. 151-152
    • Trojanowski, J.Q.1    Lee, V.M.2
  • 41
    • 10744229859 scopus 로고    scopus 로고
    • Synucleinopathy pathology and REM sleep behavior disorder plus dementia or parkinsonism
    • Boeve BF, Silber MH, Parisi JE, et al. Synucleinopathy pathology and REM sleep behavior disorder plus dementia or parkinsonism. Neurology 2003; 61:40-45.
    • (2003) Neurology , vol.61 , pp. 40-45
    • Boeve, B.F.1    Silber, M.H.2    Parisi, J.E.3
  • 42
    • 0036896790 scopus 로고    scopus 로고
    • Idiopathic rapid eye movement sleep behavior disorder is a harbinger of dementia with Lewy bodies
    • Turner RS. Idiopathic rapid eye movement sleep behavior disorder is a harbinger of dementia with Lewy bodies. J Geriatr Psychiatry Neurol 2002; 15:195-199.
    • (2002) J Geriatr Psychiatry Neurol , vol.15 , pp. 195-199
    • Turner, R.S.1
  • 43
    • 0031454241 scopus 로고    scopus 로고
    • The relationship between dementia and direct involvement of the hippocampus and amygdala in Parkinson's disease
    • Churchyard A, Lees AJ. The relationship between dementia and direct involvement of the hippocampus and amygdala in Parkinson's disease. Neurology 1997; 49:1570-1576.
    • (1997) Neurology , vol.49 , pp. 1570-1576
    • Churchyard, A.1    Lees, A.J.2
  • 44
    • 0033923545 scopus 로고    scopus 로고
    • Alpha-synuclein-immunoreactive cortical Lewy bodies are associated with cognitive impairment in Parkinson's disease
    • Mattila PM, Rinne JO, Helenius H, et al. Alpha-synuclein-immunoreactive cortical Lewy bodies are associated with cognitive impairment in Parkinson's disease. Acta Neuropathol 2000; 100:285-290.
    • (2000) Acta Neuropathol , vol.100 , pp. 285-290
    • Mattila, P.M.1    Rinne, J.O.2    Helenius, H.3
  • 45
    • 0034705015 scopus 로고    scopus 로고
    • Alpha-synuclein cortical Lewy bodies correlate with dementia in Parkinson's disease
    • Hurtig H, Trojanowski JQ, Galvin J, et al. Alpha-synuclein cortical Lewy bodies correlate with dementia in Parkinson's disease. Neurology 2000; 54:1916-1921.
    • (2000) Neurology , vol.54 , pp. 1916-1921
    • Hurtig, H.1    Trojanowski, J.Q.2    Galvin, J.3
  • 46
    • 0037058789 scopus 로고    scopus 로고
    • Fluctuations in attention: PD dementia vs DLB with parkinsonism
    • Ballard CG, Aarsland D, McKeith I, et al. Fluctuations in attention: PD dementia vs DLB with parkinsonism. Neurology 2002; 59:1714-1720.
    • (2002) Neurology , vol.59 , pp. 1714-1720
    • Ballard, C.G.1    Aarsland, D.2    McKeith, I.3
  • 47
    • 0029806563 scopus 로고    scopus 로고
    • Clinical genetic analysis of Parkinson's disease in the Contursi kindred
    • Golbe LI, Di Iorio G, Sanges G, et al. Clinical genetic analysis of Parkinson's disease in the Contursi kindred. Ann Neurol 1996; 40:767-775.
    • (1996) Ann Neurol , vol.40 , pp. 767-775
    • Golbe, L.I.1    Di Iorio, G.2    Sanges, G.3
  • 48
    • 10744230149 scopus 로고    scopus 로고
    • The new mutation, E46K, of alpha-synuclein causes Parkinson and Lewy body dementia
    • Zarranz JJ, Alegre J, Gomez-Esteban JC, et al. The new mutation, E46K, of alpha-synuclein causes Parkinson and Lewy body dementia. Ann Neurol 2004; 55:164-173.
    • (2004) Ann Neurol , vol.55 , pp. 164-173
    • Zarranz, J.J.1    Alegre, J.2    Gomez-Esteban, J.C.3
  • 49
    • 0030744876 scopus 로고    scopus 로고
    • Mutation in the alpha-synuclein gene identified in families with Parkinson's disease
    • Polymeropoulos MH, Lavedan C, Leroy E, et al. Mutation in the alpha-synuclein gene identified in families with Parkinson's disease. Science 1997; 276:2045-2047.
    • (1997) Science , vol.276 , pp. 2045-2047
    • Polymeropoulos, M.H.1    Lavedan, C.2    Leroy, E.3
  • 50
    • 0035933142 scopus 로고    scopus 로고
    • Parkinson's disease, CYP2D6 polymorphism, and age
    • Payami H, Lee N, Zareparsi S, et al. Parkinson's disease, CYP2D6 polymorphism, and age. Neurology 2001; 56:1363-1370.
    • (2001) Neurology , vol.56 , pp. 1363-1370
    • Payami, H.1    Lee, N.2    Zareparsi, S.3
  • 51
    • 9144266292 scopus 로고    scopus 로고
    • Alpha-synuclein haplotypes implicated in risk of Parkinson's disease
    • Tan EK, Chai A, Teo YY, et al. Alpha-synuclein haplotypes implicated in risk of Parkinson's disease. Neurology 2004; 62:128-131.
    • (2004) Neurology , vol.62 , pp. 128-131
    • Tan, E.K.1    Chai, A.2    Teo, Y.Y.3
  • 53
    • 0342368772 scopus 로고    scopus 로고
    • Association between early-onset Parkinson's disease and mutations in Parkin gene
    • Lucking CB, Durr A, Bonifati V, et al. Association between early-onset Parkinson's disease and mutations in Parkin gene. N Engl J Med 2000; 342:1560-1567.
    • (2000) N Engl J Med , vol.342 , pp. 1560-1567
    • Lucking, C.B.1    Durr, A.2    Bonifati, V.3
  • 55
    • 0036775723 scopus 로고    scopus 로고
    • Genetics of Parkinson's disease and biochemical studies of implicated gene products
    • Lansbury PT Jr, Brice A. Genetics of Parkinson's disease and biochemical studies of implicated gene products. Curr Opin Cell Biol 2002; 14:653-660.
    • (2002) Curr Opin Cell Biol , vol.14 , pp. 653-660
    • Lansbury Jr., P.T.1    Brice, A.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.