Mechanisms of neurodegenerative disorders. Part 2: Control of cell death

Archives of Neurology

Volumn 57, Issue 6, 2000, Pages 801-804

  Wolozin, Benjamin ^a   Behl, Christian ^b  

^a LOYOLA UNIVERSITY MEDICAL CENTER   (United States)

^b MAX PLANCK INSTITUTE OF PSYCHIATRY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID BETA PROTEIN; CASPASE; PRESENILIN 1; PRESENILIN 2;

APOPTOSIS; BRAIN PROTECTION; CELL PROTECTION; DEGENERATIVE DISEASE; HUMAN; NERVE CELL NECROSIS; NEUROTOXICITY; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; REVIEW;

EID: 0034051284     PISSN: 00039942     EISSN: None     Source Type: Journal    
DOI: 10.1001/archneur.57.6.801     Document Type: Review

References (20)

1. Hemmings BA. Akt signaling: linking membrane events to life and death decisions. Science. 1997;275:628-630.
2. Dudek H, Datta SR, Franke TF, et al. Regulation of neuronal survival by the serine-threonine protein kinase Akt, Science. 1997;275:661-665.
3. Zhou Q, Snipas S, Orth K, Muzio M, Dixit V, Salvesen G. Target protease specificity of the viral serpin CrmA: analysis of five caspases. J Biol Chem. 1997;272: 7797-7800.
4. Yang F, Sun X, Beech W, et al. Antibody to caspase-cleaved actin detects apoptosis in differentiated neuroblastoma and plaque-associated neurons and microglia in Alzheimer's disease. Am J Pathol. 1998;152:379-389.
5. Hardy J. Amyloid, the presenilins and Alzheimer's disease. Trends Neurosci. 1997; 20:154-159.
6. Wolozin B, Iwasaki K, Vito P, et al. Participation of presenilin-2 in apoptosis: enhanced basal activity conferred by Alzheimer mutation. Science. 1996;274:1710-1713.
7. Murayama M, Tanaka S, Palacino J, et al. Direct association of presenilin-1 with β-catenin. FEBS Lett. 1998;433:73-77.
8. Passer B, Pellegrini L, Vito P, Ganjei J, D'Adamio L. Interaction of Alzheimer's presenilins with Bcl-XL: a potential role in modulating the threshold of cell death. J Biol Chem. 1999;247:24007-24013.
9. Zhang Z, Hartmann H, Do V, et al. Destabilization of β-catenin by mutations in presenilin-1 potentiates neuronal apoptosis. Nature. 1998;395:698-702.
10. De Strooper B, Annaert W, Cupers P, et al. A presenilin-1-dependent γ-secretase-like protease mediates release of Notch intracellular domain. Nature. 1999;398: 518-522.
11. Behl C, Davis J, Lesley R, Schubert D. Hydrogen peroxide mediates amyloid-β protein toxicity. Cell. 1994;77:817-827.
12. Palacino J, Berechid B, Alexander P, et al. Regulation of APP processing by presenilin 1 and 2 in PS1 knockout cells. J Biol Chem. 1999;275:215-222.
13. Furukawa K, Mattson M. The transcription factor NF-κB mediates increases in calcium currents and decreases in NMDA- and AMPA/kainate-induced currents induced by tumor necrosis factor α in hippocampal neurons. J Neurochem. 1998; 70:1876-1878.
14. Baldwin AJ. The NF-κ B and I κ B proteins: new discoveries and insights. Ann Rev Immunol. 1996;14:649-683.
15. Lezoualc'h F, Sagara Y, Holsboer F, Behl C. High constitutive NF-κB activity mediates resistance to oxidative stress in neuronal cells. J Neurosci. 1998;18:3224-3232.
16. Kaltschmidt B, Uherek M, Volk B, Baeuerle PA, Kaltschmidt C. Transcription factor NF-κB is activated in primary neurons by amyloid-β peptides and in neurons surrounding early plaques from patients with Alzheimer disease. Proc Natl Acad Sci U S A. 1997;94:2642-2647
17. Heck S, Lezoualc'h F, Engert S, Behl C, Insulin-like growth factor-1-mediated neuroprotection against oxidative stress is associated with activation of nuclear factor κB. J Biol Chem. 1999;274:9828-9835.
18. Behl C, Skutella T, Lezoualc'h F, et al. Neuroprotection against oxidative stress by estrogens: structure-activity relationship. Mol Pharmacol. 1997;51:535-541
19. Sano M, Ernesto C, Thomas RG, et al. A controlled trial of selegiline, α-tocopherol, or both as treatment for Alzheimer's disease: the Alzheimer's Disease Cooperative Study. N Engl J Med. 1997;336:1216-1222.
20. Moosmann B, Behl C. The antioxidant neuroprotective effects of estrogens and phenolic compounds are independent from their estrogenic properties. Proc Natl Acad Sci U S A. 1999;96:8867-8872.