Critical period for adverse effects on development of reproductive system in male offspring of rats given di-n-butyl phthalate during late pregnancy

Toxicology Letters

Volumn 111, Issue 3, 2000, Pages 271-278

  Ema, Makoto ^a   Miyawaki, Emiko ^a   Kawashima, Kunio ^a  

^a NATIONAL INSTITUTE OF HEALTH SCIENCES   (Japan)

Author keywords

Anogenital distance; Developmental toxicity; Dibutyl phthalate; Rat; Reproductive tract malformation; Undescended testes

Indexed keywords

PHTHALIC ACID DIBUTYL ESTER;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; CRYPTORCHISM; FETUS; FETUS RESORPTION; LITTER SIZE; MALE; MALE GENITAL SYSTEM; NONHUMAN; PRIORITY JOURNAL; PROGENY; RAT; REPRODUCTIVE TOXICITY; THIRD TRIMESTER PREGNANCY;

ANIMALS; BODY WEIGHT; CRYPTORCHIDISM; DIBUTYL PHTHALATE; EMBRYONIC AND FETAL DEVELOPMENT; FEMALE; MALE; PREGNANCY; PRENATAL EXPOSURE DELAYED EFFECTS; RATS; RATS, WISTAR; TESTICULAR DISEASES; TIME FACTORS;

ANIMALIA;

EID: 0033989741     PISSN: 03784274     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-4274(99)00192-7     Document Type: Article

References (34)

1. Albro P.W., Moore B. Identification of the metabolites of simple phthalate diesters in rat urine. J. Chromatogr. 94:1974;209-218.
2. Autian J. Toxicity and health threats of phthalate esters: review of the literature. Environ. Health Perspect. 4:1973;3-26.
3. Cater B.R., Cook M.W., Gangolli S.D., Grasso P. Studies on dibutyl phthalate-induced testicular atrophy in the rat: effect on zinc metabolism. Toxicol. Appl. Pharmacol. 41:1977;609-618.
4. Clark R.L., Antonello J.M., Grossman S.J., Wise L.D., Anderson C., Bagdon W.J., Prahalada S., MacDonald J.S., Robertson R.T. External genitalia abnormalities in male rats exposed in utero to finasteride, a 5α-reductase inhibitor. Teratology. 42:1990;91-100.
5. Eigenberg D.A., Bozigian H.P., Carter D.E., Sipes I.G. Distribution, excretion, and metabolism of butylbenzyl phthalate in the rat. J. Toxicol. Environ. Health. 17:1986;445-456.
6. Ema M., Amano H., Itami T., Kawasaki H. Teratogenic evaluation of di-n-butyl phthalate in rats. Toxicol. Lett. 69:1993;197-203.
7. Ema M., Amano H., Ogawa Y. Characterization of the developmental toxicity of di-n-butyl phthalate in rats. Toxicology. 86:1994;163-174.
8. Ema M., Kurosaka R., Harazono A., Amano H., Ogawa Y. Phase specificity of developmental toxicity after oral administration of mono-n-butyl phthalate in rats. Arch. Environ. Contam. Toxicol. 31:1996;170-176.
9. Ema M., Harazono A., Miyawaki E., Ogawa Y. Developmental effects of di-n-butyl phthalate after a single administration in rats. J. Appl. Toxicol. 17:1997;223-229.
10. Ema M., Miyawaki E., Kawashima K. Further evaluation of developmental toxicity of di-n-butyl phthalate following administration during late pregnancy in rats. Toxicol. Lett. 98:1998;87-93.
11. Gangolli S.D. Testicular effects of phthalate esters. Environ. Health Perspect. 45:1982;77-84.
12. Gray L.E. Jr, Ostby J.S., Mylchreest E., Foster P.M.D., Kelce W.R. Dibutyl phthalate (DBP) induces antiandrogenic but not estrogenic in vivo effects in Long Evans hooded rats. Toxicol. Sci. 42(Suppl. 1):1998;176.
13. Harris C.A., Henttu P., Parker M.G., Sumpter J.P. The estrogenic activity of phthalate esters in vitro. Environ. Health Perspect. 105:1997;802-811.
14. Imajima T., Shono T., Zakaria O., Suita S. Prenatal phthalate causes cryptorchidism postnatally by inducing transabdominal ascent of the testis in fetal rats. J. Pediatr. Surg. 32:1997;18-21.
15. Imperato-McGinley J., Binienda Z., Arthur A., Mininberg D.T., Vaughan E.D. Jr, Quimby F.W. The development of a male pseudohermaphroditic rat using an inhibitor of the enzyme 5α-reductase. Endocrinology. 116:1985;807-812.
16. Environmental Health Criteria 189. Di-n-butyl phthalate. 1997;World Health Organization, Geneva.
17. Jaeger R.J., Rubin R.J. Plasticizer from plastic devices: extraction, metabolism, and accumulation by biological systems. Science. 170:1970;460-462.
18. Jobling S., Reynolds T., White R., Parker M.G., Sumpter J.P. A variety of environmentally persistent chemicals, including some phthalate plasticizers, are weakly estrogenic. Environ. Health Perspect. 103:1995;582-587.
19. Jost A., Viger B., Prepin J., Perchellet J.P. Studies on sex differentiation in mammals. Recent Prog. Horm. Res. 29:1973;1-41.
20. Lamb J.C. IV, Chapin R.E., Teague J., Lawton A.D., Reel J.R. Reproductive effects of four phthalic acid esters in the mouse. Toxicol. Appl. Pharmacol. 88:1987;255-269.
21. Marx J.L. Phthalic acid esters: biological impact uncertain. Science. 178:1972;46-47.
22. Mayer F.L. Jr, Stalling D.L., Johnson J.L. Phthalate esters as environmental contaminants. Nature. 238:1972;411-413.
23. Mikuriya H., Ikemoto I., Tanaka A. Urinary metabolites contributing to testicular damage induced by butylbenzyl phthalate. Jikeikai Med. J. 35:1988;403-409.
24. Mylchreest E., Cattley R.C., Foster P.M.D. Male reproductive tract malformations in rats following gestational and lactational exposure to di(n-butyl) phthalate: an antiandrogenic mechanism? Toxicol. Sci. 43:1998;47-60.
25. Mylchreest E., Sar M., Cattley R.C., Foster P.M.D. Disruption of androgen-regulated male reproductive development by di(n-butyl) phthalate during late gestation in rats is different from flutamide. Toxicol. Appl. Pharmacol. 156:1999;81-95.
26. Nikonorow M., Mazur H., Piekacz H. Effect of orally administered plasticizers and polyvinyl chloride stabilizers in the rat. Toxicol. Appl. Pharmacol. 26:1973;253-259.
27. Peters J.W., Cook R.M. Effect of phthalate esters on reproduction in rats. Environ. Health Perspect. 3:1973;91-94.
28. Saillenfait A.M., Payan J.P., Fabry J.P, Beydon D., Langonne I., Gallissot F., Sabate J.P. Assessment of the developmental toxicity, metabolism, and placental transfer of di-n-butyl phthalate administered to pregnant rats. Toxicol. Sci. 45:1998;212-224.
29. Shiota K., Chou M.J., Nishimura H. Embryotoxic effects of di-2-ethylhexyl phthalate (DEHP) and di-n-butyl phthalate (DBP) in mice. Environ. Res. 22:1980;245-253.
30. Singh A.R., Lawrence W.H., Autian J. Teratogenicity of phthalate esters in rats. J. Pharm. Sci. 61:1972;51-55.
31. Spencer J.R., Torrado T., Sanchez R.S., Vaughan E.D. Jr, Imperato-McGinley J. Effects of flutamide and finasteride on rat testicular descent. Endocrinology. 129:1991;741-748.
32. Tanaka A., Matsumoto A., Yamaha T. Biochemical studies on phthalic esters. III. Metabolism of dibutyl phthalate (DBP) in animals. Toxicology. 9:1978;109-123.
33. 14C in the rat. J. Agric. Food Chem. 23:1975;854-858.
34. Wine R.N., Li L.H., Barnes L.H., Gulati D.K., Chapin R.E. Reproductive toxicity of di-n-butylphthalate in a continuous breeding protocol in Sprague-Dawley rats. Environ. Health Perspect. 105:1997;102-107.