Overexpression of growth-associated proteins in the neurons of adult transgenic mice

Journal of Neuroscience Methods

Volumn 71, Issue 1, 1997, Pages 3-9

  Caroni, Pico ^a  

^a FRIEDRICH MIESCHER INSTITUTE FOR BIOMEDICAL RESEARCH   (Switzerland)

Author keywords

Thy 1.2; transgene expression

Indexed keywords

GROWTH ASSOCIATED PROTEIN; THY 1 ANTIGEN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN REGION; CONTROLLED STUDY; GENE EXPRESSION; MOUSE; NONHUMAN; PRIORITY JOURNAL; TRANSGENIC MOUSE;

ANIMALS; AXONS; BRAIN; CALMODULIN-BINDING PROTEINS; CHICKENS; CYTOSKELETAL PROTEINS; GAP-43 PROTEIN; GENE EXPRESSION REGULATION, DEVELOPMENTAL; MEMBRANE GLYCOPROTEINS; MICE; MICE, TRANSGENIC; MOTOR NEURONS; NERVE REGENERATION; NERVE TISSUE PROTEINS; NERVOUS SYSTEM; NEUROMUSCULAR JUNCTION; NEURONS; ORGAN SPECIFICITY; PROMOTER REGIONS (GENETICS); RECOMBINANT FUSION PROTEINS; TRANSGENES;

EID: 0030900176     PISSN: 01650270     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0165-0270(96)00121-5     Document Type: Article

References (19)

1. Aigner, L., Arber, S., Kapfhammer, J.P., Laux, T., Schneider, C., Botteri, F., Brenner, H.-R. and Caroni, P. (1995) Overexpression of the neural growth-associated protein GAP-43 induces nerve sprouting in the adult nervous system of transgenic mice, Cell, 83: 269-278.
2. Benowitz, L.I. and Routtenberg, A. (1987) A membrane phosphoprotein associated with neural development, axonal regeneration, phospholipid metabolism, and synaptic plasticity, Trends Neurosci., 10: 527-531.
3. Brown, M.C. (1984) Sprouting of motor nerves in adult muscles: a recapitulation of ontogeny, Trends Neurosci., 7: 10-14.
4. Buiakowa, O.I., Rama Krishna, N.S., Getchell, T.V. and Margolis, F.L. (1994) Human and rodent OMP genes: conservation of structural and regulatory motifs and cellular localization, Genomics, 20: 452-462.
5. Caroni, P. and Becker, M. (1992) The down-regulation of growth-associated proteins in motoneurons at the onset of synapse elimination is controlled by muscle activity and IGF-1, J. Neurosci., 12: 3849-3861.
6. Danziger, E., Mettling, C., Vidal, M., Morris, R. and Margolis, F. (1989) Olfactory marker protein gene: its structure and olfactory neuron-specific expression in transgenic mice, Proc. Natl. Acad. Sci. USA, 86: 8565-8569.
7. Gordon, J.W., Chesa, P.G., Nishimura, H., Rettig, W.J., Maccari, J.E., Endo, T., Seravalli, E., Seki, T. and Silver, J. (1987) Regulation of Thy-1 gene expression in transgenic mice, Cell. 50: 445-452.
8. Gossen, M. and Bujard, H. (1992) Tight control of gene expression in mammalian cells by tetracycline-responsive promoters, Proc. Natl. Acad. Sci. USA, 89: 5547-5551.
9. Kappen, C., Gardner, D.P., Macias, M.P. and Yaworky, P.J. (1995) Neuron-specific gene expression during development in a binary transgenic mouse system, Soc. Neurosci., 21: 1530.
10. Kelley, K.A., Sonshine, A. and Ho, A. (1995) Characterization of Thy-1 enhancer elements in transgenic mice, Soc. Neurosci. 21: 1260.
11. Liu, Y. and Storm, D.R. (1990) Regulation of free calmodulin levels by neuromodulin: neuron growth and regeneration, Trends Pharmacol. Sci., 11: 107-111.
12. Maekawa, S., Maekawa, M., Hattori, S. and Nakamura, S. (1993) Purification and molecular cloning of a novel acidic calmodulin-binding protein from rat brain, J. Biol. Chem., 268: 13703-13709.
13. Morris, R. (1992) Thy-1, the enigmatic extrovert on the neuronal surface, BioEssays, 14: 715-722.
14. Perrone-Bizzozero, N.I., Cansino, V.V. and Kohn, D.T. (1993) Posttranscriptional regulation of GAP-43 gene expression in PC12 cells through protein kinaseC-dependent stabilization of the mRNA, J. Cell Biol., 120: 1263-1270.
15. Skene, J.H.P. (1989) Axonal growth-associated proteins, Annu. Rev. Neurosci., 12: 127-156.
16. Son, Y.-J. and Thompson, W.J. (1995) Nerve sprouting in muscle is induced and guided by processes extended by Schwann cells, Neuron, 14: 133-141.
17. Vanderle, S., Nordquist, D.T., Feddersen, R.M., Tretgakoff, I., Peterson, A.C. and Orr, H.T. (1991) Purkinje cell protein 2 regulatory regions and transgene expression in cerebellar compartments, Genes Devel., 5: 1136-1148.
18. Vidal, M., Morris, R., Grosveld, F. and Spanopoulou, E. (1990) Tissue-specific control elements of the Thy-1 gene, EMBO J., 9: 833-840.
19. Widmer, F. and Caroni, P. (1990) Identification, localization, and primary structure of CAP-23, a particle-bound cytosolic protein of early development, J. Cell Biol., 111: 3035-3047.