메뉴 건너뛰기




Volumn 20, Issue 5, 2008, Pages 345-352

A Review of the Role of Insulin-like Growth Factor 2 in Malignancy and its Potential as a Modifier of Radiation Sensitivity

Author keywords

Clonogenic survival; IGF 1R; IGF1; IGF2; irradiation

Indexed keywords

3 BROMO 5 TERT BUTYL 4 HYDROXYBENZYLIDENEMALONONITRILE; 4 AMINO 5 (3 BENZYLOXYPHENYL) 7 [3 (1 PYRROLIDINYLMETHYL)CYCLOBUTYL] 7H PYRROLO[2,3 D]PYRIMIDINE; ADENOVIRUS VECTOR; ANTINEOPLASTIC AGENT; ANTISENSE OLIGONUCLEOTIDE; COMPLEMENTARY RNA; EVEROLIMUS; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY A12; OLIGONUCLEOTIDE; PROTEIN KINASE B INHIBITOR; SOMATOMEDIN; SOMATOMEDIN B; SOMATOMEDIN C; SOMATOMEDIN C RECEPTOR;

EID: 43049157995     PISSN: 09366555     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.clon.2008.02.004     Document Type: Article
Times cited : (10)

References (66)
  • 1
    • 0038398622 scopus 로고    scopus 로고
    • The insulin-like growth factor system and cancer
    • LeRoith D., and Roberts Jr. C.T. The insulin-like growth factor system and cancer. Cancer Lett 195 2 (2003) 127-137
    • (2003) Cancer Lett , vol.195 , Issue.2 , pp. 127-137
    • LeRoith, D.1    Roberts Jr., C.T.2
  • 2
    • 1942436958 scopus 로고    scopus 로고
    • Insulin-like growth factor (IGF)-I, IGF binding protein-3, and cancer risk: systematic review and meta-regression analysis
    • Renehan A.G., Zwahlen M., Minder C., et al. Insulin-like growth factor (IGF)-I, IGF binding protein-3, and cancer risk: systematic review and meta-regression analysis. Lancet 363 9418 (2004) 1346-1353
    • (2004) Lancet , vol.363 , Issue.9418 , pp. 1346-1353
    • Renehan, A.G.1    Zwahlen, M.2    Minder, C.3
  • 3
    • 0028356419 scopus 로고
    • A second signal supplied by insulin-like growth factor II in oncogene-induced tumorigenesis
    • Christofori G., Naik P., and Hanahan D. A second signal supplied by insulin-like growth factor II in oncogene-induced tumorigenesis. Nature 369 6479 (1994) 414-418
    • (1994) Nature , vol.369 , Issue.6479 , pp. 414-418
    • Christofori, G.1    Naik, P.2    Hanahan, D.3
  • 4
    • 0034665975 scopus 로고    scopus 로고
    • Patched target Igf2 is indispensable for the formation of medulloblastoma and rhabdomyosarcoma
    • Hahn H., Wojnowski L., Specht K., et al. Patched target Igf2 is indispensable for the formation of medulloblastoma and rhabdomyosarcoma. J Biol Chem 275 37 (2000) 28341-28344
    • (2000) J Biol Chem , vol.275 , Issue.37 , pp. 28341-28344
    • Hahn, H.1    Wojnowski, L.2    Specht, K.3
  • 5
    • 33846874575 scopus 로고    scopus 로고
    • The role of the IGF system in cancer growth and metastasis: overview and recent insights
    • Samani A.A., Yakar S., LeRoith D., et al. The role of the IGF system in cancer growth and metastasis: overview and recent insights. Endocr Rev 28 1 (2007) 20-47
    • (2007) Endocr Rev , vol.28 , Issue.1 , pp. 20-47
    • Samani, A.A.1    Yakar, S.2    LeRoith, D.3
  • 6
    • 14644433735 scopus 로고    scopus 로고
    • The insulin-like growth factor-I receptor kinase inhibitor, NVP-ADW742, sensitizes small cell lung cancer cell lines to the effects of chemotherapy
    • Warshamana-Greene G.S., Litz J., Buchdunger E., et al. The insulin-like growth factor-I receptor kinase inhibitor, NVP-ADW742, sensitizes small cell lung cancer cell lines to the effects of chemotherapy. Clin Cancer Res 11 4 (2005) 1563-1571
    • (2005) Clin Cancer Res , vol.11 , Issue.4 , pp. 1563-1571
    • Warshamana-Greene, G.S.1    Litz, J.2    Buchdunger, E.3
  • 7
    • 13644262798 scopus 로고    scopus 로고
    • Insulin-like growth factor ligands, receptors, and binding proteins in cancer
    • Foulstone E., Prince S., Zaccheo O., et al. Insulin-like growth factor ligands, receptors, and binding proteins in cancer. J Pathol 205 2 (2005) 145-153
    • (2005) J Pathol , vol.205 , Issue.2 , pp. 145-153
    • Foulstone, E.1    Prince, S.2    Zaccheo, O.3
  • 8
    • 12144285705 scopus 로고    scopus 로고
    • In vivo antitumor activity of NVP-AEW541 - a novel, potent, and selective inhibitor of the IGF-IR kinase
    • Garcia-Echeverria C., Pearson M.A., Marti A., et al. In vivo antitumor activity of NVP-AEW541 - a novel, potent, and selective inhibitor of the IGF-IR kinase. Cancer Cell 5 3 (2004) 231-239
    • (2004) Cancer Cell , vol.5 , Issue.3 , pp. 231-239
    • Garcia-Echeverria, C.1    Pearson, M.A.2    Marti, A.3
  • 9
    • 0037862006 scopus 로고    scopus 로고
    • Unravelling the activation mechanisms of protein kinase B/Akt
    • Scheid M.P., and Woodgett J.R. Unravelling the activation mechanisms of protein kinase B/Akt. FEBS Lett 546 1 (2003) 108-112
    • (2003) FEBS Lett , vol.546 , Issue.1 , pp. 108-112
    • Scheid, M.P.1    Woodgett, J.R.2
  • 10
    • 0035949699 scopus 로고    scopus 로고
    • AKT plays a central role in tumorigenesis
    • Testa J.R., and Bellacosa A. AKT plays a central role in tumorigenesis. Proc Natl Acad Sci U S A 98 20 (2001) 10983-10985
    • (2001) Proc Natl Acad Sci U S A , vol.98 , Issue.20 , pp. 10983-10985
    • Testa, J.R.1    Bellacosa, A.2
  • 11
    • 0034742120 scopus 로고    scopus 로고
    • AKT1/PKBalpha kinase is frequently elevated in human cancers and its constitutive activation is required for oncogenic transformation in NIH3T3 cells
    • Sun M., Wang G., Paciga J.E., et al. AKT1/PKBalpha kinase is frequently elevated in human cancers and its constitutive activation is required for oncogenic transformation in NIH3T3 cells. Am J Pathol 159 2 (2001) 431-437
    • (2001) Am J Pathol , vol.159 , Issue.2 , pp. 431-437
    • Sun, M.1    Wang, G.2    Paciga, J.E.3
  • 12
    • 0031004088 scopus 로고    scopus 로고
    • Germline mutations of the PTEN gene in Cowden disease, an inherited breast and thyroid cancer syndrome
    • Liaw D., Marsh D.J., Li J., et al. Germline mutations of the PTEN gene in Cowden disease, an inherited breast and thyroid cancer syndrome. Nat Genet 16 1 (1997) 64-67
    • (1997) Nat Genet , vol.16 , Issue.1 , pp. 64-67
    • Liaw, D.1    Marsh, D.J.2    Li, J.3
  • 13
    • 0037436509 scopus 로고    scopus 로고
    • Loss of IGF2 imprinting: a potential marker of colorectal cancer risk
    • Cui H., Cruz-Correa M., Giardiello F.M., et al. Loss of IGF2 imprinting: a potential marker of colorectal cancer risk. Science 299 5613 (2003) 1753-1755
    • (2003) Science , vol.299 , Issue.5613 , pp. 1753-1755
    • Cui, H.1    Cruz-Correa, M.2    Giardiello, F.M.3
  • 14
    • 0027496895 scopus 로고
    • Mice carrying null mutations of the genes encoding insulin-like growth factor I (Igf-1) and type 1 IGF receptor (Igf1r)
    • Liu J.P., Baker J., Perkins A.S., et al. Mice carrying null mutations of the genes encoding insulin-like growth factor I (Igf-1) and type 1 IGF receptor (Igf1r). Cell 75 1 (1993) 59-72
    • (1993) Cell , vol.75 , Issue.1 , pp. 59-72
    • Liu, J.P.1    Baker, J.2    Perkins, A.S.3
  • 15
    • 0027423419 scopus 로고
    • Role of insulin-like growth factors in embryonic and postnatal growth
    • Baker J., Liu J.P., Robertson E.J., et al. Role of insulin-like growth factors in embryonic and postnatal growth. Cell 75 1 (1993) 73-82
    • (1993) Cell , vol.75 , Issue.1 , pp. 73-82
    • Baker, J.1    Liu, J.P.2    Robertson, E.J.3
  • 16
    • 5444255150 scopus 로고    scopus 로고
    • The epigenetics of cancer etiology
    • Feinberg A.P. The epigenetics of cancer etiology. Semin Cancer Biol 14 6 (2004) 427-432
    • (2004) Semin Cancer Biol , vol.14 , Issue.6 , pp. 427-432
    • Feinberg, A.P.1
  • 17
    • 0025320906 scopus 로고
    • A growth-deficiency phenotype in heterozygous mice carrying an insulin-like growth factor II gene disrupted by targeting
    • DeChiara T.M., Efstratiadis A., and Robertson E.J. A growth-deficiency phenotype in heterozygous mice carrying an insulin-like growth factor II gene disrupted by targeting. Nature 345 6270 (1990) 78-80
    • (1990) Nature , vol.345 , Issue.6270 , pp. 78-80
    • DeChiara, T.M.1    Efstratiadis, A.2    Robertson, E.J.3
  • 18
    • 0029024277 scopus 로고
    • Disruption of imprinting caused by deletion of the H19 gene region in mice
    • Leighton P.A., Ingram R.S., Eggenschwiler J., et al. Disruption of imprinting caused by deletion of the H19 gene region in mice. Nature 375 6526 (1995) 34-39
    • (1995) Nature , vol.375 , Issue.6526 , pp. 34-39
    • Leighton, P.A.1    Ingram, R.S.2    Eggenschwiler, J.3
  • 19
    • 0025141183 scopus 로고
    • Pattern of the insulin-like growth factor II gene expression during early mouse embryogenesis
    • Lee J.E., Pintar J., and Efstratiadis A. Pattern of the insulin-like growth factor II gene expression during early mouse embryogenesis. Development 110 1 (1990) 151-159
    • (1990) Development , vol.110 , Issue.1 , pp. 151-159
    • Lee, J.E.1    Pintar, J.2    Efstratiadis, A.3
  • 20
    • 0031761362 scopus 로고    scopus 로고
    • Loss of imprinting in normal tissue of colorectal cancer patients with microsatellite instability
    • Cui H., Horon I.L., Ohlsson R., et al. Loss of imprinting in normal tissue of colorectal cancer patients with microsatellite instability. Nat Med 4 11 (1998) 1276-1280
    • (1998) Nat Med , vol.4 , Issue.11 , pp. 1276-1280
    • Cui, H.1    Horon, I.L.2    Ohlsson, R.3
  • 21
    • 0032541183 scopus 로고    scopus 로고
    • Post-translational processing of the insulin-like growth factor-2 precursor. Analysis of O-glycosylation and endoproteolysis
    • Duguay S.J., Jin Y., Stein J., et al. Post-translational processing of the insulin-like growth factor-2 precursor. Analysis of O-glycosylation and endoproteolysis. J Biol Chem 273 29 (1998) 18443-18451
    • (1998) J Biol Chem , vol.273 , Issue.29 , pp. 18443-18451
    • Duguay, S.J.1    Jin, Y.2    Stein, J.3
  • 22
    • 0035489468 scopus 로고    scopus 로고
    • PKB/AKT: functional insights from genetic models
    • Scheid M.P., and Woodgett J.R. PKB/AKT: functional insights from genetic models. Nat Rev Mol Cell Biol 2 10 (2001) 760-768
    • (2001) Nat Rev Mol Cell Biol , vol.2 , Issue.10 , pp. 760-768
    • Scheid, M.P.1    Woodgett, J.R.2
  • 23
    • 0028242350 scopus 로고
    • Evidence for a functional role of Shc proteins in mitogenic signaling induced by insulin, insulin-like growth factor-1, and epidermal growth factor
    • Sasaoka T., Rose D.W., Jhun B.H., et al. Evidence for a functional role of Shc proteins in mitogenic signaling induced by insulin, insulin-like growth factor-1, and epidermal growth factor. J Biol Chem 269 18 (1994) 13689-13694
    • (1994) J Biol Chem , vol.269 , Issue.18 , pp. 13689-13694
    • Sasaoka, T.1    Rose, D.W.2    Jhun, B.H.3
  • 24
    • 0141869078 scopus 로고    scopus 로고
    • The RAS signal transduction pathway and its role in radiation sensitivity
    • McKenna W.G., Muschel R.J., Gupta A.K., et al. The RAS signal transduction pathway and its role in radiation sensitivity. Oncogene 22 37 (2003) 5866-5875
    • (2003) Oncogene , vol.22 , Issue.37 , pp. 5866-5875
    • McKenna, W.G.1    Muschel, R.J.2    Gupta, A.K.3
  • 25
    • 0032827420 scopus 로고    scopus 로고
    • Multiple signaling pathways of the insulin-like growth factor 1 receptor in protection from apoptosis
    • Peruzzi F., Prisco M., Dews M., et al. Multiple signaling pathways of the insulin-like growth factor 1 receptor in protection from apoptosis. Mol Cell Biol 19 10 (1999) 7203-7215
    • (1999) Mol Cell Biol , vol.19 , Issue.10 , pp. 7203-7215
    • Peruzzi, F.1    Prisco, M.2    Dews, M.3
  • 26
    • 0030702123 scopus 로고    scopus 로고
    • Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery
    • Datta S.R., Dudek H., Tao X., et al. Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery. Cell 91 2 (1997) 231-241
    • (1997) Cell , vol.91 , Issue.2 , pp. 231-241
    • Datta, S.R.1    Dudek, H.2    Tao, X.3
  • 27
    • 0032493729 scopus 로고    scopus 로고
    • Role of glycogen synthase kinase-3 in the phosphatidylinositol 3-kinase/Akt cell survival pathway
    • Pap M., and Cooper G.M. Role of glycogen synthase kinase-3 in the phosphatidylinositol 3-kinase/Akt cell survival pathway. J Biol Chem 273 32 (1998) 19929-19932
    • (1998) J Biol Chem , vol.273 , Issue.32 , pp. 19929-19932
    • Pap, M.1    Cooper, G.M.2
  • 28
    • 0035949588 scopus 로고    scopus 로고
    • A phosphatidylinositol 3-kinase/Akt pathway promotes translocation of Mdm2 from the cytoplasm to the nucleus
    • Mayo L.D., and Donner D.B. A phosphatidylinositol 3-kinase/Akt pathway promotes translocation of Mdm2 from the cytoplasm to the nucleus. Proc Natl Acad Sci U S A 98 20 (2001) 11598-11603
    • (2001) Proc Natl Acad Sci U S A , vol.98 , Issue.20 , pp. 11598-11603
    • Mayo, L.D.1    Donner, D.B.2
  • 29
    • 26644449670 scopus 로고    scopus 로고
    • The BAD protein integrates survival signaling by EGFR/MAPK and PI3K/Akt kinase pathways in PTEN-deficient tumor cells
    • She Q.B., Solit D.B., Ye Q., et al. The BAD protein integrates survival signaling by EGFR/MAPK and PI3K/Akt kinase pathways in PTEN-deficient tumor cells. Cancer Cell 8 4 (2005) 287-297
    • (2005) Cancer Cell , vol.8 , Issue.4 , pp. 287-297
    • She, Q.B.1    Solit, D.B.2    Ye, Q.3
  • 30
    • 0036841293 scopus 로고    scopus 로고
    • Activation of Akt/protein kinase B overcomes a G(2)/m cell cycle checkpoint induced by DNA damage
    • Kandel E.S., Skeen J., Majewski N., et al. Activation of Akt/protein kinase B overcomes a G(2)/m cell cycle checkpoint induced by DNA damage. Mol Cell Biol 22 22 (2002) 7831-7841
    • (2002) Mol Cell Biol , vol.22 , Issue.22 , pp. 7831-7841
    • Kandel, E.S.1    Skeen, J.2    Majewski, N.3
  • 31
    • 0034845958 scopus 로고    scopus 로고
    • PKB/Akt: a key mediator of cell proliferation, survival and insulin responses?
    • Lawlor M.A., and Alessi D.R. PKB/Akt: a key mediator of cell proliferation, survival and insulin responses?. J Cell Sci 114 pt 16 (2001) 2903-2910
    • (2001) J Cell Sci , vol.114 , Issue.PART 16 , pp. 2903-2910
    • Lawlor, M.A.1    Alessi, D.R.2
  • 32
    • 0037134040 scopus 로고    scopus 로고
    • DNA repair pathway stimulated by the forkhead transcription factor FOXO3a through the Gadd45 protein
    • Tran H., Brunet A., Grenier J.M., et al. DNA repair pathway stimulated by the forkhead transcription factor FOXO3a through the Gadd45 protein. Science 296 5567 (2002) 530-534
    • (2002) Science , vol.296 , Issue.5567 , pp. 530-534
    • Tran, H.1    Brunet, A.2    Grenier, J.M.3
  • 33
    • 4544315354 scopus 로고    scopus 로고
    • New targets for therapy in breast cancer: mammalian target of rapamycin (mTOR) antagonists
    • Carraway H., and Hidalgo M. New targets for therapy in breast cancer: mammalian target of rapamycin (mTOR) antagonists. Breast Cancer Res 6 5 (2004) 219-224
    • (2004) Breast Cancer Res , vol.6 , Issue.5 , pp. 219-224
    • Carraway, H.1    Hidalgo, M.2
  • 34
    • 0041802820 scopus 로고    scopus 로고
    • Targeting mTOR signaling for cancer therapy
    • Huang S., and Houghton P.J. Targeting mTOR signaling for cancer therapy. Curr Opin Pharmacol 3 4 (2003) 371-377
    • (2003) Curr Opin Pharmacol , vol.3 , Issue.4 , pp. 371-377
    • Huang, S.1    Houghton, P.J.2
  • 35
    • 0033678447 scopus 로고    scopus 로고
    • Insulin-like growth factor I and the development of colorectal neoplasia in acromegaly
    • Jenkins P.J., Frajese V., Jones A.M., et al. Insulin-like growth factor I and the development of colorectal neoplasia in acromegaly. J Clin Endocrinol Metab 85 9 (2000) 3218-3221
    • (2000) J Clin Endocrinol Metab , vol.85 , Issue.9 , pp. 3218-3221
    • Jenkins, P.J.1    Frajese, V.2    Jones, A.M.3
  • 36
    • 0031062973 scopus 로고    scopus 로고
    • Beck-Wiedemann syndrome and Wilms' tumour
    • Ward A. Beck-Wiedemann syndrome and Wilms' tumour. Mol Hum Reprod 3 2 (1997) 157-168
    • (1997) Mol Hum Reprod , vol.3 , Issue.2 , pp. 157-168
    • Ward, A.1
  • 37
    • 0029031943 scopus 로고
    • Frequent loss of heterozygosity on 6q at the mannose 6-phosphate/insulin-like growth factor II receptor locus in human hepatocellular tumors
    • De Souza A.T., Hankins G.R., Washington M.K., et al. Frequent loss of heterozygosity on 6q at the mannose 6-phosphate/insulin-like growth factor II receptor locus in human hepatocellular tumors. Oncogene 10 9 (1995) 1725-1729
    • (1995) Oncogene , vol.10 , Issue.9 , pp. 1725-1729
    • De Souza, A.T.1    Hankins, G.R.2    Washington, M.K.3
  • 38
    • 0029934868 scopus 로고    scopus 로고
    • M6P/IGF2 receptor: a candidate breast tumor suppressor gene
    • Hankins G.R., De Souza A.T., Bentley R.C., et al. M6P/IGF2 receptor: a candidate breast tumor suppressor gene. Oncogene 12 9 (1996) 2003-2009
    • (1996) Oncogene , vol.12 , Issue.9 , pp. 2003-2009
    • Hankins, G.R.1    De Souza, A.T.2    Bentley, R.C.3
  • 39
    • 0024728211 scopus 로고
    • Significance of abnormal serum binding of insulin-like growth factor II in the development of hypoglycemia in patients with non-islet-cell tumors
    • Daughaday W.H., and Kapadia M. Significance of abnormal serum binding of insulin-like growth factor II in the development of hypoglycemia in patients with non-islet-cell tumors. Proc Natl Acad Sci U S A 86 17 (1989) 6778-6782
    • (1989) Proc Natl Acad Sci U S A , vol.86 , Issue.17 , pp. 6778-6782
    • Daughaday, W.H.1    Kapadia, M.2
  • 40
    • 34047246008 scopus 로고    scopus 로고
    • Mechanisms and management of non-islet cell tumour hypoglycaemia in gastrointestinal stromal tumour: case report and a review of published studies
    • Davda R., and Seddon B.M. Mechanisms and management of non-islet cell tumour hypoglycaemia in gastrointestinal stromal tumour: case report and a review of published studies. Clin Oncol (R Coll Radiol) 19 4 (2007) 265-268
    • (2007) Clin Oncol (R Coll Radiol) , vol.19 , Issue.4 , pp. 265-268
    • Davda, R.1    Seddon, B.M.2
  • 41
    • 0037168206 scopus 로고    scopus 로고
    • High incidence of medulloblastoma following X-ray-irradiation of newborn Ptc1 heterozygous mice
    • Pazzaglia S., Mancuso M., Atkinson M.J., et al. High incidence of medulloblastoma following X-ray-irradiation of newborn Ptc1 heterozygous mice. Oncogene 21 49 (2002) 7580-7584
    • (2002) Oncogene , vol.21 , Issue.49 , pp. 7580-7584
    • Pazzaglia, S.1    Mancuso, M.2    Atkinson, M.J.3
  • 42
    • 0026562404 scopus 로고
    • Multiple intestinal neoplasia caused by a mutation in the murine homolog of the APC gene
    • Su L.K., Kinzler K.W., Vogelstein B., et al. Multiple intestinal neoplasia caused by a mutation in the murine homolog of the APC gene. Science 256 5057 (1992) 668-670
    • (1992) Science , vol.256 , Issue.5057 , pp. 668-670
    • Su, L.K.1    Kinzler, K.W.2    Vogelstein, B.3
  • 43
    • 0034652480 scopus 로고    scopus 로고
    • Insulin-like growth factor II supply modifies growth of intestinal adenoma in Apc(Min/+) mice
    • Hassan A.B., and Howell J.A. Insulin-like growth factor II supply modifies growth of intestinal adenoma in Apc(Min/+) mice. Cancer Res 60 4 (2000) 1070-1076
    • (2000) Cancer Res , vol.60 , Issue.4 , pp. 1070-1076
    • Hassan, A.B.1    Howell, J.A.2
  • 44
    • 20144374299 scopus 로고    scopus 로고
    • Loss of imprinting of Igf2 alters intestinal maturation and tumorigenesis in mice
    • Sakatani T., Kaneda A., Iacobuzio-Donahue C.A., et al. Loss of imprinting of Igf2 alters intestinal maturation and tumorigenesis in mice. Science 307 5717 (2005) 1976-1978
    • (2005) Science , vol.307 , Issue.5717 , pp. 1976-1978
    • Sakatani, T.1    Kaneda, A.2    Iacobuzio-Donahue, C.A.3
  • 45
    • 33644506750 scopus 로고    scopus 로고
    • Soluble IGF2 receptor rescues Apc(Min/+) intestinal adenoma progression induced by Igf2 loss of imprinting
    • Harper J., Burns J.L., Foulstone E.J., et al. Soluble IGF2 receptor rescues Apc(Min/+) intestinal adenoma progression induced by Igf2 loss of imprinting. Cancer Res 66 4 (2006) 1940-1948
    • (2006) Cancer Res , vol.66 , Issue.4 , pp. 1940-1948
    • Harper, J.1    Burns, J.L.2    Foulstone, E.J.3
  • 46
    • 33847041527 scopus 로고    scopus 로고
    • Insulin-like growth factor-I receptor signaling blockade combined with radiation
    • Allen G.W., Saba C., Armstrong E.A., et al. Insulin-like growth factor-I receptor signaling blockade combined with radiation. Cancer Res 67 3 (2007) 1155-1162
    • (2007) Cancer Res , vol.67 , Issue.3 , pp. 1155-1162
    • Allen, G.W.1    Saba, C.2    Armstrong, E.A.3
  • 47
    • 0035556142 scopus 로고    scopus 로고
    • Tyrphostin AG 1024 modulates radiosensitivity in human breast cancer cells
    • Wen B., Deutsch E., Marangoni E., et al. Tyrphostin AG 1024 modulates radiosensitivity in human breast cancer cells. Br J Cancer 85 12 (2001) 2017-2021
    • (2001) Br J Cancer , vol.85 , Issue.12 , pp. 2017-2021
    • Wen, B.1    Deutsch, E.2    Marangoni, E.3
  • 48
    • 16944364325 scopus 로고    scopus 로고
    • Insulin-like growth factor-I receptor overexpression mediates cellular radioresistance and local breast cancer recurrence after lumpectomy and radiation
    • Turner B.C., Haffty B.G., Narayanan L., et al. Insulin-like growth factor-I receptor overexpression mediates cellular radioresistance and local breast cancer recurrence after lumpectomy and radiation. Cancer Res 57 15 (1997) 3079-3083
    • (1997) Cancer Res , vol.57 , Issue.15 , pp. 3079-3083
    • Turner, B.C.1    Haffty, B.G.2    Narayanan, L.3
  • 49
    • 0035811559 scopus 로고    scopus 로고
    • Downregulation of the type 1 insulin-like growth factor receptor in mouse melanoma cells is associated with enhanced radiosensitivity and impaired activation of Atm kinase
    • Macaulay V.M., Salisbury A.J., Bohula E.A., et al. Downregulation of the type 1 insulin-like growth factor receptor in mouse melanoma cells is associated with enhanced radiosensitivity and impaired activation of Atm kinase. Oncogene 20 30 (2001) 4029-4040
    • (2001) Oncogene , vol.20 , Issue.30 , pp. 4029-4040
    • Macaulay, V.M.1    Salisbury, A.J.2    Bohula, E.A.3
  • 50
    • 33947320145 scopus 로고    scopus 로고
    • Insulin-like growth factor type I biology and targeting in malignant gliomas
    • Trojan J., Cloix J.F., Ardourel M.Y., et al. Insulin-like growth factor type I biology and targeting in malignant gliomas. Neuroscience 145 3 (2007) 795-811
    • (2007) Neuroscience , vol.145 , Issue.3 , pp. 795-811
    • Trojan, J.1    Cloix, J.F.2    Ardourel, M.Y.3
  • 51
    • 0035872199 scopus 로고    scopus 로고
    • Akt/protein kinase B is constitutively active in non-small cell lung cancer cells and promotes cellular survival and resistance to chemotherapy and radiation
    • Brognard J., Clark A.S., Ni Y., et al. Akt/protein kinase B is constitutively active in non-small cell lung cancer cells and promotes cellular survival and resistance to chemotherapy and radiation. Cancer Res 61 10 (2001) 3986-3997
    • (2001) Cancer Res , vol.61 , Issue.10 , pp. 3986-3997
    • Brognard, J.1    Clark, A.S.2    Ni, Y.3
  • 52
    • 33745095268 scopus 로고    scopus 로고
    • Targeting the Akt/mammalian target of rapamycin pathway for radiosensitization of breast cancer
    • Albert J.M., Kim K.W., Cao C., et al. Targeting the Akt/mammalian target of rapamycin pathway for radiosensitization of breast cancer. Mol Cancer Ther 5 5 (2006) 1183-1189
    • (2006) Mol Cancer Ther , vol.5 , Issue.5 , pp. 1183-1189
    • Albert, J.M.1    Kim, K.W.2    Cao, C.3
  • 53
    • 0037470152 scopus 로고    scopus 로고
    • Redundancy of radioresistant signaling pathways originating from insulin-like growth factor I receptor
    • Yu D., Watanabe H., Shibuya H., et al. Redundancy of radioresistant signaling pathways originating from insulin-like growth factor I receptor. J Biol Chem 278 9 (2003) 6702-6709
    • (2003) J Biol Chem , vol.278 , Issue.9 , pp. 6702-6709
    • Yu, D.1    Watanabe, H.2    Shibuya, H.3
  • 54
    • 0142090803 scopus 로고    scopus 로고
    • Roles of the insulin-like growth factor I receptor C-terminus in cellular radioresistance
    • Yu D., Shibuya H., and Miura M. Roles of the insulin-like growth factor I receptor C-terminus in cellular radioresistance. Biochem Biophys Res Commun 311 1 (2003) 174-178
    • (2003) Biochem Biophys Res Commun , vol.311 , Issue.1 , pp. 174-178
    • Yu, D.1    Shibuya, H.2    Miura, M.3
  • 55
    • 0031586334 scopus 로고    scopus 로고
    • Effect of the insulin-like growth factor I receptor on ionizing radiation-induced cell death in mouse embryo fibroblasts
    • Nakamura S., Watanabe H., Miura M., et al. Effect of the insulin-like growth factor I receptor on ionizing radiation-induced cell death in mouse embryo fibroblasts. Exp Cell Res 235 1 (1997) 287-294
    • (1997) Exp Cell Res , vol.235 , Issue.1 , pp. 287-294
    • Nakamura, S.1    Watanabe, H.2    Miura, M.3
  • 56
    • 1642421788 scopus 로고    scopus 로고
    • The new kid on the block(ade) of the IGF-1 receptor
    • LeRoith D., and Helman L. The new kid on the block(ade) of the IGF-1 receptor. Cancer Cell 5 3 (2004) 201-202
    • (2004) Cancer Cell , vol.5 , Issue.3 , pp. 201-202
    • LeRoith, D.1    Helman, L.2
  • 57
    • 20244366701 scopus 로고    scopus 로고
    • Insulin-like growth factor I receptor blockade enhances chemotherapy and radiation responses and inhibits tumour growth in human gastric cancer xenografts
    • Min Y., Adachi Y., Yamamoto H., et al. Insulin-like growth factor I receptor blockade enhances chemotherapy and radiation responses and inhibits tumour growth in human gastric cancer xenografts. Gut 54 5 (2005) 591-600
    • (2005) Gut , vol.54 , Issue.5 , pp. 591-600
    • Min, Y.1    Adachi, Y.2    Yamamoto, H.3
  • 58
    • 0033531790 scopus 로고    scopus 로고
    • Diminished G1 checkpoint after gamma-irradiation and altered cell cycle regulation by insulin-like growth factor II overexpression
    • Zhang L., Kim M., Choi Y.H., et al. Diminished G1 checkpoint after gamma-irradiation and altered cell cycle regulation by insulin-like growth factor II overexpression. J Biol Chem 274 19 (1999) 13118-13126
    • (1999) J Biol Chem , vol.274 , Issue.19 , pp. 13118-13126
    • Zhang, L.1    Kim, M.2    Choi, Y.H.3
  • 59
    • 0034773185 scopus 로고    scopus 로고
    • Cell survival and proliferation are modified by insulin-like growth factor 2 between days 9 and 10 of mouse gestation
    • Burns J.L., and Hassan A.B. Cell survival and proliferation are modified by insulin-like growth factor 2 between days 9 and 10 of mouse gestation. Development 128 19 (2001) 3819-3830
    • (2001) Development , vol.128 , Issue.19 , pp. 3819-3830
    • Burns, J.L.1    Hassan, A.B.2
  • 60
    • 33746721468 scopus 로고    scopus 로고
    • Endogenous expression of phosphorylated histone H2AX in tumors in relation to DNA double-strand breaks and genomic instability
    • Yu T., MacPhail S.H., Banath J.P., et al. Endogenous expression of phosphorylated histone H2AX in tumors in relation to DNA double-strand breaks and genomic instability. DNA Repair (Amst) 5 8 (2006) 935-946
    • (2006) DNA Repair (Amst) , vol.5 , Issue.8 , pp. 935-946
    • Yu, T.1    MacPhail, S.H.2    Banath, J.P.3
  • 61
    • 0037402826 scopus 로고    scopus 로고
    • Radiation-induced second cancers: the impact of 3D-CRT and IMRT
    • Hall E.J., and Wuu C.S. Radiation-induced second cancers: the impact of 3D-CRT and IMRT. Int J Radiat Oncol Biol Phys 56 1 (2003) 83-88
    • (2003) Int J Radiat Oncol Biol Phys , vol.56 , Issue.1 , pp. 83-88
    • Hall, E.J.1    Wuu, C.S.2
  • 62
    • 34548018304 scopus 로고    scopus 로고
    • The insulin-like growth factor 1 receptor in cancer: old focus, new future
    • Hartog H., Wesseling J., Boezen H.M., et al. The insulin-like growth factor 1 receptor in cancer: old focus, new future. Eur J Cancer 43 13 (2007) 1895-1904
    • (2007) Eur J Cancer , vol.43 , Issue.13 , pp. 1895-1904
    • Hartog, H.1    Wesseling, J.2    Boezen, H.M.3
  • 63
    • 0035871490 scopus 로고    scopus 로고
    • Results of a pilot study involving the use of an antisense oligodeoxynucleotide directed against the insulin-like growth factor type I receptor in malignant astrocytomas
    • Andrews D.W., Resnicoff M., Flanders A.E., et al. Results of a pilot study involving the use of an antisense oligodeoxynucleotide directed against the insulin-like growth factor type I receptor in malignant astrocytomas. J Clin Oncol 19 8 (2001) 2189-2200
    • (2001) J Clin Oncol , vol.19 , Issue.8 , pp. 2189-2200
    • Andrews, D.W.1    Resnicoff, M.2    Flanders, A.E.3
  • 64
    • 23944439945 scopus 로고    scopus 로고
    • Phase II study of temsirolimus (CCI-779), a novel inhibitor of mTOR, in heavily pretreated patients with locally advanced or metastatic breast cancer
    • Chan S., Scheulen M.E., Johnston S., et al. Phase II study of temsirolimus (CCI-779), a novel inhibitor of mTOR, in heavily pretreated patients with locally advanced or metastatic breast cancer. J Clin Oncol 23 23 (2005) 5314-5322
    • (2005) J Clin Oncol , vol.23 , Issue.23 , pp. 5314-5322
    • Chan, S.1    Scheulen, M.E.2    Johnston, S.3
  • 65
    • 13944269599 scopus 로고    scopus 로고
    • Combination therapy of inhibitors of epidermal growth factor receptor/vascular endothelial growth factor receptor 2 (AEE788) and the mammalian target of rapamycin (RAD001) offers improved glioblastoma tumor growth inhibition
    • Goudar R.K., Shi Q., Hjelmeland M.D., et al. Combination therapy of inhibitors of epidermal growth factor receptor/vascular endothelial growth factor receptor 2 (AEE788) and the mammalian target of rapamycin (RAD001) offers improved glioblastoma tumor growth inhibition. Mol Cancer Ther 4 1 (2005) 101-112
    • (2005) Mol Cancer Ther , vol.4 , Issue.1 , pp. 101-112
    • Goudar, R.K.1    Shi, Q.2    Hjelmeland, M.D.3
  • 66
    • 33847353816 scopus 로고    scopus 로고
    • Functional evaluation of novel soluble insulin-like growth factor (IGF)-II-specific ligand traps based on modified domain 11 of the human IGF2 receptor
    • Prince S.N., Foulstone E.J., Zaccheo O.J., et al. Functional evaluation of novel soluble insulin-like growth factor (IGF)-II-specific ligand traps based on modified domain 11 of the human IGF2 receptor. Mol Cancer Ther 6 2 (2007) 607-617
    • (2007) Mol Cancer Ther , vol.6 , Issue.2 , pp. 607-617
    • Prince, S.N.1    Foulstone, E.J.2    Zaccheo, O.J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.