Roles of the insulin-like growth factor I receptor C-terminus in cellular radioresistance

Biochemical and Biophysical Research Communications

Volumn 311, Issue 1, 2003, Pages 174-178

  Yu, Dong ^a   Shibuya, Hitoshi ^a   Miura, Masahiko ^a  

^a TOKYO MEDICAL AND DENTAL UNIVERSITY   (Japan)

Author keywords

Insulin like growth factor I receptor; Mitogen activated protein kinase; Mutational analysis; Phosphatidylinositol 3 kinase; Radioresistance; Survival signal

Indexed keywords

MITOGEN ACTIVATED PROTEIN KINASE; MUTANT PROTEIN; PHOSPHATIDYLINOSITOL 3 KINASE; SOMATOMEDIN C RECEPTOR;

AMINO ACID SEQUENCE; ANIMAL CELL; ARTICLE; CARBOXY TERMINAL SEQUENCE; CELL ACTIVITY; CELL MUTANT; CELL SURVIVAL; CONTROLLED STUDY; EMBRYO; GENE EXPRESSION; INSULIN DEFICIENCY; MOUSE; MUTATIONAL ANALYSIS; NONHUMAN; POINT MUTATION; PREDICTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; RADIOSENSITIVITY; SIGNAL TRANSDUCTION;

EID: 0142090803     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbrc.2003.09.195     Document Type: Article

References (18)

1. Harrington E.A., Bennett M.R., Fanidi A., Evan G.I. c-Myc-induced apoptosis in fibroblasts is inhibited by specific cytokines. EMBO J. 13:1994;3286-3295.
2. O'Connor R., Kauffmann-Zeh A., Liu Y., Lehar S., Evan G.I., Baserga R., Blattler W.A. Identification of domains of the insulin-like growth factor I receptor that are required for protection from apoptosis. Mol. Cell Biol. 17:1997;427-435.
3. Turner B.C., Haffty B.G., Narayanan L., Yuan J., Havre P.A., Gumbs A.A., Kaplan L., Burgaud J.L., Carter D., Baserga R., Glazer P.M. Insulin-like growth factor I receptor overexpression mediates cellular radioresistance and local breast cancer recurrence after lumpectomy and radiation. Cancer Res. 57:1997;3079-3083.
4. Macaulay V.M., Salisbury A.J., Bohula E.A., Playford M.P., Smorodinsky N.I., Shiloh Y. Downregulation of the type 1 insulin-like growth factor in mouse melanoma cells is associated with enhanced radiosensitivity and impaired activation of Atm kinase. Oncogene. 20:2001;4029-4040.
5. Tezuka M., Watanabe H., Nakamura S., Yu D., Aung W., Sasaki T., Shibuya H., Miura M. Anti-apoptotic activity is dispensable for insulin-like growth factor I receptor-mediated clonogenic radioresistance after. γ -irradiation Clin. Cancer Res. 7:2001;3206-3214.
6. Peruzzi F., Prisco M., Dews M., Salomoni P., Grassilli E., Romano G., Calabretta B., Baserga R. Multiple signaling pathways of the insulin-like growth factor 1 receptor in protection from apoptosis. Mol. Cell Biol. 19:1999;7203-7215.
7. Peruzzi F., Prisco M., Morrione A., Valentinis B., Baserga R. Anti-apoptotic signaling of the insulin-like growth factor-I receptor through mitochondrial translocation of c-Raf and Nedd4. J. Biol. Chem. 276:2001;25990-25996.
8. Yu D., Watanabe H., Shibuya H., Miura M. Redundancy of radioresistant signaling pathways originating from insulin-like growth factor I receptor. J. Biol. Chem. 278:2003;6702-6709.
9. Ullrich A., Gray A., Tam A.W., Yang-Feng T., Tsubokawa M., Collins C., Henzel W., le Bon T., Kahuria S., Chen E., Jakobs S., Francke U., Ramachandran J., Fujita-Yamaguchi Y. Insulin-like growth factor I receptor primary structure: comparison with insulin receptor suggests structural determinants that define functional specificity. EMBO J. 5:1986;2503-2512.
10. Miura M., Surmacz E., Burgaud J.L., Baserga R. Different effects on mitogenesis and transformation of a mutation at tyrosine 1251 of the insulin-like growth factor I receptor. J. Biol. Chem. 270:1995;22639-22644.
11. Hongo A., D' Ambrosio C., Miura M., Morrione A., Baserga R. Mutational analysis of the mitogenic and transforming activities of the insulin-like growth factor I receptor. Oncogene. 12:1996;1231-1238.
12. Liu Y., Lehar S., Corvi C., Payne G., O'Connor R. Expression of the insulin-like growth factor I receptor C terminus as a myristylated protein leads to induction of apoptosis in tumor cells. Cancer Res. 58:1998;570-576.
13. Hongo A., Yumet G., Resnicoff M., Romano G., O'Connor R., Baserga R. Inhibition of tumorigenesis and induction of apoptosis in human tumor cells by the stable expression of a myristylated COOH terminus of the insulin-like growth factor I receptor. Cancer Res. 58:1998;2477-2484.
14. Girinsky T., Lubin R., Pignon J.P., Chavaudra N., Gazeau J., Dubray B., Cosset J.M., Socie G., Fertil B. Predictive value of in vitro radiosensitivity parameters in head and neck cancers and cervical carcinomas: preliminary correlations with local control and overall survival. Int. J. Radiat. Oncol. Biol. Phys. 25:1992;3-7.
15. Lammering G., Valerie K., Lin P.S., Mikkelsen R.B., Contessa J.N., Feden J.P., Farnsworth J., Dent P., Schmidt-Ullrich R. Radiosensitization of malignant glioma cells through overexpression of dominant-negative epidermal growth factor receptor. Clin. Cancer Res. 7:2001;682-690.
16. Harari P.M., Huang S.-M. Head and neck cancer as a clinical model for molecular targeting of therapy: combining EGFR blockade with radiation. Int. J. Radit. Oncol. Biol. Phys. 49:2001;427-433.
17. Merrill M.J., Edwards N.A. Insulin-like growth factor-I receptors in human glial tumors. J. Clin. Endocrinol. Metab. 70:1990;199-209.
18. LeRoith D., Baserga R., Helman L., Roberts C.T. Jr. Insulin-like growth factors and cancer. Ann. Intern. Med. 122:1995;54-59.