메뉴 건너뛰기




Volumn 205, Issue 2, 2005, Pages 145-153

Insulin-like growth factor ligands, receptors, and binding proteins in cancer

Author keywords

Cancer models; Cancer therapy; Insulin like growth factor binding proteins; Insulin like growth factor I; Insulin like growth factor I receptor; Insulin like growth factor II; Insulin like growth factor II receptor

Indexed keywords

INSULIN RECEPTOR SUBSTRATE 1; INSULIN RECEPTOR SUBSTRATE 2; MAMMALIAN TARGET OF RAPAMYCIN; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROTEIN KINASE B; PROTEIN KINASE INHIBITOR; RAPAMYCIN; RAS PROTEIN; SOMATOMEDIN; SOMATOMEDIN B; SOMATOMEDIN B RECEPTOR; SOMATOMEDIN BINDING PROTEIN; SOMATOMEDIN C; SOMATOMEDIN C RECEPTOR; TRANSCRIPTION FACTOR;

EID: 13644262798     PISSN: 00223417     EISSN: None     Source Type: Journal    
DOI: 10.1002/path.1712     Document Type: Review
Times cited : (223)

References (76)
  • 1
    • 0038398622 scopus 로고    scopus 로고
    • The insulin-like growth factor system and cancer
    • LeRoith D, Roberts CT Jr. The insulin-like growth factor system and cancer. Cancer Lett 2003; 195: 127-137.
    • (2003) Cancer Lett. , vol.195 , pp. 127-137
    • LeRoith, D.1    Roberts Jr., C.T.2
  • 3
    • 0032565746 scopus 로고    scopus 로고
    • Role of insulin-like growth factor binding proteins in controlling IGF actions
    • Clemmons DR. Role of insulin-like growth factor binding proteins in controlling IGF actions. Mol Cell Endocrinol 1998; 140: 19-24.
    • (1998) Mol. Cell Endocrinol. , vol.140 , pp. 19-24
    • Clemmons, D.R.1
  • 4
    • 0037222313 scopus 로고    scopus 로고
    • Keys to the hidden treasures of the mannose 6-phosphate/insulin-like growth factor 2 receptor
    • Hassan AB. Keys to the hidden treasures of the mannose 6-phosphate/insulin-like growth factor 2 receptor. Am J Pathol 2003; 162: 3-6.
    • (2003) Am. J. Pathol. , vol.162 , pp. 3-6
    • Hassan, A.B.1
  • 5
    • 0041802820 scopus 로고    scopus 로고
    • Targeting mTOR signaling for cancer therapy
    • Huang S, Houghton PJ. Targeting mTOR signaling for cancer therapy. Curr Op Pharm 2003; 3: 371-377.
    • (2003) Curr. Op. Pharm. , vol.3 , pp. 371-377
    • Huang, S.1    Houghton, P.J.2
  • 6
    • 2542582263 scopus 로고    scopus 로고
    • The role of the M6P/IGF-II receptor in cancer: Tumor suppression or garbage disposal?
    • Scott CD, Firth SM. The role of the M6P/IGF-II receptor in cancer: tumor suppression or garbage disposal? Horm Metab Res 2004; 36: 261-271.
    • (2004) Horm. Metab. Res. , vol.36 , pp. 261-271
    • Scott, C.D.1    Firth, S.M.2
  • 7
    • 0029948828 scopus 로고    scopus 로고
    • Involvement of IGF-II in human cancer
    • Toretsky JA, Helman LJ. Involvement of IGF-II in human cancer. J Endocrinol 1996; 149: 367-372.
    • (1996) J. Endocrinol. , vol.149 , pp. 367-372
    • Toretsky, J.A.1    Helman, L.J.2
  • 8
    • 0036439523 scopus 로고    scopus 로고
    • Regulatory principles of developmental signaling
    • Freeman M, Gurdon JB. Regulatory principles of developmental signaling. Annu Rev Cell Dev Biol 2002; 18: 515-539.
    • (2002) Annu. Rev. Cell Dev. Biol. , vol.18 , pp. 515-539
    • Freeman, M.1    Gurdon, J.B.2
  • 9
    • 0034877139 scopus 로고    scopus 로고
    • Specificity in ligand binding and intracellular signalling by insulin and insulin-like growth factor receptors
    • Siddle K, Urso B, Niesler CA, et al. Specificity in ligand binding and intracellular signalling by insulin and insulin-like growth factor receptors. Biochem Soc Trans 2001; 29: 513-525.
    • (2001) Biochem. Soc. Trans. , vol.29 , pp. 513-525
    • Siddle, K.1    Urso, B.2    Niesler, C.A.3
  • 10
    • 0027423419 scopus 로고
    • Role of insulin-like growth factors in embryonic and postnatal growth
    • Baker J, Liu JP, Robertson EJ, Efstratiadis A. Role of insulin-like growth factors in embryonic and postnatal growth. Cell 1993; 75: 73-82.
    • (1993) Cell , vol.75 , pp. 73-82
    • Baker, J.1    Liu, J.P.2    Robertson, E.J.3    Efstratiadis, A.4
  • 11
    • 0037323903 scopus 로고    scopus 로고
    • Regulation of cell survival and proliferation by the FOXO (Forkhead box, class 0) subfamily of Forkhead transcription factors
    • Birkenkamp KU, Coffer PJ. Regulation of cell survival and proliferation by the FOXO (Forkhead box, class 0) subfamily of Forkhead transcription factors. Biochem Soc Trans 2003; 31: 292-297.
    • (2003) Biochem. Soc. Trans. , vol.31 , pp. 292-297
    • Birkenkamp, K.U.1    Coffer, P.J.2
  • 12
    • 2342496712 scopus 로고    scopus 로고
    • FOXOs at the crossroads of cellular metabolism, differentiation, and transformation
    • Accili D, Arden KC. FOXOs at the crossroads of cellular metabolism, differentiation, and transformation. Cell 2004; 117 421-426.
    • (2004) Cell , vol.117 , pp. 421-426
    • Accili, D.1    Arden, K.C.2
  • 13
    • 0042092531 scopus 로고    scopus 로고
    • Genes that act downstream of DAF-16 to influence the lifespan of Caenorhabditis elegans
    • Murphy CT, McCarroll SA, Bargmann CI, et al. Genes that act downstream of DAF-16 to influence the lifespan of Caenorhabditis elegans. Nature 2003; 424: 277-283.
    • (2003) Nature , vol.424 , pp. 277-283
    • Murphy, C.T.1    McCarroll, S.A.2    Bargmann, C.I.3
  • 14
    • 1642332084 scopus 로고    scopus 로고
    • Integration of Smad and forkhead pathways in the control of neuroepithelial and glioblastoma cell proliferation
    • Seoane J, Le H-V, Shen L, Anderson SA, Massague J. Integration of Smad and forkhead pathways in the control of neuroepithelial and glioblastoma cell proliferation. Cell 2004; 117: 211-223.
    • (2004) Cell , vol.117 , pp. 211-223
    • Seoane, J.1    Le, H.-V.2    Shen, L.3    Anderson, S.A.4    Massague, J.5
  • 15
    • 11144357466 scopus 로고    scopus 로고
    • IkappaB kinase promotes tumorigenesis through inhibition of forkhead FOXO3a
    • Hu MC, Lee DF, Xia W, et al. IkappaB kinase promotes tumorigenesis through inhibition of forkhead FOXO3a. Cell 2004; 117: 225-237.
    • (2004) Cell , vol.117 , pp. 225-237
    • Hu, M.C.1    Lee, D.F.2    Xia, W.3
  • 16
    • 0035898613 scopus 로고    scopus 로고
    • The interaction of insulin-like growth factor-I with N-terminal domain of IGFBP-5
    • Zeslawski W, Beisel H-G, Kamionka M, et al. The interaction of insulin-like growth factor-I with N-terminal domain of IGFBP-5. EMBO J 2001; 20: 3638-3644.
    • (2001) EMBO J. , vol.20 , pp. 3638-3644
    • Zeslawski, W.1    Beisel, H.-G.2    Kamionka, M.3
  • 17
    • 0035185571 scopus 로고    scopus 로고
    • Structure and autoregulation of the insulin-like growth factor 1 receptor kinase
    • Favelyukis S, Hill JH, Hubbard SR, Miller WT. Structure and autoregulation of the insulin-like growth factor 1 receptor kinase. Nature Struct Biol 2001; 8: 1058-1063.
    • (2001) Nature Struct. Biol. , vol.8 , pp. 1058-1063
    • Favelyukis, S.1    Hill, J.H.2    Hubbard, S.R.3    Miller, W.T.4
  • 18
    • 2342551975 scopus 로고    scopus 로고
    • Mapping of the insulin-like growth factor II binding site of the type I insulin-like growth factor receptor by alanine scanning mutagenesis
    • Sorensen H, Whittaker L, Hinrichsen J, Groth A, Whittaker J. Mapping of the insulin-like growth factor II binding site of the type I insulin-like growth factor receptor by alanine scanning mutagenesis. FEBS Lett 2004; 565: 19-22.
    • (2004) FEBS Lett. , vol.565 , pp. 19-22
    • Sorensen, H.1    Whittaker, L.2    Hinrichsen, J.3    Groth, A.4    Whittaker, J.5
  • 20
    • 0034845958 scopus 로고    scopus 로고
    • PKB/Akt; a key mediator of cell proliferation, survival, and insulin responses?
    • Lawlor MA, Alessi DR. PKB/Akt; a key mediator of cell proliferation, survival, and insulin responses? J Cell Sci 2001; 114: 2903-2910.
    • (2001) J. Cell Sci. , vol.114 , pp. 2903-2910
    • Lawlor, M.A.1    Alessi, D.R.2
  • 21
    • 2542423752 scopus 로고    scopus 로고
    • Grb10 exceeding the boundaries of a common signaling adapter
    • Riedel H. Grb10 exceeding the boundaries of a common signaling adapter. Front Biosci 2004; 9: 603-618.
    • (2004) Front Biosci. , vol.9 , pp. 603-618
    • Riedel, H.1
  • 23
    • 5044227353 scopus 로고    scopus 로고
    • Structural determinants for high affinity binding of IGF-II to IR-A, the exon 11 minus isoform of the insulin receptor
    • Denley A, Bonython ER, Booker GW, et al. Structural determinants for high affinity binding of IGF-II to IR-A, the exon 11 minus isoform of the insulin receptor Mol. Endocrinol 2004; 18 2502-2512.
    • (2004) Mol. Endocrinol. , vol.18 , pp. 2502-2512
    • Denley, A.1    Bonython, E.R.2    Booker, G.W.3
  • 24
    • 0036905115 scopus 로고    scopus 로고
    • Cellular actions of the insulin-like growth factor binding proteins
    • Firth SM, Baxter RC. Cellular actions of the insulin-like growth factor binding proteins. Endocrine Rev 2002; 23: 824-854.
    • (2002) Endocrine Rev. , vol.23 , pp. 824-854
    • Firth, S.M.1    Baxter, R.C.2
  • 25
    • 0038070060 scopus 로고    scopus 로고
    • Insulin-like growth factor binding protein proteolysis
    • Bunn RC, Fowlkes JL. Insulin-like growth factor binding protein proteolysis. Trends Endocrinol Metab 2003; 14: 176-181.
    • (2003) Trends Endocrinol. Metab. , vol.14 , pp. 176-181
    • Bunn, R.C.1    Fowlkes, J.L.2
  • 26
    • 0033734689 scopus 로고    scopus 로고
    • Selective alterations in organ sizes in mice with a targeted disruption of the insulin-like growth factor binding protein-2 gene
    • Wood TL, Rogler LE, Czick ME, Schuller AGP, Pintar JE. Selective alterations in organ sizes in mice with a targeted disruption of the insulin-like growth factor binding protein-2 gene. Mol Endocrinol 2000; 14: 1472-1482.
    • (2000) Mol. Endocrinol. , vol.14 , pp. 1472-1482
    • Wood, T.L.1    Rogler, L.E.2    Czick, M.E.3    Schuller, A.G.P.4    Pintar, J.E.5
  • 27
    • 0035049816 scopus 로고    scopus 로고
    • Growth inhibition in giant growth hormone transgenic mice by over-expression of insulin-like growth factor binding protein-2
    • Hoflich A, Nedbal S, Blum WF, et al. Growth inhibition in giant growth hormone transgenic mice by over-expression of insulin-like growth factor binding protein-2. Endocrinology 2001; 142: 1889-1898.
    • (2001) Endocrinology , vol.142 , pp. 1889-1898
    • Hoflich, A.1    Nedbal, S.2    Blum, W.F.3
  • 28
    • 0033598169 scopus 로고    scopus 로고
    • Insulin-like growth factor II signaling in neoplastic proliferation is blocked by transgenic expression of the metalloproteinase inhibitor TIMP-1
    • Martin DC, Fowlkes JL, Babic B, Khokha R. Insulin-like growth factor II signaling in neoplastic proliferation is blocked by transgenic expression of the metalloproteinase inhibitor TIMP-1. J Cell Biol 1999; 146: 881-892.
    • (1999) J. Cell Biol. , vol.146 , pp. 881-892
    • Martin, D.C.1    Fowlkes, J.L.2    Babic, B.3    Khokha, R.4
  • 29
    • 0029946896 scopus 로고    scopus 로고
    • Involution of the lactating mammary gland is inhibited by the IGF system in a transgenic mouse model
    • Neuenschwander S, Scwartz A, Wood TL, Roberts CT, Henninghausen L. Involution of the lactating mammary gland is inhibited by the IGF system in a transgenic mouse model. J Clin Invest 1996; 97: 2225-2232.
    • (1996) J. Clin. Invest. , vol.97 , pp. 2225-2232
    • Neuenschwander, S.1    Scwartz, A.2    Wood, T.L.3    Roberts, C.T.4    Henninghausen, L.5
  • 30
    • 0035968216 scopus 로고    scopus 로고
    • Real time kinetics of insulin-like growth factor II (IGF-II) interaction with the IGF-II/mannose 6-phosphate receptor: The effects of domain 13 and pH
    • Linnell J, Groeger G, Hassan AB. Real time kinetics of insulin-like growth factor II (IGF-II) interaction with the IGF-II/mannose 6-phosphate receptor: the effects of domain 13 and pH. J Biol Chem 2001; 276: 23 986-23 991.
    • (2001) J. Biol. Chem. , vol.276 , pp. 23986-23991
    • Linnell, J.1    Groeger, G.2    Hassan, A.B.3
  • 31
    • 0036499988 scopus 로고    scopus 로고
    • Structure of a functional IGF2R fragment determined from the anomalous scattering of sulfur
    • Brown J, Esnouf RM, Jones MA, et al. Structure of a functional IGF2R fragment determined from the anomalous scattering of sulfur. EMBO J 2002; 21: 1054-1062.
    • (2002) EMBO J. , vol.21 , pp. 1054-1062
    • Brown, J.1    Esnouf, R.M.2    Jones, M.A.3
  • 32
    • 0029969904 scopus 로고    scopus 로고
    • Truncated forms of the insulin-like growth factor II (IGF-II)/mannose 6-phosphate receptor encompassing the IGF-II binding site: Characterization of a point mutation that abolishes IGF-II binding
    • Garmroudi F, Devi G, Slentz DH, Schaffer BS, MacDonald RG. Truncated forms of the insulin-like growth factor II (IGF-II)/mannose 6-phosphate receptor encompassing the IGF-II binding site: characterization of a point mutation that abolishes IGF-II binding. Mol-Endocrinol 1996; 10: 642-651.
    • (1996) Mol-Endocrinol. , vol.10 , pp. 642-651
    • Garmroudi, F.1    Devi, G.2    Slentz, D.H.3    Schaffer, B.S.4    MacDonald, R.G.5
  • 33
    • 0025320906 scopus 로고
    • A growth-deficiency phenotype in heterozygous mice carrying an insulin-like growth factor II gene disrupted by targeting
    • DeChiara TM, Efstratiadis A, Robertson EJ. A growth-deficiency phenotype in heterozygous mice carrying an insulin-like growth factor II gene disrupted by targeting. Nature 1990; 345 78-80.
    • (1990) Nature , vol.345 , pp. 78-80
    • DeChiara, T.M.1    Efstratiadis, A.2    Robertson, E.J.3
  • 34
    • 0028575985 scopus 로고
    • Loss of the imprinted IGF2/cation-independent mannose 6-phosphate receptor results in fetal overgrowth and perinatal lethality
    • Lau MM, Stewart CE, Liu Z, Bhatt H, Rotwein P, Stewart CL. Loss of the imprinted IGF2/cation-independent mannose 6-phosphate receptor results in fetal overgrowth and perinatal lethality. Genes Dev 1994; 8: 2953-2963.
    • (1994) Genes Dev. , vol.8 , pp. 2953-2963
    • Lau, M.M.1    Stewart, C.E.2    Liu, Z.3    Bhatt, H.4    Rotwein, P.5    Stewart, C.L.6
  • 35
    • 0029024277 scopus 로고
    • Disruption of imprinting caused by deletion of the H19 gene region in mice
    • [see comments]
    • Leighton PA, Ingram RS, Eggenschwiler J, Efstratiadis A, Tilghman SM. Disruption of imprinting caused by deletion of the H19 gene region in mice [see comments]. Nature 1995; 375: 34-39.
    • (1995) Nature , vol.375 , pp. 34-39
    • Leighton, P.A.1    Ingram, R.S.2    Eggenschwiler, J.3    Efstratiadis, A.4    Tilghman, S.M.5
  • 36
    • 0027496895 scopus 로고
    • Mice carrying null mutations of the genes encoding insulin-like growth factor I (Igf-1) and type 1 IGF receptor (Igf1r)
    • Liu JP, Baker J, Perkins AS, Robertson EJ, Efstratiadis A. Mice carrying null mutations of the genes encoding insulin-like growth factor I (Igf-1) and type 1 IGF receptor (Igf1r). Cell 1993; 75 59-72.
    • (1993) Cell , vol.75 , pp. 59-72
    • Liu, J.P.1    Baker, J.2    Perkins, A.S.3    Robertson, E.J.4    Efstratiadis, A.5
  • 37
    • 1642311220 scopus 로고    scopus 로고
    • Metalloproteinase pregnancy-associated plasma protein A is a critical growth regulatory factor during fetal development
    • Conover CA, Bale LK, Overgaard MT, et al. Metalloproteinase pregnancy-associated plasma protein A is a critical growth regulatory factor during fetal development. Development 2003; 131: 1187-1194.
    • (2003) Development , vol.131 , pp. 1187-1194
    • Conover, C.A.1    Bale, L.K.2    Overgaard, M.T.3
  • 38
    • 0034652480 scopus 로고    scopus 로고
    • Insulin-like growth factor II supply modifies growth of intestinal adenoma in Apc(Min/+) mice
    • Hassan AB, Howell JA. Insulin-like growth factor II supply modifies growth of intestinal adenoma in Apc(Min/+) mice. Cancer Res 2000; 60: 1070-1076.
    • (2000) Cancer Res. , vol.60 , pp. 1070-1076
    • Hassan, A.B.1    Howell, J.A.2
  • 39
    • 0036559535 scopus 로고    scopus 로고
    • Elevated levels of the IGF-I receptor convey invasive and metastatic capability in a mouse model of pancreatic islet tumourigenesis
    • Lopez T, Hanahan D. Elevated levels of the IGF-I receptor convey invasive and metastatic capability in a mouse model of pancreatic islet tumourigenesis. Cancer Cell 2002; 1: 339-353.
    • (2002) Cancer Cell , vol.1 , pp. 339-353
    • Lopez, T.1    Hanahan, D.2
  • 40
    • 0034665975 scopus 로고    scopus 로고
    • Patched target Igf2 is indispensable for the formation of medulloblastoma and rhabdomyosarcoma
    • Hahn H, Wojnowski L, Specht K, et al. Patched target Igf2 is indispensable for the formation of medulloblastoma and rhabdomyosarcoma. J Biol Chem 2000; 275: 28 341-28 344.
    • (2000) J. Biol. Chem. , vol.275 , pp. 28341-28344
    • Hahn, H.1    Wojnowski, L.2    Specht, K.3
  • 41
    • 0029006470 scopus 로고
    • Deregulation of both imprinted and expressed alleles of the insulin-like growth factor 2 gene during beta-cell tumorigenesis
    • Christofori G, Naik P, Hanahan D. Deregulation of both imprinted and expressed alleles of the insulin-like growth factor 2 gene during beta-cell tumorigenesis. Nature Genet 1995; 10: 196-201.
    • (1995) Nature Genet. , vol.10 , pp. 196-201
    • Christofori, G.1    Naik, P.2    Hanahan, D.3
  • 42
    • 0028356419 scopus 로고
    • A second signal supplied by insulin-like growth factor II in oncogene-induced tumorigenesis
    • Christofori G, Naik P, Hanahan D. A second signal supplied by insulin-like growth factor II in oncogene-induced tumorigenesis. Nature 1994; 369: 414-418.
    • (1994) Nature , vol.369 , pp. 414-418
    • Christofori, G.1    Naik, P.2    Hanahan, D.3
  • 43
    • 0030871047 scopus 로고    scopus 로고
    • Genomic imprinting and Igf2 influence liver tumorigenesis and loss of heterozygosity in SV40 T antigen transgenic mice
    • Haddad R, Held WA. Genomic imprinting and Igf2 influence liver tumorigenesis and loss of heterozygosity in SV40 T antigen transgenic mice. Cancer Res 1997; 57: 4615-4623.
    • (1997) Cancer Res. , vol.57 , pp. 4615-4623
    • Haddad, R.1    Held, W.A.2
  • 44
    • 0036018897 scopus 로고    scopus 로고
    • The insulin-like growth factor system as a therapeutic target in colorectal cancer
    • Hassan AB, Macaulay VM. The insulin-like growth factor system as a therapeutic target in colorectal cancer. Ann Oncol 2002; 13 349-356.
    • (2002) Ann. Oncol. , vol.13 , pp. 349-356
    • Hassan, A.B.1    Macaulay, V.M.2
  • 45
    • 0028332092 scopus 로고
    • Effect of a null mutation of the insulin-like growth factor I receptor gene on growth and transformation of mouse embryonic fibroblasts
    • Sell C, Dumenil G, Deveaud C, et al. Effect of a null mutation of the insulin-like growth factor I receptor gene on growth and transformation of mouse embryonic fibroblasts. Mol Cell Biol 1994; 14: 3604-3612.
    • (1994) Mol. Cell Biol. , vol.14 , pp. 3604-3612
    • Sell, C.1    Dumenil, G.2    Deveaud, C.3
  • 46
    • 0027366338 scopus 로고
    • Simian virus 40 large tumour antigen is unable to transform mouse embryonic fibroblasts lacking type I insulin-like growth factor receptor
    • Sell C, Rubini M, Rubin R, Liu JP, Efstratiadis A, Baserga R. Simian virus 40 large tumour antigen is unable to transform mouse embryonic fibroblasts lacking type I insulin-like growth factor receptor. Proc Natl Acad Sci U S A 1993; 90: 11 217-11 221.
    • (1993) Proc. Natl. Acad. Sci. U. S. A. , vol.90 , pp. 11217-11221
    • Sell, C.1    Rubini, M.2    Rubin, R.3    Liu, J.P.4    Efstratiadis, A.5    Baserga, R.6
  • 47
    • 0028068826 scopus 로고
    • The insulin-like growth factor I receptor is the target for the 15q26 amplicon in breast cancer
    • Almeida A, Muleris M, Dutrillaux B, Malloy B. The insulin-like growth factor I receptor is the target for the 15q26 amplicon in breast cancer. Genes Chromosomes Cancer 1994; 11: 63-65.
    • (1994) Genes Chromosomes Cancer , vol.11 , pp. 63-65
    • Almeida, A.1    Muleris, M.2    Dutrillaux, B.3    Malloy, B.4
  • 48
    • 0037092971 scopus 로고    scopus 로고
    • Expression of the type 1 insulin-like growth factor receptor is up-regulated in primary prostate cancer and commonly persists in metastatic disease
    • Hellawell GO, Turner GD, Davies DR, Poulsom R, Brewster SF, Macaulay VM. Expression of the type 1 insulin-like growth factor receptor is up-regulated in primary prostate cancer and commonly persists in metastatic disease. Cancer Res 2002; 62: 2942-2950.
    • (2002) Cancer Res. , vol.62 , pp. 2942-2950
    • Hellawell, G.O.1    Turner, G.D.2    Davies, D.R.3    Poulsom, R.4    Brewster, S.F.5    Macaulay, V.M.6
  • 49
    • 12144290914 scopus 로고    scopus 로고
    • Inhibition of the insulin-like growth factor receptor 1 tyrosine kinase activity as a therapeutic strategy for multiple myeloma, other hematologic malignancies and solid tumours
    • Mitsiades CS, Mitsiades NS, McMullan CJ, et al. Inhibition of the insulin-like growth factor receptor 1 tyrosine kinase activity as a therapeutic strategy for multiple myeloma, other hematologic malignancies and solid tumours. Cancer Cell 2004; 5 221-230.
    • (2004) Cancer Cell , vol.5 , pp. 221-230
    • Mitsiades, C.S.1    Mitsiades, N.S.2    McMullan, C.J.3
  • 50
    • 0029031943 scopus 로고
    • Frequent loss of heterozygosity on 6q at the mannose 6-phosphate/insulin-like growth factor II receptor locus in human hepatocellular tumors
    • De Souza AT, Hankins GR, Washington MK, Fine RL, Orton TC, Jirtle RL. Frequent loss of heterozygosity on 6q at the mannose 6-phosphate/insulin-like growth factor II receptor locus in human hepatocellular tumors. Oncogene 1995; 10: 1725-1729.
    • (1995) Oncogene , vol.10 , pp. 1725-1729
    • De Souza, A.T.1    Hankins, G.R.2    Washington, M.K.3    Fine, R.L.4    Orton, T.C.5    Jirtle, R.L.6
  • 51
    • 0029934868 scopus 로고    scopus 로고
    • M6P/IGF2 receptor: A candidate breast tumor suppressor gene
    • Hankins GR, De Souza AT, Bentley RC, et al. M6P/IGF2 receptor: a candidate breast tumor suppressor gene. Oncogene 1996; 12: 2003-2009.
    • (1996) Oncogene , vol.12 , pp. 2003-2009
    • Hankins, G.R.1    De Souza, A.T.2    Bentley, R.C.3
  • 53
  • 54
    • 0033566056 scopus 로고    scopus 로고
    • Expression of the wild-type insulin-like growth factor II receptor gene suppresses growth and causes death in colorectal cancer cells
    • Souza RF, Wang S, Thakar M, et al. Expression of the wild-type insulin-like growth factor II receptor gene suppresses growth and causes death in colorectal cancer cells. Oncogene 1999; 18 4063-4068.
    • (1999) Oncogene , vol.18 , pp. 4063-4068
    • Souza, R.F.1    Wang, S.2    Thakar, M.3
  • 55
    • 0037436509 scopus 로고    scopus 로고
    • Loss of IGF12 imprinting: A potential marker of colorectal cancer risk
    • Cui H, Cruz-Correa M, Giardiello FM, et al. Loss of IGF12 imprinting: a potential marker of colorectal cancer risk. Science 2003; 299: 1753-1755.
    • (2003) Science , vol.299 , pp. 1753-1755
    • Cui, H.1    Cruz-Correa, M.2    Giardiello, F.M.3
  • 56
    • 1842479074 scopus 로고    scopus 로고
    • IGF2 loss of imprinting: A potential heritable risk factor for colorectal cancer
    • Jirtle RL. IGF2 loss of imprinting: a potential heritable risk factor for colorectal cancer. Gastroenterology 2004; 126 1190-1201.
    • (2004) Gastroenterology , vol.126 , pp. 1190-1201
    • Jirtle, R.L.1
  • 57
    • 1942436958 scopus 로고    scopus 로고
    • Insulin-like growth factor (IGF)-I, IGF binding protein-3, and cancer risk: Systematic review and meta-regression analysis
    • Renehan AG, Zwahlen M, Minder C, O'Dwyer ST, Shalet SM, Egger M. Insulin-like growth factor (IGF)-I, IGF binding protein-3, and cancer risk: systematic review and meta-regression analysis. Lancet 2004; 363: 1346-1353.
    • (2004) Lancet , vol.363 , pp. 1346-1353
    • Renehan, A.G.1    Zwahlen, M.2    Minder, C.3    O'Dwyer, S.T.4    Shalet, S.M.5    Egger, M.6
  • 58
    • 0036173548 scopus 로고    scopus 로고
    • Circulating insulin-like growth factor-I levels regulate colon cancer growth and metastasis
    • Wu Y, Yakar S, Zhao L, Henninghausen L, LeRoith D. Circulating insulin-like growth factor-I levels regulate colon cancer growth and metastasis. Cancer Res 2002; 62: 1030-1035.
    • (2002) Cancer Res. , vol.62 , pp. 1030-1035
    • Wu, Y.1    Yakar, S.2    Zhao, L.3    Henninghausen, L.4    LeRoith, D.5
  • 59
    • 3142770705 scopus 로고    scopus 로고
    • Associations among IRS1, IRS2, IGF1 and IGFBP3 genetic polymorphisms and colorectal cancer
    • Slattery ML, Samowitz W, Curtin K, et al. Associations among IRS1, IRS2, IGF1 and IGFBP3 genetic polymorphisms and colorectal cancer. Cancer Epidemiol Biomarkers Prev 2004; 13: 1206-1214.
    • (2004) Cancer Epidemiol. Biomarkers Prev. , vol.13 , pp. 1206-1214
    • Slattery, M.L.1    Samowitz, W.2    Curtin, K.3
  • 60
    • 1642421788 scopus 로고    scopus 로고
    • The new kid on the block(ade) of the IGF-I receptor
    • LeRoith D, Helman L. The new kid on the block(ade) of the IGF-I receptor. Cancer Cell 2004; 5: 201-202.
    • (2004) Cancer Cell , vol.5 , pp. 201-202
    • LeRoith, D.1    Helman, L.2
  • 61
    • 0242624594 scopus 로고    scopus 로고
    • Growth factor receptors as therapeutic targets: Strategies to inhibit the insulin-like growth factor I receptor
    • Surmacz E. Growth factor receptors as therapeutic targets: strategies to inhibit the insulin-like growth factor I receptor. Oncogene 2003; 22: 6589-6597.
    • (2003) Oncogene , vol.22 , pp. 6589-6597
    • Surmacz, E.1
  • 62
    • 0141988681 scopus 로고    scopus 로고
    • Genetic blockade of the insulin-like growth factor-I receptor: A promising strategy for human pancreatic cancer
    • Min Y, Adachi Y, Yamamoto H, et al. Genetic blockade of the insulin-like growth factor-I receptor: a promising strategy for human pancreatic cancer. Cancer Res 2003; 63: 6432-6441.
    • (2003) Cancer Res. , vol.63 , pp. 6432-6441
    • Min, Y.1    Adachi, Y.2    Yamamoto, H.3
  • 63
    • 9144234724 scopus 로고    scopus 로고
    • A fully human monoclonal antibody to the insulin-like growth factor I receptor blocks ligand-dependent signaling and inhibits human tumour growth in vivo
    • Burtrum D, Zhu Z, Lu D, et al. A fully human monoclonal antibody to the insulin-like growth factor I receptor blocks ligand-dependent signaling and inhibits human tumour growth in vivo. Cancer Res 2003; 63: 8912-8921.
    • (2003) Cancer Res. , vol.63 , pp. 8912-8921
    • Burtrum, D.1    Zhu, Z.2    Lu, D.3
  • 64
    • 0032519539 scopus 로고    scopus 로고
    • Impairment of survival factor function potentiates chemotherapy-induced apoptosis in tumor cells
    • Lamm GM, Christofori G. Impairment of survival factor function potentiates chemotherapy-induced apoptosis in tumor cells. Cancer Res 1998; 58: 801-807.
    • (1998) Cancer Res. , vol.58 , pp. 801-807
    • Lamm, G.M.1    Christofori, G.2
  • 65
    • 1642586272 scopus 로고    scopus 로고
    • Survival signalling by Akt and eIF4E in oncogenesis and cancer therapy
    • Wendel HG, de Stanchina E, Fridman JS, et al. Survival signalling by Akt and eIF4E in oncogenesis and cancer therapy. Nature 2004; 428: 332-337.
    • (2004) Nature , vol.428 , pp. 332-337
    • Wendel, H.G.1    de Stanchina, E.2    Fridman, J.S.3
  • 66
    • 0023898621 scopus 로고
    • Structural analogs of human insulin-like growth factor I with reduced affinity for serum binding proteins and the type 2 insulin-like growth factor receptor
    • Bayne ML, Applebaum J, Chicchi GG, et al. Structural analogs of human insulin-like growth factor I with reduced affinity for serum binding proteins and the type 2 insulin-like growth factor receptor. J Biol Chem 1988; 263(13): 6233-6239.
    • (1988) J. Biol. Chem. , vol.263 , Issue.13 , pp. 6233-6239
    • Bayne, M.L.1    Applebaum, J.2    Chicchi, G.G.3
  • 67
    • 0026674156 scopus 로고
    • Competition for binding to insulin-like growth factor (IGF) binding protein-2,3,4, and 5 by the IGFs and IGF analogs
    • Clemmons DR, Dehoff ML, Busby WH, et al. Competition for binding to insulin-like growth factor (IGF) binding protein-2,3,4, and 5 by the IGFs and IGF analogs. Endocrinology 1992; 131 2): 890-895.
    • (1992) Endocrinology , vol.131 , Issue.2 , pp. 890-895
    • Clemmons, D.R.1    Dehoff, M.L.2    Busby, W.H.3
  • 68
    • 0027160909 scopus 로고
    • Insulin-like growth factor (IGF)-II binding to IGF-binding proteins and IGF receptors is modified by deletion of the N-terminal hexapeptide or substitution of arginine for glutamate-6 in IGF-II
    • Francis GL, Aplin SE, Milner SJ, et al. Insulin-like growth factor (IGF)-II binding to IGF-binding proteins and IGF receptors is modified by deletion of the N-terminal hexapeptide or substitution of arginine for glutamate-6 in IGF-II. Biochem J 1993; 293(Pt 3): 713-719.
    • (1993) Biochem. J. , vol.293 , Issue.PART 3 , pp. 713-719
    • Francis, G.L.1    Aplin, S.E.2    Milner, S.J.3
  • 69
    • 0027175177 scopus 로고
    • Binding of mutants of human insulin-like growth factor II to insulin-like growth factor binding proteins 1-6
    • Bach LA, Hsieh S, Sakano K, et al. Binding of mutants of human insulin-like growth factor II to insulin-like growth factor binding proteins 1-6. J Biol Chem 1993; 268(13): 9246-9254.
    • (1993) J. Biol. Chem. , vol.268 , Issue.13 , pp. 9246-9254
    • Bach, L.A.1    Hsieh, S.2    Sakano, K.3
  • 70
    • 0023915532 scopus 로고
    • Mutants of human insulin-like growth factor I with reduced affinity for the type 1 insulin-like growth factor receptor
    • Cascieri MA, Chicchi GG, Applebaum J, et al. Mutants of human insulin-like growth factor I with reduced affinity for the type 1 insulin-like growth factor receptor. J Biol Chem 1988; 27(9): 3229-3233.
    • (1988) J. Biol. Chem. , vol.27 , Issue.9 , pp. 3229-3233
    • Cascieri, M.A.1    Chicchi, G.G.2    Applebaum, J.3
  • 71
    • 0025113224 scopus 로고
    • The roles of tyrosines 24,31, and 60 in the high affinity binding of insulin-like growth factor-I to the type 1 insulin-like growth factor receptor
    • Bayne ML, Applebaum J, Chicchi GG, et al. The roles of tyrosines 24,31, and 60 in the high affinity binding of insulin-like growth factor-I to the type 1 insulin-like growth factor receptor. J Biol Chem 1990; 265(26): 15 648-15 652.
    • (1990) J. Biol. Chem. , vol.265 , Issue.26 , pp. 15648-15652
    • Bayne, M.L.1    Applebaum, J.2    Chicchi, G.G.3
  • 72
    • 0036186637 scopus 로고    scopus 로고
    • Characteristics of binding of insulin-like growth factor (IGF)-I and (IGF-II) analogues to the type 1 IGF receptor determined by BIAcore analysis
    • Forbes BE, Hartfield PJ, McNeil KA, et al. Characteristics of binding of insulin-like growth factor (IGF)-I and (IGF-II) analogues to the type 1 IGF receptor determined by BIAcore analysis. Eur J Biochem 2002; 269(3): 961-968.
    • (2002) Eur. J. Biochem. , vol.269 , Issue.3 , pp. 961-968
    • Forbes, B.E.1    Hartfield, P.J.2    McNeil, K.A.3
  • 73
    • 0025840174 scopus 로고
    • The design, expression, and characterization of human insulin-like growth factor II (IGF-II) mutants specific for either the IGF-II/cation-independent mannose 6-phosphate receptor or IGF-I receptor
    • Sakano K, Enjoh T, Numata F, et al. The design, expression, and characterization of human insulin-like growth factor II (IGF-II) mutants specific for either the IGF-II/cation-independent mannose 6-phosphate receptor or IGF-I receptor. J Biol Chem 1991; 266(31): 20 626-20 635.
    • (1991) J. Biol. Chem. , vol.266 , Issue.31 , pp. 20626-20635
    • Sakano, K.1    Enjoh, T.2    Numata, F.3
  • 74
    • 0035695549 scopus 로고    scopus 로고
    • Contribution of residues A54 and L55 of the human insulin-like growth factor-II (IGF-II) A domain to Type 2 IGF receptor binding specificity
    • Forbes BE, McNeil KA, Scott CD, et al. Contribution of residues A54 and L55 of the human insulin-like growth factor-II (IGF-II) A domain to Type 2 IGF receptor binding specificity. Growth Factors 2001; 19(3): 163-173.
    • (2001) Growth Factors , vol.19 , Issue.3 , pp. 163-173
    • Forbes, B.E.1    McNeil, K.A.2    Scott, C.D.3
  • 75
    • 0024581918 scopus 로고
    • Structural analogs of human insulin-like growth factor (IGF) I with altered affinity for type 2 IGF receptors
    • Cascieri MA, Chicchi GG, Applebaum J, et al. Structural analogs of human insulin-like growth factor (IGF) I with altered affinity for type 2 IGF receptors. J Biol Chem 1989; 264(4): 2199-2202.
    • (1989) J. Biol. Chem. , vol.264 , Issue.4 , pp. 2199-2202
    • Cascieri, M.A.1    Chicchi, G.G.2    Applebaum, J.3
  • 76
    • 0031009430 scopus 로고    scopus 로고
    • Alanine scanning mutagenesis of insulin
    • Kristensen C, Kjeldsen T, Wiberg FC, et al. Alanine scanning mutagenesis of insulin. J Biol Chem 1997; 272(20): 12 978-12 983.
    • (1997) J. Biol. Chem. , vol.272 , Issue.20 , pp. 12978-12983
    • Kristensen, C.1    Kjeldsen, T.2    Wiberg, F.C.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.