Myelodysplasia and anemia of chronic disease in human tumor necrosis factor-α transgenic mice

Cytometry Part A

Volumn 73, Issue 2, 2008, Pages 148-159

  Capocasale, Renold J ^a,c   Makropoulos, Dorie A ^a   Achuthanandam, Ram ^a   Stowell, Nicole ^a   Quinn, John ^b   Rafferty, Patricia A ^a   O'Brien, Joanne ^a   Emmell, Eva ^a   Bugelski, Peter J ^a  

^a CENTOCOR INC   (United States)

^b Treestar Ltd   (United States)

^c Centocor Research and Development Inc   (United States)

Author keywords

Anemia; Bone marrow; Erythropoietin; Flow cytometry; Murine models

Indexed keywords

ERYTHROPOIETIN; GAMMA INTERFERON; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; INTERLEUKIN 10; INTERLEUKIN 12P70; INTERLEUKIN 17; INTERLEUKIN 1BETA; INTERLEUKIN 5; INTERLEUKIN 6; MACROPHAGE INFLAMMATORY PROTEIN 1ALPHA; MONOCYTE CHEMOTACTIC PROTEIN; MONOCYTE CHEMOTACTIC PROTEIN 5; TRANSFERRIN RECEPTOR; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR RECEPTOR 1; UNCLASSIFIED DRUG; CYTOKINE; TNF PROTEIN, HUMAN; TNFRSF1A PROTEIN, MOUSE;

ANEMIA; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BLOOD EXAMINATION; BONE MARROW; CELL COUNT; CELL DEATH; CELL KINETICS; CELL POPULATION; CELL PROLIFERATION; CHRONIC DISEASE; CONTROLLED STUDY; CYTOMETRY; ERYTHROID PRECURSOR CELL; FEMALE; HEMATOPOIESIS; HISTOPATHOLOGY; IRON DEFICIENCY ANEMIA; MALE; MONOCYTOSIS; MOUSE; MYELODYSPLASIA; NONHUMAN; PATHOGENESIS; POLYARTHRITIS; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; STEM CELL; ANIMAL; ARTHRITIS; BLOOD; GENETICS; HUMAN; JOINT CAPSULE; METABOLISM; MYELODYSPLASTIC SYNDROME; PATHOLOGY; PHYSIOLOGY; TRANSGENIC MOUSE;

ANEMIA, HYPOCHROMIC; ANIMALS; APOPTOSIS; ARTHRITIS; BONE MARROW; CELL DEATH; CHRONIC DISEASE; CYTOKINES; HUMANS; JOINT CAPSULE; MICE; MICE, TRANSGENIC; MYELODYSPLASTIC SYNDROMES; RECEPTORS, TUMOR NECROSIS FACTOR, TYPE I; TUMOR NECROSIS FACTOR-ALPHA;

EID: 43049100072     PISSN: 15524922     EISSN: 15524930     Source Type: Journal    
DOI: 10.1002/cyto.a.20512     Document Type: Article

References (56)

1. Chen X, Baumel M, Mannel DN, Howard OM, Oppenheim JJ. Interaction of TNF with TNF receptor type 2 promotes expansion and function of mouse CD4+CD25+ T regulatory cells. J Immunol 2007;179:154-161.
2. Jurisic V, Bogdanovic G, Kojic V, Jakimov D, Srdic T. Effect of TNF-α on Raji cells at different cellular levels estimated by various methods. Ann Hematol 2006;85:86-94.
3. Lewis M, Tartaglia LA, Lee A, Bennett GL, Rice GC, Wong GHW, Chen EY, Goeddel DV. Cloning and expression of cDNAs for two distinct murine tumor necrosis factor receptors demonstrate that one receptor is species specific. Proc Natl Acad Sci USA 1991;88:2830-2824.
4. Tada Y, Ho A, Koarada S, Morito F, Ushiyama O, Suzuki N, Kikuchi Y, Ohta A, Mak TW, Nagasawa K. Collagen-induced arthritis in TNF receptor-1-deficient mice: TNF receptor-2 can modulate arthritis in the absence of TNF receptor-1. Clin Immunol 2001;99:325-333.
5. Polzer K, Schett G, Zwerina J. The lonely death: Chondrocyte apoptosis in TNF-induced arthritis. Autoimmun 2007;40:333-336.
6. Sfikakis PP, Kollias G. Tumor necrosis factor biology in experimental and clinical arthritis. Curr Opin Rheumatol 2003;15:380-386.
7. Keffer J, Probert L, Cazlaris H, Georgopoulos S, Kaslaris E, Kioussis D, Kollias G. Transgenic mice expressing human tumor necrosis factor: a predictive genetic model of arthritis. EMBO J 1991;10:4025-4031.
8. Shealy DJ, Wooley PH, Emmell E, Volk A, Rosenberg A, Treacy G, Wagner CL, Mayton L, Griswold DE, Song XR. Anti-TNFα antibody allows healing of joint damage in polyarthritic transgenic mice. Arthritis Res 2002;4:R7-R12.
9. Feldmann M, Brennan FM, Maini RN. Role of cytokines in rheumatoid arthritis. Ann Rev Immunol 1996;14:397-440.
10. Lipsky PE, Van der Heijde DM, St. Clair EW, Furst DE, Breedveld FC, Kalden JR, Smolen JS, Weisman M, Emery P, Feldmann M, Harriman GR, Maini RN. Infliximab and methotrexate in the treatment of rheumatoid arthritis. Anti-tumor necrosis factor trial in rheumatoid arthritis with concomitant therapy study group. N Engl J Med 2000;343:1594-1602.
11. Miller RK, Altz-Smith M. Usefulness of serum ferritin in detecting iron deficiency in rheumatoid arthritis (RA). Arthritis Rheum 1982;14:S114-S121.
12. Brown EB. Anemia associated with infection and chronic systemic diseases (Simple chronic anemia, Anemia of chronic disorders) In: Beeson PB, McDermott W, Wyngaarden JB, editors. Cecil Textbook of Medicine. Philadelphia, PA: W.B. Saunders; 1979. pp 1731-1732.
13. Krantz SB. Pathogenesis and treatment of anemia of chronic disease. Am J Med Sci 1994;307:353-359.
14. Greendyke RM, Sharma K, Gifford FR. Serum levels of erythropoietin and selected other cytokines in patients with anemia of chronic disease. Am J Clin Pathol 1994;101:338-341.
15. Jongen-Lavrencic M, Peeters HR, Wognum A, Vreugdenhil G, Breedveld FC, Swaak AJ. Elevated levels of inflammatory cytokines in bone marrow of patients with rheumatoid arthritis and anemia of chronic disease. J Rheumatol 1997;24:1504-1509.
16. Papadaki HA, Kritikos HD, Gemetzi C, Koutala H, Marsh JCW, Boumpas DT, Eliopoulos GD. Bone marrow progenitor cell reserve and function and stromal cell function are defective in rheumatoid arthritis: Evidence for a tumor necrosis factor alpha (TNFα)-mediated effect. Blood 2002;99:1610-1619.
17. Thomas C, Thomas L. Biochemical markers and hematologic indicies in the diagnosis of functional iron deficiency. Clin Chem 2002;48:1066-1076.
18. Spivak JL. Iron and the anemia of chronic disease. Oncology 2002;16:25-33.
19. Moldawer LL, Marano MA, Wei H, Fong Y, Silen ML, Kuo G, Manogue KR, Vlassara H, Cohen H, Cerami A. Cachectin/tumor necrosis factor-α alters red blood cell kinetics and induces anemia in vivo. FASEB J 1989;3:1637-1643.
20. Means RT. Recent developments in the anemia of chronic disease. Current Hematol Rep 2003;2:116-121.
21. Probert L, Plows D, Kontogeorgos G, Kollias G. The type I interleukin-1 receptor acts in series with tumor necrosis factor (TNF) to induce arthritis in TNF-transgenic mice. Eur J Immunol 1995;25:1794-1797.
22. Sowade O, Sowade B, Brilla K, Franke W, Stephan P, Gross J, Scigalla P, Warnke H. Kinetics of reticulocyte maturity fractions and indicies and iron status during therapy with epoietin β (recombinant human erythropoietin) in cardiac surgery patients. Am J Hematol 1997;55:89-96.
23. Balogh P, Tew JG, Szakal AK. Simultaneous blockade of Fc γ receptors and indirect labeling of mouse lymphocytes by the selective detection of allotype-restricted epitopes on the κ chain of rat monoclonal antibodies. Cytometry 2002;47:107-110.
24. Spangrude GJ, Brooks DM. Mouse strain viability in the expression of the hematopoietic stem cell antigen Ly-6A/E by bone marrow cells. Blood 1993;82:3327-3332.
25. Kondo M, Weissman IL, Akashi K. Identification of clonogenic common lymphoid progenitors in mouse bone marrow. Cell 1997;91:661-672.
26. Lagasse E, Weissman IL. Flow cytometric indentification of murine neutrophils and monocytes. J Immunol Meth 1996;197:139-150.
27. Kina T, Ikuta K, Takayama E, Wada K, Majumdar AS, Weissman IL, Katsura Y. The monoclonal antibody Ter-119 recognizes a molecule associated with glycophorin A and specifically marks the late stages of murine erythroid lineage. Br J Haematol 2000;109:280-287.
28. Henderson RB, Hobbs JAR, Mathies M, Hogg N. Rapid recruitment of inflammatory monocytes is independent of neutrophil migration. Blood 2003;102:328-335.
29. Socolovsky M, Nam HS, Fleming MD, Haase VH, Brugnara C, Lodish HF. Ineffective erythropoiesis in Stat5a -/-5b-/- mice due to decreased survival of early erythroblasts. Blood 2001;98:3261-3273.
30. Bugelski PJ, Nesspor T, Volk A, O'Brien J, Makropoulos D, Shamberger K, Fisher PW, James I, Graden D, Capocasale RJ. Pharmacodynamics of recombinant human erythropoietin in murine bone marrow. Pharm Res 2007; Epub ahead print.
31. Jecker P, Beuleke A, Dressendörfer I, Pabst R, Westerman J. Long-term oral application of 5-bromo-2-deoxyuridine does not reliably label proliferating immune cells in the Lewis rat. J Histochem Cytochem 1997;45:393-401.
32. Holm M, Thomsen M, Hoyer M, Hokland P. Optimization of a flow cytometric method for the simultaneous measurement of cell surface antigen, DNA content, and in vitro BrdUrd incorporation into normal and malignant hematopoietic cells. Cytometry 1998;32:28-36.
33. Waters WR, Harkins KR, Wannemuehler MJ. Five-color flow cytometric analysis of swine lymphocytes for detection of proliferation, apoptosis, viability, and phenotype. Cytometry 2002;48:146-152.
34. Telford WG, Komoriya A, Packard BZ. Multiparametric analysis of apoptosis by flow and image cytometry. In: Hawley TS, Hawley RG, editors. Methods in Molecular Biology: Flow Cytometry Protocols, 2nd ed. Totowa, NJ: Humana Press; 2004. pp 141-160.
35. Pennline KJ, Pellerito F, DaFonseca M, Monahan P, Siegel MI, Smith SR. Flow cytometric analysis of recombinant murine GM-CSF (rmuGM-CSF) induced changes in the distribution of specific cell populations in vivo. Cytometry 1990;11:283-291.
36. Dybedal I, Bryder D, Fosssum A, Rusten LS, Jacobsen SEW. Tumor necrosis factor (TNF)-mediated activation of the p55 TNF receptor negatively regulated maintenance of cycling reconstituting human hematopoietic stem cells. Blood 2001;98:1782-1791.
37. Veiby OP, Jacobsen FW, Cui L, Lyman SD, Jacobsen SE. The flt3 ligand promotes the survival of primitive hemopoietic progenitor cells with myeloid as well as B lymphoid potential. Suppression of apoptosis and conteraction by TNF-α and TGF-β. J Immunol 1996;157:2953-2960.
38. Testa U. Apoptotic mechanisms in the control of erythropoiesis. Leukemia 2004;18:1176-1199.
39. Johnson CS, Cook CA, Furmanski P. In vivo suppression of erythropoiesis by tumor necrosis factor-α (TNF-α): reversal with exogenous erythropoietin (EPO). Exp Hematol 1990;18:109-113.
40. Johnson RA, Waddleow TA, Caro J, Oliff A, Roodman GD. Chronic exposure to tumor necrosis factor in vivo preferentially inhibits erythropoiesis in nude mice. Blood 1989;74:130-138.
41. Roodman GD, Johnson RA, Clibon U. Tumor necrosis factor a and the anemia of chronic disease: Effects of chronic exposure to TNF on erythropoiesis in vivo. Adv Exp Biol Med 1989;271:185-196.
42. Glosli Heidi, Veiby OP, Fjerdingstad H, Mehlum A, Probert L, Kollias G, Gjernes E, Prydz H. Effects of TNF-α expression in T cells on haematopoiesis in transgenic mice. Eur J Haematol 1999;63:50-60.
43. Taverne J, Sheikh N, de Souza JB, Playfair JH, Probert L, Kollias G. Anaemia and resistance to malaria in transgenic mice expressing human tumor necrosis factor. Immunol 1994;82:397-403.
44. Porta C, Caporali R, Epis O, Ramaioli I, Invernizzi R, Rovati B, Comolli G, Danova M, Montecucco C. Impaired bone marrow hematopoietic progenitor cell function in rheumatoid arthritis patients candidated to autologus hematopoietic stem cell transplantation. Bone Marrow Transplant 2004;33:721-728.
45. Ryu SY, Jeong KS, Kang BN, Park SJ, Yoon WK, Kim SH, Kim TH. Modulation of transferrin synthesis, transferrin receptor expression, iNOS expression and NO production in mouse macrophages by cytokines, either alone or in combination. Anticancer Res 2000;20:3331-3338.
46. Nezu M, Iwagaki H, Aoki H, Tanaka N, Orita K. Tumor necrosis factor-α upregulates transferrin receptors in K562 cells. J Internat Med Res 1994;22:145-152.
47. Chan RY, Seiser C, Schulman HM, Kuhn LC, Ponka P. Regulation of transferrin receptor mRNA expression. Distinct regulatory features in erythroid cells. Eur J Biochem 1994;220:683-692.
48. Feelders RA, Vreugdenhil G, van Dijk JP, Swaak AJG van Eijk HG. Decreased affinity and number of transferrin receptors on erythroblasts in the anemia of rheumatoid arthritis. Am J Hematol 1993;43:200-204.
49. Jurisic V, Bumbasirevic V, Konjevic G, Djuricic B, Spuzic I. TNF-α induces changes in LDH isotype profile following triggering of apoptosis in PBL of non-Hodgkin's lymphomas. Ann Hematol 2004;83:84-91.
50. Majka M, Janowska-Wieczorek A, Ratajczak J, Ehrenman K, Pietrzkowski Z, Kowalska MA, Gewirtz AM, Emerson SG, Ratajczak MZ. Numerous growth factors, cytokines, and chemokines are secreted by human CD34+ cells, myeloblasts, erythroblasts and megakaryoblasts and regulate normal hematopoiesis in an autocrine/paracrine manner. Blood 2001;97:3075-3085.
51. Stahnke K, Hecker S, Kohne E, Debatin K-M. CD95 (APO-1/FAS)-mediated apoptosis in cytokine-activated hematopoietic cells. Exp Hematol 1998;26:844-850.
52. + human marrow cells is induced by interferon g and tumor necrosis factor α and potentiates cytokine-mediated hematopoietic suppression in vitro. Blood 1995;85:3183-3190.
53. De Maria R, Testa U, Luchetti L, Zeuner A, Stassi G, Pelosi E, Riccioni R, Felli N, Samoggia P, Peschle C. Apototic role of Fas/Fas ligand system in the regulation of erythropoiesis. Blood 1999;93:796-803.
54. Ratajczak J, Majka M, Kijowski J, Baj M, Pan ZK, Marquez LA, Janowska-Wieczorek A, Ratajczak MZ. Biological significance of MAPK, AKT and JAK-STAT protein activation by various erythropoietic factors in normal human early erythroid cells. Br J Haematol 2001;115:195-204.
55. Fuhler GM, Cadwallader KA, Knol GJ, Chilvers ER, Drayer AL, Vellenga E. Disturbed granulocyte macrophage-colony stimulating factor priming of phosphatidylinositol 3,4,5-trisphosphate accumulation and Rac activation in fMLP-stimulated neutrophils from patients with myelodysplasia. J Leukocyte Biol 2004;76:254-262.
56. Jurisic V, Bogdanovic G, Srdic T, Jakimov D, Mrdjanovic J, Baltic M, Baltic VV. Modulation of TNF-α activity in tumor PC cells using anti-CD45 and anti-CD95 monoclonal antibodies. Cancer Lett 2004;214:55-61.