Kinetics of reticulocyte maturity fractions and indices and iron status during therapy with epoetin beta (recombinant human erythropoietin) in cardiac surgery patients

American Journal of Hematology

Volumn 55, Issue 2, 1997, Pages 89-96

  Sowade, Olaf ^a   Sowade, Birgit ^b,d   Brilla, Kay ^a   Franke, Werner ^c   Stephan, Peter ^c   Gross, Johann ^a   Scigalla, Paul ^c   Warnke, Harry ^a  

^a HUMBOLDT UNIVERSITY   (Germany)

^b Hospital Berlin Kaulsdorf   (Germany)

^c F HOFFMANN LA ROCHE LTD   (Switzerland)

^d Hospital Berlin Kausdorf   (Germany)

Author keywords

Blood transfusion; Cardiac surgery; Erythropoietin; Flow cytometry; Iron metabolism; Reticulocyte

Indexed keywords

FERRITIN; HEMOGLOBIN; IRON; PLACEBO; RECOMBINANT ERYTHROPOIETIN; TRANSFERRIN;

ADULT; AGED; ARTICLE; BLOOD TRANSFUSION; CELL MATURATION; CLINICAL PROTOCOL; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; ERYTHROCYTE KINETICS; ERYTHROPOIESIS; FEMALE; FLOW CYTOMETRY; HEMATOCRIT; HUMAN; HUMAN CELL; INTRAVENOUS DRUG ADMINISTRATION; IRON DEFICIENCY ANEMIA; IRON METABOLISM; MAJOR CLINICAL STUDY; MALE; MEAN CORPUSCULAR HEMOGLOBIN; MEAN CORPUSCULAR VOLUME; OPEN HEART SURGERY; ORAL DRUG ADMINISTRATION; POSTOPERATIVE CARE; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; RETICULOCYTE COUNT; SURGICAL PATIENT;

CARDIAC SURGICAL PROCEDURES; ERYTHROPOIESIS; ERYTHROPOIETIN; ERYTHROPOIETIN, RECOMBINANT; HEMATOCRIT; HUMANS; IRON; MULTIVARIATE ANALYSIS; RECOMBINANT PROTEINS; REGRESSION ANALYSIS; RETICULOCYTE COUNT; RETICULOCYTES; TIME FACTORS; TRANSFERRIN;

EID: 0030835467     PISSN: 03618609     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1096-8652(199706)55:2<89::AID-AJH7>3.0.CO;2-Z     Document Type: Article

References (20)

1. Bidstrup BP, Harrison J, Royston D, Taylor KM, Treasure T: Aprotinin therapy in cardiac operations: A report on use in 41 cardiac centers in the United Kingdom. Ann Thorac Surg 55:971, 1993.
2. Eschbach JW, Egrie JC, Downing MR, Browne JK, Adamson JW: Correction of the anemia of end-stage renal disease with recombinant human erythropoietin: Results of a combined phase I and II clinical trial. N Engl J Med 316:73, 1987.
3. Schmoeckel M, Nollert G, Mempel M, Mempel W, Reichart B: Effects of recombinant human erythropoietin on autologous blood donation before open-heart surgery. Thorac Cardiovasc Surg 41:364, 1993.
4. Goodnough LT, Rudnick S, Price TH, Ballas SK, Collins ML, Crowley JP, Kosmin M, Kruskall MS, Lenes BA, Menitove JE, Silberstein LE, Smith KJ, Wallas CH, Abels R, von Tress M: Increased preoperative collection of autologous blood with recombinant human erythropoietin therapy. N Engl J Med 321:1163, 1989.
5. Sowade O, Warnke H, Scigalla P: Results of open-heart surgery in adult members of Jehovah's Witnesses. Anaesthesist 44:257, 1995.
6. Sowade O, Warnke H, Scigalla P, Sowade B, Franke W, Messinger D, Gross J: Avoidance of allogenic blood transfusions by treatment with epoetin beta (recombinant human erythropoietin in patients undergoing open-heart surgery. Blood 89:411, 1997.
7. Lee LG, Chen CH, Chiu LA: Thiazole orange. A new dye for reticulocyte analysis. Cytometry 7:508, 1986.
8. Brugnara C, Hipp MJ, Irving PJ, Lathrop H, Lee PA, Minchello EM, Winkelman J: Automated reticulocyte counting and measurement of reticulocyte cellular indices - Evaluation of the Miles H*3 blood analyzer. Am J Clin Pathol 102:623, 1994.
9. Brugnara C, Colella GM, Cremins J, Langley RC, Schneider TJ, Rutherford CJ, Goldberg MA: Effects of subcutaneous recombinant human erythropoietin in normal subjects: Development of decreased reticulocyte hemoglobin content and iron-deficient erythropoiesis J Lab Clin Med 123:660, 1994.
10. Tatsumi N, Kojima K, Tsuda I, Yamagami S, Itoh Y, Tanaka H: Reticulocyte count used to assess recombinant human erythropoietin sensitivity in hemodialysis patients. Contrib Nephrol 82:41, 1990.
11. Wells DA, Daignegault-Creeeh CA, Simrell CR: Effect of iron status on reticulocyte mean channel fluorescence. Am J Clin Pathol 97:130, 1992.
12. Sowade O, Stamminger G, Brilla K, Wamke H, Gross J: Reticulocyte indices in patients with epoetin beta therapy. Eur J Clin Chem Clin Biochem 33:37a, 1995 (abstract).
13. Labardini JT, Papyannopoulou T, Cook JD, Adamson JW, Woodson RD, Eschbach JW, Hillman RS, Finch CA: Marrow radioiron kinetics. Haematology 7:301, 1973.
14. Adamson JW, Eschbach J, Finch CA: The kidney and erythropoiesis. Am J Med 44:725, 1968.
15. Ganzoni A, Hillman RS, Finch CA: Maturation of the macroreticulocyte. Br J Haematol 16:119, 1469.
16. Lowenstein LM: The mammalian reticulocyte. Int Rev Cytol 8:135, 1959.
17. Rapoport SM: "The Reticulocyte." Boca Raton: CRC Press, Inc., 1986, pp 1-89.
18. Yataganas X, Gahrton G, Thorell B: DNA, RNA and hemoglobin during erythroblast maturation. Exp Cell Res 62:254, 1970.
19. Kampf D, Kahl A, Passlick J, Pustelnik A, Eckardt KU, Ehmer B, Jacobs C, Baumelou A, Grabensce B, Gahl GM: Single dose-kinetics of recombinant human erythropoietin after intravenous, subcutaneous and intraperitoneal administration. Contrib Nephrol 76:106, 1989.
20. Levine EA, Gould SA, Rosen AL, Sehgal LR, Egrie JC, Sehgal HL, Levine HD, Moss GS: Perioperative recombinant human erythropoietin. Surgery 106:432, 1989.