Biological significance of MAPK, AKT and JAK-STAT protein activation by various erythropoietic factors in normal human early erythroid cells

British Journal of Haematology

Volumn 115, Issue 1, 2001, Pages 195-204

  Ratajczak, Janina ^a   Majka, Marcin ^a   Kijowski, Jacek ^a   Baj, Monika ^b   Pan, Zhixing K ^a   Marquez, Leah A ^b   Janowska Wieczorek, Anna ^b   Ratajczak, Mariusz Z ^a,c  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b Polish American Hospital   (Poland)

^c UNIVERSITY OF LOUISVILLE   (United States)

Author keywords

BFU E, apoptosis, proliferation, signal transduction; CD34+ cells; Erythropoiesis

Indexed keywords

CD34 ANTIGEN; ERYTHROPOIETIN; GELATINASE A; GELATINASE B; GLYCOPHORIN; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; INTERLEUKIN 3; JANUS KINASE; MATRIX METALLOPROTEINASE INHIBITOR; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN; PROTEIN KINASE B; PROTEIN P44; SOMATOMEDIN; STAT PROTEIN; STEM CELL FACTOR; THROMBOPOIETIN; UNCLASSIFIED DRUG; VASCULOTROPIN;

ADHESION; APOPTOSIS; ARTICLE; BONE MARROW CELL; BURST FORMING UNIT E; CELL ADHESION; CELL DIFFERENTIATION; CELL PROLIFERATION; CELL SECRETION; CELL SURVIVAL; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME RELEASE; ERYTHROBLAST; ERYTHROID CELL; HUMAN; HUMAN CELL; NORMAL HUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

ANTIGENS, CD34; APOPTOSIS; CELL ADHESION; CELL DIVISION; CELLS, CULTURED; DNA-BINDING PROTEINS; ENDOTHELIAL GROWTH FACTORS; ENZYME ACTIVATION; ERYTHROID PROGENITOR CELLS; ERYTHROPOIETIN; GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR; HUMANS; INSULIN-LIKE GROWTH FACTOR I; INTERLEUKIN-3; LYMPHOKINES; MAP KINASE SIGNALING SYSTEM; MATRIX METALLOPROTEINASE 2; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT; SIGNAL TRANSDUCTION; STAT1 TRANSCRIPTION FACTOR; STEM CELL FACTOR; THROMBOPOIETIN; TRANS-ACTIVATORS; VASCULAR ENDOTHELIAL GROWTH FACTOR A; VASCULAR ENDOTHELIAL GROWTH FACTORS;

EID: 0034783093     PISSN: 00071048     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2141.2001.03058.x     Document Type: Article

References (33)

1. STAT. Protein recruitment and activation in c-Kit deletion mutants
2. Biology of thrombopoietin
3. Bcr/Abl activates transcription of the Bcl-X gene through STAT5
4. NF-kB and rel proteins: Evolutionary conserved mediators of immune response
5. The pathways connecting G protein-coupled receptors to the nucleus through divergent mitogen-activated protein kinase cascades
6. Phosphatidylinositol 3-kinase is involved in the protection of primary cultured human erythroid precursor cells from apoptosis
7. Mcl-1 is a common target of stem cell factor and interleukin-5 for apoptosis prevention activity via MEK/MAPK and PI-3K/Akt pathways
8. + cells in response to chemokines
9. A member of forkhead family transcription factor, FKHRL1, is one of the downstream molecules of phosphatidylinositol 3-kinase-Akt activation payhway in erythropoietin signal transduction
10. Akt is more than just bad kinase
11. Coreceptor/chemokine receptor expression on human hematopoietic cells. Biological implications for HIV-1 infection
12. Thrombopoietin has a differentiative effect on late-stage human erythropoiesis
13. + cells and megakaryoblasts secrete b-chemokines: Implications for infectability by M-tropic human immunodeficiency virus (R5 HIV)
14. The role of HIV related chemokine receptors and chemokines in human erythropoiesis in vitro
15. Stromal derived factor-1 and thrombopoietin regulate distinct aspects of human megakaryopoiesis
16. Numerous growth factors, cytokines and chemokines are secreted by normal human CD341 cells, myeloblasts, erythroblasts and megakarioblasts and regulate hematopoiesis in an autocrine/ paracrine manner
17. Constitutive production and thrombin-induced release of vascular endothelial growth factor by human megakaryocytes and platelets
18. + cells (long term culture-initiating cells) through endothelial cell is mediated by E-selectin
19. Expression of c-kit gene products in known cellular targets of W-mutations in normal and W mutant mice - Evidence for an impaired c-kit kinase in mutant mice
20. Erythropoietin induces tyrosine phosphorylation of Jak2, STAT5A, and STAT5B in primary cultured human erythroid precursors
21. Requirement of phosphatidylinositol 3-Kinase activity for bradykinin stimulation of NF-kb activation in cultured human epithelial cells
22. The role of insulin (INS) and insulin like growth factor-I (IGF-I) in regulating human erythropoiesis. Studies in vitro under serum free conditions - Comparison to other cytokines and growth factors
23. + cells
24. Role of the KIT protoncogene in normal and malignant human hematopoiesis
25. A reappraisal of the function of the insulin-like growth factor-I (IGF-I) in the regulation of the human hematopoiesis
26. Recombinant human thrombopoietin (TPO) stimulates erythropoiesis by Inhibiting erythroid progenitor cell apoptosis
27. Synergistic activation of MAP kinase (ERK1/2) by erythropoietin and stem cell factor is essential for expanded erythropoiesis
28. Stat5a and Stat5b protein have essential and nonessential, or redundant, roles in cytokine responses
29. The Jak-Stat pathway in normal and perturbed hematopoiesis
30. Generation of committed erythroid BFU-E and CFU-E progenitors does not require erythropoietin or the erythropoietin receptor
31. Functional interaction of erythropoietin and stem cell factor receptors is essential for erythroid colony formation
32. Akt regulates cell survival and apoptosis at a postmitochondrial level
33. Capsase activation is required for terminal erythroid differentiation