Disturbed granulocyte macrophage-colony stimulating factor priming of phosphatidylinositol 3,4,5-trisphosphate accumulation and Rac activation in fMLP-stimulated neutrophils from patients with myelodysplasia

Journal of Leukocyte Biology

Volumn 76, Issue 1, 2004, Pages 254-262

  Fuhler, Gwenny M ^a   Cadwallader, Karen A ^b   Knol, Gerlinde J ^a   Chilvers, Edwin R ^b   Drayer, A Lyndsay ^c   Vellenga, Edo ^a  

^a UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

^b UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^c Sanquin Bloedbank Regio Nordoost Groningen   (Netherlands)

Author keywords

Cellular activation; MDS; Phosphatidylinositol 3 kinase; Signal transduction

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; FORMYLMETHIONYLLEUCYLPHENYLALANINE; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE; RAC PROTEIN; RAS PROTEIN; REACTIVE OXYGEN METABOLITE;

ARTICLE; BACTERIAL INFECTION; BACTERICIDAL ACTIVITY; CELL ACTIVITY; CELL STIMULATION; CLINICAL ARTICLE; CONTROLLED STUDY; ENZYME ACTIVATION; GENE ACTIVATION; HUMAN; HUMAN CELL; LEUKOCYTE ACTIVATION; MYELODYSPLASIA; MYELODYSPLASTIC SYNDROME; PRIORITY JOURNAL; RECURRENT INFECTION;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ENZYME ACTIVATION; ENZYME INHIBITORS; GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR; HUMANS; MYELODYSPLASTIC SYNDROMES; N-FORMYLMETHIONINE LEUCYL-PHENYLALANINE; NEUTROPHIL ACTIVATION; NEUTROPHILS; PHOSPHATIDYLINOSITOL PHOSPHATES; RAC GTP-BINDING PROTEINS; RAL GTP-BINDING PROTEINS; RAS PROTEINS; REACTIVE OXYGEN SPECIES;

BACTERIA (MICROORGANISMS);

EID: 3042785606     PISSN: 07415400     EISSN: None     Source Type: Journal    
DOI: 10.1189/jlb.0204071     Document Type: Article

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