The interactions of amphotericin B with various sterols in relation to its possible use in anticancer therapy

Biophysical Chemistry

Volumn 91, Issue 2, 2001, Pages 125-133

  Charbonneau, Catherine ^a   Fournier, Isabelle ^a   Dufresne, Sonia ^a   Barwicz, Joanna ^a   Tancrède, Pierre ^a  

^a UNIVERSITÉ DU QUÉBEC À TROIS RIVIÈRES   (Canada)

Author keywords

7 DHC; Amphotericin B; Cholesterol; Hepatocellular carcinomas; Oxysterols

Indexed keywords

25 HYDROXYCHOLESTEROL; 7 DEHYDROCHOLESTEROL; 7 OXOCHOLESTEROL; 7BETA HYDROXYCHOLESTEROL; AMPHOTERICIN B; ANTINEOPLASTIC AGENT; CHOLESTEROL; ERGOSTEROL; LANOSTEROL; OXYSTEROL;

ARTICLE; DIFFERENTIAL SCANNING CALORIMETRY; DRUG BINDING; LIVER CELL CARCINOMA; PRIORITY JOURNAL; ULTRAVIOLET SPECTROSCOPY;

AMPHOTERICIN B; ANTIBIOTICS, ANTIFUNGAL; CALORIMETRY, DIFFERENTIAL SCANNING; HUMANS; NEOPLASMS; SPECTROPHOTOMETRY, ULTRAVIOLET; STEROLS;

EUKARYOTA; FUNGI;

EID: 0035796796     PISSN: 03014622     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0301-4622(01)00164-8     Document Type: Article

References (26)

1. Antifungal prophylaxis during remission induction therapy for acute leukemia fluconazole versus intravenous amphotericin B
2. Liposomal amphotericin (AmBisome) in the prophylaxis of fungal infections in neutropenic patients: a randomised, double-blind, placebo-controlled study
3. Liposomal amphotericin B prevents invasive fungal infections in liver transplant recipients
4. Amphotericin B: new life for an old drug
5. Amphotericin B inhibits the generation of the scrapie isoform of the prion protein in infected cultures
6. Amphotericin B toxicity as related to the formation of oxidatively modified low-density lipoproteins
7. Effect of the aggregation state of amphotericin B on its interaction with ergosterol
8. One-sided action of amphotericin B on cholesterol-containing membranes is determined by its self-association in the medium
9. Theoretical study of the complexation of amphotericin B with sterols
10. Comparative conformational analysis of cholesterol and ergosterol by molecular mechanics
11. Comparative analysis of the distribution of the molecular electrostatic potential for cholesterol and ergosterol
12. A kinetic study of the oxidation effects of amphotericin B on human low-density lipoproteins
13. Rapid analysis of oxidized cholesterol derivatives by high-performance liquid chromatography combined with diode-array ultraviolet and evaporative laser light-scattering detection
14. Selective modification of sterol composition of hepatomas: new opportunities for chemotherapy
15. Role of sterol structure in complex formation with polyene antibiotics
16. The effect of number and position of double bonds in tetracyclic nucleus of sterol on interaction with polyene antibiotics
17. AmB pharmacokinetics in humans
18. The structuring effects of amphotericin B on pure and ergosterol- or cholesterol-containing dipalmitoylphosphatidylcholine bilayers; a differential scanning calorimetry study
19. How do the polyene macrolide antibiotic affect the cellular membrane properties?
20. Absorption and fluorescence spectra of polyene antibiotics in the presence of cholesterol
21. Comparative internalization and recycling of different amphotericin B formulations by a macrophage-like cell line
22. Spontaneous organization of amphotericin B in aqueous medium
23. Spectroscopic studies of aggregation and autoxidation properties of the polyene antibiotic amphotericin B
24. The effect of surfactants on the aggregation state of amphotericin B
25. Effects of the detergent sucrose monolaurate on binding of amphotericin B to sterols and its toxicity for cells
26. New aspects of the interaction of cholesterol with dipalmitoylphosphatidylcholine bilayers as reviewed by high-sensitivity differential scanning calorimetry