-
1
-
-
0037247359
-
Plasticity of skeletal muscle mitochondria in response to contractile activity
-
Adhihetty PJ, Irrcher I, Joseph AM, Ljubicic V, Hood DA 2003 Plasticity of skeletal muscle mitochondria in response to contractile activity. Exp Physiol 88:99-107
-
(2003)
Exp Physiol
, vol.88
, pp. 99-107
-
-
Adhihetty, P.J.1
Irrcher, I.2
Joseph, A.M.3
Ljubicic, V.4
Hood, D.A.5
-
2
-
-
2342509057
-
Hepatic expression of malonyl-CoA decarboxylase reverses muscle, liver and whole-animal insulin resistance
-
An J, Muoio DM, Shiota M et al 2004. Hepatic expression of malonyl-CoA decarboxylase reverses muscle, liver and whole-animal insulin resistance. Nat Med 10:268-274
-
(2004)
Nat Med
, vol.10
, pp. 268-274
-
-
An, J.1
Muoio, D.M.2
Shiota, M.3
-
3
-
-
0034994570
-
Healthy lifestyles in Europe: Prevention of obesity and type II diabetes by diet and physical activity
-
Astrup A 2001 Healthy lifestyles in Europe: prevention of obesity and type II diabetes by diet and physical activity. Public Health Nutr 4:499-515
-
(2001)
Public Health Nutr
, vol.4
, pp. 499-515
-
-
Astrup, A.1
-
4
-
-
2942722772
-
Basic disturbances in skeletal muscle fatty acid metabolism in obesity and type 2 diabetes mellitus
-
Blaak EE 2004 Basic disturbances in skeletal muscle fatty acid metabolism in obesity and type 2 diabetes mellitus. Proc Nutr Soc 63:323-330
-
(2004)
Proc Nutr Soc
, vol.63
, pp. 323-330
-
-
Blaak, E.E.1
-
5
-
-
28844461131
-
Proposed mechanisms for the induction of insulin resistance by oxidative stress
-
Bloch-Damti A, Bashan N 2005 Proposed mechanisms for the induction of insulin resistance by oxidative stress. Antioxid Redox Signal 7:1553-1567
-
(2005)
Antioxid Redox Signal
, vol.7
, pp. 1553-1567
-
-
Bloch-Damti, A.1
Bashan, N.2
-
6
-
-
22544462381
-
A potential link between muscle peroxisome proliferator-activated receptor-α signaling and obesity-related diabetes
-
Finck BN, Bernal-Mizrachi C, Han DH et al 2005 A potential link between muscle peroxisome proliferator-activated receptor-α signaling and obesity-related diabetes. Cell Metab 1:133-144
-
(2005)
Cell Metab
, vol.1
, pp. 133-144
-
-
Finck, B.N.1
Bernal-Mizrachi, C.2
Han, D.H.3
-
7
-
-
0042405041
-
Peroxisome proliferator-activated receptors (PPARs): Regulators of gene expression in heart and skeletal muscle
-
Gilde AJ, Van Bilsen M 2003 Peroxisome proliferator-activated receptors (PPARs): regulators of gene expression in heart and skeletal muscle. Acta Physiol Scand 178:425-434
-
(2003)
Acta Physiol Scand
, vol.178
, pp. 425-434
-
-
Gilde, A.J.1
Van Bilsen, M.2
-
8
-
-
0035217707
-
Skeletal muscle lipid content and insulin resistance: Evidence for a paradox in endurance-trained athletes
-
Goodpaster BH, He J, Watkins S, Kelley DE 2001 Skeletal muscle lipid content and insulin resistance: evidence for a paradox in endurance-trained athletes. J Clin Endocrinol Metab 86:5755-61
-
(2001)
J Clin Endocrinol Metab
, vol.86
, pp. 5755-5761
-
-
Goodpaster, B.H.1
He, J.2
Watkins, S.3
Kelley, D.E.4
-
9
-
-
0345086474
-
Free fatty acid induced insulin resistance is associated with activation of protein kinase C theta and alterations in the insulin signaling cascade
-
Griffin ME, Marcucci MJ, Cline GW et al 1999 Free fatty acid induced insulin resistance is associated with activation of protein kinase C theta and alterations in the insulin signaling cascade. Diabetes 48:1270-1274
-
(1999)
Diabetes
, vol.48
, pp. 1270-1274
-
-
Griffin, M.E.1
Marcucci, M.J.2
Cline, G.W.3
-
10
-
-
0035653490
-
PPAR-alpha-null mice are protected from high-fat diet-induced insulin resistance
-
Guerre-Millo M, Rouault C, Poulain P et al 2001 PPAR-alpha-null mice are protected from high-fat diet-induced insulin resistance. Diabetes 50:2809-2814
-
(2001)
Diabetes
, vol.50
, pp. 2809-2814
-
-
Guerre-Millo, M.1
Rouault, C.2
Poulain, P.3
-
11
-
-
0037153158
-
A central role for JNK in obesity and insulin resistance
-
Hirosumi J, Tuncman G, Chang L et al 2002 A central role for JNK in obesity and insulin resistance. Nature 420:333-336
-
(2002)
Nature
, vol.420
, pp. 333-336
-
-
Hirosumi, J.1
Tuncman, G.2
Chang, L.3
-
13
-
-
0033400310
-
Skeletal muscle fatty acid metabolism in association with insulin resistance, obesity, and weight loss
-
Kelley DE, Goodpaster B, Wing RR, Simoneau JA 1999 Skeletal muscle fatty acid metabolism in association with insulin resistance, obesity, and weight loss. Am J Physiol 277:E1130-E1141
-
(1999)
Am J Physiol
, vol.277
-
-
Kelley, D.E.1
Goodpaster, B.2
Wing, R.R.3
Simoneau, J.A.4
-
14
-
-
25844432311
-
Peroxisome proliferator-activated receptor-gamma co-activator 1alpha-mediated metabolic remodeling of skeletal myocytes mimics exercise training and reverses lipid-induced mitochondrial inefficiency
-
Koves TR, Li P, An J et al 2005a Peroxisome proliferator-activated receptor-gamma co-activator 1alpha-mediated metabolic remodeling of skeletal myocytes mimics exercise training and reverses lipid-induced mitochondrial inefficiency. J Biol Chem 280:33588-33598
-
(2005)
J Biol Chem
, vol.280
, pp. 33588-33598
-
-
Koves, T.R.1
Li, P.2
An, J.3
-
15
-
-
17644394969
-
Subsarcolemmal and intermyofibrillar mitochondria play distinct roles in regulating skeletal muscle fatty acid metabolism
-
Koves TR, Noland RC, Bates AL, Henes ST, Muoio DM, Cortright RN 2005b Subsarcolemmal and intermyofibrillar mitochondria play distinct roles in regulating skeletal muscle fatty acid metabolism. Am J Physiol Cell Physiol 288:C1074-C1082
-
(2005)
Am J Physiol Cell Physiol
, vol.288
-
-
Koves, T.R.1
Noland, R.C.2
Bates, A.L.3
Henes, S.T.4
Muoio, D.M.5
Cortright, R.N.6
-
16
-
-
0027947379
-
Beta-cell lipotoxicity in the pathogenesis of non-insulin-dependent diabetes mellitus of obese rats: Impairment in adipocyte-beta-cell relationships
-
Lee Y, Hirose H, Ohneda M, Johnson JH, McGarry JD, Unger RH 1994 Beta-cell lipotoxicity in the pathogenesis of non-insulin-dependent diabetes mellitus of obese rats: impairment in adipocyte-beta-cell relationships. Proc Natl Acad Sci USA 91:10878-10882
-
(1994)
Proc Natl Acad Sci USA
, vol.91
, pp. 10878-10882
-
-
Lee, Y.1
Hirose, H.2
Ohneda, M.3
Johnson, J.H.4
McGarry, J.D.5
Unger, R.H.6
-
17
-
-
0033594980
-
A critical role for the peroxisome proliferator-activated receptor alpha (PPARalpha) in the cellular fasting response: The PPARalpha-null mouse as a model of fatty acid oxidation disorders
-
Leone TC, Weinheimer CJ, Kelly DP 1999 A critical role for the peroxisome proliferator-activated receptor alpha (PPARalpha) in the cellular fasting response: the PPARalpha-null mouse as a model of fatty acid oxidation disorders. Proc Natl Acad Sci USA 96:7473-7478
-
(1999)
Proc Natl Acad Sci USA
, vol.96
, pp. 7473-7478
-
-
Leone, T.C.1
Weinheimer, C.J.2
Kelly, D.P.3
-
18
-
-
0037102256
-
Transcriptional co-activator PGC-1 alpha drives the formation of slow-twitch muscle fibres
-
Lin J, Wu H, Tarr PT et al 2002 Transcriptional co-activator PGC-1 alpha drives the formation of slow-twitch muscle fibres. Nature 418:797-801
-
(2002)
Nature
, vol.418
, pp. 797-801
-
-
Lin, J.1
Wu, H.2
Tarr, P.T.3
-
19
-
-
12344305124
-
Mitochondrial dysfunction and type 2 diabetes
-
Lowell BB, Shulman GI 2005 Mitochondrial dysfunction and type 2 diabetes. Science 307:384-387
-
(2005)
Science
, vol.307
, pp. 384-387
-
-
Lowell, B.B.1
Shulman, G.I.2
-
20
-
-
2342477730
-
Erralpha and Gabpa/b specify PGC-1alpha-dependent oxidative phosphorylation gene expression that is altered in diabetic muscle
-
Mootha VK, Handschin C, Arlow D et al 2004 Erralpha and Gabpa/b specify PGC-1alpha-dependent oxidative phosphorylation gene expression that is altered in diabetic muscle. Proc Natl Acad Sci USA 101:6570-6575
-
(2004)
Proc Natl Acad Sci USA
, vol.101
, pp. 6570-6575
-
-
Mootha, V.K.1
Handschin, C.2
Arlow, D.3
-
21
-
-
33746377553
-
Obesity-related derangements in metabolic regulation
-
Muoio DM, Newgard CB 2006 Obesity-related derangements in metabolic regulation. Annu Rev Biochem 75:367-401
-
(2006)
Annu Rev Biochem
, vol.75
, pp. 367-401
-
-
Muoio, D.M.1
Newgard, C.B.2
-
22
-
-
0037135623
-
Fatty acid homeostasis and induction of lipid regulatory genes in skeletal muscles of peroxisome proliferator-activated receptor (PPAR) alpha knock-out mice-evidence for compensatory regulation by PPAR delta
-
Muoio DM, MacLean PS, Lang DB et al 2002 Fatty acid homeostasis and induction of lipid regulatory genes in skeletal muscles of peroxisome proliferator-activated receptor (PPAR) alpha knock-out mice-evidence for compensatory regulation by PPAR delta. J Biol Chem 277:26089-26097
-
(2002)
J Biol Chem
, vol.277
, pp. 26089-26097
-
-
Muoio, D.M.1
MacLean, P.S.2
Lang, D.B.3
-
23
-
-
0346250165
-
Cellular mechanism of insulin resistance: Potential links with inflammation
-
Perseghin G, Petersen K, Shulman GI 2003 Cellular mechanism of insulin resistance: potential links with inflammation. Int J Obes Relat Metab Disord 27 Suppl 3:S6-11
-
(2003)
Int J Obes Relat Metab Disord
, vol.27
, Issue.SUPPL. 3
-
-
Perseghin, G.1
Petersen, K.2
Shulman, G.I.3
-
24
-
-
0037326196
-
Peroxisome proliferator-activated receptor-gamma coactivator 1alpha (PGC-1alpha): Transcriptional coactivator and metabolic regulator
-
Puigserver P, Spiegelman BM 2003 Peroxisome proliferator-activated receptor-gamma coactivator 1alpha (PGC-1alpha): transcriptional coactivator and metabolic regulator. Endocr Rev 24:78-90
-
(2003)
Endocr Rev
, vol.24
, pp. 78-90
-
-
Puigserver, P.1
Spiegelman, B.M.2
-
25
-
-
0032549811
-
A cold-inducible coactivator of nuclear receptors linked to adaptive thermogenesis
-
Puigserver P, Wu ZD, Park CW, Graves R, Wright M, Spiegelman BM 1998 A cold-inducible coactivator of nuclear receptors linked to adaptive thermogenesis. Cell 92:829-839
-
(1998)
Cell
, vol.92
, pp. 829-839
-
-
Puigserver, P.1
Wu, Z.D.2
Park, C.W.3
Graves, R.4
Wright, M.5
Spiegelman, B.M.6
-
26
-
-
50549202600
-
The glucose fatty-acid cycle. Its role in insulin sensitivity and the metabolic disturbances of diabetes mellitus
-
Randle PJ, Garland PB, Hales CN, Newsholme EA 1963 The glucose fatty-acid cycle. Its role in insulin sensitivity and the metabolic disturbances of diabetes mellitus. Lancet 1:785-789
-
(1963)
Lancet
, vol.1
, pp. 785-789
-
-
Randle, P.J.1
Garland, P.B.2
Hales, C.N.3
Newsholme, E.A.4
-
27
-
-
0033213631
-
PPAR gamma is required for the differentiation of adipose tissue in vivo and in vitro
-
Rosen ED, Sarraf P, Troy AE et al 1999 PPAR gamma is required for the differentiation of adipose tissue in vivo and in vitro. Mol Cell Biol 4:611-617
-
(1999)
Mol Cell Biol
, vol.4
, pp. 611-617
-
-
Rosen, E.D.1
Sarraf, P.2
Troy, A.E.3
-
28
-
-
0142181286
-
Malonyl-CoA and AMP-activated protein kinase: An expanding partnership
-
Saha AK, Ruderman NB 2003 Malonyl-CoA and AMP-activated protein kinase: an expanding partnership. Mol Cell Biochem 253:65-70
-
(2003)
Mol Cell Biochem
, vol.253
, pp. 65-70
-
-
Saha, A.K.1
Ruderman, N.B.2
-
29
-
-
0036470213
-
Insulin signaling pathways in time and space
-
Saltiel AR, Pessin JE 2002 Insulin signaling pathways in time and space. Trends Cell Biol 12:65-71
-
(2002)
Trends Cell Biol
, vol.12
, pp. 65-71
-
-
Saltiel, A.R.1
Pessin, J.E.2
-
30
-
-
0346880505
-
Inflammation and the IKK beta/I kappa B/NF-kappa B axis in obesity- and diet-induced insulin resistance
-
Shoelson SE, Lee J, Yuan M 2003 Inflammation and the IKK beta/I kappa B/NF-kappa B axis in obesity- and diet-induced insulin resistance. Int J Obes Relat Metab Disord 27 Suppl 3:S49-52
-
(2003)
Int J Obes Relat Metab Disord
, vol.27
, Issue.SUPPL. 3
-
-
Shoelson, S.E.1
Lee, J.2
Yuan, M.3
-
31
-
-
0033927667
-
Cellular mechanisms of insulin resistance
-
Shulman GI 2000 Cellular mechanisms of insulin resistance. J Clin Invest 106:171-176
-
(2000)
J Clin Invest
, vol.106
, pp. 171-176
-
-
Shulman, G.I.1
-
32
-
-
21344444333
-
A high-fat diet coordinately downregulates genes required for mitochondrial oxidative phosphorylation in skeletal muscle
-
Sparks LM, Xie H, Koza RA et al 2005 A high-fat diet coordinately downregulates genes required for mitochondrial oxidative phosphorylation in skeletal muscle. Diabetes 54:1926-1933
-
(2005)
Diabetes
, vol.54
, pp. 1926-1933
-
-
Sparks, L.M.1
Xie, H.2
Koza, R.A.3
-
33
-
-
0036182137
-
Lipotoxic diseases
-
Unger RH 2002 Lipotoxic diseases. Annu Rev Med 53:319-36
-
(2002)
Annu Rev Med
, vol.53
, pp. 319-336
-
-
Unger, R.H.1
-
34
-
-
0037184925
-
Mechanism by which fatty acids inhibit insulin activation of insulin receptor substrate-1 (IRS-1)-associated phosphatidylinositol 3-kinase activity in muscle
-
Yu C, Chen Y, Cline GW et al 2002 Mechanism by which fatty acids inhibit insulin activation of insulin receptor substrate-1 (IRS-1)-associated phosphatidylinositol 3-kinase activity in muscle. J Biol Chem 277:50230-50236
-
(2002)
J Biol Chem
, vol.277
, pp. 50230-50236
-
-
Yu, C.1
Chen, Y.2
Cline, G.W.3
|