-
1
-
-
0028301094
-
p53 dependence of early apoptotic and proliferative responses within the mouse intestinal epithelium following γ-irradiation
-
Clarke AR, Gledhill S, Hooper ML, Bird CC, Wyllie AH. p53 dependence of early apoptotic and proliferative responses within the mouse intestinal epithelium following γ-irradiation. Oncogene 1994;9:1767-73.
-
(1994)
Oncogene
, vol.9
, pp. 1767-1773
-
-
Clarke, A.R.1
Gledhill, S.2
Hooper, M.L.3
Bird, C.C.4
Wyllie, A.H.5
-
2
-
-
0028047723
-
The role of p53 in spontaneous and radiation-induced apoptosis in the gastrointestinal tract of normal and p53-deficient mice
-
Merritt AJ, Potten CS, Kemp CJ, et al. The role of p53 in spontaneous and radiation-induced apoptosis in the gastrointestinal tract of normal and p53-deficient mice. Cancer Res 1994;54:614-7.
-
(1994)
Cancer Res
, vol.54
, pp. 614-617
-
-
Merritt, A.J.1
Potten, C.S.2
Kemp, C.J.3
-
3
-
-
1842529509
-
Gene therapy progress and prospects: Cancer gene therapy using tumour suppressor genes
-
McNeish IA, Bell SJ, Lemoine NR. Gene therapy progress and prospects: cancer gene therapy using tumour suppressor genes. Gene Ther 2004;11:497-503.
-
(2004)
Gene Ther
, vol.11
, pp. 497-503
-
-
McNeish, I.A.1
Bell, S.J.2
Lemoine, N.R.3
-
4
-
-
0036674617
-
Live or let die: The cell's response to p53
-
Vousden KH, Lu X. Live or let die: the cell's response to p53. Nat Rev Cancer 2002;2:594-604.
-
(2002)
Nat Rev Cancer
, vol.2
, pp. 594-604
-
-
Vousden, K.H.1
Lu, X.2
-
5
-
-
9544244796
-
Retrovirus-mediated wild-type p53 gene transfer to tumors of patients with lung cancer
-
Roth JA, Nguyen D, Lawrence DD, et al. Retrovirus-mediated wild-type p53 gene transfer to tumors of patients with lung cancer. Nat Med 1996;2:985-91.
-
(1996)
Nat Med
, vol.2
, pp. 985-991
-
-
Roth, J.A.1
Nguyen, D.2
Lawrence, D.D.3
-
6
-
-
0033526357
-
Adenovirus-mediated p53 gene transfer in advanced non-small-cell lung cancer
-
Swisher SG, Roth JA, Nemunaitis J, et al. Adenovirus-mediated p53 gene transfer in advanced non-small-cell lung cancer. J Natl Cancer Inst 1999;91:763-71.
-
(1999)
J Natl Cancer Inst
, vol.91
, pp. 763-771
-
-
Swisher, S.G.1
Roth, J.A.2
Nemunaitis, J.3
-
7
-
-
0030905284
-
Mdm2 promotes the rapid degradation of p53
-
Haupt Y, Maya R, Kazaz A, Oren M. Mdm2 promotes the rapid degradation of p53. Nature 1997;387:296-9.
-
(1997)
Nature
, vol.387
, pp. 296-299
-
-
Haupt, Y.1
Maya, R.2
Kazaz, A.3
Oren, M.4
-
9
-
-
0030812331
-
Monoallelically expressed gene related to p53 at 1p36, a region frequently deleted in neuroblastoma and other human cancers
-
Kaghad M, Bonnet H, Yang A, et al. Monoallelically expressed gene related to p53 at 1p36, a region frequently deleted in neuroblastoma and other human cancers. Cell 1997;90:809-19.
-
(1997)
Cell
, vol.90
, pp. 809-819
-
-
Kaghad, M.1
Bonnet, H.2
Yang, A.3
-
10
-
-
0031852337
-
Cloning and functional analysis of human p51, which structurally and functionally resembles p53
-
Osada M, Ohba M, Kawahara C, et al. Cloning and functional analysis of human p51, which structurally and functionally resembles p53. Nat Med 1998;4:839-43.
-
(1998)
Nat Med
, vol.4
, pp. 839-843
-
-
Osada, M.1
Ohba, M.2
Kawahara, C.3
-
11
-
-
0032161624
-
p63, a p53 homolog at 3q27-29, encodes multiple products with transactivating, death-inducing, and dominant-negative activities
-
Yang A, Kaghad M, Wang Y, et al. p63, a p53 homolog at 3q27-29, encodes multiple products with transactivating, death-inducing, and dominant-negative activities. Mol Cell 1998;2:305-16.
-
(1998)
Mol Cell
, vol.2
, pp. 305-316
-
-
Yang, A.1
Kaghad, M.2
Wang, Y.3
-
12
-
-
0033536230
-
Mdm2 binds p73α without targeting degradation
-
Balint E, Bates S, Vousden KH. Mdm2 binds p73α without targeting degradation. Oncogene 1999;18:3923-9.
-
(1999)
Oncogene
, vol.18
, pp. 3923-3929
-
-
Balint, E.1
Bates, S.2
Vousden, K.H.3
-
13
-
-
0032961828
-
MDM2 suppresses p73 function without promoting p73 degradation
-
Zeng X, Chen L, Jost CA, et al. MDM2 suppresses p73 function without promoting p73 degradation. Mol Cell Biol 1999;19:3257-66.
-
(1999)
Mol Cell Biol
, vol.19
, pp. 3257-3266
-
-
Zeng, X.1
Chen, L.2
Jost, C.A.3
-
14
-
-
15744391245
-
p73β-expressing recombinant adenovirus: A potential anticancer agent
-
Das S, Nama S, Antony S, Somasundaram K. p73β-expressing recombinant adenovirus: a potential anticancer agent. Cancer Gene Ther 2005;12:417-26.
-
(2005)
Cancer Gene Ther
, vol.12
, pp. 417-426
-
-
Das, S.1
Nama, S.2
Antony, S.3
Somasundaram, K.4
-
15
-
-
42249088655
-
Antitumor effect of adenovirus-mediated p53 family gene transfer on osteosarcoma cell lines
-
Oshima Y, Sasaki Y, Negishi Y, et al. Antitumor effect of adenovirus-mediated p53 family gene transfer on osteosarcoma cell lines. Cancer Biol Ther 2007;6:1058-66.
-
(2007)
Cancer Biol Ther
, vol.6
, pp. 1058-1066
-
-
Oshima, Y.1
Sasaki, Y.2
Negishi, Y.3
-
16
-
-
0036527775
-
Histone-deacetylase inhibitors: Novel drugs for the treatment of cancer
-
Johnstone RW. Histone-deacetylase inhibitors: novel drugs for the treatment of cancer. Nat Rev Drug Discov 2002;1:287-99.
-
(2002)
Nat Rev Drug Discov
, vol.1
, pp. 287-299
-
-
Johnstone, R.W.1
-
17
-
-
0030797585
-
Activation of p53 sequence-specific DNA binding by acetylation of the p53 C-terminal domain
-
Gu W, Roeder RG. Activation of p53 sequence-specific DNA binding by acetylation of the p53 C-terminal domain. Cell 1997;90:595-606.
-
(1997)
Cell
, vol.90
, pp. 595-606
-
-
Gu, W.1
Roeder, R.G.2
-
18
-
-
0028258610
-
-
Ueda H, Nakajima H, Hori Y, et al. FR901228, a novel antitumor bicyclic depsipeptide produced by Chromobacterium violaceum no. 968. I. Taxonomy, fermentation, isolation, physico-chemical and biological properties, and antitumor activity. J Antibiot (Tokyo) 1994;47:301-10.
-
Ueda H, Nakajima H, Hori Y, et al. FR901228, a novel antitumor bicyclic depsipeptide produced by Chromobacterium violaceum no. 968. I. Taxonomy, fermentation, isolation, physico-chemical and biological properties, and antitumor activity. J Antibiot (Tokyo) 1994;47:301-10.
-
-
-
-
19
-
-
0344431240
-
FR901228, a potent antitumor antibiotic, is a novel histone deacetylase inhibitor
-
Nakajima H, Kim YB, Terano H, Yoshida M, Horinouchi S. FR901228, a potent antitumor antibiotic, is a novel histone deacetylase inhibitor. Exp Cell Res 1998;241:126-33.
-
(1998)
Exp Cell Res
, vol.241
, pp. 126-133
-
-
Nakajima, H.1
Kim, Y.B.2
Terano, H.3
Yoshida, M.4
Horinouchi, S.5
-
20
-
-
3042785975
-
A review of depsipeptide and other histone deacetylase inhibitors in clinical trials
-
Piekarz R, Bates S. A review of depsipeptide and other histone deacetylase inhibitors in clinical trials. Curr Pharm Des 2004;10:2289-98.
-
(2004)
Curr Pharm Des
, vol.10
, pp. 2289-2298
-
-
Piekarz, R.1
Bates, S.2
-
21
-
-
0035418558
-
Enhanced adenovirus transgene expression in malignant cells treated with the histone deacetylase inhibitor FR901228
-
Kitazono M, Goldsmith ME, Aikou T, Bates S, Fojo T. Enhanced adenovirus transgene expression in malignant cells treated with the histone deacetylase inhibitor FR901228. Cancer Res 2001;61:6328-30.
-
(2001)
Cancer Res
, vol.61
, pp. 6328-6330
-
-
Kitazono, M.1
Goldsmith, M.E.2
Aikou, T.3
Bates, S.4
Fojo, T.5
-
22
-
-
0037085773
-
Histone deacetylase inhibitor FR901228 enhances adenovirus infection of hematopoietic cells
-
Kitazono M, Rao VK, Robey R, et al. Histone deacetylase inhibitor FR901228 enhances adenovirus infection of hematopoietic cells. Blood 2002;99:2248-51.
-
(2002)
Blood
, vol.99
, pp. 2248-2251
-
-
Kitazono, M.1
Rao, V.K.2
Robey, R.3
-
23
-
-
0242610345
-
The histone deacetylase inhibitor FK228 preferentially enhances adenovirus transgene expression in malignant cells
-
Goldsmith ME, Kitazono M, Fok P, Aikou T, Bates S, Fojo T. The histone deacetylase inhibitor FK228 preferentially enhances adenovirus transgene expression in malignant cells. Clin Cancer Res 2003;9:5394-401.
-
(2003)
Clin Cancer Res
, vol.9
, pp. 5394-5401
-
-
Goldsmith, M.E.1
Kitazono, M.2
Fok, P.3
Aikou, T.4
Bates, S.5
Fojo, T.6
-
24
-
-
0034834092
-
Adenovirus-mediated transfer of the p53 family genes, p73 and p51/p63 induces cell cycle arrest and apoptosis in colorectal cancer cell lines: Potential application to gene therapy of colorectal cancer
-
Sasaki Y, Morimoto I, Ishida S, Yamashita T, Imai K, Tokino T. Adenovirus-mediated transfer of the p53 family genes, p73 and p51/p63 induces cell cycle arrest and apoptosis in colorectal cancer cell lines: potential application to gene therapy of colorectal cancer. Gene Ther 2001;8:1401-8.
-
(2001)
Gene Ther
, vol.8
, pp. 1401-1408
-
-
Sasaki, Y.1
Morimoto, I.2
Ishida, S.3
Yamashita, T.4
Imai, K.5
Tokino, T.6
-
25
-
-
10744232289
-
Identification of the interleukin 4 receptor α gene as a direct target for p73
-
Sasaki Y, Mita H, Toyota M, et al. Identification of the interleukin 4 receptor α gene as a direct target for p73. Cancer Res 2003;63:8145-52.
-
(2003)
Cancer Res
, vol.63
, pp. 8145-8152
-
-
Sasaki, Y.1
Mita, H.2
Toyota, M.3
-
26
-
-
0031052263
-
Isolation of a common receptor for coxsackie B viruses and adenoviruses 2 and 5
-
Bergelson JM, Cunningham JA, Droguett G, et al. Isolation of a common receptor for coxsackie B viruses and adenoviruses 2 and 5. Science 1997;275:1320-3.
-
(1997)
Science
, vol.275
, pp. 1320-1323
-
-
Bergelson, J.M.1
Cunningham, J.A.2
Droguett, G.3
-
27
-
-
0027166647
-
Integrins αvβ3 and αvβ5 promote adenovirus internalization but not virus attachment
-
Wickham TJ, Mathias P, Cheresh DA, Nemerow GR. Integrins αvβ3 and αvβ5 promote adenovirus internalization but not virus attachment. Cell 1993;73:309-19.
-
(1993)
Cell
, vol.73
, pp. 309-319
-
-
Wickham, T.J.1
Mathias, P.2
Cheresh, D.A.3
Nemerow, G.R.4
-
28
-
-
0035694469
-
Acetylation of p53 activates transcription through recruitment of coactivators/histone acetyltransferases
-
Barlev NA, Liu L, Chehab NH, et al. Acetylation of p53 activates transcription through recruitment of coactivators/histone acetyltransferases. Mol Cell 2001;8:1243-54.
-
(2001)
Mol Cell
, vol.8
, pp. 1243-1254
-
-
Barlev, N.A.1
Liu, L.2
Chehab, N.H.3
-
29
-
-
0030780106
-
Movement of Bax from the cytosol to mitochondria during apoptosis
-
Wolter KG, Hsu YT, Smith CL, Nechushtan A, Xi XG, Youle RJ. Movement of Bax from the cytosol to mitochondria during apoptosis. J Cell Biol 1997;139:1281-92.
-
(1997)
J Cell Biol
, vol.139
, pp. 1281-1292
-
-
Wolter, K.G.1
Hsu, Y.T.2
Smith, C.L.3
Nechushtan, A.4
Xi, X.G.5
Youle, R.J.6
-
30
-
-
0033406781
-
Withdrawal of IL-7 induces Bax translocation from cytosol to mitochondria through a rise in intracellular pH
-
Khaled AR, Kim K, Hofmeister R, Muegge K, Durum SK. Withdrawal of IL-7 induces Bax translocation from cytosol to mitochondria through a rise in intracellular pH. Proc Natl Acad Sci U S A 1999;96:14476-81.
-
(1999)
Proc Natl Acad Sci U S A
, vol.96
, pp. 14476-14481
-
-
Khaled, A.R.1
Kim, K.2
Hofmeister, R.3
Muegge, K.4
Durum, S.K.5
-
31
-
-
0036776260
-
A histone deacetylase inhibitor enhances killing of undifferentiated thyroid carcinoma cells by p53 gene therapy
-
Imanishi R, Ohtsuru A, Iwamatsu M, et al. A histone deacetylase inhibitor enhances killing of undifferentiated thyroid carcinoma cells by p53 gene therapy. J Clin Endocrinol Metab 2002;87:4821-4.
-
(2002)
J Clin Endocrinol Metab
, vol.87
, pp. 4821-4824
-
-
Imanishi, R.1
Ohtsuru, A.2
Iwamatsu, M.3
-
32
-
-
25144441207
-
Augmentation of antitumor effects of p53 gene therapy by combination with HDAC inhibitor
-
Takimoto R, Kato J, Terui T, et al. Augmentation of antitumor effects of p53 gene therapy by combination with HDAC inhibitor. Cancer Biol Ther 2005;4:421-8.
-
(2005)
Cancer Biol Ther
, vol.4
, pp. 421-428
-
-
Takimoto, R.1
Kato, J.2
Terui, T.3
-
33
-
-
33847397884
-
The histone deacetylase inhibitor FK228 given prior to adenovirus infection can boost infection in melanoma xenograft model systems
-
Goldsmith ME, Aguila A, Steadman K, et al. The histone deacetylase inhibitor FK228 given prior to adenovirus infection can boost infection in melanoma xenograft model systems. Mol Cancer Ther 2007;6:496-505.
-
(2007)
Mol Cancer Ther
, vol.6
, pp. 496-505
-
-
Goldsmith, M.E.1
Aguila, A.2
Steadman, K.3
-
34
-
-
0032530486
-
DNA damage activates p53 through a phosphorylation-acetylation cascade
-
Sakaguchi K, Herrera JE, Saito S, et al. DNA damage activates p53 through a phosphorylation-acetylation cascade. Genes Dev 1998;12:2831-41.
-
(1998)
Genes Dev
, vol.12
, pp. 2831-2841
-
-
Sakaguchi, K.1
Herrera, J.E.2
Saito, S.3
-
35
-
-
0027325132
-
Oncoprotein MDM2 conceals the activation domain of tumour suppressor p53
-
Oliner JD, Pietenpol JA, Thiagalingam S, Gyuris J, Kinzler KW, Vogelstein B. Oncoprotein MDM2 conceals the activation domain of tumour suppressor p53. Nature 1993;362:857-60.
-
(1993)
Nature
, vol.362
, pp. 857-860
-
-
Oliner, J.D.1
Pietenpol, J.A.2
Thiagalingam, S.3
Gyuris, J.4
Kinzler, K.W.5
Vogelstein, B.6
-
36
-
-
0032169516
-
The alternative product from the human CDKN2A locus, p14(ARF), participates in a regulatory feedback loop with p53 and MDM2
-
Stott FJ, Bates S, James MC, et al. The alternative product from the human CDKN2A locus, p14(ARF), participates in a regulatory feedback loop with p53 and MDM2. EMBO J 1998;17:5001-14.
-
(1998)
EMBO J
, vol.17
, pp. 5001-5014
-
-
Stott, F.J.1
Bates, S.2
James, M.C.3
-
37
-
-
0027358723
-
The HPV-16 E6 and E6-AP complex functions as a ubiquitin-protein ligase in the ubiquitination of p53
-
Scheffner M, Huibregtse JM, Vierstra RD, Howley PM. The HPV-16 E6 and E6-AP complex functions as a ubiquitin-protein ligase in the ubiquitination of p53. Cell 1993;75:495-505.
-
(1993)
Cell
, vol.75
, pp. 495-505
-
-
Scheffner, M.1
Huibregtse, J.M.2
Vierstra, R.D.3
Howley, P.M.4
-
38
-
-
33749248025
-
p51/p63, a novel p53 homologue, potentiates p53 activity and is a human cancer gene therapy candidate
-
Kunisaki R, Ikawa S, Maeda T, et al. p51/p63, a novel p53 homologue, potentiates p53 activity and is a human cancer gene therapy candidate. J Gene Med 2006;8:1121-30.
-
(2006)
J Gene Med
, vol.8
, pp. 1121-1130
-
-
Kunisaki, R.1
Ikawa, S.2
Maeda, T.3
|