Comparison of inducibility of sulfotransferase and UDP-glucuronosyltransferase mRNAs by prototypical microsomal enzyme inducers in primary cultures of human and cynomolgus monkey hepatocytes

Drug Metabolism and Pharmacokinetics

Volumn 23, Issue 1, 2008, Pages 45-53

  Nishimura, Masuhiro ^a   Koeda, Akiko ^b   Shimizu, Takefumi ^b   Nakayama, Mitsuo ^a   Satoh, Tetsuo ^b,c   Narimatsu, Shizuo ^d   Naito, Shinsaku ^a  

^a OTSUKA PHARMACEUTICAL CO LTD   (Japan)

^b N   (Japan)

^c Ichikawa General Hospital   (Japan)

^d OKAYAMA UNIVERSITY   (Japan)

Author keywords

Cynomolgus monkey; Hepatocytes; Human; Induction; Sulfotransferase; UDP glucuronosyltransferase

Indexed keywords

BETA ACTIN; DEXAMETHASONE; GLUCURONOSYLTRANSFERASE; GLUCURONOSYLTRANSFERASE 1A1; GLUCURONOSYLTRANSFERASE 1A6; GLUCURONOSYLTRANSFERASE 1A9; GLUCURONOSYLTRANSFERASE 2B7; MESSENGER RNA; OMEPRAZOLE; RIFAMPICIN; SULFOTRANSFERASE; SULFOTRANSFERASE 1A1; SULFOTRANSFERASE 2A1; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL CULTURE; CELL ISOLATION; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOSE RESPONSE; DRUG EXPOSURE; ENZYME INDUCTION; FEMALE; GENE EXPRESSION; HUMAN; HUMAN CELL; LIVER CELL; MALE; NONHUMAN; NUCLEOTIDE SEQUENCE; REAL TIME POLYMERASE CHAIN REACTION; AGED; ANIMAL; BIOSYNTHESIS; COMPARATIVE STUDY; DRUG EFFECT; ENZYMOLOGY; GENETICS; INFANT; LIVER MICROSOME; MACACA; NEWBORN; PRESCHOOL CHILD; SPECIES DIFFERENCE;

AGED; ANIMALS; CELLS, CULTURED; CHILD, PRESCHOOL; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INDUCTION; FEMALE; GLUCURONOSYLTRANSFERASE; HUMANS; INFANT; INFANT, NEWBORN; MACACA FASCICULARIS; MALE; MICROSOMES, LIVER; RIFAMPIN; RNA, MESSENGER; SPECIES SPECIFICITY; SULFOTRANSFERASES;

EID: 42249102967     PISSN: 13474367     EISSN: 18800920     Source Type: Journal    
DOI: 10.2133/dmpk.23.45     Document Type: Article

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