New lupane triterpenoids from Solidago canadensis that inhibit the lyase activity of DNA polymerase β

Bioorganic and Medicinal Chemistry

Volumn 12, Issue 23, 2004, Pages 6271-6275

  Chaturvedula, V S Prakash ^a   Zhou, Bing Nan ^a   Gao, Zhijie ^b   Thomas, Shannon J ^b   Hecht, Sidney M ^b   Kingston, David G I ^a  

^a VIRGINIA POLYTECHNIC INSTITUTE AND STATE UNIVERSITY   (United States)

^b UNIVERSITY OF VIRGINIA   (United States)

Author keywords

Bioassay; DNA; Solidago; Triterpenoid

Indexed keywords

2 BUTANONE; 3BETA (3 KETOHEXADECANOYLOXY) 29 NORLUPAN 20 ONE; 3BETA (3 KETOHEXADECANOYLOXY)LUP 20(29) ENE; 3BETA (ACETOXYHEXADECANOYLOXY) 29 NORLUPAN 20 ONE; 3BETA (ACETOXYHEXADECANOYLOXY)LUP 20(29) ENE; ALPHA AMYRIN; CYCLOARTENOL; CYCLOARTENYL PALMITATE; DNA DIRECTED DNA POLYMERASE BETA; LUPEOL; LUPEYL ACETATE; LYASE; SOLIDAGO CANADENSIS EXTRACT; STIGMASTEROL; TRITERPENOID; UNCLASSIFIED DRUG; URSOLIC ACID;

ARTICLE; BIOASSAY; CHEMICAL MODIFICATION; CONTROLLED STUDY; DRUG ISOLATION; DRUG SCREENING; DRUG STRUCTURE; ENZYME ACTIVITY; ENZYME INHIBITION; FRACTIONATION; IC 50; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; RAT; SOLIDAGO;

DNA POLYMERASE BETA; ENZYME INHIBITORS; INHIBITORY CONCENTRATION 50; LYASES; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; PLANT EXTRACTS; SOLIDAGO; STRUCTURE-ACTIVITY RELATIONSHIP; TRITERPENES;

ASTERACEAE; SOLIDAGO; SOLIDAGO CANADENSIS;

EID: 7444231485     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2004.08.048     Document Type: Article

References (16)

1. V.S.P. Chaturvedula, Z. Gao, S.H. Jones, S.M. Hecht, and D.G.I. Kingston Tetrahedron 60 2004 9991 9995
2. A.A. Kasali, O. Ekundayo, C. Paul, and W.A. Konig Phytochemistry 59 2002 805 810
3. T. Lu, M.A. Menelaou, D. Vargas, F.R. Fronczek, and N.H. Fischer Phytochemistry 32 1993 1483 1488
4. G. Reznicek, J. Jurenitsch, M. Plasun, S. Korhammer, E. Haslinger, K. Hiller, and W. Kubelka Phytochemistry 30 1991 1629 1633
5. V.S. Batyuk, and S.N. Kovaleva Khim. Prir. Soed. 1985 566 567
6. S.B. Mahato, and A.P. Kundu Phytochemistry 37 1994 1517 1575
7. P. Pant, and R.P. Rastogi Indian J. Chem. 15B 1977 911 913
8. Y.-H. Zhang, J.-K. Cheng, L. Yang, and D.-L. Cheng J. Chin. Chem. Soc. (Taipei) 49 2002 117 124
9. B.J. Hopkins, and F. Scheinmann Phytochemistry 10 1971 1956 1961
10. H. Gaspar, F.M.S.B. Palma, M.C. de la Torre, and B. Rodriguez Phytochemistry 43 1996 613 615
11. C.H. Brieskorn, and L. Capuano Chem. Ber. 86 1953 866 873
12. S.-J. Lee, A.A. Ahmed, A. Wood, and T.J. Mabry Nat. Prod. Lett. 10 1997 313 317
13. B. Jakob, G. Voss, and H. Gerlach Tetrahedron: Asymmetry 7 1996 3255 3262
14. V.U. Ahmad, and F.V. Mohammad J. Nat. Prod. 49 1986 523 527
15. The name of compound 12 reported as 30-nor-lup-3β-ol-20-one in reference 14 has been cited as to 3β-hydroxy-29-nor-lup-3β-ol-20-one
16. V.S.P. Chaturvedula, Z. Gao, S.M. Hecht, S.H. Jones, and D.G.I. Kingston J. Nat. Prod. 66 2003 1463 1465